UA45948C2 - Спосіб лікування та/або профілактики протозойної паразитарної інфекції та комбінація атовакуону та прогуанілу, що застосовується в ньому - Google Patents
Спосіб лікування та/або профілактики протозойної паразитарної інфекції та комбінація атовакуону та прогуанілу, що застосовується в ньому Download PDFInfo
- Publication number
- UA45948C2 UA45948C2 UA95058430A UA95058430A UA45948C2 UA 45948 C2 UA45948 C2 UA 45948C2 UA 95058430 A UA95058430 A UA 95058430A UA 95058430 A UA95058430 A UA 95058430A UA 45948 C2 UA45948 C2 UA 45948C2
- Authority
- UA
- Ukraine
- Prior art keywords
- proguanil
- fact
- chlorophenyl
- naphthoquinone
- cyclohexyl
- Prior art date
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- 238000011282 treatment Methods 0.000 title claims abstract description 17
- 208000030852 Parasitic disease Diseases 0.000 title claims abstract 7
- 229960005385 proguanil Drugs 0.000 title claims description 49
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- 208000015181 infectious disease Diseases 0.000 claims abstract description 14
- 201000004792 malaria Diseases 0.000 claims abstract description 14
- IOTAOYHKWICOBK-UHFFFAOYSA-N 1-[amino-(4-chloroanilino)methylidene]-2-propan-2-ylguanidine;3-[4-(4-chlorophenyl)cyclohexyl]-4-hydroxynaphthalene-1,2-dione;hydrochloride Chemical compound Cl.CC(C)N=C(N)\N=C(/N)NC1=CC=C(Cl)C=C1.O=C1C(=O)C2=CC=CC=C2C(O)=C1C(CC1)CCC1C1=CC=C(Cl)C=C1 IOTAOYHKWICOBK-UHFFFAOYSA-N 0.000 claims abstract description 12
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- 229910052708 sodium Inorganic materials 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 1
- 229940001584 sodium metabisulfite Drugs 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- NVSDADJBGGUCLP-UHFFFAOYSA-N trisulfur Chemical compound S=S=S NVSDADJBGGUCLP-UHFFFAOYSA-N 0.000 description 1
- 235000013522 vodka Nutrition 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929224739A GB9224739D0 (en) | 1992-11-26 | 1992-11-26 | Medicaments |
| PCT/GB1993/002425 WO1994012164A1 (en) | 1992-11-26 | 1993-11-25 | Combination of atovaquone with proguanil for the treatment of protozoal infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA45948C2 true UA45948C2 (uk) | 2002-05-15 |
Family
ID=10725687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA95058430A UA45948C2 (uk) | 1992-11-26 | 1993-11-25 | Спосіб лікування та/або профілактики протозойної паразитарної інфекції та комбінація атовакуону та прогуанілу, що застосовується в ньому |
Country Status (38)
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9224739D0 (en) * | 1992-11-26 | 1993-01-13 | Wellcome Found | Medicaments |
| GB9424013D0 (en) * | 1994-11-29 | 1995-01-18 | Wellcome Found | Medicaments |
| DE19737463A1 (de) * | 1997-08-28 | 1999-03-04 | Hoechst Marion Roussel De Gmbh | Verwendung von Inhibitoren des Natrium-Wasserstoff-Austauschers zur Herstellung eines Arzneimittels zur Behandlung von Erkrankungen, die durch Protozoen verursacht werden |
| GB9822681D0 (en) * | 1998-10-16 | 1998-12-09 | Vitabiotics Ltd | Method of treatment |
| CN1152676C (zh) * | 1999-04-09 | 2004-06-09 | 葛兰素集团有限公司 | 治疗疟疾的组合物制剂 |
| US7104076B2 (en) * | 2004-06-24 | 2006-09-12 | Carrier Corporation | Lubricant return schemes for use in refrigerant cycle |
| ITMI20070941A1 (it) * | 2007-05-09 | 2008-11-10 | Chimico Internazi0Nale S P A L | Procedimento per la preparazione di naftochinoni trans2,3-disostituiti |
| WO2011021230A2 (en) * | 2009-08-20 | 2011-02-24 | Ipca Laboratories Limited | Novel complex for treatment and/or prophylaxis of parasitic infections |
