ATE449596T1 - Verfahren zur herstellung von mikropartikeln - Google Patents

Verfahren zur herstellung von mikropartikeln

Info

Publication number
ATE449596T1
ATE449596T1 AT01964090T AT01964090T ATE449596T1 AT E449596 T1 ATE449596 T1 AT E449596T1 AT 01964090 T AT01964090 T AT 01964090T AT 01964090 T AT01964090 T AT 01964090T AT E449596 T1 ATE449596 T1 AT E449596T1
Authority
AT
Austria
Prior art keywords
stream
producing microparticles
diameter
particle
vibrating
Prior art date
Application number
AT01964090T
Other languages
English (en)
Inventor
Kyekyoon Kim
Daniel Pack
Cory Berkland
Original Assignee
Univ Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Illinois filed Critical Univ Illinois
Application granted granted Critical
Publication of ATE449596T1 publication Critical patent/ATE449596T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y40/00—Manufacture or treatment of nanostructures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nanotechnology (AREA)
  • Organic Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Manufacturing & Machinery (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
AT01964090T 2000-08-15 2001-08-15 Verfahren zur herstellung von mikropartikeln ATE449596T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22552500P 2000-08-15 2000-08-15
US22562000P 2000-08-15 2000-08-15
PCT/US2001/025674 WO2002013786A2 (en) 2000-08-15 2001-08-15 Method of forming microparticles

Publications (1)

Publication Number Publication Date
ATE449596T1 true ATE449596T1 (de) 2009-12-15

Family

ID=26919678

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01964090T ATE449596T1 (de) 2000-08-15 2001-08-15 Verfahren zur herstellung von mikropartikeln

Country Status (9)

Country Link
US (3) US6669961B2 (de)
EP (1) EP1355630B1 (de)
JP (1) JP2004505761A (de)
KR (2) KR100867392B1 (de)
AT (1) ATE449596T1 (de)
AU (1) AU2001284982A1 (de)
CA (1) CA2419115C (de)
DE (1) DE60140625D1 (de)
WO (1) WO2002013786A2 (de)

