PL2729161T3 - Chimeryczne i hybrydowe polipeptydy czynnika VIII i sposoby ich stosowania - Google Patents
Chimeryczne i hybrydowe polipeptydy czynnika VIII i sposoby ich stosowaniaInfo
- Publication number
- PL2729161T3 PL2729161T3 PL12811808T PL12811808T PL2729161T3 PL 2729161 T3 PL2729161 T3 PL 2729161T3 PL 12811808 T PL12811808 T PL 12811808T PL 12811808 T PL12811808 T PL 12811808T PL 2729161 T3 PL2729161 T3 PL 2729161T3
- Authority
- PL
- Poland
- Prior art keywords
- methods
- factor viii
- hybrid polypeptides
- viii chimeric
- chimeric
- Prior art date
Links
- 229960000301 factor viii Drugs 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Food Science & Technology (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161506015P | 2011-07-08 | 2011-07-08 | |
| US201161522647P | 2011-08-11 | 2011-08-11 | |
| US201161541561P | 2011-09-30 | 2011-09-30 | |
| US201161569158P | 2011-12-09 | 2011-12-09 | |
| US201261586443P | 2012-01-13 | 2012-01-13 | |
| US201261622789P | 2012-04-11 | 2012-04-11 | |
| US201261657641P | 2012-06-08 | 2012-06-08 | |
| EP12811808.0A EP2729161B1 (en) | 2011-07-08 | 2012-07-06 | Factor viii chimeric and hybrid polypeptides, and methods of use thereof |
| PCT/US2012/045784 WO2013009627A2 (en) | 2011-07-08 | 2012-07-06 | Factor viii chimeric and hybrid polypeptides, and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2729161T3 true PL2729161T3 (pl) | 2019-08-30 |
Family
ID=47506823
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL18211156T PL3513804T3 (pl) | 2011-07-08 | 2012-07-06 | Chimeryczne i hybrydowe polipeptydy czynnika VIII i sposoby ich stosowania |
| PL12811808T PL2729161T3 (pl) | 2011-07-08 | 2012-07-06 | Chimeryczne i hybrydowe polipeptydy czynnika VIII i sposoby ich stosowania |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL18211156T PL3513804T3 (pl) | 2011-07-08 | 2012-07-06 | Chimeryczne i hybrydowe polipeptydy czynnika VIII i sposoby ich stosowania |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US10010622B2 (pl) |
| EP (3) | EP3513804B1 (pl) |
| JP (5) | JP2014522838A (pl) |
| KR (2) | KR101829603B1 (pl) |
| CN (2) | CN107261122A (pl) |
| AR (1) | AR087091A1 (pl) |
| AU (3) | AU2012282875B2 (pl) |
| BR (1) | BR112014000466A2 (pl) |
| CA (1) | CA2841066C (pl) |
| CL (1) | CL2014000024A1 (pl) |
| CO (1) | CO6940381A2 (pl) |
| CY (1) | CY1122900T1 (pl) |
| DK (2) | DK3513804T3 (pl) |
| EA (1) | EA029045B1 (pl) |
| ES (2) | ES2913994T3 (pl) |
| HR (2) | HRP20220639T1 (pl) |
| HU (1) | HUE043763T2 (pl) |
| IL (2) | IL230333B (pl) |
| LT (2) | LT3513804T (pl) |
| MX (1) | MX350581B (pl) |
| MY (1) | MY180714A (pl) |
| PL (2) | PL3513804T3 (pl) |
| PT (2) | PT2729161T (pl) |
| RS (2) | RS63241B1 (pl) |
| SI (2) | SI3513804T1 (pl) |
| TW (3) | TWI764092B (pl) |
| WO (1) | WO2013009627A2 (pl) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE497783T1 (de) * | 2003-05-06 | 2011-02-15 | Syntonix Pharmaceuticals Inc | Gerinnungsfaktor vii-fc chimäre proteine zur behandlung von hämostatischen krankheiten |
| WO2008074032A1 (en) | 2006-12-15 | 2008-06-19 | Baxter International Inc. | Factor viia- (poly) sialic acid conjugate having prolonged in vivo half-life |
