UA120035C2 - Індукуючі апоптоз засоби для лікування злоякісної пухлини й імунологічних і аутоімунних захворювань - Google Patents

Індукуючі апоптоз засоби для лікування злоякісної пухлини й імунологічних і аутоімунних захворювань Download PDF

Info

Publication number
UA120035C2
UA120035C2 UAA201509683A UAA201509683A UA120035C2 UA 120035 C2 UA120035 C2 UA 120035C2 UA A201509683 A UAA201509683 A UA A201509683A UA A201509683 A UAA201509683 A UA A201509683A UA 120035 C2 UA120035 C2 UA 120035C2
Authority
UA
Ukraine
Prior art keywords
methyl
dimethylcyclohex
pyrrolo
yloxy
piperazin
Prior art date
Application number
UAA201509683A
Other languages
English (en)
Ukrainian (uk)
Inventor
Чжи-фу ТАО
Сілу Ван
Силу ВАН
Майкл Д. Уендт
Майкл Д. УЭНДТ
Ендрю Дж. Сауерс
Эндрю Дж. САУЭРС
Ендрю С. Джадд
Эндрю С. ДЖАДД
Аарон КАНЗЕР
Джерард Салліван
Джэрард Салливан
Original Assignee
Еббві Інк.
Эббви Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51529947&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA120035(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Еббві Інк., Эббви Инк. filed Critical Еббві Інк.
Publication of UA120035C2 publication Critical patent/UA120035C2/uk

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
UAA201509683A 2013-03-14 2014-02-21 Індукуючі апоптоз засоби для лікування злоякісної пухлини й імунологічних і аутоімунних захворювань UA120035C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361781070P 2013-03-14 2013-03-14
US14/176,506 US20140275082A1 (en) 2013-03-14 2014-02-10 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
PCT/US2014/017751 WO2014158528A1 (en) 2013-03-14 2014-02-21 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases

Publications (1)

Publication Number Publication Date
UA120035C2 true UA120035C2 (uk) 2019-09-25

Family

ID=51529947

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201509683A UA120035C2 (uk) 2013-03-14 2014-02-21 Індукуючі апоптоз засоби для лікування злоякісної пухлини й імунологічних і аутоімунних захворювань

Country Status (35)

