TWI596115B - 具有ｐＨ－依賴性結合特性之抗－ＰＣＳＫ９抗體 - Google Patents

具有ｐＨ－依賴性結合特性之抗－ＰＣＳＫ９抗體 Download PDF

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Publication number
TWI596115B
TWI596115B TW102128784A TW102128784A TWI596115B TW I596115 B TWI596115 B TW I596115B TW 102128784 A TW102128784 A TW 102128784A TW 102128784 A TW102128784 A TW 102128784A TW I596115 B TWI596115 B TW I596115B
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Taiwan
Prior art keywords
antibody
pcsk9
synthetic
artificial sequence
antigen
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TW102128784A
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English (en)
Chinese (zh)
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TW201420605A (zh
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喬治 洋寇普羅斯
尼可拉斯 帕帕度普羅斯
安德魯 墨菲
尼爾 史塔賀
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再生元醫藥公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
TW102128784A 2012-08-13 2013-08-12 具有ｐＨ－依賴性結合特性之抗－ＰＣＳＫ９抗體 TWI596115B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261682349P 2012-08-13 2012-08-13
US201261703342P 2012-09-20 2012-09-20
US201261734398P 2012-12-07 2012-12-07
US201361761383P 2013-02-06 2013-02-06
US201361828258P 2013-05-29 2013-05-29

Publications (2)

Publication Number Publication Date
TW201420605A TW201420605A (zh) 2014-06-01
TWI596115B true TWI596115B (zh) 2017-08-21

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TW102128784A TWI596115B (zh) 2012-08-13 2013-08-12 具有ｐＨ－依賴性結合特性之抗－ＰＣＳＫ９抗體

Country Status (15)

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US (1) US9540449B2 (cg-RX-API-DMAC7.html)
EP (1) EP2882778B1 (cg-RX-API-DMAC7.html)
JP (1) JP6309521B2 (cg-RX-API-DMAC7.html)
KR (1) KR20150041662A (cg-RX-API-DMAC7.html)
CN (1) CN104540852B (cg-RX-API-DMAC7.html)
AR (1) AR092098A1 (cg-RX-API-DMAC7.html)
AU (1) AU2013302925B2 (cg-RX-API-DMAC7.html)
CA (1) CA2881679C (cg-RX-API-DMAC7.html)
EA (1) EA028244B1 (cg-RX-API-DMAC7.html)
IL (1) IL236785B (cg-RX-API-DMAC7.html)
MX (1) MX363213B (cg-RX-API-DMAC7.html)
NZ (1) NZ704771A (cg-RX-API-DMAC7.html)
TW (1) TWI596115B (cg-RX-API-DMAC7.html)
UY (1) UY34975A (cg-RX-API-DMAC7.html)
WO (1) WO2014028354A1 (cg-RX-API-DMAC7.html)

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