| US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| PL2459224T3 (pl) | 2009-07-27 | 2017-08-31 | Baxalta GmbH | Koniugaty białka związanego z krzepnięciem krwi |
| US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| NZ597600A (en) | 2009-07-27 | 2014-05-30 | Lipoxen Technologies Ltd | Glycopolysialylation of non-blood coagulation proteins |
| DK2459224T3 (en) | 2009-07-27 | 2016-07-25 | Baxalta GmbH | Blodstørkningsproteinkonjugater |
| AU2010325787B2 (en) | 2009-12-06 | 2016-05-12 | Bioverativ Therapeutics Inc. | Factor VIII-Fc chimeric and hybrid polypeptides, and methods of use thereof |
| HUE049352T2 (hu) | 2010-12-22 | 2020-09-28 | Baxalta GmbH | Anyagok és módszerek egy vízoldható zsírsavszármazéknak egy fehérjéhez való konjugálására |
| EP3513804B1 (en) * | 2011-07-08 | 2022-03-23 | Bioverativ Therapeutics Inc. | Factor viii chimeric and hybrid polypeptides, and methods of use thereof |
| SI2802668T1 (sl) * | 2012-01-12 | 2019-01-31 | Bioverativ Therapeutics Inc. | Zmanjšanje imunogeničnosti proti faktorju VIII pri posameznikih, ki se zdravijo zaradi faktorja VIII |
| EP3521321B1 (en) | 2012-04-11 | 2020-11-04 | Bioverativ Therapeutics Inc. | Methods of detecting glycosaminoglycans |
| EP2863940A4 (en) | 2012-06-08 | 2016-08-10 | Biogen Ma Inc | CHIMERIC COAGULATION FACTORS |
| AU2013270682A1 (en) | 2012-06-08 | 2014-12-11 | Biogen Ma Inc. | Procoagulant compounds |
| US10023628B2 (en) | 2012-07-06 | 2018-07-17 | Bioverativ Therapeutics Inc. | Cell line expressing single chain factor VIII polypeptides and uses thereof |
| WO2014070953A1 (en) * | 2012-10-30 | 2014-05-08 | Biogen Idec Ma Inc. | Methods of Using FVIII Polypeptide |
| ES2959747T3 (es) * | 2013-02-15 | 2024-02-28 | Bioverativ Therapeutics Inc | Gen del factor VIII optimizado |
| ES2926798T3 (es) | 2013-03-15 | 2022-10-28 | Bioverativ Therapeutics Inc | Formulaciones de polipéptido de factor VIII |
| US9234757B2 (en) | 2013-11-29 | 2016-01-12 | Fedex Corporate Services, Inc. | Determining node location using a variable power characteristic of a node in a wireless node network |
| US10453023B2 (en) | 2014-05-28 | 2019-10-22 | Fedex Corporate Services, Inc. | Methods and node apparatus for adaptive node communication within a wireless node network |
| US11238397B2 (en) | 2015-02-09 | 2022-02-01 | Fedex Corporate Services, Inc. | Methods, apparatus, and systems for generating a corrective pickup notification for a shipped item using a mobile master node |
| US10305744B2 (en) * | 2015-07-08 | 2019-05-28 | Fedex Corporate Services, Inc. | System, apparatus, and methods of event monitoring for an event candidate related to an ID node within a wireless node network |
| PE20231949A1 (es) | 2015-10-30 | 2023-12-05 | Spark Therapeutics Inc | VARIANTES DEL FACTOR VIII REDUCIDO CON CpG, COMPOSICIONES Y METODOS Y USOS PARA EL TRATAMIENTO DE TRASTORNOS DE LA HEMOSTASIA |
| HRP20221089T1 (hr) | 2016-02-01 | 2022-11-25 | Bioverativ Therapeutics Inc. | Optimizirani geni faktora viii |
