CO6430426A2 - Compuestos de triazolopiridina, y su accion comominhibidor de prolil hidroxilasa e inductor de la produccion de eritropoyetina - Google Patents

Compuestos de triazolopiridina, y su accion comominhibidor de prolil hidroxilasa e inductor de la produccion de eritropoyetina

Info

Publication number
CO6430426A2
CO6430426A2 CO12014916A CO12014916A CO6430426A2 CO 6430426 A2 CO6430426 A2 CO 6430426A2 CO 12014916 A CO12014916 A CO 12014916A CO 12014916 A CO12014916 A CO 12014916A CO 6430426 A2 CO6430426 A2 CO 6430426A2
Authority
CO
Colombia
Prior art keywords
production
erythropoietin
compound
triazolopiridine
proomil
Prior art date
Application number
CO12014916A
Other languages
English (en)
Spanish (es)
Inventor
Ikuo Mitani
Yosuke Ogoshi
Takuya Matsui
Masahiro Yokota
Masakazu Terashita
Dai Motoda
Kazuhito Ueyama
Hiroyuki Abe
Takahiro Hotta
Takashi Ito
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of CO6430426A2 publication Critical patent/CO6430426A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
CO12014916A 2009-07-17 2012-01-31 Compuestos de triazolopiridina, y su accion comominhibidor de prolil hidroxilasa e inductor de la produccion de eritropoyetina CO6430426A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2009169565 2009-07-17
US27312709P 2009-07-30 2009-07-30

Publications (1)

Publication Number Publication Date
CO6430426A2 true CO6430426A2 (es) 2012-04-30

Family

ID=43449466

Family Applications (1)

Application Number Title Priority Date Filing Date
CO12014916A CO6430426A2 (es) 2009-07-17 2012-01-31 Compuestos de triazolopiridina, y su accion comominhibidor de prolil hidroxilasa e inductor de la produccion de eritropoyetina

Country Status (27)

