UA43362C2 - Спосіб діастереоселективного синтезу аналогів нуклеозиду та саліцилати, одержані за цим способом - Google Patents
Спосіб діастереоселективного синтезу аналогів нуклеозиду та саліцилати, одержані за цим способомInfo
- Publication number
- UA43362C2 UA43362C2 UA96103961A UA96103961A UA43362C2 UA 43362 C2 UA43362 C2 UA 43362C2 UA 96103961 A UA96103961 A UA 96103961A UA 96103961 A UA96103961 A UA 96103961A UA 43362 C2 UA43362 C2 UA 43362C2
- Authority
- UA
- Ukraine
- Prior art keywords
- inlet
- outlet
- water
- purification
- nucleoside analogues
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Treatment Of Water By Oxidation Or Reduction (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Винахід відноситься до технології обробки води, зокрема, до установки для очищення води методом фільтрації, сорбції та озонування, яка може бути застосована для очищення як питної, так і стічної води. Установка містить фільтр механічної обробки води, вхід якого через подавальний трубопровід з’єднано з пристроєм осушки повітря, а вихід – з входом резервуару вихідної води. Вхід пристрою осушки повітря з’єднано з компресором, а вихід – з входом озонаторного агрегата, який з’єднано з ежекційним змішувачем та контактною колоною, яка паралельно з’єднана з пристроєм вторинного озонування. Пристрій вторинного озонування розташовано в резервуарі чистої води, до якого приєднано адсорбер залишкового озону. Вихід фільтра механічного очищення води з’єднано з входом ежекційного змішувача. Установка дає змогу зекономити енерговтрати на генерування озону, покращити якість очищуваної води та спростити конструкцію.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9408112A GB9408112D0 (en) | 1994-04-23 | 1994-04-23 | Process |
GB9408103A GB9408103D0 (en) | 1994-04-23 | 1994-04-23 | Chemical compounds |
GB9408091A GB9408091D0 (en) | 1994-04-23 | 1994-04-23 | Process |
PCT/EP1995/001503 WO1995029174A1 (en) | 1994-04-23 | 1995-04-21 | Process for the diastereoselective synthesis of nucleoside analogues |
Publications (1)
Publication Number | Publication Date |
---|---|
UA43362C2 true UA43362C2 (uk) | 2001-12-17 |
Family
ID=27267157
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA96103961A UA43362C2 (uk) | 1994-04-23 | 1995-04-21 | Спосіб діастереоселективного синтезу аналогів нуклеозиду та саліцилати, одержані за цим способом |
Country Status (30)
Country | Link |
---|---|
US (2) | US6051709A (uk) |
EP (1) | EP0757684B1 (uk) |
JP (2) | JP4056558B2 (uk) |
KR (1) | KR100241842B1 (uk) |
CN (2) | CN1290841C (uk) |
AP (1) | AP704A (uk) |
AT (1) | ATE181326T1 (uk) |
AU (1) | AU696612B2 (uk) |
BG (1) | BG62810B1 (uk) |
BR (1) | BR9507499A (uk) |
CZ (1) | CZ293827B6 (uk) |
DE (1) | DE69510347T2 (uk) |
DK (1) | DK0757684T3 (uk) |
EE (1) | EE03442B1 (uk) |
ES (1) | ES2133769T3 (uk) |
FI (1) | FI120401B (uk) |
GR (1) | GR3031043T3 (uk) |
HK (1) | HK1004221A1 (uk) |
HU (1) | HU218044B (uk) |
IL (1) | IL113432A (uk) |
IS (1) | IS1844B (uk) |
NO (2) | NO307179B1 (uk) |
NZ (1) | NZ285396A (uk) |
PL (1) | PL180090B1 (uk) |
RO (2) | RO117916B1 (uk) |
RU (1) | RU2158736C2 (uk) |
SK (1) | SK281327B6 (uk) |
TW (1) | TW487704B (uk) |
UA (1) | UA43362C2 (uk) |
WO (1) | WO1995029174A1 (uk) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5684164A (en) * | 1988-04-11 | 1997-11-04 | Biochem Pharma Inc. | Processes for preparing substituted 1,3-oxathiolanes with antiviral properties |