Families Citing this family (253)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101460240B1 (ko) * 2008-06-13 2014-11-21 삼성전자주식회사 메모리 기반 저장 장치 및 그것의 블록 관리 기법
US7615373B2 (en) 1999-02-25 2009-11-10 Virginia Commonwealth University Intellectual Property Foundation Electroprocessed collagen and tissue engineering
US20020081732A1 (en) 2000-10-18 2002-06-27 Bowlin Gary L. Electroprocessing in drug delivery and cell encapsulation
DE60140625D1 (de) * 2000-08-15 2010-01-07 Univ Illinois Verfahren zur herstellung von mikropartikeln
US9700866B2 (en) * 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US6884436B2 (en) * 2000-12-22 2005-04-26 Baxter International Inc. Method for preparing submicron particle suspensions
US20050048126A1 (en) 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
US6977085B2 (en) 2000-12-22 2005-12-20 Baxter International Inc. Method for preparing submicron suspensions with polymorph control
US7193084B2 (en) 2000-12-22 2007-03-20 Baxter International Inc. Polymorphic form of itraconazole
US6607784B2 (en) 2000-12-22 2003-08-19 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US6951656B2 (en) 2000-12-22 2005-10-04 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US6518330B2 (en) * 2001-02-13 2003-02-11 Board Of Trustees Of University Of Illinois Multifunctional autonomically healing composite material
US6610223B2 (en) 2001-03-30 2003-08-26 Picoliter Inc. Focused acoustic energy in the generation of solid particles
KR20040007742A (ko) * 2001-06-22 2004-01-24 세키스이가가쿠 고교가부시키가이샤 수지 미립자의 제조 방법, 수지 미립자 및 수지 미립자의제조 장치
AU2002345328A1 (en) 2001-06-27 2003-03-03 Remon Medical Technologies Ltd. Method and device for electrochemical formation of therapeutic species in vivo
WO2003022248A1 (en) * 2001-09-13 2003-03-20 Korea Institute Of Science And Technology Oily paclitaxel composition and formulation for chemoembolization and preparation method thereof
WO2003026611A2 (en) * 2001-09-26 2003-04-03 Baxter International Inc. Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
US7112340B2 (en) 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
US7131997B2 (en) 2002-03-29 2006-11-07 Scimed Life Systems, Inc. Tissue treatment
US7094369B2 (en) 2002-03-29 2006-08-22 Scimed Life Systems, Inc. Processes for manufacturing polymeric microspheres
US7462366B2 (en) 2002-03-29 2008-12-09 Boston Scientific Scimed, Inc. Drug delivery particle
US7053134B2 (en) 2002-04-04 2006-05-30 Scimed Life Systems, Inc. Forming a chemically cross-linked particle of a desired shape and diameter
AU2003247515A1 (en) * 2002-06-10 2003-12-22 Wyeth Novel formate salt of o-desmethyl-venlafaxine
US10004729B2 (en) 2002-07-05 2018-06-26 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
US7449236B2 (en) 2002-08-09 2008-11-11 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US7842377B2 (en) * 2003-08-08 2010-11-30 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US8012454B2 (en) 2002-08-30 2011-09-06 Boston Scientific Scimed, Inc. Embolization
US7883490B2 (en) 2002-10-23 2011-02-08 Boston Scientific Scimed, Inc. Mixing and delivery of therapeutic compositions
US7588825B2 (en) 2002-10-23 2009-09-15 Boston Scientific Scimed, Inc. Embolic compositions
US7623908B2 (en) 2003-01-24 2009-11-24 The Board Of Trustees Of The University Of Illinois Nonlinear interferometric vibrational imaging
JP2006524738A (ja) * 2003-02-25 2006-11-02 マンフレッド・アール・クーンル 紫外線帯域の電磁エネルギー吸収用のカプセル化されたナノ粒子
US20080199701A1 (en) * 2003-02-25 2008-08-21 Kuehnle Manfred R Encapsulated nanoparticles for the absorption of electromagnetic energy
US20050074611A1 (en) * 2003-02-25 2005-04-07 Manfred R. Kuehnle Encapsulated nanoparticles for the absorption of electromagnetic energy
US7511079B2 (en) * 2003-03-24 2009-03-31 Baxter International Inc. Methods and apparatuses for the comminution and stabilization of small particles
JP4305729B2 (ja) 2003-03-28 2009-07-29 セイコーエプソン株式会社 液体吐出装置及びマイクロカプセルの製造方法
EP3023140B1 (de) * 2003-04-10 2019-10-09 President and Fellows of Harvard College Erzeugung und kontrolle von fluiden
US7285306B1 (en) * 2003-04-18 2007-10-23 United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Process for self-repair of insulation material
US8545463B2 (en) 2003-05-20 2013-10-01 Optimyst Systems Inc. Ophthalmic fluid reservoir assembly for use with an ophthalmic fluid delivery device
ATE501766T1 (de) 2003-05-20 2011-04-15 James F Collins Ophthalmisches arzneimittelabgabesystem
US7217410B2 (en) * 2003-06-17 2007-05-15 The Board Of Trustees Of The Universtiy Of Illinois Surface modified protein microparticles
US7198777B2 (en) * 2003-06-17 2007-04-03 The Board Of Trustees Of The University Of Illinois Optical contrast agents for optically modifying incident radiation
EP1659094B1 (de) * 2003-07-31 2019-05-15 SIJTechnology, Inc. Verfahren zur herstellung einer dreidimensionalen struktur
EP2662136A3 (de) 2003-08-27 2013-12-25 President and Fellows of Harvard College Verfahren zur Handhabung und Mischung von Tröpfchen
US7976823B2 (en) 2003-08-29 2011-07-12 Boston Scientific Scimed, Inc. Ferromagnetic particles and methods
US20070158450A1 (en) * 2003-09-09 2007-07-12 John Scattergood Systems and methods for producing fine particles
US7901770B2 (en) 2003-11-04 2011-03-08 Boston Scientific Scimed, Inc. Embolic compositions
US20050175836A1 (en) * 2003-11-12 2005-08-11 Xmx Corporation Physical color new concepts for color pigments
US20070141342A1 (en) * 2003-11-12 2007-06-21 Kuehnle Manfred R Physical color new concepts for color pigments
US7309500B2 (en) * 2003-12-04 2007-12-18 The Board Of Trustees Of The University Of Illinois Microparticles
US9040090B2 (en) 2003-12-19 2015-05-26 The University Of North Carolina At Chapel Hill Isolated and fixed micro and nano structures and methods thereof
KR20120105062A (ko) 2003-12-19 2012-09-24 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 소프트 또는 임프린트 리소그래피를 이용하여 분리된 마이크로- 및 나노- 구조를 제작하는 방법