Country Link
US (3) US8283465B2 (enExample)
EP (3) EP3594213A1 (enExample)
JP (9) JP5021797B2 (enExample)
KR (5) KR20180042443A (enExample)
CN (1) CN102471337B (enExample)
AR (1) AR077417A1 (enExample)
AU (1) AU2010271732B2 (enExample)
CA (1) CA2768505C (enExample)
CO (1) CO6430426A2 (enExample)
DK (1) DK2455381T5 (enExample)
ES (1) ES2477968T3 (enExample)
HR (1) HRP20140705T1 (enExample)
IL (1) IL217541A (enExample)
ME (1) ME01858B (enExample)
MX (1) MX2012000766A (enExample)
MY (1) MY160814A (enExample)
NZ (1) NZ598242A (enExample)
PE (1) PE20120629A1 (enExample)
PL (1) PL2455381T3 (enExample)
PT (1) PT2455381E (enExample)
RS (1) RS53499B1 (enExample)
RU (1) RU2538963C2 (enExample)
SG (1) SG178049A1 (enExample)
SI (1) SI2455381T1 (enExample)
SM (1) SMT201500122B (enExample)
TW (1) TWI485150B (enExample)
WO (1) WO2011007856A1 (enExample)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8283465B2 (en) * 2009-07-17 2012-10-09 Japan Tobacco Inc. Triazolopyridine compound, and action thereof as prolyl hydroxylase inhibitor or erythropoietin production-inducing agent
JP2011168582A (ja) * 2010-01-21 2011-09-01 Ishihara Sangyo Kaisha Ltd トリアゾロピリジン誘導体又はその塩、それらの製造方法及びそれらを含有する有害生物防除剤
WO2012065297A1 (en) * 2010-11-16 2012-05-24 Impact Therapeutics, Inc. 3-ARYL-6-ARYL-[1,2,4]TRIAZOLO[4,3-a]PYRIDINES AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF
HK1215179A1 (zh) 2012-11-26 2016-08-19 国立大学法人东北大学 促红细胞生成素表达增强剂
AP2015008502A0 (en) 2012-12-24 2015-06-30 Cadila Healthcare Ltd Novel quinolone derivatives
HUE066123T2 (hu) 2013-06-13 2024-07-28 Akebia Therapeutics Inc Készítmények és módszerek anémia kezelésére
RU2534804C1 (ru) * 2013-08-05 2014-12-10 Общество С Ограниченной Ответственностью "Ньювак" (Ооо "Ньювак") ЗАМЕЩЕННЫЕ [1,2,4]ТРИАЗОЛО[4,3-a]ПИРИДИНЫ, ПРОЯВЛЯЮЩИЕ СВОЙСТВА АНТАГОНИСТОВ АДЕНОЗИНОВЫХ А2А РЕЦЕПТОРОВ, И ИХ ПРИМЕНЕНИЕ
SI3052096T1 (en) 2013-10-03 2018-04-30 Kura Oncology, Inc. EAQ inhibitors and application procedures
CA2959688C (en) 2014-09-02 2024-02-27 Sunshine Lake Pharma Co., Ltd. Quinolone compounds and their use to treat diseases related to hypoxia inducible factor and/or erythropoietin
JP2018039733A (ja) * 2014-12-22 2018-03-15 株式会社富士薬品 新規複素環誘導体
GB201504565D0 (en) * 2015-03-18 2015-05-06 Takeda Pharmaceutical Novel compounds
CN106146395B (zh) * 2015-03-27 2019-01-01 沈阳三生制药有限责任公司 3-羟基吡啶化合物、其制备方法及其制药用途
EP4667059A3 (en) 2015-05-28 2026-04-08 Japan Tobacco Inc. Method for treating or preventing diabetic nephropathy
MX2019006083A (es) * 2016-11-25 2019-07-10 Japan Tobacco Inc Metodo para la produccion de compuesto de triazolopiridina.
JP7142406B2 (ja) 2017-05-09 2022-09-27 カインド ファーマシューティカル インドリジン誘導体及びその医学的応用