IL113432A (en) * | 1994-04-23 | 2000-11-21 | Glaxo Group Ltd | Process for the diastereoselective synthesis of nucleoside analogues |
WO1996012716A1 (en) * | 1994-10-22 | 1996-05-02 | Chong Kun Dang Corp. | Nucleoside derivatives and process for preparing thereof |
GB9506644D0 (en) * | 1995-03-31 | 1995-05-24 | Wellcome Found | Preparation of nucleoside analogues |
US6113920A (en) * | 1996-10-31 | 2000-09-05 | Glaxo Wellcome Inc. | Pharmaceutical compositions |
KR101208429B1 (ko) * | 1998-08-12 | 2012-12-05 | 길리애드 사이언시즈, 인코포레이티드 | 1,3-옥사티올란 뉴클레오시드의 제조 방법 |
GB9820417D0 (en) * | 1998-09-18 | 1998-11-11 | Glaxo Group Ltd | Antiviral combinations |
US6432966B2 (en) | 1999-10-29 | 2002-08-13 | Smithkline Beecham Corporation | Antiviral combinations |
KR20040002871A (ko) | 2001-03-01 | 2004-01-07 | 트라이앵글 파마슈티칼스 인코포레이티드 | 시스-ftc의 다형 및 기타 결정형 |
CA2351049C (en) | 2001-06-18 | 2007-03-13 | Brantford Chemicals Inc. | Process for recovery of the desired cis-1,3-oxathiolane nucleosides from their undesired trans-isomers |
WO2003027106A1 (en) * | 2001-09-25 | 2003-04-03 | Cadila Healthcar Limited | Process for the preparation of crystalline polymorph ii of lamivudine |
ITMI20030578A1 (it) * | 2003-03-24 | 2004-09-25 | Clariant Lsm Italia Spa | Processo ed intermedi per la preparazione di emtricitabina |
US20050187913A1 (en) | 2003-05-06 | 2005-08-25 | Yoram Nelken | Web-based customer service interface |
CN101307048B (zh) | 2007-05-18 | 2011-03-23 | 上海迪赛诺医药发展有限公司 | 立体选择性制备拉米夫定的方法 |
US20100190982A1 (en) * | 2007-09-17 | 2010-07-29 | Janardhana Rao Vascuri | Process for the preparation of lamivudine form i |
EP2048151A1 (en) * | 2007-10-10 | 2009-04-15 | Cilag AG | Method for producing nucleosides by direct glycosylation of the nucleoside base |
BRPI0820226A2 (pt) | 2007-11-29 | 2015-06-16 | Ranbaxy Lab Ltd | Processo para o preparo de um 1,3-oxatiolana, para o preparo de lamivudina e para isolar lamivudina, lamivudina e composição farmacêutica |
EP2227465A1 (en) * | 2007-11-29 | 2010-09-15 | Ranbaxy Laboratories Limited | Crystalline form i of lamivudine and its preparation |
WO2009069012A1 (en) * | 2007-11-29 | 2009-06-04 | Ranbaxy Laboratories Limited | Process and intermediates for the preparation of substituted 1, 3-oxathiolanes, especially lamivudine |
US8350030B2 (en) * | 2007-12-07 | 2013-01-08 | Matrix Laboratories Limited | Process for producing 5-fluoro-1-(2R, 5S)-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine |
CN101391997B (zh) * | 2008-09-18 | 2010-12-22 | 江苏科本医药化学有限公司 | 一种恩曲他滨中间体的合成方法 |
CN101362752B (zh) * | 2008-09-18 | 2011-12-28 | 浙江教育学院 | 一种拉米夫定中间体的合成方法 |
US20110282046A1 (en) | 2009-01-19 | 2011-11-17 | Rama Shankar | Process for preparation of cis-nucleoside derivative |
KR101474570B1 (ko) | 2009-04-13 | 2014-12-19 | 주식회사 대희화학 | 라미부딘의 신규한 중간체 및 이의 제조방법 |
CN101544632B (zh) * | 2009-04-24 | 2011-09-07 | 湖南千金湘江药业股份有限公司 | 拉米夫定非对映选择合成方法 |
WO2011045815A2 (en) | 2009-10-14 | 2011-04-21 | Matrix Laboratories Ltd. | Process for the preparation of lamivudine and novel salts in the manufacture thereof |
KR101883750B1 (ko) | 2010-01-27 | 2018-07-31 | 비이브 헬쓰케어 컴퍼니 | 항바이러스 치료 |
WO2011095987A1 (en) | 2010-02-03 | 2011-08-11 | Matrix Laboratories Ltd. | Novel process for the preparation of cis-nucleoside derivative |
CN102167696B (zh) | 2010-02-25 | 2013-09-18 | 南京正大天晴制药有限公司 | 拉米夫定草酸盐及其制备方法 |
PL2542551T3 (pl) | 2010-03-04 | 2015-01-30 | Ranbaxy Laboratories Ltd | Sposób stereoselektywnego otrzymywania 5-fluoro-1-(2R,SS)-[2-(hydroksymetylo)-1,3-oksatiolan--5-ylo]cytozyny |
