UA118989C2 - Дигідропіролопіридинові інгібітори ror-гамма - Google Patents

Дигідропіролопіридинові інгібітори ror-гамма Download PDF

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Publication number
UA118989C2
UA118989C2 UAA201702666A UAA201702666A UA118989C2 UA 118989 C2 UA118989 C2 UA 118989C2 UA A201702666 A UAA201702666 A UA A201702666A UA A201702666 A UAA201702666 A UA A201702666A UA 118989 C2 UA118989 C2 UA 118989C2
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Ukraine
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tert
mixture
mmol
disease
compound
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UAA201702666A
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English (en)
Ukrainian (uk)
Inventor
Девід А. Клейрмон
Лоуренс Уейн Діллард
Ченггуо Донг
Йі Фань
Ланкі Джіа
Стефан Д. Лотеста
Ендрю Маркус
Суреш Б. Сінгх
Колін М. Тайс
Цзін Юань
Вей ЖАО
Яцзюнь Женг
Лінгханг Чжуан
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Вітае Фармасьютікалс, Інк.
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Publication of UA118989C2 publication Critical patent/UA118989C2/uk

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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  • Psychiatry (AREA)
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UAA201702666A 2014-10-14 2015-10-14 Дигідропіролопіридинові інгібітори ror-гамма UA118989C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462063912P 2014-10-14 2014-10-14
US201462074406P 2014-11-03 2014-11-03
PCT/US2015/055420 WO2016061160A1 (en) 2014-10-14 2015-10-14 Dihydropyrrolopyridine inhibitors of ror-gamma

Publications (1)

Publication Number Publication Date
UA118989C2 true UA118989C2 (uk) 2019-04-10

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Country Status (28)

Country Link
US (3) US9796710B2 (OSRAM)
EP (1) EP3207043B3 (OSRAM)
JP (1) JP6564029B2 (OSRAM)
KR (1) KR20170066628A (OSRAM)
CN (1) CN107074852B (OSRAM)
AU (1) AU2015333610B2 (OSRAM)
BR (1) BR112017007460A2 (OSRAM)
CA (1) CA2963140A1 (OSRAM)
CL (1) CL2017000902A1 (OSRAM)
CO (1) CO2017004525A2 (OSRAM)
CY (1) CY1121413T1 (OSRAM)
DK (1) DK3207043T6 (OSRAM)
EA (1) EA031967B1 (OSRAM)
EC (1) ECSP17029371A (OSRAM)
ES (1) ES2715458T7 (OSRAM)
HU (1) HUE042335T2 (OSRAM)
IL (1) IL251584B (OSRAM)
MX (1) MX371304B (OSRAM)
MY (1) MY182454A (OSRAM)
PH (1) PH12017500583B1 (OSRAM)
PL (1) PL3207043T6 (OSRAM)
PT (1) PT3207043T (OSRAM)
SG (1) SG11201702362SA (OSRAM)
SI (1) SI3207043T1 (OSRAM)
TW (1) TWI675032B (OSRAM)
UA (1) UA118989C2 (OSRAM)
WO (1) WO2016061160A1 (OSRAM)
ZA (1) ZA201702237B (OSRAM)

