TWI489992B - 醯胺系胰高血糖素超級家族之胜肽前驅藥物 - Google Patents
醯胺系胰高血糖素超級家族之胜肽前驅藥物 Download PDFInfo
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- TWI489992B TWI489992B TW098143717A TW98143717A TWI489992B TW I489992 B TWI489992 B TW I489992B TW 098143717 A TW098143717 A TW 098143717A TW 98143717 A TW98143717 A TW 98143717A TW I489992 B TWI489992 B TW I489992B
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- glucagon
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
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Landscapes
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- Chemical & Material Sciences (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
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| US14427109P | 2009-01-13 | 2009-01-13 | |
| US18755609P | 2009-06-16 | 2009-06-16 |
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| TW201028162A TW201028162A (en) | 2010-08-01 |
| TWI489992B true TWI489992B (zh) | 2015-07-01 |
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| TW098143717A TWI489992B (zh) | 2008-12-19 | 2009-12-18 | 醯胺系胰高血糖素超級家族之胜肽前驅藥物 |
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| EP (2) | EP2376097A4 (enExample) |
| JP (2) | JP2012512903A (enExample) |
| KR (1) | KR20110110174A (enExample) |
| CN (1) | CN102325539A (enExample) |
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| AU (1) | AU2009327418A1 (enExample) |
| BR (1) | BRPI0922969A2 (enExample) |
| CA (1) | CA2747499A1 (enExample) |
| CL (1) | CL2011001498A1 (enExample) |
| IL (1) | IL213113A (enExample) |
| MX (1) | MX2011006524A (enExample) |
| PE (1) | PE20120332A1 (enExample) |
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| SG (1) | SG172291A1 (enExample) |
| TW (1) | TWI489992B (enExample) |
| WO (1) | WO2010071807A1 (enExample) |
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| WO2007056362A2 (en) | 2005-11-07 | 2007-05-18 | Indiana University Research And Technology Corporation | Glucagon analogs exhibiting physiological solubility and stability |
| CA2674354A1 (en) | 2007-01-05 | 2008-07-17 | Indiana University Research And Technology Corporation | Glucagon analogs exhibiting enhanced solubility in physiological ph buffers |
| EA017849B1 (ru) | 2007-02-15 | 2013-03-29 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | Соагонисты глюкагоновых/glp-1-рецепторов |
| WO2009058734A1 (en) * | 2007-10-30 | 2009-05-07 | Indiana University Research And Technology Corporation | Compounds exhibiting glucagon antagonist and glp-1 agonist activity |
| AU2008318986B2 (en) | 2007-10-30 | 2014-12-04 | Indiana University Research And Technology Corporation | Glucagon antagonists |
| JP2011511778A (ja) * | 2008-01-30 | 2011-04-14 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション | エステルに基づいたペプチドプロドラッグ |
| US8450270B2 (en) * | 2008-06-17 | 2013-05-28 | Indiana University Research And Technology Corporation | Glucagon analogs exhibiting enhanced solubility and stability in physiological pH buffers |
| EA020326B9 (ru) * | 2008-06-17 | 2015-03-31 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | Агонисты смешанного действия на основе глюкозозависимого инсулинотропного пептида для лечения нарушений обмена веществ и ожирения |
| PA8830501A1 (es) | 2008-06-17 | 2010-07-27 | Univ Indiana Res & Tech Corp | Co-agonistas del receptor de glucagon/glp-1 |
| CN102325539A (zh) | 2008-12-19 | 2012-01-18 | 印第安纳大学研究及科技有限公司 | 基于酰胺的胰高血糖素超家族肽前药 |
| CA2747195A1 (en) * | 2008-12-19 | 2010-07-15 | Indiana University Research And Technology Corporation | Dipeptide linked medicinal agents |
| AU2009335715B2 (en) | 2008-12-19 | 2016-09-15 | Indiana University Research And Technology Corporation | Amide-based insulin prodrugs |
| US8481485B2 (en) | 2008-12-19 | 2013-07-09 | Indiana University Research And Technology Corporation | Insulin analogs |
| WO2010096052A1 (en) | 2009-02-19 | 2010-08-26 | Merck Sharp & Dohme Corp. | Oxyntomodulin analogs |
| CN102459325B (zh) | 2009-06-16 | 2015-03-25 | 印第安纳大学科技研究有限公司 | 胃抑胜肽受体活化的胰高血糖素化合物 |
| US8703701B2 (en) | 2009-12-18 | 2014-04-22 | Indiana University Research And Technology Corporation | Glucagon/GLP-1 receptor co-agonists |
| EP2528618A4 (en) | 2010-01-27 | 2015-05-27 | Univ Indiana Res & Tech Corp | GLUCAGON ANTAGONISTE AND GIP AGONISTS CONJUGATES AND COMPOSITIONS FOR THE TREATMENT OF METABOLISM DISEASES AND ADIPOSITAS |
| CN103179976A (zh) | 2010-05-13 | 2013-06-26 | 印第安纳大学研究及科技有限公司 | 呈现g蛋白偶联受体活性的胰高血糖素超家族肽 |
| EP2569000B1 (en) | 2010-05-13 | 2017-09-27 | Indiana University Research and Technology Corporation | Glucagon superfamily peptides exhibiting nuclear hormone receptor activity |
| AU2011268327B2 (en) | 2010-06-16 | 2016-02-25 | Indiana University Research And Technology Corporation | Single chain insulin agonists exhibiting high activity at the insulin receptor |
