AR087091A1 - Polipeptidos quimericos e hibridos del factor viii, y sus metodos de uso - Google Patents
Polipeptidos quimericos e hibridos del factor viii, y sus metodos de usoInfo
- Publication number
- AR087091A1 AR087091A1 ARP120102464A ARP120102464A AR087091A1 AR 087091 A1 AR087091 A1 AR 087091A1 AR P120102464 A ARP120102464 A AR P120102464A AR P120102464 A ARP120102464 A AR P120102464A AR 087091 A1 AR087091 A1 AR 087091A1
- Authority
- AR
- Argentina
- Prior art keywords
- factor viii
- subject
- chain
- administering
- level
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Peptides Or Proteins (AREA)
Abstract
Reivindicación 1: Un método de administrar Factor VIII a un sujeto que lo necesita, que comprende administrar al sujeto una dosis terapéutica de un polipéptido quimérico que comprende una porción del Factor VIII y una segunda porción en un intervalo de dosis al menos aproximadamente una y medio veces más largo que el intervalo de dosis requerido para una dosis equivalente de un polipéptido que consiste en dicha porción del Factor VIII, donde dicha porción del Factor VIII comprende el Factor VIII procesado, que tiene dos cadenas, una primera cadena que comprende una cadena pesada y una segunda cadena que comprende una cadena liviana, donde dicha primera cadena y dicha segunda cadena se asocian con un enlace metálico. Reivindicación 39: Una composición que comprende un polipéptido quimérico que tiene actividad de Factor VIII, donde al menos aproximadamente 30%, aproximadamente 40%, aproximadamente 50%, aproximadamente 60%, aproximadamente 70%, aproximadamente 80%, aproximadamente 90%, aproximadamente 95%, aproximadamente 96%, aproximadamente 97%, aproximadamente 98%, aproximadamente 99%, o aproximadamente 100% de dicho polipéptido comprende a porción del Factor VIII, que es el Factor VIII de cadena simple, y una segunda porción, donde dicho Factor VIII de cadena simple es al menos 90% ó 95% idéntica a una secuencia de aminoácidos del Factor VIII que se muestra en la Tabla 2 sin una secuencia señal (aminoácidos 20 a 1457 de la SEQ ID Nº 2 o aminoácidos 20 a 2351 de la SEQ ID Nº 6). Reivindicación 73: Un método de tratar una afección de sangrado que comprende administrar una cantidad terapéuticamente efectiva de la composición de acuerdo con cualquiera de las reivindicaciones 39 - 72. Reivindicación 81: Un método de mantener el Factor VIII en una población de pacientes a un nivel superior a 1% durante al menos un día, dos días, o tres días que comprende administrar una cantidad terapéuticamente efectiva de rFVIIIFc a dicha población, donde la cantidad terapéuticamente efectiva es al menos 25 IU/kg de rFVIIIFc y donde al menos 90% de dicha población mantiene el nivel mínimo del Factor VIII al menos 1% o más. Reivindicación 105: Un método de prevenir, disminuir, o tratar un episodio de sangrado en un sujeto que comprende: (a) identifican un sujeto que tiene niveles altos de VWF por la medición del nivel de VWF en el plasma de dicho sujeto, donde un nivel de VWF de al menos aproximadamente 100 IU/dL identifica el sujeto que tiene un alto nivel de VWF; y (b) administrar al sujeto una cantidad efectiva de una proteína de FVIII de acción prolongada.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161506015P | 2011-07-08 | 2011-07-08 | |
US201161522647P | 2011-08-11 | 2011-08-11 | |
US201161541561P | 2011-09-30 | 2011-09-30 | |
US201161569158P | 2011-12-09 | 2011-12-09 | |
US201261586443P | 2012-01-13 | 2012-01-13 | |
US201261622789P | 2012-04-11 | 2012-04-11 | |
US201261657641P | 2012-06-08 | 2012-06-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR087091A1 true AR087091A1 (es) | 2014-02-12 |
Family
ID=47506823
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP120102464A AR087091A1 (es) | 2011-07-08 | 2012-07-06 | Polipeptidos quimericos e hibridos del factor viii, y sus metodos de uso |
Country Status (27)
Country | Link |
---|---|
US (3) | US10010622B2 (es) |
EP (3) | EP4169525A1 (es) |
JP (5) | JP2014522838A (es) |
KR (2) | KR101829603B1 (es) |
CN (2) | CN103796670A (es) |
AR (1) | AR087091A1 (es) |
AU (3) | AU2012282875B2 (es) |
BR (1) | BR112014000466A2 (es) |
CA (1) | CA2841066C (es) |
CL (1) | CL2014000024A1 (es) |
CO (1) | CO6940381A2 (es) |
CY (1) | CY1122900T1 (es) |
DK (2) | DK3513804T3 (es) |
EA (1) | EA029045B1 (es) |
ES (2) | ES2913994T3 (es) |
HR (2) | HRP20220639T1 (es) |
HU (1) | HUE043763T2 (es) |
IL (2) | IL230333B (es) |