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PL2900669T3 (pl) 2012-09-25 2020-01-31 F. Hoffmann-La Roche Ag Pochodne heksahydropirolo[3,4-C]pirolu i związki pokrewne jako inhibitory autotaksyny (ATX) oraz inhibitory produkcji kwasu lizofosfatydowego (LPA) do leczenia np. chorób nerek
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
HUE036117T2 (hu) 2013-11-26 2018-06-28 Hoffmann La Roche Oktahidro-ciklobuta[1,2-C;3,4-C']dipirrol származékok, mint autotaxin inhibitorok
UA121309C2 (uk) 2014-02-03 2020-05-12 Вітае Фармасьютікалс, Ллс Дигідропіролопіридинові інгібітори ror-гамма
JP6554481B2 (ja) 2014-03-26 2019-07-31 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft オートタキシン(atx)及びリゾホスファチジン酸(lpa)産生の阻害剤としての縮合[1,4]ジアゼピン化合物
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BR112017007460A2 (pt) 2014-10-14 2017-12-19 Vitae Pharmaceuticals Inc inibidores de di-hidropirrolopiridina de ror-gama
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
MX385357B (es) 2015-05-15 2025-03-18 Aurigene Discovery Tech Ltd Compuestos de tetrahidroquinolinona sustituidos como moduladores de ror gamma
HRP20200064T1 (hr) 2015-06-09 2020-04-03 Abbvie Inc. Modulatori nuklearnih receptora (ror) namijenjeni liječenju upalnih i autoimunih bolesti
ES2856931T3 (es) 2015-08-05 2021-09-28 Vitae Pharmaceuticals Llc Moduladores de ROR-gamma
CR20180058A (es) 2015-09-04 2018-02-26 Hoffmann La Roche Nuevos derivados de fenoximetilo
MX2017015034A (es) 2015-09-24 2018-04-13 Hoffmann La Roche Nuevos compuestos biciclicos como inhibidores duales de autotaxina (atx)/anhidrasa carbonica (ca).
KR20180054830A (ko) 2015-09-24 2018-05-24 에프. 호프만-라 로슈 아게 오토탁신(atx) 억제제로서의 이환형 화합물
EP3353178B1 (en) 2015-09-24 2021-07-14 F. Hoffmann-La Roche AG Bicyclic compounds as dual atx/ca inhibitors
CN107922412B (zh) 2015-09-24 2021-02-23 豪夫迈·罗氏有限公司 作为atx抑制剂的二环化合物
MX385332B (es) 2015-11-20 2025-03-18 Vitae Pharmaceuticals Llc Moduladores de ror-gamma.
TWI728017B (zh) 2015-12-15 2021-05-21 瑞典商阿斯特捷利康公司 異吲哚化合物、包含其之醫藥組成物及其用途
TW202220968A (zh) 2016-01-29 2022-06-01 美商維它藥物有限責任公司 ROR-γ調節劑
JP2020059651A (ja) * 2016-12-26 2020-04-16 科研製薬株式会社 ピラゾール誘導体及びそれを含有する医薬
EP3596060B1 (en) 2017-03-16 2023-09-20 F. Hoffmann-La Roche AG New bicyclic compounds as atx inhibitors
RU2019132254A (ru) 2017-03-16 2021-04-16 Ф. Хоффманн-Ля Рош Аг Гетероциклические соединения, пригодные в качестве дуальных ингибиторов atx/ca
CN110730780A (zh) 2017-06-14 2020-01-24 阿斯利康(瑞典)有限公司 用作ROR-γ调节剂的2,3-二氢异吲哚-1-甲酰胺
JP2020142989A (ja) * 2017-06-21 2020-09-10 Meiji Seikaファルマ株式会社 イミダゾール誘導体及びそれを含有する医薬
CN109952298B (zh) 2017-07-06 2021-09-03 江苏恒瑞医药股份有限公司 吲哚甲酰胺类衍生物、其制备方法及其在医药上的应用
WO2019018975A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. INHIBITORS OF ROR GAMMA
CN111225914B (zh) 2017-07-24 2022-10-11 生命医药有限责任公司 RORγ的抑制剂
EP3663299B1 (en) 2017-08-01 2023-03-08 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Bicyclic compound acting as ror gamma inhibitor
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EP3927329A4 (en) * 2019-02-20 2022-11-23 The Regents of the University of California TREATMENT OF RETINIC ACID RECEPTOR-RELATED ORPHAN RECEPTOR-Y(RORY)-DEPENDENT CANCER
WO2023232870A1 (en) 2022-05-31 2023-12-07 Immunic Ag Rorg/rorgt modulators for the treatment of virus infections like covid-19

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