| EP3433809A4 (en) | 2016-03-23 | 2019-10-02 | Fedex Corporate Services, Inc. | SYSTEMS, APPARATUS AND METHODS FOR AUTOMATIC ADJUSTMENT OF BROADCAST ADJUSTMENT OF A NODE IN A WIRELESS NODE NETWORK |
| WO2018032638A1 (zh) | 2016-08-19 | 2018-02-22 | 安源医药科技（上海）有限公司 | 用于构建融合蛋白的连接肽 |
| CN106279437B (zh) | 2016-08-19 | 2017-10-31 | 安源医药科技（上海）有限公司 | 高糖基化人凝血因子viii融合蛋白及其制备方法与用途 |
| CN107759696A (zh) | 2016-08-19 | 2018-03-06 | 安源医药科技（上海）有限公司 | 人白介素7融合蛋白及其制备方法 |
| CN110520149A (zh) * | 2016-12-02 | 2019-11-29 | 比奥维拉迪维治疗股份有限公司 | 诱导对凝血因子的免疫耐受性的方法 |
| JP7370974B2 (ja) | 2017-11-07 | 2023-10-30 | ラニ セラピューティクス， エルエルシー | 嚥下可能薬物送達デバイスを使用する腸管組織への送達のための凝固因子調製物 |
| WO2019175380A2 (en) | 2018-03-16 | 2019-09-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antigenic peptides deriving from secretogranin v and uses thereof for the diagnosis and treatment of type 1 diabetes |
| EP3765064A1 (en) | 2018-03-16 | 2021-01-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antigenic peptides deriving from pcsk2 and uses thereof for the diagnosis and treatment of type 1 diabetes |
| US12098179B2 (en) | 2018-03-16 | 2024-09-24 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Antigenic peptides deriving from urocortin 3 and uses thereof for the diagnosis and treatment of type 1 diabetes |
| KR20210005872A (ko) * | 2018-03-28 | 2021-01-15 | 오리오니스 바이오사이언시즈 인코포레이티드 | 이작용성 단백질 및 이의 작제물 |
| JP2021523878A (ja) | 2018-05-18 | 2021-09-09 | バイオベラティブ セラピューティクス インコーポレイテッド | 血友病ａを処置する方法 |
| CA3137539A1 (en) * | 2019-05-03 | 2020-10-20 | Rani Therapeutics, Llc | Clotting factor preparations for delivery into tissue of the intestinal tract using a swallowable drug delivery device |
| CA3144630A1 (en) | 2019-06-19 | 2020-12-24 | Bioverativ Therapeutics Inc. | Methods and compositions for treating hemophilia and low bone mineral density with factor viiifc protein |
| US11981718B2 (en) | 2020-05-27 | 2024-05-14 | Ampsource Biopharma Shanghai Inc. | Dual-function protein for lipid and blood glucose regulation |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4757006A (en) | 1983-10-28 | 1988-07-12 | Genetics Institute, Inc. | Human factor VIII:C gene and recombinant methods for production |
| DE3572982D1 (en) | 1984-03-06 | 1989-10-19 | Takeda Chemical Industries Ltd | Chemically modified lymphokine and production thereof |
| US4965199A (en) | 1984-04-20 | 1990-10-23 | Genentech, Inc. | Preparation of functional human factor VIII in mammalian cells using methotrexate based selection |
| CA1341174C (en) | 1985-04-12 | 2001-01-30 | John J. Toole Jr. | Procoagulant proteins derived from factor viii: c |
| KR910006424B1 (ko) | 1985-08-21 | 1991-08-24 | 인코텍스 비.브이 | 편성브리프(brief) 제조방법 |
| DE3785102T2 (de) | 1986-01-03 | 1993-07-22 | Genetics Inst | Verfahren zur herstellung von faktor-viii:c-typ-proteinen. |
| US5595886A (en) | 1986-01-27 | 1997-01-21 | Chiron Corporation | Protein complexes having Factor VIII:C activity and production thereof |
| US5543502A (en) | 1986-06-24 | 1996-08-06 | Novo Nordisk A/S | Process for producing a coagulation active complex of factor VIII fragments |
| US4912040A (en) | 1986-11-14 | 1990-03-27 | Genetics Institute, Inc. | Eucaryotic expression system |
