CN102532134A - 适用作詹纳斯激酶抑制剂的吖吲哚类 - Google Patents

适用作詹纳斯激酶抑制剂的吖吲哚类 Download PDF

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Publication number
CN102532134A
CN102532134A CN2011104033161A CN201110403316A CN102532134A CN 102532134 A CN102532134 A CN 102532134A CN 2011104033161 A CN2011104033161 A CN 2011104033161A CN 201110403316 A CN201110403316 A CN 201110403316A CN 102532134 A CN102532134 A CN 102532134A
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compound
disease
group
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treat
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CN2011104033161A
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Chinese (zh)
Inventor
L·法莫
G·马蒂内兹-伯塔拉
A·皮尔斯
F·萨利特罗
王健
M·沃纳姆科
王天生
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38197739&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN102532134(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of CN102532134A publication Critical patent/CN102532134A/zh
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D495/10—Spiro-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/10—Protein-tyrosine kinases (2.7.10)
    • C12Y207/10002—Non-specific protein-tyrosine kinase (2.7.10.2), i.e. spleen tyrosine kinase

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  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
CN2011104033161A 2006-01-17 2007-01-17 适用作詹纳斯激酶抑制剂的吖吲哚类 Pending CN102532134A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US75936706P 2006-01-17 2006-01-17
US60/759,367 2006-01-17
US84247106P 2006-09-06 2006-09-06
US60/842,471 2006-09-06

Related Parent Applications (1)

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CNA2007800032602A Division CN101374839A (zh) 2006-01-17 2007-01-17 适用作詹纳斯激酶抑制剂的吖吲哚类

Publications (1)

Publication Number Publication Date
CN102532134A true CN102532134A (zh) 2012-07-04

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ID=38197739

Family Applications (3)

Application Number Title Priority Date Filing Date
CN2011104033161A Pending CN102532134A (zh) 2006-01-17 2007-01-17 适用作詹纳斯激酶抑制剂的吖吲哚类
CN201510004860.7A Pending CN104650077A (zh) 2006-01-17 2007-01-17 适用作詹纳斯激酶抑制剂的吖吲哚类
CN2011103519191A Pending CN102532133A (zh) 2006-01-17 2007-01-17 适用作詹纳斯激酶抑制剂的吖吲哚类

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN201510004860.7A Pending CN104650077A (zh) 2006-01-17 2007-01-17 适用作詹纳斯激酶抑制剂的吖吲哚类
CN2011103519191A Pending CN102532133A (zh) 2006-01-17 2007-01-17 适用作詹纳斯激酶抑制剂的吖吲哚类

Country Status (19)

Country Link
US (6) US7767816B2 (enExample)
EP (3) EP2537849A3 (enExample)
JP (4) JP5591471B2 (enExample)
KR (3) KR101409727B1 (enExample)
CN (3) CN102532134A (enExample)
AR (1) AR060316A1 (enExample)
AU (1) AU2007207533B8 (enExample)
BR (2) BRPI0706537A2 (enExample)
CA (1) CA2636189A1 (enExample)
CL (1) CL2008002140A1 (enExample)
HK (1) HK1210780A1 (enExample)
IL (1) IL191902A0 (enExample)
NO (1) NO20083501L (enExample)
NZ (3) NZ569899A (enExample)
RU (2) RU2453548C2 (enExample)
TW (4) TW201412738A (enExample)
UA (1) UA95940C2 (enExample)
WO (1) WO2007084557A2 (enExample)
ZA (2) ZA200805053B (enExample)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101676285A (zh) 2004-03-30 2010-03-24 沃泰克斯药物股份有限公司 用作jak和其它蛋白激酶抑制剂的氮杂吲哚
EP2354139A1 (en) * 2005-05-20 2011-08-10 Vertex Pharmaceuticals Incorporated Pyrrolopyridines useful as inhibitors of protein kinase
EP2270014A1 (en) 2005-09-22 2011-01-05 Incyte Corporation Azepine inhibitors of janus kinases
PT2474545T (pt) 2005-12-13 2017-02-14 Incyte Holdings Corp Pirrolo[2,3-b]piridinas e pirrolo[2,3-b]pirimidinas substituídas com heteroarilo como inibidores de janus quinase
UA95940C2 (uk) * 2006-01-17 2011-09-26 Вертекс Фармасьютикалс Інкорпорейтед Азаіндоли як інгібітори кіназ януса
KR20090018895A (ko) * 2006-04-05 2009-02-24 버텍스 파마슈티칼스 인코포레이티드 야누스 키나제의 억제제로서 유용한 데아자푸린
US7754838B2 (en) * 2006-08-08 2010-07-13 E.I. Du Pont De Nemours And Company Poly(meth)acrylamides and poly(meth)acrylates containing fluorinated amide
CA2673472A1 (en) 2006-12-21 2008-07-03 Vertex Pharmaceuticals Incorporated 5-cyan0-4- (pyrrolo) [2, 3b] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors
WO2008079965A1 (en) 2006-12-22 2008-07-03 Incyte Corporation Substituted heterocycles as janus kinase inhibitors
CN101778825A (zh) * 2007-03-22 2010-07-14 沃泰克斯药物股份有限公司 适用作詹纳斯激酶抑制剂的n-杂环类化合物
GEP20125533B (en) 2007-06-13 2012-05-25 Incyte Corp Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentyl propanenitrile
CL2008001709A1 (es) 2007-06-13 2008-11-03 Incyte Corp Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
JP2011513483A (ja) * 2008-03-10 2011-04-28 バーテックス ファーマシューティカルズ インコーポレイテッド タンパク質キナーゼの阻害剤として有用なピリミジンおよびピリジン
EA017218B1 (ru) 2008-03-11 2012-10-30 Инсайт Корпорейшн Производные азетидина и циклобутана как ингибиторы jak-киназ
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RU2453548C2 (ru) 2012-06-20
US20140336171A1 (en) 2014-11-13
US20070203142A1 (en) 2007-08-30
AU2007207533B8 (en) 2012-06-28
TWI423976B (zh) 2014-01-21
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TW201302747A (zh) 2013-01-16
WO2007084557A3 (en) 2007-09-27
US8822681B2 (en) 2014-09-02
US7767816B2 (en) 2010-08-03
US9120790B2 (en) 2015-09-01
BRPI0706537A2 (pt) 2011-03-29
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EP1973911B1 (en) 2016-01-13
CA2636189A1 (en) 2007-07-26
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US20160008359A1 (en) 2016-01-14
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