SG11202003005PA (en) * 2017-10-04 2020-04-29 Japan Tobacco Inc Nitrogen-containing heteroaryl compound, and pharmaceutical use thereof
CN107739378A (zh) * 2017-11-14 2018-02-27 杭州安道药业有限公司 吲哚嗪衍生物及其在医药上的应用
DK3808747T3 (da) * 2018-09-13 2025-02-03 Kissei Pharmaceutical Imidazopyridinon-forbindelse
CN110105355B (zh) * 2019-05-24 2021-09-21 烟台大学 一种1,2,3-三唑-[1,5-a]并喹啉类化合物的制备方法
JP7566008B2 (ja) * 2020-03-11 2024-10-11 キッセイ薬品工業株式会社 イミダゾピリジノン化合物又はその塩の結晶
JP7504822B2 (ja) * 2020-03-12 2024-06-24 キッセイ薬品工業株式会社 イミダゾピリジノン化合物を含む医薬組成物
WO2021216530A1 (en) 2020-04-20 2021-10-28 Akebia Therapeutics, Inc. Treatment of viral infections, of organ injury, and of related conditions using a hif prolyl hydroxylase inhibitor or a hif-alpha stabilizer
WO2022150623A1 (en) 2021-01-08 2022-07-14 Akebia Therapeutics, Inc. Compounds and composition for the treatment of anemia
CN113387948B (zh) * 2021-02-06 2022-06-10 成都诺和晟泰生物科技有限公司 一种稠环杂芳基衍生物及其药物组合物和治疗方法及用途
BR112023018949A2 (pt) 2021-03-19 2023-10-17 Zydus Lifesciences Ltd Composto, uso do mesmo para tratar anemia falciforme e composição farmacêutica compreendendo o referido composto
CN115197210A (zh) * 2021-04-06 2022-10-18 广东东阳光药业有限公司 一种酸的晶型及其制备方法
EP4347022A1 (en) 2021-05-27 2024-04-10 Keryx Biopharmaceuticals, Inc. Pediatric formulations of ferric citrate
CN113582843A (zh) * 2021-09-09 2021-11-02 无锡捷化医药科技有限公司 一种5-氯-2-氟-3-羟基苯甲酸乙酯的制备方法
CN116496269B (zh) * 2021-12-02 2025-02-28 苏中药业集团股份有限公司 一种脯氨酰羟化酶抑制剂及其用途
CN114031619A (zh) * 2021-12-17 2022-02-11 山东汇海医药化工有限公司 一种图卡替尼中间体的制备方法
CN117327066A (zh) * 2022-06-30 2024-01-02 上海济煜医药科技有限公司 一种新多晶型、其制备方法及其用于制备药物的用途
EP4578855A1 (en) * 2022-09-19 2025-07-02 Suzhong Pharmaceutical Group Co., Ltd. Prolyl hydroxylase inhibitor and use thereof
TWI905781B (zh) * 2023-06-02 2025-11-21 大陸商蘇中藥業集團股份有限公司 脯胺醯羥化酶抑制劑及其用途
TW202506675A (zh) * 2023-08-08 2025-02-16 美商富曼西公司 用於防治和對抗無脊椎有害生物的連接的雙環化合物
KR20260061246A (ko) 2023-10-24 2026-05-06 카인드 파마슈티컬 저산소증 유도인자-프로릴히드록시라제 억제제를 함유하는 장시간 작용형 경구 의약품 및 그 사용
CN117486878B (zh) * 2023-10-27 2026-05-05 扬州市普林斯医药科技有限公司 一种恩那司他的制备方法
WO2025137158A1 (en) * 2023-12-19 2025-06-26 Akebia Therapeutics, Inc. Derivatives of ([1,2,4]triazolo[5,1-a]isoquinoline-5-carbonyl)glycinate as phd inhibitor compounds, compositions, and methods of use
CN119700755B (zh) * 2024-02-05 2026-01-30 深圳信立泰药业股份有限公司 化合物在制备预防和/或治疗高原病的药物中的应用
WO2025167738A1 (zh) * 2024-02-05 2025-08-14 深圳信立泰药业股份有限公司 化合物在制备治疗非髓系恶性肿瘤患者的贫血药物中的应用
CN119039291A (zh) * 2024-09-09 2024-11-29 南京药坦生物科技有限公司 一种恩那度司他中间体及其制备方法
CN122036726A (zh) * 2026-04-20 2026-05-15 天津辰欣药物研究有限公司 一种三唑并吡啶化合物的制备方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19746287A1 (de) * 1997-10-20 1999-04-22 Hoechst Marion Roussel De Gmbh Substituierte Isochinolin-2-Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