CN101830893A (zh) * | 2010-05-31 | 2010-09-15 | 安徽一帆香料有限公司 | 一种拉米夫定中间体hdms的合成制备工艺 |
CN102399213A (zh) * | 2010-09-08 | 2012-04-04 | 重庆医药工业研究院有限责任公司 | 拉米夫定单邻苯二甲酸盐及其合成方法 |
CN103221037A (zh) | 2010-11-12 | 2013-07-24 | 葛兰素惠尔康制造业私人有限公司 | 新药物组合物 |
WO2012137227A2 (en) | 2011-04-08 | 2012-10-11 | Laurus Labs Private Limited | Solid forms of antiretroviral compounds, process for the preparation and their pharmaceutical composition thereof |
CN102796088B (zh) * | 2012-05-21 | 2015-06-10 | 湖南千金湘江药业股份有限公司 | 一种拉米夫定的制备方法 |
CN103450166A (zh) * | 2012-05-31 | 2013-12-18 | 上海迪赛诺药业有限公司 | 制备核苷化合物的方法 |
CN103864835A (zh) * | 2013-03-26 | 2014-06-18 | 安徽贝克联合制药有限公司 | 一种提高拉米夫定中间体立体选择性制备方法 |
CN103288806A (zh) * | 2013-07-02 | 2013-09-11 | 山东大学 | 一种曲沙他滨的合成方法 |
CN103694231A (zh) * | 2013-11-28 | 2014-04-02 | 安徽一帆香料有限公司 | 一种拉米夫定中间体hdms的合成制备方法 |
US9571109B2 (en) * | 2015-03-27 | 2017-02-14 | International Business Machines Corporation | Voltage controlled oscillator runaway prevention |
CN106146481A (zh) * | 2015-04-07 | 2016-11-23 | 江苏普信制药有限公司 | 一种核苷类似物的制备方法 |
CN105037340B (zh) * | 2015-07-14 | 2018-08-10 | 福建广生堂药业股份有限公司 | 一种拉米夫定关键中间体手性异构体杂质的制备方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5047407A (en) * | 1989-02-08 | 1991-09-10 | Iaf Biochem International, Inc. | 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties |
US5466806A (en) * | 1989-02-08 | 1995-11-14 | Biochem Pharma Inc. | Processes for preparing substituted 1,3-oxathiolanes with antiviral properties |
US5684164A (en) * | 1988-04-11 | 1997-11-04 | Biochem Pharma Inc. | Processes for preparing substituted 1,3-oxathiolanes with antiviral properties |
JP3160291B2 (ja) * | 1989-02-08 | 2001-04-25 | バイオケム ファーマ インコーポレイテッド | 抗ウイルス特性を有する置換1,3‐オキサチオランを調製する方法 |
US5204466A (en) * | 1990-02-01 | 1993-04-20 | Emory University | Method and compositions for the synthesis of bch-189 and related compounds |
GB9009861D0 (en) * | 1990-05-02 | 1990-06-27 | Glaxo Group Ltd | Chemical compounds |
US5587480A (en) * | 1990-11-13 | 1996-12-24 | Biochem Pharma, Inc. | Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties |
IL100502A (en) * | 1991-01-03 | 1995-12-08 | Iaf Biochem Int | PHARMACEUTICAL PREPARATIONS CONTAINING CIS-4-AMINO-1-) 2-HYDROXIMETHIL-1,3-OXETYOLEN-5-IL (- |
CZ285232B6 (cs) | 1991-05-16 | 1999-06-16 | Glaxo Group Limited | Protivirové směsi |
GB9110874D0 (en) * | 1991-05-20 | 1991-07-10 | Iaf Biochem Int | Medicaments |
ZA923641B (en) * | 1991-05-21 | 1993-02-24 | Iaf Biochem Int | Processes for the diastereoselective synthesis of nucleosides |
GB9116601D0 (en) * | 1991-08-01 | 1991-09-18 | Iaf Biochem Int | 1,3-oxathiolane nucleoside analogues |
IL113432A (en) * | 1994-04-23 | 2000-11-21 | Glaxo Group Ltd | Process for the diastereoselective synthesis of nucleoside analogues |
-
1995
- 1995-04-20 IL IL11343295A patent/IL113432A/xx not_active IP Right Cessation
- 1995-04-21 RO RO96-02034A patent/RO117916B1/ro unknown
- 1995-04-21 KR KR1019960705918A patent/KR100241842B1/ko not_active IP Right Cessation
- 1995-04-21 DE DE69510347T patent/DE69510347T2/de not_active Expired - Lifetime
- 1995-04-21 EE EE9600134A patent/EE03442B1/xx unknown
- 1995-04-21 AP APAP/P/1996/000871A patent/AP704A/en active
- 1995-04-21 NZ NZ285396A patent/NZ285396A/xx not_active IP Right Cessation
- 1995-04-21 RO ROA200101248A patent/RO118714B1/ro unknown
