TWI891060B - 編碼胃抑肽受體（ｇｉｐｒ）特異性抗體之核酸分子及製造該抗體之方法 - Google Patents

編碼胃抑肽受體（ｇｉｐｒ）特異性抗體之核酸分子及製造該抗體之方法

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Publication number
TWI891060B
TWI891060B TW112134736A TW112134736A TWI891060B TW I891060 B TWI891060 B TW I891060B TW 112134736 A TW112134736 A TW 112134736A TW 112134736 A TW112134736 A TW 112134736A TW I891060 B TWI891060 B TW I891060B
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Taiwan
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seq
variable region
heavy chain
chain variable
light chain
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TW112134736A
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English (en)
Chinese (zh)
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TW202400655A (zh
Inventor
朱銘 尹
冬惠 史
尼拉吉 阿格沃
大衛 Ｊ 洛伊德
達倫 Ｌ 貝茲
布蘭登 Ｃ Ｐ 克利夫提
伊恩 Ｎ 佛茲
淑英 何
克里斯多福 姆勞斯基
王錦洪
葛蘭 Ｎ 二世 席維特斯
伊利森 默瑞爾 Ｍ 凡尼亞特
瑞尼 寇莫羅斯基
閔小山
祖倫 王
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美商安美基公司
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Publication of TW202400655A publication Critical patent/TW202400655A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
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    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/55—Fab or Fab'
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    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
TW112134736A 2015-12-23 2016-12-23 編碼胃抑肽受體（ｇｉｐｒ）特異性抗體之核酸分子及製造該抗體之方法 TWI891060B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201562387486P 2015-12-23 2015-12-23
US62/387,486 2015-12-23
US201662337799P 2016-05-17 2016-05-17
US62/337,799 2016-05-17
US201662420415P 2016-11-10 2016-11-10
US62/420,415 2016-11-10

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TW202400655A TW202400655A (zh) 2024-01-01
TWI891060B true TWI891060B (zh) 2025-07-21

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TW112134736A TWI891060B (zh) 2015-12-23 2016-12-23 編碼胃抑肽受體（ｇｉｐｒ）特異性抗體之核酸分子及製造該抗體之方法
TW110124017A TWI818277B (zh) 2015-12-23 2016-12-23 使用胃抑肽受體(gipr)結合蛋白與glp-1促效劑之組合來治療或改善代謝病症之方法
TW105143109A TWI734722B (zh) 2015-12-23 2016-12-23 使用胃抑肽受體（gipr）結合蛋白與glp-1促效劑之組合來治療或改善代謝病症之方法

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TW110124017A TWI818277B (zh) 2015-12-23 2016-12-23 使用胃抑肽受體(gipr)結合蛋白與glp-1促效劑之組合來治療或改善代謝病症之方法
TW105143109A TWI734722B (zh) 2015-12-23 2016-12-23 使用胃抑肽受體（gipr）結合蛋白與glp-1促效劑之組合來治療或改善代謝病症之方法

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US (4) US10294303B2 (enExample)
EP (1) EP3394104A2 (enExample)
JP (4) JP6948330B2 (enExample)
KR (2) KR102844773B1 (enExample)
CN (2) CN109715662B (enExample)
AU (2) AU2016378739A1 (enExample)
CA (2) CA3009650A1 (enExample)
CL (2) CL2018001695A1 (enExample)
CO (1) CO2018007582A2 (enExample)
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EA (1) EA201891323A1 (enExample)
IL (2) IL296682B1 (enExample)
MA (1) MA44154A (enExample)
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PE (1) PE20181327A1 (enExample)
PH (1) PH12018501322A1 (enExample)
SG (1) SG11201805255TA (enExample)
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UA (1) UA127495C2 (enExample)
UY (1) UY37049A (enExample)
WO (1) WO2017112824A2 (enExample)
ZA (2) ZA201803979B (enExample)

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JP2025537215A (ja) 2022-11-02 2025-11-14 ▲蘇▼州康▲寧▼杰瑞生物科技有限公司 Ｇｉｐｒ結合タンパク質及びその使用
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