Country Link
US (6) US20140275082A1 (enExample)
EP (2) EP3415514A1 (enExample)
JP (4) JP6449222B2 (enExample)
KR (2) KR20210021613A (enExample)
CN (2) CN105026394B (enExample)
AR (2) AR095263A1 (enExample)
AU (2) AU2014242104B2 (enExample)
BR (1) BR112015021115B1 (enExample)
CA (2) CA3110552A1 (enExample)
CL (2) CL2015002640A1 (enExample)
CR (1) CR20150510A (enExample)
CY (1) CY1120862T1 (enExample)
DK (1) DK2970257T3 (enExample)
DO (1) DOP2018000026A (enExample)
ES (1) ES2689679T3 (enExample)
GT (1) GT201500248A (enExample)
HR (1) HRP20181403T8 (enExample)
HU (1) HUE038983T2 (enExample)
IL (3) IL240010B (enExample)
LT (1) LT2970257T (enExample)
MX (2) MX360541B (enExample)
MY (1) MY178821A (enExample)
NZ (1) NZ631701A (enExample)
PE (2) PE20151555A1 (enExample)
PL (1) PL2970257T4 (enExample)
PT (1) PT2970257T (enExample)
RS (1) RS57750B1 (enExample)
RU (2) RU2662812C2 (enExample)
SG (2) SG10201908388UA (enExample)
SI (1) SI2970257T1 (enExample)
TW (2) TWI717662B (enExample)
UA (1) UA120035C2 (enExample)
UY (1) UY35406A (enExample)
WO (1) WO2014158528A1 (enExample)
ZA (1) ZA201505203B (enExample)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120156134A1 (en) 2007-12-20 2012-06-21 Shayne Squires Compositions and methods for detecting or eliminating senescent cells to diagnose or treat disease
WO2012177927A1 (en) 2011-06-21 2012-12-27 Mayo Foundation For Medical Education And Research Transgenic animals capable of being induced to delete senescent cells
CA2859385A1 (en) 2011-12-13 2013-06-20 Buck Institute For Research On Aging Methods for improving medical therapies
WO2013158664A2 (en) 2012-04-17 2013-10-24 Kythera Biopharmaceuticals, Inc. Use of engineered viruses to specifically kill senescent cells
US9901081B2 (en) 2012-08-23 2018-02-27 Buck Institute For Research On Aging Transgenic mouse for determining the role of senescent cells in cancer
US9901080B2 (en) 2012-08-23 2018-02-27 Buck Institute For Research On Aging Transgenic mouse having a transgene that converts a prodrug into a cytotoxic compound in senescent cells
US20140275082A1 (en) * 2013-03-14 2014-09-18 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
WO2014140075A1 (en) 2013-03-14 2014-09-18 Boehringer Ingelheim International Gmbh Substituted 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin c
PE20160685A1 (es) 2013-10-04 2016-07-23 Infinity Pharmaceuticals Inc Compuestos heterociclicos y usos de los mismos
US20170216286A1 (en) 2014-01-28 2017-08-03 Mayo Foundation For Medical Education And Research Killing senescent cells and treating senescence-associated conditions using a src inhibitor and a flavonoid
US20190269675A1 (en) 2014-01-28 2019-09-05 Buck Institute for Research and Aging Treatment of parkinson's disease and other conditions caused or mediated by senescent astrocytes using small molecule senolytic agents
US10328058B2 (en) 2014-01-28 2019-06-25 Mayo Foundation For Medical Education And Research Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques
IL311537A (en) 2014-01-28 2024-05-01 Mayo Found Medical Education & Res Methods and preparations for killing aging cells and for the treatment of diseases and disorders related to aging