US7610074B2 (en) * 2004-01-08 2009-10-27 The Board Of Trustees Of The University Of Illinois Multi-functional plasmon-resonant contrast agents for optical coherence tomography
EP1711163A2 (de) * 2004-02-05 2006-10-18 Baxter International Inc. Unter verwendung von selbststabilisierenden mitteln hergestellte dispersionen
DE602005016540D1 (de) * 2004-02-23 2009-10-22 Novartis Ag Verfahren zur herstellung von mikrokugeln auf basis von ionisch vernetztem polysaccharid
US7736671B2 (en) 2004-03-02 2010-06-15 Boston Scientific Scimed, Inc. Embolization
US8173176B2 (en) 2004-03-30 2012-05-08 Boston Scientific Scimed, Inc. Embolization
US7566747B2 (en) * 2004-05-07 2009-07-28 The Board Of Trustees Of The University Of Illinois Wax particles for protection of activators, and multifunctional autonomically healing composite materials
US7311861B2 (en) 2004-06-01 2007-12-25 Boston Scientific Scimed, Inc. Embolization
CA2569958C (en) 2004-06-12 2016-03-22 Jane C. Hirsh Abuse-deterrent drug formulations
JP4762517B2 (ja) * 2004-09-09 2011-08-31 株式会社オプトニクス精密 プリンター用トナーの製造方法
US8241651B2 (en) 2004-11-10 2012-08-14 The Regents Of The University Of Michigan Multiphasic biofunctional nano-components and methods for use thereof
US7947772B2 (en) 2004-11-10 2011-05-24 The Regents Of The University Of Michigan Multiphasic nano-components comprising colorants
US8043480B2 (en) * 2004-11-10 2011-10-25 The Regents Of The University Of Michigan Methods for forming biodegradable nanocomponents with controlled shapes and sizes via electrified jetting
EP1809719B1 (de) * 2004-11-10 2013-01-16 The Regents of The University of Michigan Mehrphasige nanopartikel
US7748343B2 (en) 2004-11-22 2010-07-06 The Board Of Trustees Of The University Of Illinois Electrohydrodynamic spraying system
US20060140843A1 (en) * 2004-12-23 2006-06-29 In-Kyung Sung Macroporous structures for heterogeneous catalyst support
US20060147536A1 (en) * 2004-12-30 2006-07-06 Fiore Robert A Method for removing fluids containing dissolved or suspended carbohydrates, lipids, metals, salts, and/or toxins from biological systems
ES2257968B1 (es) * 2005-01-28 2007-07-01 Universidad De Sevilla Procedimiento y dispositivo para la obtencion de particulas de tamaño micro y nanometrico.
WO2006086654A2 (en) * 2005-02-11 2006-08-17 Battelle Memorial Institute Nanoformulations
US20090104269A1 (en) * 2005-02-11 2009-04-23 Brian Graham Nanoformulations
US7586618B2 (en) * 2005-02-28 2009-09-08 The Board Of Trustees Of The University Of Illinois Distinguishing non-resonant four-wave-mixing noise in coherent stokes and anti-stokes Raman scattering
US7727555B2 (en) * 2005-03-02 2010-06-01 Boston Scientific Scimed, Inc. Particles
US7858183B2 (en) 2005-03-02 2010-12-28 Boston Scientific Scimed, Inc. Particles
US7725169B2 (en) * 2005-04-15 2010-05-25 The Board Of Trustees Of The University Of Illinois Contrast enhanced spectroscopic optical coherence tomography
US7963287B2 (en) 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
US7612152B2 (en) * 2005-05-06 2009-11-03 The Board Of Trustees Of The University Of Illinois Self-healing polymers
US10070977B2 (en) 2005-05-24 2018-09-11 Inspire M.D. Ltd Stent apparatuses for treatment via body lumens and methods of use
US8961586B2 (en) 2005-05-24 2015-02-24 Inspiremd Ltd. Bifurcated stent assemblies
US8043323B2 (en) 2006-10-18 2011-10-25 Inspiremd Ltd. In vivo filter assembly
US20060280787A1 (en) * 2005-06-14 2006-12-14 Baxter International Inc. Pharmaceutical formulation of the tubulin inhibitor indibulin for oral administration with improved pharmacokinetic properties, and process for the manufacture thereof
WO2006138202A2 (en) * 2005-06-14 2006-12-28 Baxter International Inc. Pharmaceutical formulations for minimizing drug-drug interactions
US9463426B2 (en) * 2005-06-24 2016-10-11 Boston Scientific Scimed, Inc. Methods and systems for coating particles
JP4854240B2 (ja) * 2005-09-09 2012-01-18 株式会社オプトニクス精密 加圧振動及び噴射造粒による超微粒子
US20070059370A1 (en) * 2005-09-15 2007-03-15 Industrial Technology Research Institute Method and apparatus for fabricating nanoparticles
US7855279B2 (en) 2005-09-27 2010-12-21 Amunix Operating, Inc. Unstructured recombinant polymers and uses thereof
WO2007038619A2 (en) * 2005-09-27 2007-04-05 Amunix, Inc. Proteinaceous pharmaceuticals and uses thereof
US20090099031A1 (en) * 2005-09-27 2009-04-16 Stemmer Willem P Genetic package and uses thereof
US7846445B2 (en) * 2005-09-27 2010-12-07 Amunix Operating, Inc. Methods for production of unstructured recombinant polymers and uses thereof
US7709544B2 (en) * 2005-10-25 2010-05-04 Massachusetts Institute Of Technology Microstructure synthesis by flow lithography and polymerization
BRPI0618661A2 (pt) * 2005-11-15 2011-09-06 Baxter Int composições de inibidores de lipoxigenase
CN1785153B (zh) * 2005-12-06 2010-04-21 青岛大学 纳米级材料制备装置及纳米抗氧化活性多肽药物的制备方法
EP1968550A2 (de) * 2005-12-16 2008-09-17 University Of Kansas Nanocluster zur abgabe von therapeutika
JP4823675B2 (ja) * 2005-12-16 2011-11-24 花王株式会社 ハイドロゲル粒子の製造方法、並びに、それによって製造されるハイドロゲル粒子及びそれを用いた分散体
US7993749B2 (en) * 2005-12-16 2011-08-09 University Of Kansas Nanoparticles comprising a nanoparticle template and a polymer shell having an amide side chain, and method of making thereof
US8101197B2 (en) 2005-12-19 2012-01-24 Stryker Corporation Forming coils
US7501179B2 (en) 2005-12-21 2009-03-10 Boston Scientific Scimed, Inc. Block copolymer particles
US7947368B2 (en) 2005-12-21 2011-05-24 Boston Scientific Scimed, Inc. Block copolymer particles
EP3363455A1 (de) 2005-12-30 2018-08-22 Zensun (Shanghai) Science & Technology, Co., Ltd. Verlängerte freisetzung von neuregulin für verbesserte herzfunktion
WO2007082153A2 (en) 2006-01-05 2007-07-19 The Board Of Trustees Of The University Of Illinois Self-healing coating system
US8840660B2 (en) 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US7787129B2 (en) 2006-01-31 2010-08-31 The Board Of Trustees Of The University Of Illinois Method and apparatus for measurement of optical properties in tissue
