UA48940C2 - Рекомбінатні il4 антитіла, які використовуються для лікування il4-опосередкованих порушень - Google Patents

Рекомбінатні il4 антитіла, які використовуються для лікування il4-опосередкованих порушень

Info

Publication number
UA48940C2
UA48940C2 UA96041300A UA96041300A UA48940C2 UA 48940 C2 UA48940 C2 UA 48940C2 UA 96041300 A UA96041300 A UA 96041300A UA 96041300 A UA96041300 A UA 96041300A UA 48940 C2 UA48940 C2 UA 48940C2
Authority
UA
Ukraine
Prior art keywords
treatment
mediated diseases
mabs used
mabs
humanized
Prior art date
Application number
UA96041300A
Other languages
English (en)
Russian (ru)
Inventor
Стефен Дадлі Холмс
Мітчел Стюарт Гросс
Деніел Р. Сільвестр
Original Assignee
Смітклайн Бічам Корпорейшн
Смитклайн Бичам Корпорейшн
Смітклайн Бічам Плс
Смитклайн Бичам Плс
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Смітклайн Бічам Корпорейшн, Смитклайн Бичам Корпорейшн, Смітклайн Бічам Плс, Смитклайн Бичам Плс filed Critical Смітклайн Бічам Корпорейшн
Publication of UA48940C2 publication Critical patent/UA48940C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/247—IL-4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869—Interleukin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Pulmonology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Описані химерні та гуманізовані моноклональні антитіла проти ІЛ-4, які є похідними високоафінних моноклональних антитіл, фармацевтичні композиції , що містять такі антитіла та способи лікування.
UA96041300A 1993-09-07 1994-09-07 Рекомбінатні il4 антитіла, які використовуються для лікування il4-опосередкованих порушень UA48940C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11736693A 1993-09-07 1993-09-07
US13678393A 1993-10-14 1993-10-14
PCT/US1994/010308 WO1995007301A1 (en) 1993-09-07 1994-09-07 Recombinant il4 antibodies useful in treatment of il4 mediated disorders

Publications (1)

Publication Number Publication Date
UA48940C2 true UA48940C2 (uk) 2002-09-16

Family

ID=26815208

Family Applications (1)

Application Number Title Priority Date Filing Date
UA96041300A UA48940C2 (uk) 1993-09-07 1994-09-07 Рекомбінатні il4 антитіла, які використовуються для лікування il4-опосередкованих порушень

Country Status (21)

Country Link
EP (1) EP0730609B1 (uk)
JP (4) JPH09502708A (uk)
KR (1) KR100362340B1 (uk)
CN (2) CN1473854A (uk)
AP (1) AP583A (uk)
AT (1) ATE286510T1 (uk)
AU (1) AU695726B2 (uk)
BG (1) BG63549B1 (uk)
BR (1) BR9407575A (uk)
CA (1) CA2171336C (uk)
CZ (1) CZ295928B6 (uk)
DE (1) DE69434223T2 (uk)
ES (1) ES2236693T3 (uk)
FI (1) FI119733B (uk)
HU (1) HU222041B1 (uk)
NO (1) NO960956L (uk)
NZ (1) NZ274338A (uk)
PL (1) PL180125B1 (uk)
SK (1) SK285556B6 (uk)
UA (1) UA48940C2 (uk)
WO (1) WO1995007301A1 (uk)

Families Citing this family (33)