CN113620958A (zh) 2014-03-19 2021-11-09 无限药品股份有限公司 用于治疗PI3K-γ介导的障碍的杂环化合物
CN108047240B (zh) 2014-09-12 2020-08-04 勃林格殷格翰国际有限公司 组织蛋白酶c的螺环化合物抑制剂
US9708348B2 (en) 2014-10-03 2017-07-18 Infinity Pharmaceuticals, Inc. Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
CN104370905B (zh) * 2014-10-22 2016-06-01 南京友杰医药科技有限公司 Bcl-2抑制剂ABT-199的合成
SG11201703262UA (en) 2014-10-24 2017-05-30 Hpvvax Llc Cancer and skin lesion treatment
US10799574B2 (en) 2014-10-24 2020-10-13 Hpvvax. Llc Method and composition for treating cancer or skin lesion using a vaccine
US10195213B2 (en) 2015-03-13 2019-02-05 Unity Biotechnology, Inc. Chemical entities that kill senescent cells for use in treating age-related disease
PH12018500554B1 (en) 2015-09-14 2024-01-24 Infinity Pharmaceuticals Inc Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same
EP3383891A1 (en) 2015-12-04 2018-10-10 Novartis AG Antibody cytokine engrafted compositions and methods of use for immunoregulation
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
CO2018009205A2 (es) * 2016-02-27 2018-09-20 Hpvvax Llc Método y composición para tratamiento del cáncer o una lesión de la piel utilizando una vacuna
WO2017161116A1 (en) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
WO2017214269A1 (en) 2016-06-08 2017-12-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CN109641897B (zh) * 2016-09-01 2021-12-07 北京赛林泰医药技术有限公司 Bcl-2选择性抑制剂及其制备和用途
EP3565815B1 (en) * 2017-01-07 2024-03-13 Fochon Pharmaceuticals, Ltd. Compounds as bcl-2-selective apoptosis-inducing agents
SI3612531T1 (sl) 2017-04-18 2022-11-30 Shanghai Fochon Pharmaceutical Co., Ltd. Sredstva, ki sprožajo apoptozo
CN110759908B (zh) * 2017-06-26 2021-03-12 深圳市塔吉瑞生物医药有限公司 用于抑制Bcl-2蛋白的N-苯磺酰基苯甲酰胺类化合物及其组合物及应用
SG11202005785XA (en) 2018-01-10 2020-07-29 Recurium Ip Holdings Llc Benzamide compounds
HUE071493T2 (hu) 2018-04-29 2025-09-28 Beigene Switzerland Gmbh Bcl-2 inhibitorok
CN110577525A (zh) * 2018-06-11 2019-12-17 北京万全德众医药生物技术有限公司 一种维奈妥拉中间体的制备方法
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
US12371431B2 (en) * 2018-10-29 2025-07-29 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Trifluoromethyl-substituted sulfonamide as BCL-2-selective inhibitor
US12319689B2 (en) * 2019-05-24 2025-06-03 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Methyl- and trifluoromethyl-containing disubstituted sulfonamide selective BCL-2 inhibitor
BR112022019525A2 (pt) 2020-04-15 2023-11-14 Beigene Ltd Composto, composição farmacêutica e método para tratar doenças apoptóticas desreguladas
CN114057728A (zh) * 2020-08-06 2022-02-18 北京诺诚健华医药科技有限公司 作为bcl-2抑制剂的杂环化合物
US20230301989A1 (en) * 2020-08-21 2023-09-28 Ascentage Pharma (Suzhou) Co., Ltd. Compositions and methods for treating systemic lupus erythematosus
WO2022161496A1 (en) * 2021-02-01 2022-08-04 Ascentage Pharma (Suzhou) Co., Ltd. Sulfonyl benzamide derivatives as bcl-2 inhibitors
CN113046433B (zh) * 2021-03-19 2022-12-02 武汉大学 细胞因子il1f9在制备检测、预防和治疗肿瘤的产品中的应用
CN115260191B (zh) * 2022-09-29 2022-12-27 上海睿跃生物科技有限公司 哌啶类化合物及其制备方法和应用