US6355653B1 (en) * 1999-09-06 2002-03-12 Hoffmann-La Roche Inc. Amino-triazolopyridine derivatives
US6514989B1 (en) * 2001-07-20 2003-02-04 Hoffmann-La Roche Inc. Aromatic and heteroaromatic substituted 1,2,4-triazolo pyridine derivatives
BR0213172A (pt) * 2001-10-08 2004-09-14 Hoffmann La Roche Amida do ácido 8-amino-[1,2,4]triazolo[1,5-a]piridina-6-carboxìlico
US7544699B2 (en) 2003-08-08 2009-06-09 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions, and methods of use
MX2007001431A (es) * 2004-08-05 2007-04-02 Hoffmann La Roche Derivados de indol, de indazol o de indolina.
FR2889383A1 (fr) * 2005-08-01 2007-02-02 France Telecom Procede et dispositif de detection pour systeme mimo, systeme mimo, programme et support d'information
PE20071020A1 (es) * 2006-03-07 2007-12-11 Smithkline Beecham Corp Compuestos derivados de glicina n-sustituidos como inhibidores de prolil hidroxilasa
JP2009537558A (ja) * 2006-05-16 2009-10-29 スミスクライン・ビーチャム・コーポレイション プロリルヒドロキシラーゼ阻害剤
TWI394747B (zh) 2006-06-23 2013-05-01 Smithkline Beecham Corp 脯胺醯基羥化酶抑制劑
NZ623002A (en) * 2006-06-26 2015-08-28 Akebia Therapeutics Inc Prolyl hydroxylase inhibitors and methods of use
AU2007272009A1 (en) 2006-07-12 2008-01-17 Syngenta Limited Triazolopyridine derivatives as herbicides
CL2008000066A1 (es) * 2007-01-12 2008-08-01 Smithkline Beecham Corp Compuestos derivados de (5-hidroxi-3-oxo-2,3-dihidropiridazina-4-carbonil)glicina, inhibidores de hif prolil hidroxilasas; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso en el tratamiento de la anem
EP2142509B1 (en) 2007-04-18 2013-12-04 Amgen, Inc Quinolones and azaquinolones that inhibit prolyl hydroxylase
CA2685219C (en) 2007-05-04 2012-06-19 Amgen Inc. Diazaquinolones that inhibit prolyl hydroxylase activity
EP2172447A4 (en) 2007-07-03 2011-08-24 Astellas Pharma Inc amide
JP2011505367A (ja) * 2007-11-30 2011-02-24 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー プロリルヒドロキシラーゼ阻害剤
WO2009073497A2 (en) * 2007-11-30 2009-06-11 Smithkline Beecham Corporation Prolyl hydroxylase inhibitors
US8324241B2 (en) * 2008-04-11 2012-12-04 Bristol-Myers Squibb Company Triazolo compounds useful as DGAT1 inhibitors
WO2009134850A1 (en) 2008-04-30 2009-11-05 Smithkline Beecham Corporation Prolyl hydroxylase inhibitors
CN102112475A (zh) 2008-05-29 2011-06-29 西特里斯药业公司 作为沉默调节蛋白调节剂的咪唑并吡啶和相关的类似物
PL2379548T3 (pl) 2008-12-19 2016-08-31 Leo Pharma As Triazolopirydyny jako inhibitory fosfodiesterazy do leczenia chorób skórnych
US8283465B2 (en) * 2009-07-17 2012-10-09 Japan Tobacco Inc. Triazolopyridine compound, and action thereof as prolyl hydroxylase inhibitor or erythropoietin production-inducing agent