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US7964192B1 (en) 1997-12-02 2011-06-21 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidgenic disease
US6761888B1 (en) 2000-05-26 2004-07-13 Neuralab Limited Passive immunization treatment of Alzheimer's disease
TWI239847B (en) 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
US20080050367A1 (en) 1998-04-07 2008-02-28 Guriq Basi Humanized antibodies that recognize beta amyloid peptide
US7790856B2 (en) 1998-04-07 2010-09-07 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
US7588766B1 (en) 2000-05-26 2009-09-15 Elan Pharma International Limited Treatment of amyloidogenic disease
US7700751B2 (en) 2000-12-06 2010-04-20 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize β-amyloid peptide
PE20020574A1 (es) 2000-12-06 2002-07-02 Wyeth Corp Anticuerpos humanizados que reconocen el peptido amiloideo beta
US6768004B2 (en) * 2001-01-11 2004-07-27 Mueller Sybille Nucleotide sequences encoding variable regions of heavy and light chains of monoclonal antibody 1F7, an anti-idiotypic antibody reactive with anti-HIV antibodies
MY139983A (en) 2002-03-12 2009-11-30 Janssen Alzheimer Immunotherap Humanized antibodies that recognize beta amyloid peptide
TWI374893B (en) * 2003-05-30 2012-10-21 Janssen Alzheimer Immunotherap Humanized antibodies that recognize beta amyloid peptide
ES2337473T3 (es) 2004-02-19 2010-04-26 Genentech, Inc. Anticuerpos reparadores con cdr.
PE20060560A1 (es) * 2004-08-03 2006-06-27 Novartis Ag Anticuerpos de interleucina-4 humana
TW200635607A (en) 2004-12-15 2006-10-16 Elan Pharm Inc Humanized Aβ antibodies for use in improving cognition
EP1838854B1 (en) 2004-12-15 2012-10-31 Janssen Alzheimer Immunotherapy Antibodies that recognize Beta Amyloid Peptide
CA2646626A1 (en) * 2006-03-22 2007-09-27 Apogenix Gmbh Antibody specific for human il-4 for the treatment of cancer
WO2009017467A1 (en) 2007-07-27 2009-02-05 Elan Pharma International Limited Treatment of amyloidogenic diseases
US8784810B2 (en) 2006-04-18 2014-07-22 Janssen Alzheimer Immunotherapy Treatment of amyloidogenic diseases
ES2371287T3 (es) 2006-06-21 2011-12-29 Apogenix Gmbh Expresión diferencial de la citocina en cáncer humano.
US8003097B2 (en) 2007-04-18 2011-08-23 Janssen Alzheimer Immunotherapy Treatment of cerebral amyloid angiopathy
JP4971872B2 (ja) 2007-05-23 2012-07-11 株式会社トプコン 眼底観察装置及びそれを制御するプログラム
EP2050764A1 (en) 2007-10-15 2009-04-22 sanofi-aventis Novel polyvalent bispecific antibody format and uses thereof
JO3076B1 (ar) 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap نظم العلاج المناعي المعتمد على حالة apoe
JP5324839B2 (ja) 2008-06-19 2013-10-23 株式会社トプコン 光画像計測装置
US9067981B1 (en) 2008-10-30 2015-06-30 Janssen Sciences Ireland Uc Hybrid amyloid-beta antibodies
CN102294024B (zh) * 2011-01-17 2013-03-13 广东现代农业集团研究院有限公司 一种多肽疫苗及其制备方法
CN107614762B (zh) * 2015-02-24 2022-08-05 台湾地区“中央研究院” 一种由噬菌体表达的单链变异片段抗体库
MA60122B1 (fr) * 2020-06-26 2025-07-31 Bioarctic Ab Anticorps se liant à la protofibrille d'alpha-synucléine
CN114773466B (zh) * 2020-11-26 2023-08-29 江苏荃信生物医药股份有限公司 一种抗人白介素23及包含其的试剂盒及其检测方法
CN112646040B (zh) * 2020-12-31 2022-03-25 中元汇吉生物技术股份有限公司 特异性结合人IgG4的蛋白及其应用
CN119998316A (zh) * 2022-03-03 2025-05-13 辉瑞大药厂 多特异性抗体及其用途
JP2025036273A (ja) * 2023-08-30 2025-03-14 ファイザー・インク 多重特異性抗体およびその使用
WO2025076048A1 (en) * 2023-10-02 2025-04-10 Fred Hutchinson Cancer Center Anti-cd90 antibodies, binding fragments, and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
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US5041381A (en) * 1986-07-03 1991-08-20 Schering Corporation Monoclonal antibodies against human interleukin-4 and hybridomas producing the same
JP2646007B2 (ja) * 1988-01-30 1997-08-25 財団法人 化学及血清療法研究所 抗ｈｉｖ抗体可変領域をコードする遺伝子断片およびこれらを用いて発現された抗ｈｉｖキメラ抗体ならびにその製法
EP0365209A3 (en) * 1988-10-17 1990-07-25 Becton, Dickinson and Company Anti-leu 3a amino acid sequence
IL162181A (en) * 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
JPH07119238B2 (ja) * 1989-12-18 1995-12-20 小野薬品工業株式会社 ヒトインターロイキン―４に対するモノクローナル抗体および該抗体の利用方法
CA2071908C (en) * 1989-12-20 2002-04-30 Lata Ramanathan Antibody antagonists of human interleukin-4
JPH04141095A (ja) * 1990-10-02 1992-05-14 Chemo Sero Therapeut Res Inst 組換え抗ｈｉｖ改変抗体および改変抗体の調製方法
JPH07502901A (ja) * 1992-02-19 1995-03-30 シェリング・コーポレーション ヒトインターロイキン−４に対するヒト化モノクローナル抗体のクローニング及び発現
JPH06269663A (ja) * 1993-03-17 1994-09-27 Toyobo Co Ltd Ｃｄ４陽性細胞捕集材
WO2001009059A1 (en) * 1999-07-30 2001-02-08 Battelle Memorial Institute Glass-ceramic joining material and method of joining

Also Published As

Publication number Publication date
ES2236693T3 (es) 2005-07-16
DE69434223T2 (de) 2005-12-22
HUT75833A (en) 1997-05-28
JP2006333870A (ja) 2006-12-14
KR100362340B1 (ko) 2003-02-26
FI961083L (fi) 1996-05-06
SK285556B6 (sk) 2007-03-01
DE69434223D1 (de) 2005-02-10
BG100480A (bg) 1996-12-31
FI961083A0 (fi) 1996-03-07
CN1473854A (zh) 2004-02-11
HU222041B1 (hu) 2003-04-28
JP2009191077A (ja) 2009-08-27
AP583A (en) 1997-04-14
CZ69896A3 (en) 1996-10-16
CZ295928B6 (cs) 2005-12-14
CN1105728C (zh) 2003-04-16
CN1133599A (zh) 1996-10-16
AU695726B2 (en) 1998-08-20
FI119733B (fi) 2009-02-27
AP9600782A0 (en) 1996-04-30
PL180125B1 (pl) 2000-12-29
SK33396A3 (en) 1996-10-02
JP2007045831A (ja) 2007-02-22
BR9407575A (pt) 1996-07-16
NO960956L (no) 1996-05-06
NO960956D0 (no) 1996-03-07
ATE286510T1 (de) 2005-01-15
WO1995007301A1 (en) 1995-03-16
EP0730609B1 (en) 2005-01-05
CA2171336A1 (en) 1995-03-16
AU7834094A (en) 1995-03-27
EP0730609A1 (en) 1996-09-11
CA2171336C (en) 2011-06-21
JPH09502708A (ja) 1997-03-18
NZ274338A (en) 1998-02-26
EP0730609A4 (en) 2000-05-10
PL313491A1 (en) 1996-07-08
BG63549B1 (bg) 2002-04-30
HU9600616D0 (en) 1996-05-28

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