| US8946147B2 (en) | 2010-06-24 | 2015-02-03 | Indiana University Research And Technology Corporation | Amide-based insulin prodrugs |
| RU2580317C2 (ru) * | 2010-06-24 | 2016-04-10 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | Пептидные пролекарства, принадлежащие к суперсемейству амид-содержащих глюкагонов |
| WO2011162968A1 (en) * | 2010-06-24 | 2011-12-29 | Indiana University Research And Technology Corporation | Dipeptide linked medicinal agents |
| US9023986B2 (en) | 2010-10-25 | 2015-05-05 | Hoffmann-La Roche Inc. | Glucose-dependent insulinotropic peptide analogs |
| BR112013015389A2 (pt) * | 2010-12-22 | 2016-11-22 | Univ Indiana Res & Tech Corp | análogo de glucagon exibindo atividade de receptor gip |
| AR084558A1 (es) | 2010-12-22 | 2013-05-22 | Marcadia Biotech | Metodos para tratar trastornos metabolicos y obesidad con peptidos basados en glucagon activos para el receptor de peptido insulinotropico dependiente de glucosa (gip)/peptido-1 similar al glucagon (glp-1) |
| RU2739209C2 (ru) | 2011-06-10 | 2020-12-21 | Ханми Сайенс Ко., Лтд. | Новые производные оксинтомодулина и содержащая их фармацевтическая композиция для лечения ожирения |
| EP2718317B1 (en) * | 2011-06-10 | 2018-11-14 | Beijing Hanmi Pharmaceutical Co., Ltd. | Glucose dependent insulinotropic polypeptide analogs, pharmaceutical compositions and use thereof |
| SI2721062T1 (sl) | 2011-06-17 | 2019-03-29 | Hanmi Science Co., Ltd. | Konjugat, obsegajoč oksintomodulinski in imunoglobinski fragment, in uporaba le-tega |
| PE20140724A1 (es) * | 2011-06-22 | 2014-07-10 | Univ Indiana Res & Tech Corp | Coagonistas del receptor de glucagon/glp-1 |
| CA2839867A1 (en) | 2011-06-22 | 2012-12-27 | Indiana University Research And Technology Corporation | Glucagon/glp-1 receptor co-agonists |
| EP2729493B1 (en) | 2011-07-04 | 2020-06-10 | IP2IPO Innovations Limited | Novel compounds and their effects on feeding behaviour |
| EP2578599A1 (en) * | 2011-10-07 | 2013-04-10 | LanthioPep B.V. | Cyclic analogs of GLP-1 and GLP-1 related peptides |
| US8859491B2 (en) | 2011-11-17 | 2014-10-14 | Indiana University Research And Technology Corporation | Glucagon superfamily peptides exhibiting glucocorticoid receptor activity |
| BR112014015156A2 (pt) | 2011-12-20 | 2020-10-27 | Indiana University Research And Technology Corporation | análogos de insulina à base de ctp, seus métodos de produção e uso no tratamento de hiperglicemia, bem como sequência de ácido nucleico e célula hospedeira |
| DK2802598T3 (en) * | 2012-01-12 | 2018-03-12 | Univ Ulster | PEPTIDES AND PEPTID DERIVATIVES BASED ON XENIN |
| WO2013127779A1 (en) | 2012-03-01 | 2013-09-06 | Novo Nordisk A/S | Glp-1 prodrugs |
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- 2009-12-18 KR KR1020117016193A patent/KR20110110174A/ko not_active Abandoned
- 2009-12-18 RU RU2011129784/04A patent/RU2550696C2/ru not_active IP Right Cessation
- 2009-12-18 AR ARP090104993A patent/AR074811A1/es not_active Application Discontinuation
- 2009-12-18 US US13/130,962 patent/US8969288B2/en active Active
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- 2009-12-18 AU AU2009327418A patent/AU2009327418A1/en not_active Abandoned
- 2009-12-18 WO PCT/US2009/068745 patent/WO2010071807A1/en not_active Ceased
- 2009-12-18 EP EP09833836A patent/EP2376097A4/en not_active Ceased
- 2009-12-18 EP EP16164599.9A patent/EP3075385A1/en not_active Withdrawn
- 2009-12-18 PE PE2011001238A patent/PE20120332A1/es not_active Application Discontinuation
- 2009-12-18 TW TW098143717A patent/TWI489992B/zh not_active IP Right Cessation
- 2009-12-18 BR BRPI0922969A patent/BRPI0922969A2/pt not_active IP Right Cessation
- 2009-12-18 SG SG2011045283A patent/SG172291A1/en unknown
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- 2011-06-17 CL CL2011001498A patent/CL2011001498A1/es unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| CL2011001498A1 (es) | 2012-03-09 |
| SG172291A1 (en) | 2011-07-28 |
| TW201028162A (en) | 2010-08-01 |
| EP3075385A1 (en) | 2016-10-05 |
| RU2550696C2 (ru) | 2015-05-10 |
| CA2747499A1 (en) | 2010-06-24 |
| WO2010071807A1 (en) | 2010-06-24 |
| PE20120332A1 (es) | 2012-04-14 |
| EP2376097A4 (en) | 2012-10-03 |
| JP2012512903A (ja) | 2012-06-07 |
| US20110288003A1 (en) | 2011-11-24 |
| KR20110110174A (ko) | 2011-10-06 |
| AU2009327418A1 (en) | 2010-06-24 |
| US8969288B2 (en) | 2015-03-03 |
| CN102325539A (zh) | 2012-01-18 |
| BRPI0922969A2 (pt) | 2019-09-24 |
| IL213113A (en) | 2017-09-28 |
| MX2011006524A (es) | 2011-08-17 |
| RU2011129784A (ru) | 2013-01-27 |
| AR074811A1 (es) | 2011-02-16 |
| EP2376097A1 (en) | 2011-10-19 |
| JP2015180649A (ja) | 2015-10-15 |
| IL213113A0 (en) | 2011-07-31 |
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