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY115155A (en) 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
BE1009856A5 (fr) 1995-07-14 1997-10-07 Sandoz Sa Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule.
PT1019385E (pt) 1995-09-15 2004-06-30 Upjohn Co N-oxidos de aminoaril-oxazolidinona
CN103275221B (zh) 1996-02-09 2016-08-17 艾伯维生物技术有限公司 结合人TNFα的人抗体
US20030220234A1 (en) 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
KR20010083092A (ko) 1998-07-06 2001-08-31 스티븐 비. 데이비스 이중 안지오텐신 엔도텔린 수용체 길항제로서의 비페닐술폰아미드
DE19913692A1 (de) 1999-03-25 2000-09-28 Basf Ag Mechanisch stabile pharmazeutische Darreichungsformen, enthaltend flüssige oder halbfeste oberflächenaktive Substanzen
DE19929361A1 (de) 1999-06-25 2001-01-04 Basf Ag Mechanisch stabile pharmazeutische Darreichungsformen, enthaltend flüssige oder halbfeste oberflächenaktive Substanzen
US20030236236A1 (en) 1999-06-30 2003-12-25 Feng-Jing Chen Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
GB9918037D0 (en) 1999-07-30 1999-09-29 Biochemie Gmbh Organic compounds
KR100641802B1 (ko) 1999-12-28 2006-11-02 에자이 가부시키가이샤 술폰아미드 함유 복소환 화합물
AR031130A1 (es) 2000-09-20 2003-09-10 Abbott Lab N-acilsulfonamidas promotoras de la apoptosis
US6720338B2 (en) 2000-09-20 2004-04-13 Abbott Laboratories N-acylsulfonamide apoptosis promoters
US20020055631A1 (en) 2000-09-20 2002-05-09 Augeri David J. N-acylsulfonamide apoptosis promoters
US6995162B2 (en) 2001-01-12 2006-02-07 Amgen Inc. Substituted alkylamine derivatives and methods of use
JP4167173B2 (ja) 2001-06-06 2008-10-15 イーライ リリー アンド カンパニー 抗腫瘍剤としての使用のためのベンゾイルスルホンアミドおよびスルホンベンズアミジン
GB0123400D0 (en) 2001-09-28 2001-11-21 Novartis Ag Organic compounds
KR20040086452A (ko) 2002-02-26 2004-10-08 아스트라제네카 아베 항암 화합물 zd1839의 신규한 결정질 형태
RU2318518C2 (ru) 2002-02-26 2008-03-10 Астразенека Аб Фармацевтическая композиция, обладающая антипролиферативным действием (варианты), способ ее получения и способы с ее использованием
FR2836914B1 (fr) 2002-03-11 2008-03-14 Aventis Pharma Sa Indazoles substitues, compositions les contenant, procede de fabrication et utilisation
JO2479B1 (en) 2002-04-29 2009-01-20 ميرك شارب اند دوم ليمتد Rates for the activity of the chemokine receptor of tetrahydrobranyl cycloneptil tetrahydrobredo predine
US7642260B2 (en) 2003-11-13 2010-01-05 Abbott Laboratories, Inc. Apoptosis promoters
US7767684B2 (en) 2003-11-13 2010-08-03 Abbott Laboratories Apoptosis promoters
US8614318B2 (en) 2003-11-13 2013-12-24 Abbvie Inc. Apoptosis promoters
US7973161B2 (en) 2003-11-13 2011-07-05 Abbott Laboratories Apoptosis promoters
WO2005049593A2 (en) 2003-11-13 2005-06-02 Abbott Laboratories N-acylsulfonamide apoptosis promoters
US7790190B2 (en) 2004-03-20 2010-09-07 Yasoo Health, Inc. Aqueous emulsions of lipophile solubilized with vitamin E TPGS and linoleic acid
US7307163B2 (en) 2004-04-19 2007-12-11 Symed Labs Limited Process for the preparation of linezolid and related compounds
PL1768967T3 (pl) 2004-07-20 2009-09-30 Symed Labs Ltd Nowe związki pośrednie do wytwarzania linezolidu oraz związki pokrewne
DE602005007048D1 (de) 2004-08-27 2008-07-03 Bayer Pharmaceuticals Corp Pharmazeutische zusammensetzungen in form fester dispersionen zur behandlung von krebs
US7511013B2 (en) 2004-09-29 2009-03-31 Amr Technology, Inc. Cyclosporin analogues and their pharmaceutical uses
FR2884821B1 (fr) * 2005-04-26 2007-07-06 Aventis Pharma Sa Pyrrolopyridines substitues, compositions les contenant, procede de fabrication et utilisation
US8624027B2 (en) 2005-05-12 2014-01-07 Abbvie Inc. Combination therapy for treating cancer and diagnostic assays for use therein
TWI337608B (en) 2005-05-12 2011-02-21 Abbott Lab Apoptosis promoters
BRPI0610828A2 (pt) 2005-05-16 2010-07-27 Irm Llc compostos e composições como inibidores de proteìna quinase
TW200716636A (en) 2005-05-31 2007-05-01 Speedel Experimenta Ag Heterocyclic spiro-compounds
DK2395004T3 (en) 2005-06-22 2016-03-21 Plexxikon Inc Pyrrolo [2,3-b] pyridine derivatives as protein kinase inhibitors
US7514068B2 (en) 2005-09-14 2009-04-07 Concert Pharmaceuticals Inc. Biphenyl-pyrazolecarboxamide compounds
EP1880715A1 (en) 2006-07-19 2008-01-23 Abbott GmbH & Co. KG Pharmaceutically acceptable solubilizing composition and pharmaceutical dosage form containing same
