RS61387B2 - Gen optimizovanog faktora viii - Google Patents

Gen optimizovanog faktora viii

Info

Publication number
RS61387B2
RS61387B2 RS20210126A RSP20210126A RS61387B2 RS 61387 B2 RS61387 B2 RS 61387B2 RS 20210126 A RS20210126 A RS 20210126A RS P20210126 A RSP20210126 A RS P20210126A RS 61387 B2 RS61387 B2 RS 61387B2
Authority
RS
Serbia
Prior art keywords
factor viii
viii gene
optimized factor
optimized
gene
Prior art date
Application number
RS20210126A
Other languages
English (en)
Inventor
Siyuan Tan
Robert T Peters
Original Assignee
Bioverativ Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51354568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RS61387(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bioverativ Therapeutics Inc filed Critical Bioverativ Therapeutics Inc
Publication of RS61387B1 publication Critical patent/RS61387B1/sr
Publication of RS61387B2 publication Critical patent/RS61387B2/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RS20210126A 2013-02-15 2014-02-14 Gen optimizovanog faktora viii RS61387B2 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361765626P 2013-02-15 2013-02-15
PCT/US2014/016441 WO2014127215A1 (en) 2013-02-15 2014-02-14 Optimized factor viii gene
EP14751254.5A EP2956477B2 (en) 2013-02-15 2014-02-14 Optimized factor viii gene

Publications (2)

Publication Number Publication Date
RS61387B1 RS61387B1 (sr) 2021-02-26
RS61387B2 true RS61387B2 (sr) 2024-06-28

Family

ID=51354568

Family Applications (2)

Application Number Title Priority Date Filing Date
RS20210126A RS61387B2 (sr) 2013-02-15 2014-02-14 Gen optimizovanog faktora viii
RS20230892A RS64664B1 (sr) 2013-02-15 2014-02-14 Gen optimizovanog faktora viii

Family Applications After (1)

Application Number Title Priority Date Filing Date
RS20230892A RS64664B1 (sr) 2013-02-15 2014-02-14 Gen optimizovanog faktora viii

Country Status (13)

Country Link
US (3) US10370431B2 (sr)
EP (3) EP4223772A3 (sr)
DK (2) DK3889173T5 (sr)
ES (2) ES2959747T3 (sr)
FI (2) FI2956477T4 (sr)
HR (2) HRP20210185T4 (sr)
HU (2) HUE053136T2 (sr)
LT (2) LT3889173T (sr)
PL (2) PL3889173T3 (sr)
PT (2) PT3889173T (sr)
RS (2) RS61387B2 (sr)
SI (2) SI2956477T2 (sr)
WO (1) WO2014127215A1 (sr)

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EP3180022B1 (en) * 2014-08-13 2024-07-03 The Children's Hospital of Philadelphia An improved expression cassette for packaging and expression of variant factor viii for the treatment of hemostasis disorders
KR102554850B1 (ko) 2015-02-06 2023-07-13 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 최적화된 인간 응고 인자 viii 유전자 발현 카세트 및 그의 용도
EP3626274B1 (en) * 2015-04-16 2025-01-22 Emory University Recombinant promoters and vectors for protein expression in liver and use thereof
AU2016353353B2 (en) 2015-11-13 2020-07-09 Takeda Pharmaceutical Company Limited Viral vectors encoding recombinant FVIII variants with increased expression for gene therapy of hemophilia A
AU2016354550B2 (en) 2015-11-13 2020-04-16 Takeda Pharmaceutical Company Limited Viral vectors encoding recombinant fviii variants with increased expression for gene therapy of hemophilia a
SI3411478T1 (sl) 2016-02-01 2022-10-28 Bioverativ Therapeutics Inc. Optimirani geni dejavnika VIII
JP7145083B2 (ja) 2016-03-20 2022-09-30 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 高等植物の葉緑体におけるトランス遺伝子発現を増加させるためのコドン最適化及びリボソームプロファイリング
CN111918674A (zh) 2018-02-01 2020-11-10 比奥维拉迪维治疗股份有限公司 表达因子viii的慢病毒载体的用途
MX2021000582A (es) 2018-07-16 2021-04-12 Baxalta Inc Terapia genica de hemofilia a mediante el uso de vectores virales que codifican variantes del factor viii (fviii) recombinantes con mayor expresion.
MX2021001599A (es) 2018-08-09 2021-07-02 Bioverativ Therapeutics Inc Moleculas de acido nucleico y sus usos para la terapia genica no viral.
TWI851647B (zh) 2019-01-16 2024-08-11 日商武田藥品工業股份有限公司 用於a型血友病基因治療之編碼表現增加之重組fviii變異體的病毒載體
MA55313A (fr) * 2019-03-13 2022-01-19 Generation Bio Co Vecteurs d'adn non viraux et leurs utilisations pour exprimer des agents thérapeutiques du facteur viii
CN110295150A (zh) * 2019-07-17 2019-10-01 天津润德生物科技有限公司 一类腺依赖病毒病毒重组质粒、重组病毒及构建方法
EP4017521A1 (en) * 2019-09-02 2022-06-29 Biotest AG Factor viii protein with increased half-life
EP4038182A1 (en) 2019-09-30 2022-08-10 Bioverativ Therapeutics Inc. Lentiviral vector formulations
WO2021119357A2 (en) 2019-12-12 2021-06-17 Baxalta Incorporated Gene therapy of hemophilia a using viral vectors encoding recombinant fviii variants with increased expression
KR20230074703A (ko) 2020-06-24 2023-05-31 바이오버라티브 테라퓨틱스 인크. 유리 인자 viii을 상기 단백질이 발현되도록 변형된 렌티바이러스 벡터의 제제로부터 제거하는 방법
US20240269241A1 (en) 2021-06-14 2024-08-15 Takeda Pharmaceutical Company Limited Gene therapy of hemophilia a using viral vectors encoding recombinant fviii variants with increased expression
CN117836319A (zh) * 2021-08-23 2024-04-05 比奥维拉迪维治疗股份有限公司 优化的因子viii基因
WO2023135273A2 (en) 2022-01-14 2023-07-20 Anjarium Biosciences Ag Compositions of dna molecules encoding factor viii, methods of making thereof, and methods of use thereof
US20250276093A1 (en) * 2022-04-20 2025-09-04 AskBio Inc. Therapeutic adeno-associated virus using codon optimized nucleic acid encoding factor viii
WO2025008774A1 (en) 2023-07-05 2025-01-09 Takeda Pharmaceutical Company Limited Viral vectors encoding recombinant fviii variants with increased expression for gene therapy of hemophilia a

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