TWI741992B - 因子ｉｘ融合蛋白以及其製備及使用方法 - Google Patents
因子ｉｘ融合蛋白以及其製備及使用方法 Download PDFInfo
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| DK3178835T3 (da) * | 2009-02-03 | 2019-06-24 | Amunix Pharmaceuticals Inc | Forlængede rekombinante polypeptider og sammensætninger omfattende samme |
| CA2771999A1 (en) * | 2009-08-24 | 2011-03-10 | Amunix Operating Inc. | Coagulation factor vii compositions and methods of making and using same |
| EA038705B1 (ru) * | 2012-01-12 | 2021-10-07 | Биовератив Терапьютикс Инк. | Способы снижения иммуногенности фактора свёртывания крови viii у пациентов, получающих лечение фактором viii |
| RS61387B2 (sr) | 2013-02-15 | 2024-06-28 | Bioverativ Therapeutics Inc | Gen optimizovanog faktora viii |
| EA201691111A1 (ru) | 2014-01-10 | 2017-01-30 | Байоджен Ма Инк. | Химерные белки фактора viii и их применение |
| US11008561B2 (en) | 2014-06-30 | 2021-05-18 | Bioverativ Therapeutics Inc. | Optimized factor IX gene |
| GB201420139D0 (en) | 2014-11-12 | 2014-12-24 | Ucl Business Plc | Factor IX gene therapy |
| UA126016C2 (uk) * | 2015-08-03 | 2022-08-03 | Біовератів Терапеутікс Інк. | Злитий білок фактора іх |
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| KR20190090827A (ko) | 2016-12-02 | 2019-08-02 | 바이오버라티브 테라퓨틱스 인크. | 키메라 응고 인자를 사용해 혈우병성 관절증을 치료하는 방법 |
| CA3044838A1 (en) | 2016-12-02 | 2018-06-07 | Bioverativ Therapeutics Inc. | Methods of inducing immune tolerance to clotting factors |
| BR112019015569A2 (pt) * | 2017-01-31 | 2020-03-17 | Bioverativ Therapeutics Inc. | Proteínas de fusão do fator ix e métodos para a sua produção e uso |
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| US10842885B2 (en) | 2018-08-20 | 2020-11-24 | Ucl Business Ltd | Factor IX encoding nucleotides |
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| MY204234A (en) | 2018-08-27 | 2024-08-16 | Regeneron Pharma | Use of raman spectroscopy in downstream purification |
| CA3121786A1 (en) | 2018-12-06 | 2020-06-11 | Bioverativ Therapeutics Inc. | Use of lentiviral vectors expressing factor ix |
| ES3062513T3 (en) | 2019-03-19 | 2026-04-13 | CSL Innovation Pty Ltd | Factor ix variants and uses thereof in therapy |
| WO2020215010A1 (en) | 2019-04-17 | 2020-10-22 | Codiak Biosciences, Inc. | Compositions of exosomes and aav |
| CN112175088B (zh) * | 2019-07-02 | 2023-03-28 | 江苏晟斯生物制药有限公司 | 改进的fix融合蛋白、缀合物及其应用 |
| JP7803014B2 (ja) | 2019-09-30 | 2026-01-21 | バイオベラティブ セラピューティクス インコーポレイテッド | レンチウイルスベクター製剤 |
| CN111647625A (zh) * | 2019-12-25 | 2020-09-11 | 深圳三智医学科技有限公司 | 一种提高人凝血因子ix表达水平的方法 |
| LT3972987T (lt) | 2020-04-10 | 2023-09-25 | Akston Biosciences Corporation | Antigenui specifinė imunoterapija, skirta sulietiems covid-19 baltymams ir naudojimo būdai |
| JP2023537565A (ja) | 2020-06-24 | 2023-09-04 | バイオベラティブ セラピューティクス インコーポレイテッド | タンパク質を発現するように改変されたレンチウイルスベクターの調製物から遊離第ｖｉｉｉ因子を除去する方法 |
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| CN113817759B (zh) * | 2020-07-10 | 2023-06-02 | 南京吉迈生物技术有限公司 | 修饰的因子ix、组合物、方法及其在基因治疗中的应用 |
| WO2023275024A1 (en) * | 2021-07-01 | 2023-01-05 | CSL Behring Lengnau AG | Factor ix subcutaneous administration with enhanced safety |
| CN114989307B (zh) * | 2022-05-11 | 2023-08-01 | 华兰生物工程股份有限公司 | 一种重组人凝血因子Ⅷ-Fc融合蛋白及制备方法 |
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| CN102741275A (zh) * | 2009-08-24 | 2012-10-17 | 阿穆尼克斯运营公司 | 凝血因子ix组合物及其制备和使用方法 |
| CN103140237A (zh) * | 2010-07-09 | 2013-06-05 | 比奥根艾迪克依蒙菲利亚公司 | 因子ix多肽及其使用方法 |
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- 2016-08-03 UA UAA201800755A patent/UA126016C2/uk unknown
- 2016-08-03 AU AU2016301303A patent/AU2016301303B2/en not_active Ceased
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102741275A (zh) * | 2009-08-24 | 2012-10-17 | 阿穆尼克斯运营公司 | 凝血因子ix组合物及其制备和使用方法 |
| CN103140237A (zh) * | 2010-07-09 | 2013-06-05 | 比奥根艾迪克依蒙菲利亚公司 | 因子ix多肽及其使用方法 |
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| US20210032616A1 (en) | 2021-02-04 |
| TW201716433A (zh) | 2017-05-16 |
| US10745680B2 (en) | 2020-08-18 |
| BR112018002150A2 (pt) | 2018-09-18 |
| JP2022171790A (ja) | 2022-11-11 |
| EP3331608A4 (en) | 2019-05-01 |
| JP6909203B2 (ja) | 2021-07-28 |
| CA2994547A1 (en) | 2017-02-09 |
| PH12018500252A1 (en) | 2018-08-13 |
| CN108472337B (zh) | 2022-11-25 |
| CL2018000302A1 (es) | 2018-07-13 |
| EP3331608A1 (en) | 2018-06-13 |
| WO2017024060A1 (en) | 2017-02-09 |
| KR102659212B1 (ko) | 2024-04-18 |
| CO2018002196A2 (es) | 2018-05-10 |
| IL257231A (en) | 2018-03-29 |
| IL257231B (en) | 2022-09-01 |
| AU2016301303A1 (en) | 2018-02-15 |
| JP2018522563A (ja) | 2018-08-16 |
| CN108472337A (zh) | 2018-08-31 |
| KR20180029262A (ko) | 2018-03-20 |
| EA201890423A1 (ru) | 2018-07-31 |
| US20180355341A1 (en) | 2018-12-13 |
| HK1248162A1 (zh) | 2018-10-12 |
| MX2018001497A (es) | 2018-05-15 |
| UA126016C2 (uk) | 2022-08-03 |
| JP7418519B2 (ja) | 2024-01-19 |
| AU2016301303B2 (en) | 2021-10-07 |
| JP2021078526A (ja) | 2021-05-27 |
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