LT (2) | LT3513804T (es) |
MX (1) | MX350581B (es) |
MY (1) | MY180714A (es) |
PL (2) | PL2729161T3 (es) |
PT (2) | PT2729161T (es) |
RS (2) | RS58578B1 (es) |
SI (2) | SI2729161T1 (es) |
TW (3) | TWI626947B (es) |
WO (1) | WO2013009627A2 (es) |
Families Citing this family (36)
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US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
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MX345608B (es) | 2010-12-22 | 2017-02-07 | Baxalta Inc | Materiales y metodos para conjugar un derivado de acido graso soluble en agua a una proteina. |
EA029045B1 (ru) * | 2011-07-08 | 2018-02-28 | Байоджен Хемофилия Инк. | Химерные и гибридные полипептиды фактора viii и способы их применения |
US10317376B2 (en) | 2012-04-11 | 2019-06-11 | Bioverativ Therapeutics Inc. | Methods of detecting glycosaminoglycans |
CA2875247A1 (en) | 2012-06-08 | 2013-12-12 | Biogen Idec Ma Inc. | Chimeric clotting factors |
AU2013270682A1 (en) | 2012-06-08 | 2014-12-11 | Biogen Ma Inc. | Procoagulant compounds |
EP2870250B2 (en) | 2012-07-06 | 2022-06-29 | Bioverativ Therapeutics Inc. | Cell line expressing single chain factor viii polypeptides and uses thereof |
WO2014070953A1 (en) * | 2012-10-30 | 2014-05-08 | Biogen Idec Ma Inc. | Methods of Using FVIII Polypeptide |
DK3889173T3 (da) | 2013-02-15 | 2023-10-09 | Bioverativ Therapeutics Inc | Optimeret faktor viii-gen |
EA201890671A1 (ru) * | 2013-03-15 | 2019-01-31 | Биовератив Терапьютикс Инк. | Препараты полипептида фактора viii |
US9234757B2 (en) | 2013-11-29 | 2016-01-12 | Fedex Corporate Services, Inc. | Determining node location using a variable power characteristic of a node in a wireless node network |
US10453023B2 (en) | 2014-05-28 | 2019-10-22 | Fedex Corporate Services, Inc. | Methods and node apparatus for adaptive node communication within a wireless node network |
US11238397B2 (en) | 2015-02-09 | 2022-02-01 | Fedex Corporate Services, Inc. | Methods, apparatus, and systems for generating a corrective pickup notification for a shipped item using a mobile master node |
US10305744B2 (en) | 2015-07-08 | 2019-05-28 | Fedex Corporate Services, Inc. | System, apparatus, and methods of event monitoring for an event candidate related to an ID node within a wireless node network |
PE20231949A1 (es) | 2015-10-30 | 2023-12-05 | Spark Therapeutics Inc | VARIANTES DEL FACTOR VIII REDUCIDO CON CpG, COMPOSICIONES Y METODOS Y USOS PARA EL TRATAMIENTO DE TRASTORNOS DE LA HEMOSTASIA |
SG10201913278PA (en) | 2016-02-01 | 2020-02-27 | Bioverativ Therapeutics Inc | Optimized factor viii genes |
CN108780538A (zh) | 2016-03-23 | 2018-11-09 | 联邦快递服务公司 | 用于自调整无线节点网络中的节点的广播设定的系统、设备和方法 |
EP3502143A4 (en) | 2016-08-19 | 2020-07-15 | Ampsource Biopharma Shanghai Inc. | BINDING PEPTIDE FOR THE CONSTRUCTION OF A FUSION PROTEIN |
CN106279437B (zh) | 2016-08-19 | 2017-10-31 | 安源医药科技(上海)有限公司 | 高糖基化人凝血因子viii融合蛋白及其制备方法与用途 |
CN107759694B (zh) | 2016-08-19 | 2023-01-13 | 安源医药科技(上海)有限公司 | 双特异性抗体及其制备方法与用途 |
AU2018366110A1 (en) | 2017-11-07 | 2020-06-04 | Rani Therapeutics, Llc | Clotting factor preparations for delivery into tissue of the intestinal tract using a swallowable drug delivery device |
EP3765064A1 (en) | 2018-03-16 | 2021-01-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antigenic peptides deriving from pcsk2 and uses thereof for the diagnosis and treatment of type 1 diabetes |
US20210024603A1 (en) | 2018-03-16 | 2021-01-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antigenic peptides deriving from urocortin 3 and uses thereof for the diagnosis and treatment of type 1 diabetes |
EP3765065A2 (en) | 2018-03-16 | 2021-01-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antigenic peptides deriving from secretogranin v and uses thereof for the diagnosis and treatment of type 1 diabetes |
US20210024631A1 (en) * | 2018-03-28 | 2021-01-28 | Orionis Biosciences, Inc. | Bi-functional proteins and construction thereof |
SG11202010767SA (en) * | 2018-05-18 | 2020-11-27 | Bioverativ Therapeutics Inc | Methods of treating hemophilia a |
EP3962516A4 (en) * | 2019-05-03 | 2023-01-04 | Rani Therapeutics, LLC | COAGULATION FACTOR PREPARATIONS TO BE DELIVERED INTO INTESTINAL TRACT TISSUE BY MEANS OF A SWALLOWED DRUG DELIVERY DEVICE |
KR20220024628A (ko) | 2019-06-19 | 2022-03-03 | 바이오버라티브 테라퓨틱스 인크. | 혈우병 및 낮은 골 무기질 밀도를 치료하기 위한 재조합 인자 viii-fc |
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