| CA1331157C (en) | 1987-04-06 | 1994-08-02 | Randal J. Kaufman | Method for producing factor viii:c-type proteins |
| US6060447A (en) | 1987-05-19 | 2000-05-09 | Chiron Corporation | Protein complexes having Factor VIII:C activity and production thereof |
| IE69026B1 (en) | 1987-06-12 | 1996-08-07 | Immuno Ag | Novel proteins with factor VIII activity process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them |
| US6346513B1 (en) | 1987-06-12 | 2002-02-12 | Baxter Trading Gmbh | Proteins with factor VIII activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them |
| DE3720246A1 (de) | 1987-06-19 | 1988-12-29 | Behringwerke Ag | Faktor viii:c-aehnliches molekuel mit koagulationsaktivitaet |
| FR2619314B1 (fr) | 1987-08-11 | 1990-06-15 | Transgene Sa | Analogue du facteur viii, procede de preparation et composition pharmaceutique le contenant |
| US4994371A (en) | 1987-08-28 | 1991-02-19 | Davie Earl W | DNA preparation of Christmas factor and use of DNA sequences |
| US5004803A (en) | 1988-11-14 | 1991-04-02 | Genetics Institute, Inc. | Production of procoagulant proteins |
| CA2006596C (en) | 1988-12-22 | 2000-09-05 | Rika Ishikawa | Chemically-modified g-csf |
| ATE148171T1 (de) | 1989-02-21 | 1997-02-15 | Univ Washington | Modifizierte formen von fortpflanzungshormonen |
| SE465222C5 (sv) | 1989-12-15 | 1998-02-10 | Pharmacia & Upjohn Ab | Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning |
| US6552170B1 (en) | 1990-04-06 | 2003-04-22 | Amgen Inc. | PEGylation reagents and compounds formed therewith |
| SG47099A1 (en) | 1991-03-15 | 1998-03-20 | Amgen Boulder Inc | Pegylation of polypeptides |
| FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| US6376463B1 (en) | 1992-04-07 | 2002-04-23 | Emory University | Modified factor VIII |
| US5859204A (en) | 1992-04-07 | 1999-01-12 | Emory University | Modified factor VIII |
| US5364771A (en) | 1992-04-07 | 1994-11-15 | Emory University | Hybrid human/porcine factor VIII |
| US5563045A (en) * | 1992-11-13 | 1996-10-08 | Genetics Institute, Inc. | Chimeric procoagulant proteins |
| SE504074C2 (sv) | 1993-07-05 | 1996-11-04 | Pharmacia Ab | Proteinberedning för subkutan, intramuskulär eller intradermal administrering |
| SE9503380D0 (sv) | 1995-09-29 | 1995-09-29 | Pharmacia Ab | Protein derivatives |
| US6458563B1 (en) | 1996-06-26 | 2002-10-01 | Emory University | Modified factor VIII |
| CA2225189C (en) | 1997-03-06 | 2010-05-25 | Queen's University At Kingston | Canine factor viii gene, protein and methods of use |
| US6200560B1 (en) | 1998-10-20 | 2001-03-13 | Avigen, Inc. | Adeno-associated virus vectors for expression of factor VIII by target cells |
| WO2001058957A2 (en) | 2000-02-11 | 2001-08-16 | Lexigen Pharmaceuticals Corp. | Enhancing the circulating half-life of antibody-based fusion proteins |
| EP1572889B1 (en) * | 2001-10-05 | 2008-12-17 | Expression Therapeutics, LLC | Nucleic acid and amino acid sequences encoding high-level expressor factor viii polypeptides and methods of use |
| EP2261250B1 (en) | 2001-12-21 | 2015-07-01 | Human Genome Sciences, Inc. | GCSF-Albumin fusion proteins |
