TWI485150B - 三唑并吡啶化合物及其作為脯胺醯基羥化酶抑制劑或紅血球生成素生產誘導劑之作用 - Google Patents

三唑并吡啶化合物及其作為脯胺醯基羥化酶抑制劑或紅血球生成素生產誘導劑之作用 Download PDF

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Publication number
TWI485150B
TWI485150B TW099123410A TW99123410A TWI485150B TW I485150 B TWI485150 B TW I485150B TW 099123410 A TW099123410 A TW 099123410A TW 99123410 A TW99123410 A TW 99123410A TW I485150 B TWI485150 B TW I485150B
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Taiwan
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compound
group
pharmaceutically acceptable
acceptable salt
alkyl
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TW099123410A
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TW201105671A (en
Inventor
三谷育生
生越洋介
松井拓也
橫田正宏
寺下正和
元田大
上山和人
阿部博行
堀田隆宏
伊東敬史
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日本煙草產業股份有限公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
TW099123410A 2009-07-17 2010-07-16 三唑并吡啶化合物及其作為脯胺醯基羥化酶抑制劑或紅血球生成素生產誘導劑之作用 TWI485150B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2009169565 2009-07-17

Publications (2)

Publication Number Publication Date
TW201105671A TW201105671A (en) 2011-02-16
TWI485150B true TWI485150B (zh) 2015-05-21

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TW099123410A TWI485150B (zh) 2009-07-17 2010-07-16 三唑并吡啶化合物及其作為脯胺醯基羥化酶抑制劑或紅血球生成素生產誘導劑之作用

Country Status (28)

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US (3) US8283465B2 (enExample)
EP (3) EP2455381B9 (enExample)
JP (9) JP5021797B2 (enExample)
KR (5) KR20260012830A (enExample)
CN (1) CN102471337B (enExample)
AR (1) AR077417A1 (enExample)
AU (1) AU2010271732B2 (enExample)
BR (1) BR112012001157A2 (enExample)
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CO (1) CO6430426A2 (enExample)
DK (1) DK2455381T5 (enExample)
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HR (1) HRP20140705T1 (enExample)
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ME (1) ME01858B (enExample)
MX (1) MX2012000766A (enExample)
MY (1) MY160814A (enExample)
NZ (1) NZ598242A (enExample)
PE (1) PE20120629A1 (enExample)
PL (1) PL2455381T3 (enExample)
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RS (1) RS53499B1 (enExample)
RU (1) RU2538963C2 (enExample)
SG (1) SG178049A1 (enExample)
SI (1) SI2455381T1 (enExample)
SM (1) SMT201500122B (enExample)
TW (1) TWI485150B (enExample)
WO (1) WO2011007856A1 (enExample)

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CN104936591B (zh) 2012-11-26 2018-05-29 国立大学法人东北大学 促红细胞生成素表达增强剂
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SMT202400092T1 (it) 2013-06-13 2024-05-14 Akebia Therapeutics Inc Composizioni e metodi per il trattamento dell'anemia
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RU2752384C2 (ru) * 2016-11-25 2021-07-26 Джапан Тобакко Инк. Способ получения триазолопиридинового соединения
CA3062972C (en) 2017-05-09 2021-09-14 Kind Pharmaceutical Indolizine derivatives and their application in medicine
WO2019069973A1 (ja) * 2017-10-04 2019-04-11 日本たばこ産業株式会社 含窒素ヘテロアリール化合物およびその医薬用途
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CN110105355B (zh) * 2019-05-24 2021-09-21 烟台大学 一种1,2,3-三唑-[1,5-a]并喹啉类化合物的制备方法
JP7566008B2 (ja) * 2020-03-11 2024-10-11 キッセイ薬品工業株式会社 イミダゾピリジノン化合物又はその塩の結晶
JP7504822B2 (ja) * 2020-03-12 2024-06-24 キッセイ薬品工業株式会社 イミダゾピリジノン化合物を含む医薬組成物
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CN113387948B (zh) * 2021-02-06 2022-06-10 成都诺和晟泰生物科技有限公司 一种稠环杂芳基衍生物及其药物组合物和治疗方法及用途
EP4308120A4 (en) 2021-03-19 2024-11-27 Zydus Lifesciences Limited TREATMENT OF SICKLE CELL ANEMIA
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CN113582843A (zh) * 2021-09-09 2021-11-02 无锡捷化医药科技有限公司 一种5-氯-2-氟-3-羟基苯甲酸乙酯的制备方法
CN116496269B (zh) * 2021-12-02 2025-02-28 苏中药业集团股份有限公司 一种脯氨酰羟化酶抑制剂及其用途
CN114031619A (zh) * 2021-12-17 2022-02-11 山东汇海医药化工有限公司 一种图卡替尼中间体的制备方法
CN117327066A (zh) * 2022-06-30 2024-01-02 上海济煜医药科技有限公司 一种新多晶型、其制备方法及其用于制备药物的用途
EP4578855A1 (en) * 2022-09-19 2025-07-02 Suzhong Pharmaceutical Group Co., Ltd. Prolyl hydroxylase inhibitor and use thereof
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TW202506675A (zh) * 2023-08-08 2025-02-16 美商富曼西公司 用於防治和對抗無脊椎有害生物的連接的雙環化合物
WO2025087207A1 (zh) 2023-10-24 2025-05-01 杭州安道药业有限公司 含有缺氧诱导因子-脯酰胺羟基化酶抑制剂的长效口服药物及其应用
CN117486878B (zh) * 2023-10-27 2026-05-05 扬州市普林斯医药科技有限公司 一种恩那司他的制备方法
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CN119818492B (zh) * 2024-02-05 2026-01-30 深圳信立泰药业股份有限公司 化合物在制备治疗非髓系恶性肿瘤患者的贫血药物中的应用
WO2025167739A1 (zh) * 2024-02-05 2025-08-14 深圳信立泰药业股份有限公司 化合物在制备预防和/或治疗高原病的药物中的应用
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Also Published As