US8089029B2 (en) 2006-02-01 2012-01-03 Boston Scientific Scimed, Inc. Bioabsorbable metal medical device and method of manufacture
US8048150B2 (en) 2006-04-12 2011-11-01 Boston Scientific Scimed, Inc. Endoprosthesis having a fiber meshwork disposed thereon
US7569625B2 (en) * 2006-06-02 2009-08-04 The Board Of Trustees Of The University Of Illinois Self-healing elastomer system
US8465775B2 (en) 2006-07-27 2013-06-18 The University Of North Carolina At Chapel Hill Nanoparticle fabrication methods, systems, and materials for fabricating artificial red blood cells
JP2009545407A (ja) * 2006-08-02 2009-12-24 ボストン サイエンティフィック サイムド，インコーポレイテッド 三次元分解制御を備えたエンドプロテーゼ
WO2008034048A2 (en) * 2006-09-15 2008-03-20 Boston Scientific Limited Bioerodible endoprosthesis with biostable inorganic layers
EP2959925B1 (de) 2006-09-15 2018-08-29 Boston Scientific Limited Medizinische vorrichtungen und verfahren zu ihrer herstellung
JP2010503490A (ja) * 2006-09-15 2010-02-04 ボストン サイエンティフィック リミテッド 調整可能な表面特徴を備えた内部人工器官
CA2663271A1 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Bioerodible endoprostheses and methods of making the same
CA2663250A1 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Bioerodible endoprostheses and methods of making the same
US8002821B2 (en) 2006-09-18 2011-08-23 Boston Scientific Scimed, Inc. Bioerodible metallic ENDOPROSTHESES
US20110165236A1 (en) * 2006-09-22 2011-07-07 Biokey, Inc. Controlled release hydrogel formulation
US20080075785A1 (en) * 2006-09-22 2008-03-27 San-Laung Chow Controlled release hydrogel formulation
WO2008047369A2 (en) 2006-10-18 2008-04-24 Inspiremd Ltd. Knitted stent jackets
US20100324664A1 (en) * 2006-10-18 2010-12-23 Asher Holzer Bifurcated Stent Assemblies
US20080097577A1 (en) * 2006-10-20 2008-04-24 Boston Scientific Scimed, Inc. Medical device hydrogen surface treatment by electrochemical reduction
US8920845B2 (en) * 2006-11-02 2014-12-30 National University Corporation Nagoya University Method of producing microcapsules
EP1958622A1 (de) * 2006-11-07 2008-08-20 Royal College of Surgeons in Ireland Verfahren zur Herstellung von Mikrokapseln
CN101578078B (zh) 2006-11-22 2013-01-02 印斯拜尔Md有限公司 优化的支架套
WO2008080047A2 (en) * 2006-12-23 2008-07-03 Baxter International Inc. Magnetic separation of fine particles from compositions
ATE488259T1 (de) 2006-12-28 2010-12-15 Boston Scient Ltd Bioerodierbare endoprothesen und herstellungsverfahren dafür
US20080182019A1 (en) * 2007-01-30 2008-07-31 Robert Retter Hollow Microsphere Particle Generator
US20080182056A1 (en) * 2007-01-30 2008-07-31 Eric Bakker Hollow Microsphere Particles
US7872563B2 (en) * 2007-04-09 2011-01-18 The Board Of Trustees Of The University Of Illinois Variably porous structures
US8237538B2 (en) * 2007-04-09 2012-08-07 The Board Of Trustees Of The University Of Illinois Porous battery electrode for a rechargeable battery and method of making the electrode
US8222988B2 (en) * 2007-04-09 2012-07-17 The Board Of Trustees Of The University Of Illinois Porous device for optical and electronic applications and method of fabricating the porous device
US8426467B2 (en) * 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
US8722736B2 (en) * 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
US20080293814A1 (en) * 2007-05-22 2008-11-27 Deepak Tiwari Concentrate esmolol
US20080299391A1 (en) * 2007-05-31 2008-12-04 White Scott R Capsules, methods for making capsules, and self-healing composites including the same
BRPI0815416A2 (pt) 2007-08-15 2014-10-21 Amunix Inc Composições e métodos para modificar propriedades de polipeptídeos biologicamente ativos
US8052745B2 (en) 2007-09-13 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis
EP2205221A2 (de) * 2007-10-23 2010-07-14 Koninklijke Philips Electronics N.V. Verfahren zur herstellung von polymermikropartikeln
EP2055299A1 (de) * 2007-10-23 2009-05-06 Koninklijke Philips Electronics N.V. Verfahren zur Herstellung von Polymermikropartikeln
ES2718612T3 (es) 2007-12-20 2019-07-03 Evonik Corp Procedimiento para preparar micropartículas que tienen un bajo volumen de disolvente residual
EP2172264A1 (de) * 2008-01-02 2010-04-07 Ziel Biopharma Ltd Verfahren und Gerät zur Herstellung von Mikrokapseln
US20090181254A1 (en) * 2008-01-15 2009-07-16 The Board Of Trustees Of The University Of Illinois Multi-capsule system and its use for encapsulating active agents
US8983580B2 (en) * 2008-01-18 2015-03-17 The Board Of Trustees Of The University Of Illinois Low-coherence interferometry and optical coherence tomography for image-guided surgical treatment of solid tumors
US8115934B2 (en) 2008-01-18 2012-02-14 The Board Of Trustees Of The University Of Illinois Device and method for imaging the ear using optical coherence tomography
US7751057B2 (en) 2008-01-18 2010-07-06 The Board Of Trustees Of The University Of Illinois Magnetomotive optical coherence tomography
EP2085080A1 (de) 2008-01-30 2009-08-05 LEK Pharmaceuticals D.D. Herstellung von Nanoteilchen durch Verwendung einer vibrierenden Düsenvorrichtung
JP4656167B2 (ja) * 2008-03-03 2011-03-23 株式会社日立プラントテクノロジー 流体機器装置
US7998192B2 (en) 2008-05-09 2011-08-16 Boston Scientific Scimed, Inc. Endoprostheses
US20090297621A1 (en) * 2008-06-03 2009-12-03 Abbott Cardiovascular Systems Inc. Microparticles For The Treatment Of Disease
US8236046B2 (en) 2008-06-10 2012-08-07 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
EP2306991B1 (de) 2008-06-27 2019-12-25 Tepha, Inc. Verbesserte injektionsabgabe von mikroteilchen und zusammensetzungen dafür
WO2010011641A2 (en) * 2008-07-21 2010-01-28 The Regents Of The University Of Michigan Microphasic micro-components and methods for controlling morphology via electrified jetting
US20100012712A1 (en) * 2008-07-21 2010-01-21 Dixie Consumer Products Llc Paper cup manufacture with microencapsulated adhesive
US7985252B2 (en) 2008-07-30 2011-07-26 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
