AU2009327418A1 - Amide based glucagon superfamily peptide prodrugs - Google Patents
Amide based glucagon superfamily peptide prodrugs Download PDFInfo
- Publication number
- AU2009327418A1 AU2009327418A1 AU2009327418A AU2009327418A AU2009327418A1 AU 2009327418 A1 AU2009327418 A1 AU 2009327418A1 AU 2009327418 A AU2009327418 A AU 2009327418A AU 2009327418 A AU2009327418 A AU 2009327418A AU 2009327418 A1 AU2009327418 A1 AU 2009327418A1
- Authority
- AU
- Australia
- Prior art keywords
- alkyl
- amino acid
- group
- glucagon
- prodrug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims description 443
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 title claims description 416
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- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims description 12
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Chemical group CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 12
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- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 claims description 9
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- 239000003877 glucagon like peptide 1 receptor agonist Substances 0.000 claims description 8
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
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Applications Claiming Priority (7)
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| US61/139,210 | 2008-12-19 | ||
| US14427109P | 2009-01-13 | 2009-01-13 | |
| US61/144,271 | 2009-01-13 | ||
| US18755609P | 2009-06-16 | 2009-06-16 | |
| US61/187,556 | 2009-06-16 | ||
| PCT/US2009/068745 WO2010071807A1 (en) | 2008-12-19 | 2009-12-18 | Amide based glucagon superfamily peptide prodrugs |
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- 2009-12-18 KR KR1020117016193A patent/KR20110110174A/ko not_active Abandoned
- 2009-12-18 RU RU2011129784/04A patent/RU2550696C2/ru not_active IP Right Cessation
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- 2009-12-18 AU AU2009327418A patent/AU2009327418A1/en not_active Abandoned
- 2009-12-18 WO PCT/US2009/068745 patent/WO2010071807A1/en not_active Ceased
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| CL2011001498A1 (es) | 2012-03-09 |
| SG172291A1 (en) | 2011-07-28 |
| TW201028162A (en) | 2010-08-01 |
| EP3075385A1 (en) | 2016-10-05 |
| RU2550696C2 (ru) | 2015-05-10 |
| CA2747499A1 (en) | 2010-06-24 |
| WO2010071807A1 (en) | 2010-06-24 |
| PE20120332A1 (es) | 2012-04-14 |
| EP2376097A4 (en) | 2012-10-03 |
| JP2012512903A (ja) | 2012-06-07 |
| US20110288003A1 (en) | 2011-11-24 |
| KR20110110174A (ko) | 2011-10-06 |
| US8969288B2 (en) | 2015-03-03 |
| CN102325539A (zh) | 2012-01-18 |
| BRPI0922969A2 (pt) | 2019-09-24 |
| TWI489992B (zh) | 2015-07-01 |
| IL213113A (en) | 2017-09-28 |
| MX2011006524A (es) | 2011-08-17 |
| RU2011129784A (ru) | 2013-01-27 |
| AR074811A1 (es) | 2011-02-16 |
| EP2376097A1 (en) | 2011-10-19 |
| JP2015180649A (ja) | 2015-10-15 |
| IL213113A0 (en) | 2011-07-31 |
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