MX2009002422A (es) 2006-09-05 2009-03-20 Abbott Lab Inhibidores bcl para tratar exceso de plaquetas.
US8796267B2 (en) 2006-10-23 2014-08-05 Concert Pharmaceuticals, Inc. Oxazolidinone derivatives and methods of use
US20080182845A1 (en) 2006-11-16 2008-07-31 Abbott Laboratories Method of preventing or treating organ, hematopoietic stem cell or bone marrow transplant rejection
JP5130305B2 (ja) 2007-02-15 2013-01-30 エフ.ホフマン−ラ ロシュ アーゲー Taar1リガンドとしての2−アミノオキサゾリン
WO2008124878A1 (en) 2007-04-13 2008-10-23 Cryptopharma Pty Ltd Non-steroidal compounds
CN101687824A (zh) 2007-04-19 2010-03-31 康塞特医药品公司 氘化吗啉基化合物
US7531685B2 (en) 2007-06-01 2009-05-12 Protia, Llc Deuterium-enriched oxybutynin
WO2009035598A1 (en) 2007-09-10 2009-03-19 Concert Pharmaceuticals, Inc. Deuterated pirfenidone
US20090118238A1 (en) 2007-09-17 2009-05-07 Protia, Llc Deuterium-enriched alendronate
US20090088416A1 (en) 2007-09-26 2009-04-02 Protia, Llc Deuterium-enriched lapaquistat
US20090082471A1 (en) 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched fingolimod
US20110123482A1 (en) 2007-10-01 2011-05-26 The Johns Hopkins University Methods of Treating Neurological Autoimmune Disorders with Cyclophosphamide
JP2010540635A (ja) 2007-10-02 2010-12-24 コンサート ファーマシューティカルズ インコーポレイテッド ピリミジンジオン誘導体
US20090105338A1 (en) 2007-10-18 2009-04-23 Protia, Llc Deuterium-enriched gabexate mesylate
EP2212298B1 (en) 2007-10-18 2013-03-27 Concert Pharmaceuticals Inc. Deuterated etravirine
WO2009055006A1 (en) 2007-10-26 2009-04-30 Concert Pharmaceuticals, Inc. Deuterated darunavir
KR101585848B1 (ko) 2007-11-16 2016-01-15 애브비 인코포레이티드 관절염의 치료 방법
US20090149461A1 (en) 2007-12-06 2009-06-11 Abbott Laboratories Method of treating cancer
ES2579231T3 (es) 2008-01-15 2016-08-08 Abbvie Inc Vectores de expresión de mamíferos mejorados y usos de los mismos
NZ592719A (en) 2008-10-07 2012-09-28 Astrazeneca Uk Ltd PHARMACEUTICAL FORMULATION 514 comprising 4-[3-( 4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one
US8557983B2 (en) 2008-12-04 2013-10-15 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
UA108193C2 (uk) 2008-12-04 2015-04-10 Апоптозіндукуючий засіб для лікування раку і імунних і аутоімунних захворювань
US20100160322A1 (en) 2008-12-04 2010-06-24 Abbott Laboratories Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8586754B2 (en) 2008-12-05 2013-11-19 Abbvie Inc. BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
CN106008322B (zh) 2008-12-05 2018-09-04 Abbvie 公司 作为用于治疗癌症和免疫疾病的bcl-2-选择性诱发细胞凋亡药剂的磺酰胺衍生物
US8563735B2 (en) 2008-12-05 2013-10-22 Abbvie Inc. Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
US20110245156A1 (en) 2008-12-09 2011-10-06 Cytokine Pharmasciences, Inc. Novel antiviral compounds, compositions, and methods of use
GB2466622A (en) * 2008-12-23 2010-06-30 Trinity College Dublin Alpha2-Adrenoceptor Ligands
WO2010072734A2 (en) 2008-12-23 2010-07-01 The Provost Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin Targeting prodrugs and compositions for the treatment of gastrointestinal diseases
NZ593594A (en) 2009-01-19 2013-08-30 Abbvie Inc Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
HUE025527T2 (en) 2009-01-19 2016-04-28 Abbvie Inc Apoptosis inducers for the treatment of cancer, immune and autoimmune diseases
US20100297194A1 (en) 2009-04-30 2010-11-25 Nathaniel Catron Formulation for oral administration of apoptosis promoter
PH12015500297B1 (en) 2009-05-26 2023-10-20 Abbvie Ireland Unlimited Co Adoptosis-inducing agents for the treatment of cancer and immune and automoimmune disease
US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
TWI540132B (zh) 2009-06-08 2016-07-01 亞培公司 Bcl-2族群抑制劑之口服醫藥劑型
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
KR20180059560A (ko) * 2010-10-29 2018-06-04 애브비 인코포레이티드 아폽토시스―유도제를 포함하는 고체 분산체
PH12013501006A1 (en) * 2010-11-23 2022-03-30 Abbvie Ireland Unlimited Co Methods of treatment using selective bcl-2 inhibitors
PT2643322T (pt) 2010-11-23 2017-11-13 Abbvie Inc Sais e formas cristalinas de um agente indutor de apoptose
US20140275082A1 (en) * 2013-03-14 2014-09-18 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases

Also Published As

Publication number Publication date
PT2970257T (pt) 2018-10-25
US20180354952A1 (en) 2018-12-13
PL2970257T3 (pl) 2018-11-30
IL287315A (en) 2021-12-01
LT2970257T (lt) 2018-09-25
CN105026394A (zh) 2015-11-04
PE20191555A1 (es) 2019-10-24
RU2015143917A (ru) 2017-04-18
KR20150130486A (ko) 2015-11-23
RS57750B1 (sr) 2018-12-31
MX360541B (es) 2018-10-19
RU2662812C2 (ru) 2018-07-31
HRP20181403T1 (hr) 2018-11-30
PL2970257T4 (pl) 2019-01-31
MX384490B (es) 2025-03-14
PE20151555A1 (es) 2015-12-06
ZA201505203B (en) 2016-07-27
RU2018127315A (ru) 2019-03-13
NZ631701A (en) 2017-05-26
DOP2018000026A (es) 2018-10-31
CA2899041A1 (en) 2014-10-02
CY1120862T1 (el) 2019-12-11
US20140275082A1 (en) 2014-09-18
US20200331907A1 (en) 2020-10-22
TW201524976A (zh) 2015-07-01
EP2970257A1 (en) 2016-01-20
KR20210021613A (ko) 2021-02-26
US10081628B2 (en) 2018-09-25
TWI717662B (zh) 2021-02-01
JP2019038820A (ja) 2019-03-14
UY35406A (es) 2014-09-30
EP2970257B1 (en) 2018-05-30
WO2014158528A1 (en) 2014-10-02
RU2018127315A3 (enExample) 2021-10-05
AU2018226476A1 (en) 2018-09-27
IL265296A (en) 2019-05-30
AR095263A1 (es) 2015-09-30
SI2970257T1 (sl) 2018-10-30
AU2018226476B2 (en) 2019-10-10
EP3415514A1 (en) 2018-12-19
CA3110552A1 (en) 2014-10-02
US20150299197A1 (en) 2015-10-22
CN107987075A (zh) 2018-05-04
BR112015021115B1 (pt) 2022-05-03
AR117768A2 (es) 2021-08-25
BR112015021115A2 (pt) 2017-10-10
CR20150510A (es) 2015-12-11
JP2020180145A (ja) 2020-11-05
HRP20181403T8 (hr) 2018-12-28
ES2689679T3 (es) 2018-11-15
CL2015002640A1 (es) 2016-03-18
JP6449222B2 (ja) 2019-01-09
IL240010B (en) 2019-09-26
GT201500248A (es) 2017-09-14
IL240010A0 (en) 2015-09-24
US20210403467A1 (en) 2021-12-30
CN107987075B (zh) 2020-12-01
HUE038983T2 (hu) 2018-12-28
HK1220189A1 (en) 2017-04-28
JP2016517406A (ja) 2016-06-16
MY178821A (en) 2020-10-20
CN105026394B (zh) 2017-12-29
KR102260645B1 (ko) 2021-06-08
US20170008891A1 (en) 2017-01-12
AU2014242104B2 (en) 2018-07-05
CL2018000353A1 (es) 2018-07-13
DK2970257T3 (en) 2018-09-10
SG11201507363UA (en) 2015-10-29
AU2014242104A1 (en) 2015-07-30
JP2021167330A (ja) 2021-10-21
MX2015011641A (es) 2015-12-16
SG10201908388UA (en) 2019-10-30
TW201908316A (zh) 2019-03-01
TWI675835B (zh) 2019-11-01
AU2018226476C1 (en) 2020-01-16