WO2010033452A2 (en) * 2008-09-19 2010-03-25 Delaware State University Foundation, Inc. Mono-and multi-element coded libs assays and methods
US8382824B2 (en) 2008-10-03 2013-02-26 Boston Scientific Scimed, Inc. Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides
US20110046060A1 (en) 2009-08-24 2011-02-24 Amunix Operating, Inc., Coagulation factor IX compositions and methods of making and using same
PL2393828T3 (pl) 2009-02-03 2017-06-30 Amunix Operating Inc. Wydłużone rekombinowane polipeptydy i zawierające je kompozycje
JP6126783B2 (ja) 2009-03-02 2017-05-10 セブンス センス バイオシステムズ，インコーポレーテッド 被検体の皮膚から、および／または該皮膚の下から引き抜かれた媒体の分析用のデバイス
US9295417B2 (en) 2011-04-29 2016-03-29 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
WO2010101901A2 (en) 2009-03-02 2010-09-10 Boston Scientific Scimed, Inc. Self-buffering medical implants
US9033898B2 (en) 2010-06-23 2015-05-19 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
WO2010127119A2 (en) * 2009-04-29 2010-11-04 The Regents Of The University Of Michigan Multiphasic microfibers for spatially guided cell growth
US20120123355A1 (en) * 2009-07-30 2012-05-17 Cook Medical Technologied Erodible embolization material
WO2011053675A2 (en) 2009-10-30 2011-05-05 Cns Therapeutics, Inc. Improved neurturin molecules
US10668060B2 (en) 2009-12-10 2020-06-02 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
WO2011084620A2 (en) * 2009-12-16 2011-07-14 Brigham And Women's Hospital, Inc. Particles for multiple agent delivery
WO2011094573A1 (en) 2010-01-28 2011-08-04 Seventh Sense Biosystems, Inc. Monitoring or feedback systems and methods
JP5432767B2 (ja) * 2010-02-25 2014-03-05 日本光電工業株式会社 リモートメンテナンスシステム及び中継ユニット
EA015780B1 (ru) * 2010-03-11 2011-12-30 Общество С Ограниченной Ответственностью "Цэм" (Ооо "Цэм") Фармацевтическая композиция пролонгированного действия для снижения аппетита
WO2011119573A1 (en) 2010-03-23 2011-09-29 Boston Scientific Scimed, Inc. Surface treated bioerodible metal endoprostheses
US10154923B2 (en) 2010-07-15 2018-12-18 Eyenovia, Inc. Drop generating device
EP2593055A1 (de) 2010-07-15 2013-05-22 Corinthian Ophthalmic, Inc. Verfahren und system zur durchführung von ferngesteuerten behandlungen und überwachung
CN103118642B (zh) 2010-07-15 2015-09-09 艾诺维亚股份有限公司 液滴生成装置
CA2805425C (en) 2010-07-15 2019-07-23 Corinthian Ophthalmic, Inc. Ophthalmic drug delivery
US20120016308A1 (en) 2010-07-16 2012-01-19 Seventh Sense Biosystems, Inc. Low-pressure packaging for fluid devices
US20130158482A1 (en) 2010-07-26 2013-06-20 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
US20120039809A1 (en) 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Systems and techniques for monitoring subjects
GB201016436D0 (en) 2010-09-30 2010-11-17 Q Chip Ltd Method of making solid beads
GB201016433D0 (en) 2010-09-30 2010-11-17 Q Chip Ltd Apparatus and method for making solid beads
US9482861B2 (en) 2010-10-22 2016-11-01 The Regents Of The University Of Michigan Optical devices with switchable particles
EP2637562B1 (de) 2010-11-09 2016-01-27 Seventh Sense Biosystems, Inc. Systeme und schnittstellen zur blutabnahme
GB201102148D0 (en) * 2011-02-08 2011-03-23 Ucl Business Plc Layered bodies, compositions containing them and processes for producing them
WO2012149126A1 (en) 2011-04-29 2012-11-01 Seventh Sense Biosystems, Inc. Plasma or serum production and removal of fluids under reduced pressure
US20130158468A1 (en) 2011-12-19 2013-06-20 Seventh Sense Biosystems, Inc. Delivering and/or receiving material with respect to a subject surface
BR112013027351B1 (pt) 2011-04-29 2022-03-03 Seventh Sense Biosystems, Inc Dispositivo para receber fluido de um indivíduo
EP2790729A4 (de) 2011-12-12 2015-08-12 Orbis Biosciences Inc Partikelformulierungen mit verzögerter freisetzung
US20130150812A1 (en) 2011-12-12 2013-06-13 Corinthian Ophthalmic, Inc. High modulus polymeric ejector mechanism, ejector device, and methods of use
CN119192402A (zh) 2012-02-15 2024-12-27 比奥贝拉蒂治疗公司 因子viii组合物及其制备和使用方法
WO2013123457A1 (en) 2012-02-15 2013-08-22 Biogen Idec Ma Inc. Recombinant factor viii proteins
US9163169B2 (en) 2012-03-13 2015-10-20 Georgia-Pacific Chemicals Llc Adhesive compositions having a reduced cure time and methods for making and using same
CA2871479A1 (en) 2012-04-27 2013-10-31 Georgia-Pacific Chemicals Llc Composite products made with lewis acid catalyzed binder compositions that include tannins and multifunctional aldehydes
WO2014008207A1 (en) 2012-07-02 2014-01-09 Boston Scientific Scimed, Inc. Prosthetic heart valve formation
US20140294944A1 (en) 2013-03-28 2014-10-02 Kimberly-Clark Worldwide, Inc. Microencapsulation of oxygen liberating reactants
RU2015144632A (ru) 2013-05-02 2017-06-07 Глаксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед Терапевтические пептиды
WO2015023891A2 (en) 2013-08-14 2015-02-19 Biogen Idec Ma Inc. Factor viii-xten fusions and uses thereof
WO2015130760A1 (en) 2014-02-25 2015-09-03 Orbis Biosciences, Inc. Taste masking drug formulations
WO2015153520A1 (en) 2014-04-02 2015-10-08 Georgia-Pacific Chemicals Llc Methods for making lignocellulose composite products with oxidative binders and encapsulated catalyst
EP3984525A1 (de) 2014-06-12 2022-04-20 Adare Pharmaceuticals USA, Inc. Wirkstoffausgabezusammensetzungen mit verzögerter freisetzung
WO2015198521A1 (ja) * 2014-06-26 2015-12-30 ソニー株式会社 正極、電池、電池パック、電子機器、電動車両、蓄電装置および電力システム
US10149826B2 (en) * 2015-01-20 2018-12-11 Hyalo Technologies, LLC Method of preparing microspheres
US10309880B2 (en) 2015-03-26 2019-06-04 Dover Photonics Llc Preparation of fluid samples for laser induced breakdown spectroscopy and/or imaging analysis
US10426609B2 (en) 2015-04-09 2019-10-01 Boston Scientific Scimed, Inc. Fiber reinforced prosthetic heart valve having undulating fibers
US10299915B2 (en) 2015-04-09 2019-05-28 Boston Scientific Scimed, Inc. Synthetic heart valves composed of zwitterionic polymers
