TWI423976B - 適合作為傑納斯激酶（ｊａｎｕｓ ｋｉｎａｓｅ）抑制劑之氮雜吲哚 - Google Patents

適合作為傑納斯激酶（ｊａｎｕｓ ｋｉｎａｓｅ）抑制劑之氮雜吲哚 Download PDF

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TWI423976B
TWI423976B TW101137542A TW101137542A TWI423976B TW I423976 B TWI423976 B TW I423976B TW 101137542 A TW101137542 A TW 101137542A TW 101137542 A TW101137542 A TW 101137542A TW I423976 B TWI423976 B TW I423976B
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ring
disease
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TW101137542A
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TW201302747A (zh
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Luc Farmer
Martinez-Botella Gabriel
Pierce Albert
Salituro Francesco
Jian Wang
Wannamaker Marion
Tiansheng Wang
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Vertex Pharma
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/10—Protein-tyrosine kinases (2.7.10)
    • C12Y207/10002—Non-specific protein-tyrosine kinase (2.7.10.2), i.e. spleen tyrosine kinase

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  • General Engineering & Computer Science (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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  • Biotechnology (AREA)
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  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
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TW101137542A 2006-01-17 2007-01-17 適合作為傑納斯激酶（ｊａｎｕｓ ｋｉｎａｓｅ）抑制劑之氮雜吲哚 TWI423976B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75936706P 2006-01-17 2006-01-17
US84247106P 2006-09-06 2006-09-06

Publications (2)

Publication Number Publication Date
TW201302747A TW201302747A (zh) 2013-01-16
TWI423976B true TWI423976B (zh) 2014-01-21

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ID=38197739

Family Applications (4)

Application Number Title Priority Date Filing Date
TW101137542A TWI423976B (zh) 2006-01-17 2007-01-17 適合作為傑納斯激酶（ｊａｎｕｓ ｋｉｎａｓｅ）抑制劑之氮雜吲哚
TW96101771A TWI405761B (zh) 2006-01-17 2007-01-17 適合作為傑納斯激酶（ｊａｎｕｓ ｋｉｎａｓｅ）抑制劑之氮雜吲哚
TW101137037A TWI424999B (zh) 2006-01-17 2007-01-17 適合作為傑納斯激酶（ｊａｎｕｓ ｋｉｎａｓｅ）抑制劑之氮雜吲哚
TW102147300A TW201412738A (zh) 2006-01-17 2007-01-17 適合作為傑納斯激酶（ｊａｎｕｓ ｋｉｎａｓｅ）抑制劑之氮雜吲哚

Family Applications After (3)

Application Number Title Priority Date Filing Date
TW96101771A TWI405761B (zh) 2006-01-17 2007-01-17 適合作為傑納斯激酶（ｊａｎｕｓ ｋｉｎａｓｅ）抑制劑之氮雜吲哚
TW101137037A TWI424999B (zh) 2006-01-17 2007-01-17 適合作為傑納斯激酶（ｊａｎｕｓ ｋｉｎａｓｅ）抑制劑之氮雜吲哚
TW102147300A TW201412738A (zh) 2006-01-17 2007-01-17 適合作為傑納斯激酶（ｊａｎｕｓ ｋｉｎａｓｅ）抑制劑之氮雜吲哚

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US (6) US7767816B2 (enExample)
EP (3) EP2537849A3 (enExample)
JP (4) JP5591471B2 (enExample)
KR (3) KR101235103B1 (enExample)
CN (3) CN102532133A (enExample)
AR (1) AR060316A1 (enExample)
AU (1) AU2007207533B8 (enExample)
BR (2) BRPI0706537A2 (enExample)
CA (1) CA2636189A1 (enExample)
CL (1) CL2008002140A1 (enExample)
HK (1) HK1210780A1 (enExample)
IL (1) IL191902A0 (enExample)
NO (1) NO20083501L (enExample)
NZ (3) NZ592968A (enExample)
RU (2) RU2453548C2 (enExample)
TW (4) TWI423976B (enExample)
UA (1) UA95940C2 (enExample)
WO (1) WO2007084557A2 (enExample)
ZA (2) ZA200805053B (enExample)

Families Citing this family (101)

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CA2560454C (en) 2004-03-30 2013-05-21 Vertex Pharmaceuticals Incorporated Azaindoles useful as inhibitors of jak and other protein kinases
ES2380795T3 (es) * 2005-05-20 2012-05-18 Vertex Pharmaceuticals, Inc. Pirrolopiridinas útiles como inhibidores de proteínas quinasas
EP2270014A1 (en) 2005-09-22 2011-01-05 Incyte Corporation Azepine inhibitors of janus kinases
DK3184526T3 (en) 2005-12-13 2019-01-14 Incyte Holdings Corp PYRROLO [2,3-D] PYRIMIDINE DERIVATIVES AS A JANUS-KINASE INHIBITOR
EP2537849A3 (en) * 2006-01-17 2013-04-03 Vertex Pharmaceuticals, Inc. Azaindoles useful as inhibitors of janus kinases
RU2008143361A (ru) * 2006-04-05 2010-05-10 Вертекс Фармасьютикалз Инкорпорейтед (Us) Деазапурины в качестве ингибиторов янус-киназ
US7754838B2 (en) * 2006-08-08 2010-07-13 E.I. Du Pont De Nemours And Company Poly(meth)acrylamides and poly(meth)acrylates containing fluorinated amide
NZ577798A (en) * 2006-12-21 2012-04-27 Vertex Pharma 5-cyano-4- (pyrrolo [2, 3b] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors
US8513270B2 (en) 2006-12-22 2013-08-20 Incyte Corporation Substituted heterocycles as Janus kinase inhibitors
AU2008228768A1 (en) * 2007-03-22 2008-09-25 Vertex Pharmaceuticals Incorporated N-heterocyclic compounds useful as inhibitors of Janus Kinases
EP2740731B1 (en) 2007-06-13 2016-03-23 Incyte Holdings Corporation Crystalline salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile
CL2008001709A1 (es) 2007-06-13 2008-11-03 Incyte Corp Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
WO2009145814A2 (en) * 2008-03-10 2009-12-03 Vertex Pharmaceuticals Incorporated Pyrimidines and pyridines useful as inhibitors of protein kinases
ES2602577T3 (es) 2008-03-11 2017-02-21 Incyte Holdings Corporation Derivados de azetidina y ciclobutano como inhibidores de JAK
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US20160008359A1 (en) 2016-01-14
KR20080085174A (ko) 2008-09-23
JP2013010793A (ja) 2013-01-17
US20130237516A1 (en) 2013-09-12
RU2011151085A (ru) 2013-06-20
RU2008133613A (ru) 2010-02-27
EP2559694A2 (en) 2013-02-20
BRPI0706537A2 (pt) 2011-03-29
US8822681B2 (en) 2014-09-02
WO2007084557A2 (en) 2007-07-26
US9120790B2 (en) 2015-09-01
AU2007207533B8 (en) 2012-06-28
TW200806664A (en) 2008-02-01
EP2537849A2 (en) 2012-12-26
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CL2008002140A1 (es) 2009-03-06

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