| US20180055835A1 (en) | 2016-08-25 | 2018-03-01 | Immune Therapeutics Inc. | Method for Treating And Preventing Protozoal Infections |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2533648A (en) * | 1949-03-05 | 1950-12-12 | Joseph H Warburg | Circular saw making |
| NL6411993A (US07224749-20070529-P00002.png) * | 1963-10-18 | 1965-04-20 | ||
| US3347830A (en) * | 1964-07-30 | 1967-10-17 | Grace W R & Co | Process of polymerizing formaldehyde |
| GB1141735A (en) * | 1966-11-23 | 1969-01-29 | Pfizer & Co C | Pharmaceutical anti-tumor composition |
| NL6817526A (US07224749-20070529-P00002.png) * | 1968-01-24 | 1969-07-28 | ||
| US3655699A (en) * | 1970-03-02 | 1972-04-11 | Pfizer | Analogues of lapachol as antitumor agents |
| DE2601458A1 (de) * | 1975-01-20 | 1976-07-22 | Ciba Geigy Ag | Loesliche, von phenylindandiaminen abgeleitete polyamide |
| JPS5492945A (en) * | 1977-11-22 | 1979-07-23 | Wellcome Found | Naphthoquinone derivative |
| US4485117A (en) * | 1981-10-16 | 1984-11-27 | Hudson Alan T | Antiprotozoal compounds |
| US4485116A (en) * | 1981-10-16 | 1984-11-27 | Hudson Alan T | Antiprotozoal compounds |
| GB8310140D0 (en) * | 1983-04-14 | 1983-05-18 | Wellcome Found | Antiprotozoal agents |
| GB8310141D0 (en) * | 1983-04-14 | 1983-05-18 | Wellcome Found | Naphthoquinone derivatives |
| US5053432A (en) * | 1983-04-14 | 1991-10-01 | Burroughs Wellcome Co. | Naphthoquinone derivatives |
| JPS59196467A (ja) * | 1983-04-23 | 1984-11-07 | Nissan Motor Co Ltd | 車輪速及びまたは車輪加減速度検出方法 |
| US5206268A (en) * | 1988-08-16 | 1993-04-27 | Burroughs Wellcome Co. | Medicaments |
| IL91308A (en) * | 1988-08-16 | 1994-07-31 | Wellcome Found | Pharmaceutical preparations containing naphthokinone for the treatment and / or prevention of radiation-induced pneumocystis |
| GB8819477D0 (en) * | 1988-08-16 | 1988-09-21 | Wellcome Found | Medicaments |
| US5225184A (en) * | 1988-08-16 | 1993-07-06 | Burroughs Wellcome Co. | Medicaments |
| GB8921516D0 (en) * | 1989-09-22 | 1989-11-08 | Wellcome Found | Medicaments |
| GB8923254D0 (en) * | 1989-10-16 | 1989-12-06 | Wellcome Found | Medicaments |
| US5014737A (en) * | 1989-11-13 | 1991-05-14 | Allan Berman | Quartz integrated trough/sump recirculating filtered high-purity chemical bath |
| GB9121316D0 (en) * | 1991-10-09 | 1991-11-20 | Wellcome Found | Heterocyclic compounds |
| GB9224739D0 (en) * | 1992-11-26 | 1993-01-13 | Wellcome Found | Medicaments |
| GB9226905D0 (en) * | 1992-12-24 | 1993-02-17 | Wellcome Found | Pharmaceutical preparation |
| RU2121838C1 (ru) * | 1993-05-05 | 1998-11-20 | Пало Альто Медикал Фаундейшн | Способ снижения тяжести токсоплазмоза, фармацевтическая композиция, применение производных рифамицина для получения лекарственных препаратов для лечения токсоплазмоза |
| US5529994A (en) * | 1993-05-05 | 1996-06-25 | Palo Alto Medical Foundation | Treatment for toxoplasmosis |
| US5733932A (en) * | 1995-01-06 | 1998-03-31 | The Picower Institute For Medical Research | Compounds and methods of use to derivatize neighboring lysine residues in proteins under physiological conditions |
| US5827543A (en) * | 1995-12-07 | 1998-10-27 | The Procter & Gamble Company | Methods and compositions for the prevention and treatment of urogenital disorders |
| US5744168A (en) * | 1995-12-07 | 1998-04-28 | The Procter & Gamble Company | Methods and compositions for the prevention and treatment of gastrointestinal disorders |