US10314696B2 (en) 2015-04-09 2019-06-11 Boston Scientific Scimed, Inc. Prosthetic heart valves having fiber reinforced leaflets
US10716671B2 (en) 2015-07-02 2020-07-21 Boston Scientific Scimed, Inc. Prosthetic heart valve composed of composite fibers
US10413403B2 (en) 2015-07-14 2019-09-17 Boston Scientific Scimed, Inc. Prosthetic heart valve including self-reinforced composite leaflets
CA2994547A1 (en) 2015-08-03 2017-02-09 Bioverativ Therapeutics Inc. Factor ix fusion proteins and methods of making and using same
US10195023B2 (en) 2015-09-15 2019-02-05 Boston Scientific Scimed, Inc. Prosthetic heart valves including pre-stressed fibers
EP3389862B1 (de) 2015-12-16 2023-12-06 6K Inc. Verfahren zur herstellung von kugelförmigen, dehydrierten titanlegierungspartikeln
US10987735B2 (en) 2015-12-16 2021-04-27 6K Inc. Spheroidal titanium metallic powders with custom microstructures
GB2551944B (en) * 2015-12-18 2021-09-01 Midatech Pharma Wales Ltd Microparticle production process and apparatus
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil
CN109414401B (zh) 2016-04-26 2023-06-13 阿代尔制药股份有限公司 用于胃肠外给药的生物可降解聚合物微球组合物
WO2017200920A1 (en) 2016-05-19 2017-11-23 Boston Scientific Scimed, Inc. Prosthetic valves, valve leaflets and related methods
WO2017222575A1 (en) 2016-06-23 2017-12-28 Collegium Pharmaceutical, Inc. Process of making more stable abuse-deterrent oral formulations
WO2017223482A1 (en) * 2016-06-23 2017-12-28 Amastan Technologies Llc Lithium ion battery materials
US20180000744A1 (en) * 2016-06-30 2018-01-04 Georgia Southern Research and Service Foundation, Inc. Nanoencapsulated compositions
US10654040B2 (en) 2016-08-18 2020-05-19 Northeastern University Platform for liquid droplet formation and isolation
US10707531B1 (en) 2016-09-27 2020-07-07 New Dominion Enterprises Inc. All-inorganic solvents for electrolytes
US10967102B2 (en) 2016-09-28 2021-04-06 Boston Scientific Limited Cell encapsulation membranes, devices and methods
US11471419B2 (en) 2016-09-30 2022-10-18 The Board Of Trustees Of The University Of Illinois Capsules with intracapsular microspheres for improved survival and function of encapsulated cells
TWI631985B (zh) * 2016-10-26 2018-08-11 財團法人金屬工業研究發展中心 微粒製造方法
US12161696B2 (en) 2016-12-02 2024-12-10 Bioverativ Therapeutics Inc. Methods of treating hemophilic arthropathy using chimeric clotting factors
CN110494170A (zh) 2017-04-25 2019-11-22 波士顿科学国际有限公司 生物相容性聚异丁烯-纤维复合材料和方法
WO2018227190A1 (en) 2017-06-10 2018-12-13 Eyenovia, Inc. Methods and devices for handling a fluid and delivering the fluid to the eye
US11173461B2 (en) 2018-03-22 2021-11-16 Lawrence Livermore National Security, Llc Fabricating structured particles through rapid hardening and tailored collection methods
TW202015723A (zh) 2018-05-18 2020-05-01 美商百歐維拉提夫治療公司 治療ａ型血友病的方法
CA3104080A1 (en) 2018-06-19 2019-12-26 6K Inc. Process for producing spheroidized powder from feedstock materials
US11684498B2 (en) 2018-10-19 2023-06-27 Inspire M.D Ltd. Methods of using a self-adjusting stent assembly and kits including same
TR201818352A2 (tr) * 2018-12-02 2020-06-22 Bursa Teknik Ueniversitesi Mi̇kroenkapsülasyon yöntemleri̇nde parti̇kül boyutunu küçülten damlatma düzeneği̇
FR3089391A1 (fr) 2018-12-05 2020-06-12 V. Mane Fils Méthode d’amelioration de l’expérience sensorielle d’un arome
KR20220002998A (ko) 2019-04-30 2022-01-07 6케이 인크. 기계적으로 합금된 분말 공급원료
US11611130B2 (en) 2019-04-30 2023-03-21 6K Inc. Lithium lanthanum zirconium oxide (LLZO) powder
AU2020400980A1 (en) 2019-11-18 2022-03-31 6K Inc. Unique feedstocks for spherical powders and methods of manufacturing
US12245935B2 (en) 2019-11-26 2025-03-11 Boston Scientific Limited Composite web-polymer heart valve
CN115038414A (zh) 2019-12-11 2022-09-09 艾诺维亚股份有限公司 用于向眼睛输送流体的系统和装置及使用方法
US11590568B2 (en) 2019-12-19 2023-02-28 6K Inc. Process for producing spheroidized powder from feedstock materials
CA3180426A1 (en) 2020-06-25 2021-12-30 Richard K. Holman Microcomposite alloy structure
NL2025932B1 (en) 2020-06-26 2022-02-21 Iamfluidics Holding B V Micro-fluidic system and method
US11351514B2 (en) 2020-07-02 2022-06-07 Lawrence Livermore National Security, Llc Parallelized multiple nozzle system and method to produce layered droplets and fibers for microencapsulation
KR20230038183A (ko) 2020-07-10 2023-03-17 아데어 파마슈티컬스 인코포레이티드 팽윤성 경구 제약 조성물
EP4165957A4 (de) 2020-09-24 2024-07-24 6K Inc. Systeme, vorrichtungen und verfahren zum starten von plasma
CA3196653A1 (en) 2020-10-30 2022-05-05 Sunil Bhalchandra BADWE Systems and methods for synthesis of spheroidized metal powders
NL2027229B1 (en) * 2020-12-24 2022-07-20 Medspray B V Device and method to aerosolize nanoparticle formulations
CN116711095A (zh) 2021-01-11 2023-09-05 6K有限公司 使用微波等离子体处理用于回收锂离子阴极材料的方法和系统
WO2022212291A1 (en) 2021-03-31 2022-10-06 6K Inc. Systems and methods for additive manufacturing of metal nitride ceramics
BR112023024086A2 (pt) 2021-05-20 2024-02-06 V Mane Fils Grânulos saborizantes e método de fabricar e usar os mesmos
WO2022246285A1 (en) * 2021-05-21 2022-11-24 The Trustees Of Columbia University In The City Of New York Bio-microbur therapeutic delivery platform
GB202205123D0 (en) * 2022-04-07 2022-05-25 Univ Oxford Innovation Ltd Encapsulation method and particle
US12261023B2 (en) 2022-05-23 2025-03-25 6K Inc. Microwave plasma apparatus and methods for processing materials using an interior liner
US12040162B2 (en) 2022-06-09 2024-07-16 6K Inc. Plasma apparatus and methods for processing feed material utilizing an upstream swirl module and composite gas flows
US12094688B2 (en) 2022-08-25 2024-09-17 6K Inc. Plasma apparatus and methods for processing feed material utilizing a powder ingress preventor (PIP)
US12195338B2 (en) 2022-12-15 2025-01-14 6K Inc. Systems, methods, and device for pyrolysis of methane in a microwave plasma for hydrogen and structured carbon powder production
US12435622B2 (en) 2023-08-22 2025-10-07 Saudi Arabian Oil Company Identifying drill cuttings with tracer pills