Similar Documents

Publication Publication Date Title
UA120035C2 (uk) Індукуючі апоптоз засоби для лікування злоякісної пухлини й імунологічних і аутоімунних захворювань
JP7675777B2 (ja) 免疫調節剤としての複素環式化合物
JP7559059B2 (ja) 免疫調節剤としてのピリド[3,2-d]ピリミジン化合物
JP6395893B2 (ja) 癌ならびに免疫疾患および自己免疫疾患の治療のためのアポトーシス誘発剤としての8−カルバモイル−2−(2,3−ジ置換ピリド−6−イル)−1,2,3,4−テトラヒドロイソキノリン誘導体
TWI717061B (zh) 新穎經取代吲唑、其製法、包含其之醫藥製劑及其製備藥劑之用途
JP2023162216A (ja) Pd-l1免疫調節剤としてのテトラヒドロ-イミダゾ[4,5-c]ピリジン誘導体
KR102373017B1 (ko) N-{6-(2-히드록시프로판-2-일)-2-[2-(메틸술포닐)에틸]-2h-인다졸-5-일}-6-(트리플루오로메틸)피리딘-2-카르복스아미드의 다형체 형태
AU2019272342B2 (en) Aminopyrazine diol compounds as PI3K-y inhibitors
KR20190066604A (ko) Ido 및 tdo 조정을 위한 화합물 및 방법, 및 그에 대한 적응증
JP2019527718A (ja) Tlr7/8アンタゴニストおよびそれらの使用
JP6619420B2 (ja) Metap−2阻害剤としてのピロリジノン誘導体
KR102379948B1 (ko) N-[2-(3-히드록시-3-메틸부틸)-6-(2-히드록시프로판-2-일)-2h-인다졸-5-일]-6-(트리플루오로메틸)피리딘-2-카르복스아미드의 결정질 형태
TW201734004A (zh) 新穎2-取代吲唑、其製備方法、包含其之醫藥製劑及其於製備藥物之用途
AU2013296627A1 (en) Deuterated ibrutinib
IL273983B2 (en) Condensed imidazole derivatives substituted by tertiary hydroxy groups as pi3k-gamma inhibitors
CA3070013A1 (en) Substituted pyrrolopyridine-derivatives
KR20170042711A (ko) 치환된 비시클릭 화합물
JP2020503293A (ja) β−セクレターゼ阻害剤としてのオキサジン誘導体および使用方法
KR20230035311A (ko) Nek7 키나제의 억제제
KR20210038590A (ko) 보론산 유도체
HK40080900A (en) Aminopyrazine diol compounds as pi3k-y inhibitors
CA3174252A1 (en) Compounds active towards nuclear receptors
BR112020003368A2 (pt) derivados de ácido borônico