| US5747476A (en) * | 1996-07-17 | 1998-05-05 | Mortar & Pestle Veterinary Pharmacy, Inc. | Treatment of equine protozoal myeloencephalitis |
| ZA983331B (en) * | 1997-05-01 | 1998-10-27 | Allegheny University Of The He | Method for treating protozoal infections |
| AUPO821097A0 (en) * | 1997-07-25 | 1997-08-14 | Cultor Ltd. | A prophylactic |
| DE19737463A1 (de) * | 1997-08-28 | 1999-03-04 | Hoechst Marion Roussel De Gmbh | Verwendung von Inhibitoren des Natrium-Wasserstoff-Austauschers zur Herstellung eines Arzneimittels zur Behandlung von Erkrankungen, die durch Protozoen verursacht werden |
| CN1152676C (zh) * | 1999-04-09 | 2004-06-09 | 葛兰素集团有限公司 | 治疗疟疾的组合物制剂 |
-
1992
- 1992-11-26 GB GB929224739A patent/GB9224739D0/en active Pending
-
1993
- 1993-11-25 CZ CZ19951192A patent/CZ289171B6/cs not_active IP Right Cessation
- 1993-11-25 RO RO95-00963A patent/RO119280B1/ro unknown
- 1993-11-25 EP EP94900254A patent/EP0670719B1/en not_active Expired - Lifetime
- 1993-11-25 KR KR1019950702071A patent/KR100294802B1/ko not_active IP Right Cessation
- 1993-11-25 TW TW082109940A patent/TW253835B/zh not_active IP Right Cessation
- 1993-11-25 WO PCT/GB1993/002425 patent/WO1994012164A1/en active IP Right Grant
- 1993-11-25 HU HU9501537A patent/HU225918B1/hu unknown
- 1993-11-25 DK DK94900254T patent/DK0670719T3/da active
- 1993-11-25 SK SK570-95A patent/SK281559B6/sk not_active IP Right Cessation
- 1993-11-25 AP APAP/P/1993/000592A patent/AP517A/en active
- 1993-11-25 CA CA002150234A patent/CA2150234E/en not_active Expired - Lifetime
- 1993-11-25 CN CN93114723A patent/CN1087935C/zh not_active Expired - Lifetime
- 1993-11-25 SI SI9300614A patent/SI9300614A/sl unknown
- 1993-11-25 SG SG1996005505A patent/SG45387A1/en unknown
- 1993-11-25 AU AU55322/94A patent/AU685408B2/en not_active Expired
- 1993-11-25 PL PL93309222A patent/PL174323B1/pl unknown
- 1993-11-25 DE DE69328307T patent/DE69328307T2/de not_active Expired - Lifetime
- 1993-11-25 PE PE1993231837A patent/PE55694A1/es not_active IP Right Cessation
- 1993-11-25 ZA ZA938832A patent/ZA938832B/xx unknown
- 1993-11-25 MY MYPI93002479A patent/MY114241A/en unknown
- 1993-11-25 RU RU95113501A patent/RU2108092C1/ru active
- 1993-11-25 PT PT94900254T patent/PT670719E/pt unknown
- 1993-11-25 AT AT94900254T patent/ATE191340T1/de active
- 1993-11-25 IL IL10775593A patent/IL107755A/xx not_active IP Right Cessation
- 1993-11-25 UA UA95058430A patent/UA45948C2/uk unknown
- 1993-11-25 NZ NZ257901A patent/NZ257901A/en not_active IP Right Cessation
- 1993-11-25 ES ES94900254T patent/ES2145114T3/es not_active Expired - Lifetime
- 1993-11-25 MX MX9307402A patent/MX9307402A/es unknown
- 1993-11-25 JP JP51291494A patent/JP3768231B2/ja not_active Expired - Lifetime
- 1993-12-22 SA SA93140434A patent/SA93140434B1/ar unknown
-
1995
- 1995-05-19 NO NO19951995A patent/NO313225B1/no not_active IP Right Cessation
- 1995-05-22 BG BG99656A patent/BG62595B1/bg unknown
- 1995-05-26 OA OA60668A patent/OA10352A/en unknown
-
1997
- 1997-10-31 US US08/962,273 patent/US5998449A/en not_active Expired - Lifetime
-
1998
- 1998-04-23 HK HK98103412A patent/HK1004468A1/xx not_active IP Right Cessation
-
1999
- 1999-03-09 CZ CZ1999805A patent/CZ289692B6/cs not_active IP Right Cessation
- 1999-10-01 US US09/409,871 patent/US6166046A/en not_active Expired - Lifetime
-
2000
- 2000-06-22 GR GR20000401440T patent/GR3033745T3/el unknown
- 2000-08-29 CY CY0000044A patent/CY2193B1/xx unknown
- 2000-10-04 US US09/678,485 patent/US6291488B1/en not_active Expired - Lifetime
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