| US7041635B2 (en) | 2003-01-28 | 2006-05-09 | In2Gen Co., Ltd. | Factor VIII polypeptide |
| US7348004B2 (en) | 2003-05-06 | 2008-03-25 | Syntonix Pharmaceuticals, Inc. | Immunoglobulin chimeric monomer-dimer hybrids |
| ATE497783T1 (de) | 2003-05-06 | 2011-02-15 | Syntonix Pharmaceuticals Inc | Gerinnungsfaktor vii-fc chimäre proteine zur behandlung von hämostatischen krankheiten |
| TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| US7211559B2 (en) | 2003-10-31 | 2007-05-01 | University Of Maryland, Baltimore | Factor VIII compositions and methods |
| PT2371856T (pt) | 2004-11-12 | 2022-08-12 | Bayer Healthcare Llc | Modificação de fviii direcionada a sítio |
| US8367805B2 (en) | 2004-11-12 | 2013-02-05 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| SG123635A1 (en) | 2004-12-28 | 2006-07-26 | Nanoscience Innovation Pte Ltd | Nanostructured zinc oxide and a method of producing the same |
| US7855279B2 (en) | 2005-09-27 | 2010-12-21 | Amunix Operating, Inc. | Unstructured recombinant polymers and uses thereof |
| US8048848B2 (en) | 2006-02-03 | 2011-11-01 | Prolor Biotech Ltd. | Long-acting interferons and derivatives thereof and methods thereof |
| EP1996937A4 (en) | 2006-03-06 | 2009-04-08 | Amunix Inc | GENETIC PACKS AND USES THEREOF |
| CA2673459C (en) * | 2006-12-22 | 2016-09-13 | Stefan Schulte | Modified coagulation factors with prolonged in vivo half-life |
| DK2369005T3 (da) | 2007-06-21 | 2013-06-24 | Univ Muenchen Tech | Biologisk aktive proteiner med forøget stabilitet in vivo og/eller in vitro |
| AU2008287340A1 (en) | 2007-08-15 | 2009-02-19 | Amunix, Inc. | Compositions and methods for modifying properties of biologically active polypeptides |
| US8239182B2 (en) | 2007-12-04 | 2012-08-07 | Spansion Llc | Data transmission system-on-chip memory model based validation |
| CN102348715B (zh) | 2009-02-03 | 2017-12-08 | 阿穆尼克斯运营公司 | 延伸重组多肽和包含该延伸重组多肽的组合物 |
| AU2010325787B2 (en) | 2009-12-06 | 2016-05-12 | Bioverativ Therapeutics Inc. | Factor VIII-Fc chimeric and hybrid polypeptides, and methods of use thereof |
| NZ605400A (en) * | 2010-07-09 | 2015-05-29 | Biogen Idec Hemophilia Inc | Chimeric clotting factors |
| EP3508573A1 (en) * | 2010-07-09 | 2019-07-10 | Bioverativ Therapeutics Inc. | Systems for factor viii processing and methods thereof |
| EP3513804B1 (en) * | 2011-07-08 | 2022-03-23 | Bioverativ Therapeutics Inc. | Factor viii chimeric and hybrid polypeptides, and methods of use thereof |
-
2012
- 2012-07-06 EP EP18211156.7A patent/EP3513804B1/en active Active
- 2012-07-06 BR BR112014000466A patent/BR112014000466A2/pt not_active Application Discontinuation
- 2012-07-06 WO PCT/US2012/045784 patent/WO2013009627A2/en active Application Filing
- 2012-07-06 TW TW109104200A patent/TWI764092B/zh active
- 2012-07-06 RS RS20220491A patent/RS63241B1/sr unknown
- 2012-07-06 PT PT12811808T patent/PT2729161T/pt unknown
- 2012-07-06 TW TW106131035A patent/TWI687226B/zh active
- 2012-07-06 HR HRP20220639TT patent/HRP20220639T1/hr unknown
- 2012-07-06 HU HUE12811808A patent/HUE043763T2/hu unknown
- 2012-07-06 DK DK18211156.7T patent/DK3513804T3/da active