- 1995-04-21 RU RU96122244/04A patent/RU2158736C2/ru active
- 1995-04-21 DK DK95918579T patent/DK0757684T3/da active
- 1995-04-21 SK SK1355-96A patent/SK281327B6/sk not_active IP Right Cessation
- 1995-04-21 WO PCT/EP1995/001503 patent/WO1995029174A1/en active IP Right Grant
- 1995-04-21 CZ CZ19963096A patent/CZ293827B6/cs not_active IP Right Cessation
- 1995-04-21 ES ES95918579T patent/ES2133769T3/es not_active Expired - Lifetime
- 1995-04-21 BR BR9507499A patent/BR9507499A/pt not_active Application Discontinuation
- 1995-04-21 PL PL95316904A patent/PL180090B1/pl unknown
- 1995-04-21 JP JP52734995A patent/JP4056558B2/ja not_active Expired - Lifetime
- 1995-04-21 CN CNB031452116A patent/CN1290841C/zh not_active Expired - Lifetime
- 1995-04-21 AU AU24471/95A patent/AU696612B2/en not_active Expired
- 1995-04-21 HU HU9602925A patent/HU218044B/hu unknown
- 1995-04-21 US US08/722,224 patent/US6051709A/en not_active Expired - Lifetime
- 1995-04-21 AT AT95918579T patent/ATE181326T1/de active
- 1995-04-21 UA UA96103961A patent/UA43362C2/uk unknown
- 1995-04-21 CN CNB95193466XA patent/CN1151146C/zh not_active Expired - Lifetime
- 1995-04-21 EP EP95918579A patent/EP0757684B1/en not_active Expired - Lifetime
- 1995-04-27 TW TW084104194A patent/TW487704B/zh not_active IP Right Cessation
-
1996
- 1996-09-27 IS IS4366A patent/IS1844B/is unknown
- 1996-10-16 BG BG100916A patent/BG62810B1/bg unknown
- 1996-10-22 FI FI964251A patent/FI120401B/fi not_active IP Right Cessation
- 1996-10-22 NO NO964487A patent/NO307179B1/no not_active IP Right Cessation
-
1998
- 1998-04-27 HK HK98103525A patent/HK1004221A1/xx not_active IP Right Cessation
-
1999
- 1999-06-23 US US09/338,493 patent/US6329522B1/en not_active Expired - Lifetime
- 1999-08-19 GR GR990402121T patent/GR3031043T3/el unknown
- 1999-11-17 NO NO19995646A patent/NO313096B1/no not_active IP Right Cessation
-
2007
- 2007-05-16 JP JP2007130607A patent/JP2007217425A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
UA43362C2 (uk) | Спосіб діастереоселективного синтезу аналогів нуклеозиду та саліцилати, одержані за цим способом | |
CA2132931A1 (en) | Water decontaminating device | |
ATE69441T1 (de) | Wasseraufbereitungsgeraet. | |
RU2002111009A (ru) | Установка для озонирования воды и способ озонирования воды | |
UA24728C2 (uk) | Гірка настоянка "старка медова" | |
RU2158234C2 (ru) | Бытовой водоочиститель | |
UA41533A (uk) | Установка очищення питної води | |
SU1578084A1 (ru) | Устройство дл очистки и обеззараживани сточных вод | |
JPH07328660A (ja) | 浄水装置 | |
KR101398348B1 (ko) | 스컴 해소가 가능한 폐수 처리 장치 | |
RU2038317C1 (ru) | Способ обработки воды | |
RU90785U1 (ru) | Агрегат для очистки и обеззараживания питьевой воды | |
RU99115129A (ru) | Способ очистки воды и модульное устройство для его осуществления | |
JPH04293589A (ja) | 浄水及び滅菌水製造装置 | |
JP2949674B2 (ja) | プール水浄化装置 | |
JPH1177090A (ja) | 活性波動uv滅菌浄水装置 | |
KR200289280Y1 (ko) | 오존에 의한 상수도 정수처리장치 | |
RU94024593A (ru) | Способ получения особо чистой воды и устройство для его реализации | |
RU2021211C1 (ru) | Установка для очистки воды | |
RU2003103915A (ru) | Установка для очистки воды озонированием | |
RU2233798C2 (ru) | Бактерицидный аппарат для обеззараживания воды на подводных обитаемых объектах | |
JP2002001338A (ja) | プール水浄化装置 | |
RU93054883A (ru) | Способ очистки водных потоков и устройство для его осуществления | |
KR950023602A (ko) | 정수용 오존발생장치 | |
RU4970U1 (ru) | Установка для очистки и обеззараживания воды |