Also Published As

Publication number Publication date
EP2455381A1 (en) 2012-05-23
CA2768505C (en) 2018-06-12
JP2015003933A (ja) 2015-01-08
AR077417A1 (es) 2011-08-24
CA2768505A1 (en) 2011-01-20
DK2455381T5 (en) 2015-02-09
JP2011037841A (ja) 2011-02-24
EP2746282A1 (en) 2014-06-25
EP2455381B1 (en) 2014-05-28
KR101850661B1 (ko) 2018-04-19
CN102471337B (zh) 2014-12-10
JP2012144571A (ja) 2012-08-02
JP6434575B2 (ja) 2018-12-05
NZ598242A (en) 2013-09-27
DK2455381T3 (da) 2014-07-21
RU2538963C2 (ru) 2015-01-10
HRP20140705T1 (hr) 2014-09-12
MY160814A (en) 2017-03-31
SI2455381T1 (sl) 2014-08-29
ME01858B (me) 2014-12-20
US8283465B2 (en) 2012-10-09
US20130096155A1 (en) 2013-04-18
US20110077267A1 (en) 2011-03-31
ES2477968T3 (es) 2014-07-18
IL217541A0 (en) 2012-02-29
EP2455381B9 (en) 2014-10-22
HK1168346A1 (en) 2012-12-28
AU2010271732A1 (en) 2012-03-08
KR20120051704A (ko) 2012-05-22
JP2016040321A (ja) 2016-03-24
PE20120629A1 (es) 2012-05-30
MX2012000766A (es) 2012-02-08
KR20230165366A (ko) 2023-12-05
SMT201500122B (it) 2015-07-09
RS53499B1 (sr) 2015-02-27
JP2024091878A (ja) 2024-07-05
JP2020111612A (ja) 2020-07-27
US20160145254A1 (en) 2016-05-26
IL217541A (en) 2014-07-31
TWI485150B (zh) 2015-05-21
CN102471337A (zh) 2012-05-23
TW201105671A (en) 2011-02-16
BR112012001157A2 (pt) 2016-02-23
PL2455381T3 (pl) 2014-10-31
SG178049A1 (en) 2012-03-29
KR20260012830A (ko) 2026-01-27
JP2019019144A (ja) 2019-02-07
KR101706803B1 (ko) 2017-02-14
PT2455381E (pt) 2014-06-24
KR20180042443A (ko) 2018-04-25
RU2012105467A (ru) 2013-08-27
KR20170018105A (ko) 2017-02-15
WO2011007856A1 (ja) 2011-01-20
JP2022126843A (ja) 2022-08-30
JP5021797B2 (ja) 2012-09-12
EP3594213A1 (en) 2020-01-15
AU2010271732B2 (en) 2016-08-25
JP2017214404A (ja) 2017-12-07
EP2455381A4 (en) 2012-12-12
ES2477968T9 (es) 2014-11-13

Similar Documents

Publication Publication Date Title
MX2012000766A (es) Compuestos triazolopiridina, y su accion como inhibidor de prolil hidroxilasa e inductor de la produccion de eritropoyetina.
ECSP18063798A (es) Una forma amorfa y una cristalina de hemitartrato genz 112638 como inhibidor de glucosilceramida sintasa
CO6480931A2 (es) Sulfonamidas heterocíclicas, usos y composiciones farmacéuticas de las mismas.
CU20140072A7 (es) Derivados de dihidro-oxazina y dihidro-pirido-oxazina
JO3204B1 (ar) 4- أريل-n- فنيل-5،3،1- ترايازين-2- أمينات محتوية على مجموعة سلفوكسيمين
PH12014501967B1 (en) Benzodioxanes in combination with other actives for inhibiting leukotriene production
MX2010002732A (es) Inhibidores de f1f0-atpasa y metodos relacionados.
MY171577A (en) 2',4'-difluoro-2'-methyl substituted nucleoside derivatives as inhibitors of hcv rna replication
MX375872B (es) Procedimiento de preparacion de 5-fluoro-1h-pirazolopiridinas sustituidas.
PE20151005A1 (es) Composicion farmaceutica recubierta que contiene regorafenib
UA117032C2 (uk) Селективний інгібітор фосфатидилінозитол-3-кінази-гамма
ECSP11011048A (es) Inhibidores de cinasa akt y p70 s6
CR20140553A (es) Compuestos de fenoxietil piperidina
WO2014028600A3 (en) 3-AMINOCYCLOALKYL COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF
ECSP11010992A (es) Derivados de anilina-pirimidina sustituidos con sulfoximina como inhibidores de quinasas dependientes de ciclina (cdk), producción y uso de los mismos como productos medicinales
MX2013012233A (es) 4-aril-n-fenil-1,3,5-triazin-2-aminas sustituidas.
BR112015010136A2 (pt) derivados de oxazolidin-2-ona-pirimidina
ECSP11011483A (es) Piperidinas sustituidas
CR20130693A (es) Composición farmacéutica ortalmológica tópica que contiene regorafenib
CR20110627A (es) Piperidinas sustituidas
MX2013006670A (es) Derivado de 2-carboxamida-4-piperazinil-benzofurano.
BR112014015300A2 (pt) derivado de hidroximetilfurfural
MX2014002343A (es) Inhibidores de parp.

Legal Events

Date Code Title Description
FG Application granted