- 2012-07-06 TW TW101124461A patent/TWI626947B/zh active
- 2012-07-06 LT LTEP18211156.7T patent/LT3513804T/lt unknown
- 2012-07-06 CN CN201710301935.7A patent/CN107261122A/zh active Pending
- 2012-07-06 CA CA2841066A patent/CA2841066C/en active Active
- 2012-07-06 AU AU2012282875A patent/AU2012282875B2/en active Active
- 2012-07-06 PT PT182111567T patent/PT3513804T/pt unknown
- 2012-07-06 JP JP2014519074A patent/JP2014522838A/ja not_active Withdrawn
- 2012-07-06 MY MYPI2014000038A patent/MY180714A/en unknown
- 2012-07-06 SI SI201232000T patent/SI3513804T1/sl unknown
- 2012-07-06 RS RS20190355A patent/RS58578B1/sr unknown
- 2012-07-06 ES ES18211156T patent/ES2913994T3/es active Active
- 2012-07-06 DK DK12811808.0T patent/DK2729161T3/en active
- 2012-07-06 AR ARP120102464A patent/AR087091A1/es not_active Application Discontinuation
- 2012-07-06 LT LTEP12811808.0T patent/LT2729161T/lt unknown
- 2012-07-06 CN CN201280043194.2A patent/CN103796670A/zh active Pending
- 2012-07-06 ES ES12811808T patent/ES2722209T3/es active Active
- 2012-07-06 PL PL18211156T patent/PL3513804T3/pl unknown
- 2012-07-06 MX MX2014000202A patent/MX350581B/es active IP Right Grant
- 2012-07-06 US US14/131,600 patent/US10010622B2/en active Active
- 2012-07-06 EA EA201490039A patent/EA029045B1/ru not_active IP Right Cessation
- 2012-07-06 PL PL12811808T patent/PL2729161T3/pl unknown
- 2012-07-06 SI SI201231567T patent/SI2729161T1/sl unknown
- 2012-07-06 EP EP22163636.8A patent/EP4169525A1/en active Pending
- 2012-07-06 EP EP12811808.0A patent/EP2729161B1/en active Active
- 2012-07-06 KR KR1020147003130A patent/KR101829603B1/ko active IP Right Grant
- 2012-07-06 KR KR1020187003966A patent/KR102110736B1/ko active IP Right Grant
-
2014
- 2014-01-06 IL IL230333A patent/IL230333B/en active IP Right Grant
- 2014-01-07 CL CL2014000024A patent/CL2014000024A1/es unknown
- 2014-01-21 CO CO14011134A patent/CO6940381A2/es unknown
-
2016
- 2016-07-15 AU AU2016204986A patent/AU2016204986B2/en active Active
-
2017
- 2017-02-20 JP JP2017028814A patent/JP2017088623A/ja active Pending
-
2018
- 2018-04-27 AU AU2018202936A patent/AU2018202936B2/en active Active
- 2018-05-29 US US15/991,629 patent/US10881742B2/en active Active
- 2018-11-29 JP JP2018223631A patent/JP7273487B2/ja active Active
-
2019
- 2019-03-19 HR HRP20190535TT patent/HRP20190535T1/hr unknown
- 2019-03-19 CY CY20191100325T patent/CY1122900T1/el unknown
-
2020
- 2020-01-06 IL IL271870A patent/IL271870B/en unknown
- 2020-12-04 US US17/112,280 patent/US20210220476A1/en active Pending
-
2021
- 2021-10-18 JP JP2021170188A patent/JP2022003096A/ja not_active Withdrawn
-
2023
- 2023-07-31 JP JP2023124309A patent/JP2023134851A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL271870B (en) | Factor viii chimeric and hybrid polypeptides and methods of using them | |
| HK1253887A1 (zh) | 因子viii-fc嵌合多肽和雜交多肽及其使用方法 | |
| IL261632B (en) | Chimeric factor viii polypeptides and uses thereof | |
| IL260045B (en) | Polypeptide structures and their uses | |
| EP2728002A4 (en) | HETERODIMIZED POLYPEPTIDE | |
| EP2721063A4 (en) | PCSK9 BINDING POLYPEPTIDES AND METHOD OF USE THEREOF |