Publication number Publication date
NZ598242A (en) 2013-09-27
KR20120051704A (ko) 2012-05-22
SMT201500122B (it) 2015-07-09
KR20170018105A (ko) 2017-02-15
JP2016040321A (ja) 2016-03-24
EP2455381B9 (en) 2014-10-22
CO6430426A2 (es) 2012-04-30
JP2011037841A (ja) 2011-02-24
RU2538963C2 (ru) 2015-01-10
AU2010271732B2 (en) 2016-08-25
EP2455381B1 (en) 2014-05-28
SG178049A1 (en) 2012-03-29
JP2022126843A (ja) 2022-08-30
CA2768505C (en) 2018-06-12
CN102471337B (zh) 2014-12-10
PL2455381T3 (pl) 2014-10-31
KR101850661B1 (ko) 2018-04-19
EP3594213A1 (en) 2020-01-15
AR077417A1 (es) 2011-08-24
WO2011007856A1 (ja) 2011-01-20
TW201105671A (en) 2011-02-16
AU2010271732A1 (en) 2012-03-08
JP2024091878A (ja) 2024-07-05
US20130096155A1 (en) 2013-04-18
JP2017214404A (ja) 2017-12-07
DK2455381T3 (da) 2014-07-21
CN102471337A (zh) 2012-05-23
CA2768505A1 (en) 2011-01-20
ES2477968T3 (es) 2014-07-18
IL217541A0 (en) 2012-02-29
ME01858B (me) 2014-12-20
JP2015003933A (ja) 2015-01-08
EP2455381A1 (en) 2012-05-23
IL217541A (en) 2014-07-31
HK1168346A1 (en) 2012-12-28
EP2746282A1 (en) 2014-06-25
JP6434575B2 (ja) 2018-12-05
MY160814A (en) 2017-03-31
PE20120629A1 (es) 2012-05-30
ES2477968T9 (es) 2014-11-13
KR20260012830A (ko) 2026-01-27
KR20180042443A (ko) 2018-04-25
KR20230165366A (ko) 2023-12-05
US8283465B2 (en) 2012-10-09
PT2455381E (pt) 2014-06-24
RS53499B1 (sr) 2015-02-27
BR112012001157A2 (pt) 2016-02-23
US20110077267A1 (en) 2011-03-31
EP2455381A4 (en) 2012-12-12
RU2012105467A (ru) 2013-08-27
SI2455381T1 (sl) 2014-08-29
HRP20140705T1 (hr) 2014-09-12
KR101706803B1 (ko) 2017-02-14
JP5021797B2 (ja) 2012-09-12
MX2012000766A (es) 2012-02-08
DK2455381T5 (en) 2015-02-09
US20160145254A1 (en) 2016-05-26
JP2012144571A (ja) 2012-08-02
JP2019019144A (ja) 2019-02-07
JP2020111612A (ja) 2020-07-27

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