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US617469A (en) * 1899-01-10 Isaac moore
US2766064A (en) * 1955-08-22 1956-10-09 Howard V Schweitzer Paint gun
US3579245A (en) * 1967-12-07 1971-05-18 Teletype Corp Method of transferring liquid
IE45426B1 (en) * 1976-07-15 1982-08-25 Ici Ltd Atomisation of liquids
DE2725849C3 (de) 1977-06-08 1980-11-13 Hobeg Hochtemperaturreaktor-Brennelement Gmbh, 6450 Hanau Vorrichtung zur Herstellung von kugelförmigen Teilchen
US4313403A (en) * 1979-09-07 1982-02-02 Bie Jr Norman Internal combustion engine
CA1166413A (en) * 1980-10-30 1984-05-01 Edward E. Timm Process and apparatus for preparing uniform size polymer beads
US4748043A (en) * 1986-08-29 1988-05-31 Minnesota Mining And Manufacturing Company Electrospray coating process
DE3787700T3 (de) * 1986-10-29 1998-12-24 Kanegafuchi Kagaku Kogyo K.K., Osaka Gleichförmige Polymerteilchen.
US5985354A (en) * 1995-06-07 1999-11-16 Brown University Research Foundation Preparation of multiwall polymeric microcapsules from hydrophilic polymers
US4861627A (en) * 1987-05-01 1989-08-29 Massachusetts Institute Of Technology Preparation of multiwall polymeric microcapsules
CH675370A5 (en) 1988-06-03 1990-09-28 Ciba Geigy Ag Filled pill mfr. - by concentric nozzles receiving ingredients from oscillating diaphragms
US5019400A (en) 1989-05-01 1991-05-28 Enzytech, Inc. Very low temperature casting of controlled release microspheres
US5226948A (en) * 1990-08-30 1993-07-13 University Of Southern California Method and apparatus for droplet stream manufacturing
US5260002A (en) * 1991-12-23 1993-11-09 Vanderbilt University Method and apparatus for producing uniform polymeric spheres
DE69324280T2 (de) * 1992-01-13 1999-08-12 Hercules Inc., Wilmington, Del. Wärmeverbindbare Fasern für wiederstandsfähige Vliesstoffe
US5912015A (en) 1992-03-12 1999-06-15 Alkermes Controlled Therapeutics, Inc. Modulated release from biocompatible polymers
US5716644A (en) 1992-06-11 1998-02-10 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
US5674534A (en) 1992-06-11 1997-10-07 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
US5711968A (en) 1994-07-25 1998-01-27 Alkermes Controlled Therapeutics, Inc. Composition and method for the controlled release of metal cation-stabilized interferon
US5344676A (en) 1992-10-23 1994-09-06 The Board Of Trustees Of The University Of Illinois Method and apparatus for producing nanodrops and nanoparticles and thin film deposits therefrom
EP1013270A3 (de) 1992-12-02 2001-03-28 Alkermes Controlled Therapeutics, Inc. Wachstumhormon enthaltende Mikrosphaeren mit kontrollierter Freisetzung
DE4242645C2 (de) * 1992-12-17 1997-12-18 Deutsche Forsch Luft Raumfahrt Verfahren und Einrichtung zur Herstellung von Metallkügelchen annähernd gleichen Durchmessers
EP0729353B2 (de) 1993-11-19 2012-09-12 Alkermes, Inc. Herstellung biologisch abbaubarer, einen biologisch aktiven stoff enthaltender, mikropartikel
HU219487B (hu) 1993-11-19 2001-04-28 Janssen Pharmaceutica Nv. Riszperidont tartalmazó mikrorészecskék, eljárás előállításukra, alkalmazásuk és ezeket tartalmazó gyógyászati készítmények és előállításuk
US5650173A (en) 1993-11-19 1997-07-22 Alkermes Controlled Therapeutics Inc. Ii Preparation of biodegradable microparticles containing a biologically active agent
GB9324250D0 (en) * 1993-11-25 1994-01-12 Minnesota Mining & Mfg Inhaler
GB9406255D0 (en) * 1994-03-29 1994-05-18 Electrosols Ltd Dispensing device
US5922253A (en) 1995-05-18 1999-07-13 Alkermes Controlled Therapeutics, Inc. Production scale method of forming microparticles
CA2230494A1 (en) 1995-08-31 1997-03-06 Alkermes Controlled Therapeutics Inc. Composition for sustained release of an agent
AU709384B2 (en) 1996-03-01 1999-08-26 University Of Kansas, The Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents
US5792477A (en) 1996-05-07 1998-08-11 Alkermes Controlled Therapeutics, Inc. Ii Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent
US6187214B1 (en) 1996-05-13 2001-02-13 Universidad De Seville Method and device for production of components for microfabrication
US6196525B1 (en) 1996-05-13 2001-03-06 Universidad De Sevilla Device and method for fluid aeration via gas forced through a liquid within an orifice of a pressure chamber
ES2140998B1 (es) 1996-05-13 2000-10-16 Univ Sevilla Procedimiento de atomizacion de liquidos.
US6116516A (en) 1996-05-13 2000-09-12 Universidad De Sevilla Stabilized capillary microjet and devices and methods for producing same
US6189803B1 (en) 1996-05-13 2001-02-20 University Of Seville Fuel injection nozzle and method of use
US5817343A (en) 1996-05-14 1998-10-06 Alkermes, Inc. Method for fabricating polymer-based controlled-release devices
US6254854B1 (en) * 1996-05-24 2001-07-03 The Penn Research Foundation Porous particles for deep lung delivery
US5874111A (en) * 1997-01-07 1999-02-23 Maitra; Amarnath Process for the preparation of highly monodispersed polymeric hydrophilic nanoparticles
US5948483A (en) * 1997-03-25 1999-09-07 The Board Of Trustees Of The University Of Illinois Method and apparatus for producing thin film and nanoparticle deposits
US5989463A (en) 1997-09-24 1999-11-23 Alkermes Controlled Therapeutics, Inc. Methods for fabricating polymer-based controlled release devices
US5954907A (en) * 1997-10-07 1999-09-21 Avery Dennison Corporation Process using electrostatic spraying for coating substrates with release coating compositions, pressure sensitive adhesives, and combinations thereof
ATE262976T1 (de) * 1998-03-07 2004-04-15 Inotech Ag Verfahren und vorrichtung zum verkapseln von mikrobiellen, pflanzlichen und tierischen zellen bzw. von biologischen und chemischen substanzen
US6224794B1 (en) 1998-05-06 2001-05-01 Angiotech Pharmaceuticals, Inc. Methods for microsphere production
GB2345010B (en) * 1998-12-17 2002-12-31 Electrosols Ltd A delivery device
US6194006B1 (en) 1998-12-30 2001-02-27 Alkermes Controlled Therapeutics Inc. Ii Preparation of microparticles having a selected release profile
WO2000064590A1 (en) * 1999-04-23 2000-11-02 Battelle Memorial Institute Directionally controlled ehd aerosol sprayer
US6458387B1 (en) * 1999-10-18 2002-10-01 Epic Therapeutics, Inc. Sustained release microspheres
DE60140625D1 (de) * 2000-08-15 2010-01-07 Univ Illinois Verfahren zur herstellung von mikropartikeln
AU2001298061A1 (en) * 2000-12-13 2003-07-09 Purdue Research Foundation Microencapsulation of drugs by solvent exchange
US7309500B2 (en) * 2003-12-04 2007-12-18 The Board Of Trustees Of The University Of Illinois Microparticles
US7748343B2 (en) * 2004-11-22 2010-07-06 The Board Of Trustees Of The University Of Illinois Electrohydrodynamic spraying system

