PL2542551T3 - Sposób stereoselektywnego otrzymywania 5-fluoro-1-(2R,SS)-[2-(hydroksymetylo)-1,3-oksatiolan--5-ylo]cytozyny - Google Patents

Sposób stereoselektywnego otrzymywania 5-fluoro-1-(2R,SS)-[2-(hydroksymetylo)-1,3-oksatiolan--5-ylo]cytozyny

Info

Publication number
PL2542551T3
PL2542551T3 PL11713057T PL11713057T PL2542551T3 PL 2542551 T3 PL2542551 T3 PL 2542551T3 PL 11713057 T PL11713057 T PL 11713057T PL 11713057 T PL11713057 T PL 11713057T PL 2542551 T3 PL2542551 T3 PL 2542551T3
Authority
PL
Poland
Prior art keywords
oxathiolan
cytosine
hydroxymethyl
fluoro
stereoselective synthesis
Prior art date
Application number
PL11713057T
Other languages
English (en)
Inventor
Prakash Bhimaji Kshirsagar
Satish Manohar Bhoge
Santosh Richhariya
Kaptan Singh
Original Assignee
Ranbaxy Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Laboratories Ltd filed Critical Ranbaxy Laboratories Ltd
Publication of PL2542551T3 publication Critical patent/PL2542551T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL11713057T 2010-03-04 2011-02-25 Sposób stereoselektywnego otrzymywania 5-fluoro-1-(2R,SS)-[2-(hydroksymetylo)-1,3-oksatiolan--5-ylo]cytozyny PL2542551T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN489DE2010 2010-03-04
PCT/IB2011/050824 WO2011107920A1 (en) 2010-03-04 2011-02-25 A process for stereoselective synthesis of 5-fluoro-1-(2r,5s)-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
EP11713057.5A EP2542551B1 (en) 2010-03-04 2011-02-25 A process for stereoselective synthesis of 5-fluoro-1-(2r,5s)-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine

Publications (1)

Publication Number Publication Date
PL2542551T3 true PL2542551T3 (pl) 2015-01-30

Family

ID=43904045

Family Applications (1)

Application Number Title Priority Date Filing Date
PL11713057T PL2542551T3 (pl) 2010-03-04 2011-02-25 Sposób stereoselektywnego otrzymywania 5-fluoro-1-(2R,SS)-[2-(hydroksymetylo)-1,3-oksatiolan--5-ylo]cytozyny

Country Status (7)

Country Link
US (1) US8748604B2 (pl)
EP (1) EP2542551B1 (pl)
AU (1) AU2011222471B2 (pl)
CA (1) CA2792044A1 (pl)
PL (1) PL2542551T3 (pl)
WO (1) WO2011107920A1 (pl)
ZA (1) ZA201207419B (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102516078B (zh) * 2011-12-31 2014-06-04 浙江先锋科技有限公司 乙醛酸l-薄荷醇酯及其一水合物的制备方法
CN105585564A (zh) * 2014-11-18 2016-05-18 正大天晴药业集团股份有限公司 恩曲他滨的纯化方法
CN105130972B (zh) * 2015-08-04 2018-04-20 中孚药业股份有限公司 苯甲酸恩曲他滨盐、其制备方法以及用苯甲酸恩曲他滨盐制备恩曲他滨的方法
GB201610327D0 (en) * 2016-06-14 2016-07-27 Univ Nelson Mandela Metropolitan Process for producing Lamivudine and Entricitabine
CN106187988A (zh) * 2016-07-28 2016-12-07 厦门市蔚嘉化学科技有限公司 一种制备恩曲他滨中间体的新工艺
CN106478618A (zh) * 2016-10-14 2017-03-08 上海礼泰医药科技有限公司 恩曲他滨氢卤酸盐的制备方法
CN106496208A (zh) * 2016-10-19 2017-03-15 上海博志研新药物技术有限公司 恩曲他滨的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA923640B (en) 1991-05-21 1993-02-24 Iaf Biochem Int Processes for the diastereoselective synthesis of nucleosides
IL113432A (en) 1994-04-23 2000-11-21 Glaxo Group Ltd Process for the diastereoselective synthesis of nucleoside analogues
ITMI20030578A1 (it) * 2003-03-24 2004-09-25 Clariant Lsm Italia Spa Processo ed intermedi per la preparazione di emtricitabina
WO2007077505A2 (en) * 2005-12-30 2007-07-12 Ranbaxy Laboratories Limited Crystalline l-menthyl (2r, 5s)-5-(4-amino-5-fluoro-2-oxo-2h-pyrimidin-1-yl)[1, 3]oxathiolan-2-carboxylate and process for preparation thereof
WO2009084033A2 (en) * 2007-12-07 2009-07-09 Matrix Laboratories Limited Process for producing 5-fluoro-1-(2r,5s)-[2-(hydroxymethyl)-1,3-oxathiolan-5-yi]cytosine

Also Published As

Publication number Publication date
AU2011222471A1 (en) 2012-09-27
EP2542551B1 (en) 2014-08-27
ZA201207419B (en) 2013-06-26
US20130072681A1 (en) 2013-03-21
CA2792044A1 (en) 2011-09-09
EP2542551A1 (en) 2013-01-09
US8748604B2 (en) 2014-06-10
AU2011222471B2 (en) 2014-07-31
WO2011107920A1 (en) 2011-09-09

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