Also Published As

Publication number Publication date
US20040022939A1 (en) 2004-02-05
CA2419115C (en) 2011-03-08
AU2001284982A1 (en) 2002-02-25
WO2002013786A3 (en) 2003-08-28
DE60140625D1 (de) 2010-01-07
KR100867392B1 (ko) 2008-11-06
CA2419115A1 (en) 2002-02-21
US20080175915A1 (en) 2008-07-24
KR20030067660A (ko) 2003-08-14
EP1355630B1 (de) 2009-11-25
WO2002013786A2 (en) 2002-02-21
KR20080050540A (ko) 2008-06-05
US7368130B2 (en) 2008-05-06
KR100902625B1 (ko) 2009-06-15
JP2004505761A (ja) 2004-02-26
EP1355630A2 (de) 2003-10-29
US20020054912A1 (en) 2002-05-09
US6669961B2 (en) 2003-12-30

Similar Documents

Publication Publication Date Title
ATE449596T1 (de) Verfahren zur herstellung von mikropartikeln
ATE375370T1 (de) Verfahren zur herstellung einer wässrigen dispersion von aus polymerisat und feinteiligem anorganischem feststoff aufgebauten partikeln
DE50005599D1 (de) Verfahren zur herstellung von morphologisch einheitlichen mikro- und nanopartikeln mittels eines mikromischers
ATE402213T1 (de) Verfahren und vorrichtung zur herstellung von polyester
WO2005055988A3 (en) Microparticles
ATE236208T1 (de) Verfahren zur herstellung von perlpolymerisaten
CO5090925A1 (es) Metodo y aparato para la formacion de almohadillas o nucleos absorbentes fibrosos tendidos por aire
ATE375145T1 (de) Induziertes phasenübergangs verfahren zur herstellung von hydrophile wirkstoffe enthaltende mikropartikeln
JP2004505761A5 (de)
ATE457373T1 (de) Verfahren zur herstellung von kolloidale nanokristalle in nicht koordinierenden lösungsmitteln
DE60020732D1 (de) Verfahren zur herstellung von nanometer partikeln durch fliessbett- sprühtrocknung
DE50002593D1 (de) Verfahren und mikrovermischer zur herstellung einer dispersion
ATE352520T1 (de) Siliziumnanoteilchen und verfahren zur herstellung derselben
DE10134056B8 (de) Verfahren zur Herstellung von nanokristallinen Magnetkernen sowie Vorrichtung zur Durchführung des Verfahrens
DK1257604T3 (da) Bariumsulfat, fremgangsmåde til fremstilling deraf og dets anvendelse
ATE380016T1 (de) Aufstreuverfahren zur herstellung von pulverformulierungen
EP1688169A4 (de) Verfahren zur herstellung von feinen teilchen einer organischen verbindung
ATE361334T1 (de) Verfahren zur herstellung von hochreinem polycarbonat
DE60141616D1 (de) Verfahren zur Herstellung von kleinen, sphärischen Siliconharzpartikeln
ATE334159T1 (de) Verfahren zur herstellung von gut in wasser redispergierbaren und mit wasser benetzbaren polymerisatpulvern
DE60120586D1 (de) Verfahren zur Herstellung eines Siliziumnitridfilters
JP2002534613A5 (de)
DE60225203D1 (de) Verfahren zur Herstellung von Polymerpartikeln mit enger Teilchengrössen-Verteilung
ATE392203T1 (de) Verfahren zur verkapselung eines wirkstoffs
ATE277963T1 (de) Verfahren und vorrichtung zur herstellung von cellulosepartikeln

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties