TWI248948B - Soft contact lenses - Google Patents

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Publication number
TWI248948B
TWI248948B TW088103109A TW88103109A TWI248948B TW I248948 B TWI248948 B TW I248948B TW 088103109 A TW088103109 A TW 088103109A TW 88103109 A TW88103109 A TW 88103109A TW I248948 B TWI248948 B TW I248948B
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Taiwan
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soft contact
contact lens
reaction mixture
containing monomer
monomer
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TW088103109A
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English (en)
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Douglas G Vanderlaan
Marcie Hargiss
Susan Williams
Ivan Nunez
Michele L Alton
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Johnson & Johnson Vision Prod
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    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00—Optical parts
    • G02C7/02—Lenses; Lens systems ; Methods of designing lenses
    • G02C7/04—Contact lenses for the eyes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
    • G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
    • G02B1/041—Lenses
    • G02B1/043—Contact lenses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S524/00—Synthetic resins or natural rubbers -- part of the class 520 series
    • Y10S524/916—Hydrogel compositions

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  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Health & Medical Sciences (AREA)
  • Eyeglasses (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Silicon Polymers (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Description

1248948 Α7 Β7 五、發明説明（J ) 螢明領域 本發明關於藉由硬化含矽氧單體之反應混合物所形成的 並且歹被用於形成軟性隱形眼鏡之石夕氧水凝膠。 發明背景 水凝膠是一種包含水的水合交聯聚合體系統，其中水是 處於平衡狀態。水凝膠一般是可透氧和可生物互容的，使 其成為製造生物醫學裝置，特別是隱形眼鏡或眼内鏡片之 較佳材料。 慣用的水凝膠是由主要包含親水性單體如2_羥基乙基甲 基丙烯酸酯（HEMA)或N-乙烯基吡略烧酮（Nvp)之單體混合 物所製成的。美國專利4,495,313 ; 4,889,664和5,039,459 揭示慣用水凝膠的形成。這些慣用水凝膠材料的透氧性與 材料的水含量有關，其一般是低於2〇_3〇barrer。對於由慣 用水凝膠材料所製成的隱形眼鏡，其透氧程度適合短期佩 戴的隱形眼鏡；但是其透氧程度在長期佩戴隱形眼鏡期間 (如佩戴30天無卸下）則不足以保持健康的眼角膜。所以， 持續努力以增加慣用水凝膠的透氧性。 一種已知增加水凝膠透氧性的方法是將含矽氧的單體加 入水凝膠調配物中，因此製成矽氧水凝膠。與慣用水凝膠 比較，含矽氧的聚合物一般具有較高的透氧性。矽氧水凝 膠可藉聚合含至少一種含矽氧單體和至少一種親水性單體 之混合物而製成。不論含矽氧單體或親水性單體皆可當作 (謂先閱讀背面之注意事項再填寫本頁) m m m ' n m、1TI . --. n m m 本紙細《；(料(&S )^4規格（210 X 297公楚） ~ 1248948 :·· * A7 * '^_____ _ 五、發明説明（2 ) 〜〜'— 父聯劑（父聯劑是一種具多個可聚合官能基的單體）或者可 另外使用父聯劑。矽氧水凝膠的調配物曾揭示於美國專利 4,954b587 ; 5,010，141 ; 5,〇79 319 ; 5115 〇56 ; 5 26〇 〇〇〇，· 5,336,797 ; 5,358,995 ; 5,387,632 ; 5,451，617 ;和 5,486,579 以及 W096/31792。 美國專利3,808，178揭示小含矽氧單體和許多親水性單 體之共聚物的調配物。 美國專利5,034,461描述許多由矽氧-聚胺基甲酸酯巨單 盔和親水性單體如HEMA或N，N-二甲基丙烯醯胺（DMA)之 組合所製成的矽氧水凝膠。·甲基丙烯氧基丙基參（三甲基矽 烷氧基）矽烷（TRIS)的添加降低此種水凝膠的模數，但是， 在許多實例中，模數仍比理想值高。 美國專利5,358,995和5,387,632描述由許多矽氧巨單 體、TR1S、正乙烯基吡咯烷酮（Nvp)和dma之組合所製成 的水凝膠。以TRIS取代矽氧巨單體中大部份會降低所得水 凝恥的彳莫數。在巨大聚石夕氧烧基烧基甲基丙稀酸醋在聚胺 基甲酸酯-聚矽氧烷水凝膠中的角色”，應用聚合物科學期 刊，第60卷，1193_1199頁（1996年）和"巨大聚矽氧烷基烷 基甲基丙烯酸酯在透氧水凝膠材料中的角色”，應用聚合物 科學期刊，第56卷，317-324頁（1995年）等兩篇由相同作 者所發表的刊物中描述由矽氧-巨單體和親水性單體如 DMA之反應混合物所製成之水凝膠的模數隨著tRis的添 加而降低之實驗結果。 -4 - 本紙张尺度诚川中阀1¾家標彳（rNS ) &規格（2丨0X 297公釐） (請先閱讀背面之注意事項再填I本頁)
^48948 Μ Β7 五、發明説明（3 ) — 將甲基丙烯氧基丙基雙（三甲基石夕烷氧基）甲基矽烷 (ΜΒΜ)用於製造硬式隱形眼鏡是描述於w〇9n〇〗55和 JP611丨23609 中。 ， 將相當大量的巨大含矽氧單體如TRIS摻入由含钞氧旦 單體和親水性單體所製成的水凝膠時，會將聚合物在受力 後恢復其原形時的彈力或速度降低至隱形眼鏡使用者無法 接受的程度。 在技術上仍對軟得足以製造具有高透氧性、適當的水含 量及足夠的彈力並且令隱形眼鏡的使用者感到舒適之軟性 隱形眼鏡的聚矽氧水凝保有需求。 - — (謂先閲讀背面之注意事項再填寫本頁) 發明概述 本發明提供一種藉由硬化含具下列結構之含矽氧單體之 反應混合物所製成的矽氡-水凝膠·· I Χ'Γ\ r51 八 （严)Γ 〇勺I \χ—(L)~(CH2\_si—(〇SiR52R53R5^) " T^* 、· 訂 t 結構 其中RW是H或CH3，q是1或2，對於各個q，R52、R53 和是獨立的乙基、甲基、苯甲基、苯基或包含從1至 100個重複的Si-Ο單位之單價矽氧烷鏈，p是1至1〇， r=(3-q)，X是〇或NR55，其中R55是Η或具1至4個碳原 本紙张尺度適州中國1¾家標;？（（’NS ) Λ4規格（210X297公潑） 1248948 ¾浅部屮呔疗^-.^MJ.消贽合：^社印y A7 --—_-______B7_ 五、發明説明（4 ) ~ " 子的單價炫基，a是〇或卜以及[是二價連接基，其最好 包含從2至5個碳原子，也可視情況包含謎或經基，例如 聚乙一醇鏈。 在較佳具體實例中，矽氧水凝膠另外包含第二種含矽氧 單體和親水性單體。 本發明的優點是結構J之含矽氧單體用於矽氧水凝膠中' 降低水凝膠的模數，特別是在包含結構丨之切氧單體和額 外作為交聯劑之含矽氧單體的水凝膠中。當結構！單遨以 低於先前技術所描述的單體量存在時，基可有效地降低矽 氧水凝膠的模數，因此可使用較低量的結構Z之含矽氧單體 以維持本發明矽氧水凝膠的彈性。相似地，此作用似乎是 因為矽氧烷基不如先前技術所用的含矽氧單體如tris般巨 大。根據本發明所製造的聚合物可用於製造可提供高透氧 性、彈性佳並可經濟地和有效地製得之軟性隱形眼鏡。本 發明聚合物可用於製造需要生物互容性和高透氧性之生物 醫學裝置’較佳係隱形眼鏡。 發明細節描诚 在此所用’’單體”一詞相當於可被聚合之低分子量化合物 (即一般具有低於700之數目平均分子量）和中至高分子量化 合物或聚合物，有時相當於包含可進一步聚合之官能基的 巨單體（即一般具有高於700之數目平均分子量）。所以，可 了解含矽氡單體”及’’親水性單體，，一詞包括單體、巨單體和 裝-----ΙΓ 訂-----参 (讀先閱讀背面之注意事項再填寫本頁) 本紙KHLH》(^NS ) Λ4規格（210X 297公楚） 1248948 A7
五、發明説明（ :聚物。預聚物是部―進-步聚合之單 “贪石夕氧單體，，是指在包含至少兩個抑 單體、巨單體或預聚物。較佳係， =二 的存在量是™單體總=。重 /〇 ’較佳係大於30重量％。 可用於形成本發日㈣氧水凝膠之結^切氧單體的實氧基丙㈣三甲基錢氧基)甲基魏、甲基 '其)Ί雔了五甲基—矽氧院、(3_甲基丙烯氧基_2_羥基丙 基又（三甲基石夕院氧基）子基石夕貌和如結構π之末端 為早-甲基丙烯氧基丙基之聚二甲基矽氧烷：0 (謂先閲讀背面之注意事- 4 項再填· 裝- •寫本頁)
每 ijf.v 、11 费
結構II 其中b=0至loo。 較佳結構I之含矽氧單體是f基丙烯氧基丙基雙（三甲基 石夕烧氧基）甲基矽烷、甲基丙烯氧基丙基五甲基二矽氧烷和 末端為單-甲基丙烯氧基丙基之聚二甲基矽氧烷。最佳結構I 之含石夕氧單體是甲基丙烯氧基丙基雙（三甲基矽烷氧基）甲 基石夕、院和曱基丙烯氧基丙基五甲基二矽氧烷。其中結構I 之含石夕氧單體又以甲基丙烯氧基丙基雙（三甲基矽烷氧基） 本紙张尺度適财_ l248948 Λ7 * ----- B7 五、發明説明（6 ) --- 甲基矽烷（MBM)為佳。 結構I含矽氧單體最好與附加的含矽氧單體摻合以形成 本發曰月軟性隱形眼鏡。任何已知可用於製造石夕氧水凝膠的 含矽氧單體皆可用於與結構丨含矽氧單體摻合以形成本發 明軟性隱形眼鏡。許多此目的可用的含石夕氧單體是揭示於 1997年10月9日入檔之美國系列編號〇8/948，128中，在此 將其併入以為參考。較佳可與結構〗含矽氧單體摻合以形成 本發明矽氧水凝膠之附加含矽氧單體是羥基烷基胺_官能性 的3矽氧單體，其揭示於同時由Vanderlaan等人以矽氧水 凝膠聚合誤為標題入檔的美國系列編號—(VTN_〇389)中， (讀先閲讀背面之注意事 4 •項再填. 裝— :寫本頁) 在此將其併入以為參考。較佳的含矽氧線性或經接枝羥基 烷基胺-官能性的單體包含下列結構之嵌段或不規則單體：
訂 奸·';;/^部屮决«.^-^U_T.消贽合仍社印¥ 結構III 其中： n疋〇至500和m是〇至500以及（η+ηι)=10至500和較佳 係20至250，R2、R4、r5、以和R7是獨立的單價烷基或芳 基，其可進一步以醇、酯、胺、酮、羧基或醚基取代，較 佳係未經取代的單價烷基或芳基；以及R1、！^和R8是獨立 的單價烷基或芳基，其可進一步以醇、酯、胺、酮、羧基 -8 - 〇 χ 2㈤-- Ϊ248948
裝 訂 參 I248948 A7 五、發明説明（8 烯酸酯取代的烷基；R12、Rl3 θ 或芳基，其可進-步以醇、5旨、胺^立的Η、單價烧基 或者叫，或R]5* 、綱、致酸或喊取代， - 5^ 鍵結在—起以形成一個環狀 、。構’ 4疋至少部份單體上的結構！
團。f、R13和f最好是H。 …H 在另—個具體實财，包含結構！切氧單體之本發明 虱水物可包括附加含石夕氧單體之添加或不添加， 是非根據結構T之切氧單體，較佳係包含 親水性早祖。視情況可用於製造本發明水凝膠聚合物之親 水性早體可為任何先前技術揭示可製造水凝膝之已 單體。 X用於製造本發明聚合物之較佳親水性單料含丙缔或乙 烯的單體。此種親水性單體本身可时交聯劑。"乙稀類I, 或”含乙稀”單體-詞相當於含乙稀基（_CH=CH2)的單體，其 一般反應性高。已知此種親水性含乙烯單體是相當容易聚 合的。”丙烯基類”或”含丙烯基"單體是這些包含丙；基：單 (ch2=crc〇x) 其中R是Η或CH3,以及X是〇或N，已知其也是易 聚合的，如N，N-二甲基丙烯基醯胺pMA)、2_羥基乙基甲 基丙烯酸酯（HEMA)、甘油甲基丙烯酸酯、2_羥基乙基甲基 丙烯醯鉍、聚乙二醇單甲基丙烯酸酯、甲基丙烯酸和丙烯 酸。 -10 - 本紙張幻ii㈣巾關H彳（（，NS ) &規格（210xi97公f ) 1248948 A7 B7 五、發明説明（9 ) 可摻入本發明矽氧水凝膠之親水性含乙烯基單體包括如 N-乙烯基内醯胺（如N-乙烯基吡咯烷酮（NVP))、N-乙烯基-N-甲奉乙醯胺、N_乙烯基乙基乙醯胺、N_乙烯基_N_乙基 甲酸胺、N-乙稀基甲醯胺等單體，以nvp為佳。 其他可用本發明的親水性單體包括含一或多個末端羥基 被含可聚合雙鍵之官能基取代之聚氧基乙烯多元醇。實例 包括聚乙二醇、乙氧基化烷基配糖和乙氧基化雙酚A，其可 與一或多個莫耳當量末端保持基如異氰氧基乙基甲基丙烯 酸酯（’’IEM”）、甲基丙烯酸酐、氯化甲基丙烯醯基、氯化乙 基苯甲醯基或類似物反應產生含一個或多個末端可聚合烯 系基之聚乙二醇，其中可聚合烯系基是經由連結部份如氨 基甲酸酯或酯基鍵結在聚乙二醇上。 其他實例為揭示於美國專利編號5,〇7〇,215的親水性乙 烯基灰酸S曰或乙浠基氨基甲酸酯單體以及揭示於美國專利 編唬4,910,277的親水性噁唑酮單體。其他適合的親水性單 體對熟諳此技者而言皆十分熟悉。 可摻入本發明聚合物中之較佳親水性單體包括如n，n_ 一甲基丙烯醯胺（DMA)、2-羥基乙基甲基丙烯酸酯 (HEMA)、甘油甲基丙烯酸酯、2_羥基乙基甲基丙烯醯胺、 N-乙烯基吡咯烷酮（NVP)、聚乙二醇單甲基丙烯酸酯、甲基 丙烯酸和丙烯酸等親水性單體，以DMA為佳。 其他可存在用於形成本發明矽氧水凝膠之反應混合物中 的單體包括紫外線吸收單體、反應性著色劑和類似物。也 -11 - (讀先閱讀背面之注意事 4 項再填· 裝— :寫本頁) 、11 1248948
訂 t 1248948 A7 B7 好淖部屮-'ιι^^^θ,τ-^^^^^.θ^ 五、發明説明（〗丨） 如乙醇、甲醇、異丙醇，其混合物或類似物，或者一種或 夕種此有機液體與水的混合物，接著以純水（或生理食鹽水） 卞取奉生包含經水膨服過之乾單體聚合物的石夕氧水凝膠。 聚合物水合後的矽氧水凝膠最好包含佔係氧水凝膠總量之 2至50重量％的水，較佳係15至45重量％的水，最佳係2〇 至40重量％的水。這些石夕氧水凝膠視特別適合用於製造隱 形眼鏡或眼内鏡片，較佳矽軟性隱形眼鏡。在隱形眼鏡的 製造上，已知許多模製反應混合物的方法，其包括旋轉澆 鑄和靜態澆鑄。旋轉洗鑄方法是揭示於美國專利編號 3,408,429和3,660,545，靜態澆鑄方法是揭示於美國專利編 號4，113,224和4，197,266。直接模製石夕氧水凝膠是較佳製造 含本發明聚合物之隱形眼鏡的方法，其較經濟且可精確地 控制水合鏡片精細的形狀。對於此方法，將反應混合物放 在具最終理想的矽氧水凝膠如經水膨脹之聚合物形狀的模 型中，然後讓反應混合物處於使單體聚合的條件下·，因此 可產生一個具最終理想產物近似形狀的聚合物。然後，視 情况以 >谷劑處理聚合物混合物，然後用水處理之，產生一 種具最終大小和形狀的矽氧水凝膠，其最終大小和形狀語 原模製聚合物物品的大小和形狀十分相似。此方法可用形 成隱形眼鏡，其另外被描述於美國專利4,495,313 ; 4,680,336 ; 4,889,664 ;和5,039,459，在此將其併入以為參 考。待矽氧水凝膠製造後，鏡片最好以親水性塗料塗敷。 先鈾技術已揭示一些添加水性塗層至鏡片上的方法，其包-13 - 本紙张尺度❹1中關家標彳（rNS ) Λ4規格(77^197公漦） (詞先閲讀背面之注意事項再填寫本頁} -裝- J5一ά .會 1248948
括美國專利編號 3,854,982、3,916,033、4,920，184 和 5,002,794，WO91/04283 和 EPO93810399。 若丨混合的結構I之含矽氧單體和附加含矽氧單體存在於 反應混合物中，其較佳範圍是佔反應混合物中之反應性成 份的從約5至100重量％，較佳係約1〇至9〇重量％，最佳 係約15至80重量％。若視情況選用的親水性單體存在於上 述發明中，其較佳範圍是佔反應混合物中之反應性成份的 從約5至80重量％，較佳係約1〇至6〇重量％，最佳係約 20至50重量％。稀釋劑的較佳範圍是佔總反應混合物之從 約0至70重量％，較佳係約〇至5〇重量％，最佳係約〇至 20重量％。稀釋劑量需視反應性成份的性質和相對量而改 變。 在較佳反應性成份的組合中，1〇至6〇，較佳係至5〇 重量％之反應性成份是含矽氧單體，20至50重量％之反應 性成份是結構I之含矽氧單體，丨0至5〇重量％之反應性成 份是親水性單體，較佳係DMA，〇丨至〗〇重量％之反應性 成份是UV或可見光-活化光引發劑以及佔總反應混合物之 至2 0重里/〇疋一級或二級醇稀釋劑，較佳係三級醇。較 佳具體實例包括結構I之含矽氧單體、親水性單體和附加含 矽氧單體，較佳係根據根據結構III。最佳具體實例包括較 佳結構I之含矽氧單體、親水性單體和根據描述於上之結構 III附力α含石夕氧單體。 本發明反應混合物可以任何熟請此技者已知的方法，如 -14 - ^wi 1T (τί先閱讀背面之注意事項再填寫本頁) 本紙张尺廋1¾ 中關家標今（（，NS ) ( 210xl97^vf ) 1248948 Α7 Β7 五、發明説明 13 搖晃或攪拌形成，其以先前描述的方法用於形成聚合體物 品或元件。對於部份單體反應混合物，反應混合物的聚合 最好泰在微高於室溫的溫度下，如30-40°C或低於室溫如 0-10°C進行以防止成份的相分離。 以下列實例進一步說明本發明。部份實例中所用的材料 表示如下： 'DAROCURE 1173M 丨DMA丨， 2 -經基-2 -甲基-1 -苯基-丙基-1 -酉同 N，N-二甲基丙烯醯胺 3-曱基丙烯氧基丙基雙（三甲基矽烷 氧基）甲基矽烷 (麴先閱讀背面之注意事項再填寫本頁)
I 樣 局 k ：τ. 消 A 社 印 製備1-聚矽氧烷單體之製備 500克α，ω-雙胺基丙基聚二甲基矽氧烷（5000MW)和68 克縮水甘油甲基丙烯酸酯混合並在l〇〇°C下攪拌加熱10小 時。以1500毫升乙腈萃取產物五次以除去殘留的縮水甘油 甲基丙稀酸自旨而獲得澄清油狀物。IR : 3441、2962、1944、 1725、1638、1612、1412厘米―1。此產物相當於'’縮水甘油 甲基丙烯酸酯和5000MW之α，ω -雙胺基丙基聚二甲基矽 氧烷π或者雙（Ν，Ν-雙-2-羥基-3-甲基丙烯氧基丙基）胺基丙 基聚二甲基矽氧烷。 實例1 38.2份重之製備1的產物與28.8份ΜΒΜ、33份DMA 和1份DAROCUR 1173混合並以3-甲基-3-戊醇稀釋以製造 -15 - 本纸张尺度適州中國囤家標蜱（rNS ) Μ規格（2】ΟΧ297公漦） 1248948 A7 J , ^ ------一 B7 五、發明説明（^~一 ' -------
種反應此口物，其中稀釋劑佔全部反應混合物質量的 斤得反應，合物是澄清、均勻溶液。填滿聚丙婦隱形 眼鏡構型，閉合並以總數為3 2焦耳/平方厘米之發自W 光源的UV光照射3〇分鐘。打開模型並將鏡片放至異丙醇 中’然後移至去離子水中。 ' 鏡片.·是透明的且其張力模數為2〇5士12克/平方釐米，斷 裂時的拉長度為133士37%和平衡水含量為24 2士〇 2%。利用 Instr〇nTMli22型張力試驗機測量張力性質。平衡水含量 (EWC)是重力測得並可表示為： %EW〇 l〇〇x(水合鏡片質量_乾鏡片質量）/水合鏡片的質 •量 實例2-16 利用..實例1的調配物，但以表1所列數量來製造反應混 合物。 表1-矽氧水凝膠調配物和性質 實例 1 2 ^^^3 ' 4 組成 預巨單體 38.2 33.5 27.6 22.3 MBM 28.8 33.5 39.4 44.7 DMA 33 33 33 33 Darocur 0.4 0.4 0.4 0.4 稀釋劑％ 9 7 5 4 EWC(%) 24.2±0.2 23·3±〇·3 22.4 土 0.2 24.2土0.3 |模數（psi) 205±12 178土11 136土4 109±3 -16 - 本紙尺度適W中1¾ 1¾家標今（Gs ) μ規格（210X 297公§7 扣衣------ITI----- (諳先閱讀背面之注意事項再填寫本頁) 18 8 124 A7 B7 、 五 M月説明 16 *反應性成份和稀釋劑佔反應混合物之％ 實例17 ---2-)- 21.5%平均分子量為测克/莫耳之α，ω_雙甲基丙稀氧 基丙基聚一甲基石夕氧烧與42.5%MBM ' 350/〇DMA和 1%DAR0CUR 1173混合並以3_甲基_3_戊醇稀釋以獲得一 種包含22重量％稀釋劑之澄清溶液。依照實例i的步驟製 造鏡片。鏡片性質表示於表2中。 實例18 利用實例17所描述的步驟和反應混合物製造鏡片。但】 甲基丙稀氧基丙基五甲基二碎氧院(MPD)取代mbm。鏡》 性質表示於表2中。 對照實例1 利用實例17之調配物但以TRIS取代MBM和以2〇%牙 釋劑製備反應混合物。依照實例丨的步驟製造鏡片。表2 中所示之鏡片性質顯示MBM(實例17)或甲基丙烯氧基丙^ 五甲基一矽氧烷(MPD)(實例18)用以取代TRIS時會得到幸 低模數。 (邡先閱讀背面之注意事項再填寫本頁) 4 項再填」 裝. 訂 .屮决S^^uc-T消卟合：^社印％
實例17 PDMS* 21.5 TRIS MBM 42.5 MPD
Ζ5Ζ5ΓΓ -18 - L質 11 實例18 21.5 42.5 本紙张尺度诚州中國阀家標冷（rNS ) Λ4規枱（210X^97公漦） 1248948 Α7 Β7 五、發明説明（ 17
DMA 35 35 35 單體/劑 模數, 斷裂每石長唐 Dk EWC: ~ Τ>ΊΠ\Λ >Γ Ο 5fe 78/22 80/20 78/22 _j5 土 2psi 27 8 士 60% 1 lObarrers 28.2 土 0.3% ^87±3psi T〇7±88%" 55 士 2psi ^63±81% 147barrers 28.9 土 0.3% 75.6barrers 31.0 士 0.3% 「十次^1:^-而U(.T.消贽合竹社印¥ = 甲基丙烯氧基丙基聚二甲基矽氧烷，平均 Mw為5000克/莫耳 實例19 29.0%平均分子量為5〇〇〇克/莫耳之α，ω_雙甲基丙烯氧 基丙基聚二甲基矽氧烷與35%末端為單-曱基丙烯氧基丙基 之 PDMS(1H，結構 Π，MW=800 至 1000)、35%DMA 和 1 /i)DAR〇CUR 1173混合並以3 -甲基-3-戊醇稀釋以獲得一 種包含23.0重量％稀釋劑之澄清溶液。依照實例1的步驟 製造鏡片。鏡片性質表示於表3中。 實例20 29.0%平均分子量為5000克/莫耳之雙曱基丙稀氧 基丙基聚二曱基矽氧烷與35%(3-甲基丙烯氧基經基丙氧 基）丙基雙（三甲基矽烷氧基）甲基矽烷（Τ2)、35%DMA和 1 %DAR〇CUR 1173混合並以3 -曱基-3-戍醇稀釋以許得一 種包含37.6重量％稀釋劑之澄清溶液。依照實例】的步驟 製造鏡片。鏡片性質表示於表3中。 -19 - 本紙张尺度述川中國1¾家標冷（（、NS ) Λ4规格（21〇X 297公釐） (請先閱讀背面之注意事' 4 ▼項再填· 裝— 寫本頁) ,ιτ Φ. 1248948 A7 B7 五、發明説明（） 18 表3矽氧水凝膠聚合物之組合物與性質 實例19 實例20 PDMS 29.0 29.0 T1 35.0 T2 35.0 DMA 35.0 35.0 DAROCUR117 1.0 1.0 稀釋劑％ 23.0 37.6 模數 193 士 15psi 175 士 llpsi 斷裂時拉長度 87.9 土 42% 108 土 54% Dk 17 lbarrers 94barrers EWC 31.1 士 0.2% 33.4±0.2% (請先閱讀背面之注意事項再填寫本頁) 經濟部中央標準局員工消費合作社印製 實例顯示利用結構I之含矽氧單體所製成的隱形眼铬可 提供澄清且模數比根攄對照實例租製鈦的隱形眼鏡低的隱 形眼鏡。低模數是想要的以提供佩戴舒適的隱形眼鏡。 -20 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐）

Claims (1)

  1. 8 8 8 8 A B c D 1248«% 曰修V更)正本 六、申請專利範圍 專利申請案第88103109號 ROC Patent Appln. No.88103109 修正後無劃線之申請蓴利範圍中文本-附件(一） Amended Claims in Chinese - Encl/D (民國94年6月S日送呈） (Submitted on June S , 2005) 一種軟性隱形眼鏡，其包含藉由硬化含具下列結構之 含矽氧單體之反應混合物所製成的矽氧-水凝膠： 10 15 20 結構I RlLl
    (〒η3)γ 【—(Q~(CH2)^_si—^OSiR52R53R5 4 訂 經濟部智慧財產局員工消費合作社印製 其中R51是H或CH3，q是1或2，對於各個q，R52、 r53和R54是獨立的乙基、甲基、苯曱基、苯基或包含 從1至100個重複的Si-Ο單位之單價矽氧烷鏈，P是 1至10，r=(3-q)，X是〇或NR55，其中R55是Η或具 1至4個碳原子的單價烷基，a是〇或1，以及L是 伸烷基之二價連接基，其可包含醚或羥基。 2.根據申請專利範圍第丨項之軟性隱形眼鏡，其中該含 石夕氧單體是選自包含曱基丙烯氧基丙基雙(三甲基矽烷 25 氧基）曱基矽烷、甲基丙烯氧基丙基五曱基二矽氧烷、 -21 本紙張尺度適用中國國家標準(CNS)A4規格（21〇 X297公釐） 88069B-接 1 8 8 8 8 A B c D 1248948 六、申請專利範圍 (3-甲基丙烯氧基-2-羥基丙氧基）丙基雙(三甲基矽烷氧 基）甲基矽烷和如結構II之末端為單_甲基丙烯氧基丙 基之聚二曱基矽氧烷：
    結構II 其中b=0至100。 10 3.根據申請專利範圍第1項之軟性隱形眼鏡，其中該含 矽氧單體是甲基丙烯氧基丙基雙(三曱基矽烷氧基）甲基 矽烷。 15 4.根據申請專利範圍第1項之軟性隱形眼鏡，其中該反 應混合物另外包含一種親水性單體。 經濟部智慧財產局員工消費合作社印製 5.根據申請專利範圍第4項之軟性隱形眼鏡，其中該親 水性單體是選自包含N，N-二甲基丙烯基醯胺、2-羥基 20 乙基甲基丙烯酸酯、甘油甲基丙烯酸酯、2-羥基乙基 甲基丙烯醯胺、N-乙烯基吡咯烷酮、聚乙二醇單甲基 丙烯酸酯、甲基丙烯酸和丙烯酸。 -22 - 本紙張尺度適用中國國家標準(CNS)A4規格（210x297公釐） A8 B8 C8 D8 經濟部智慧財產局員工消費合作社印製 1248948 六、申請專利範圍 6. 根據申請專利範圍第1項之軟性隱形眼鏡，其中該反 應混合物另外包含附加含矽氧單體。 7. 根據申請專利範圍第6項之軟性隱形眼鏡，其中該附 5 加含矽氧單體是一種含羥基烷基胺官能基單體。 8. 根據申請專利範圍第4項之軟性隱形眼鏡，其中該反 應混合物另外包含一種附加含石夕氧單體。 10 9.根據申請專利範圍第8項之軟性隱形眼鏡，其中該附 加含矽氧單體是一種含羥基烷基胺官能基單體。 10·根據申請專利範圍第1項之軟性隱形眼鏡，其中該反 應混合物另外包含一種稀釋劑。 15 1L根據申請專利範圍第10項之軟性隱形眼鏡，其中該稀 釋劑是三級醇。 12.根據申請專利範圍第8項之軟性隱形眼鏡，其中該結 20 構I之含矽氧單體和該附加含矽氧單體於反應混合物 中之混合總和是佔該反應混合物中之反應性成份的從 5至100重量％，以及該親水性單體是佔該反應混合物 -23 - 本紙張尺度適用中國國家標準(CNS)A4規格（210 X 297公釐）
    經濟部智慧財產局員工消费合作社印製 1248948 六、申請專利範圍 中之反應性成份的從5至80重量％。 13·根據申請專利範圍第8項之軟性隱形眼鏡，其中存在 於該反應混合物中之該結構I含矽氧單體和該附加含 5 矽氧單體的混合總和是佔該反應混合物中之反應性成 份的從10至60重量％，以及該親水性單體是佔該反 應混合物中之反應性成份的從10至50重量％。 14·根據申請專利範圍第1項之軟性隱形眼鏡，其中該反 10 應混合物包含甲基丙烯氧基丙基雙(三甲基矽烷氧基）甲 基矽烷、N，N-二甲基丙浠醯胺以及縮水甘油甲基丙烯 酸酯和5000MW之α，ω-雙胺基丙基聚二曱基矽氧烷 的反應產物。 本紙張尺度適用中國國家標準(CNS)A4規格（210 x 297公漦）
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AR018131A1 (es) 2001-10-31
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KR100598469B1 (ko) 2006-07-11
DE69938940D1 (de) 2008-07-31
EP0940693B1 (en) 2005-06-22
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SG73617A1 (en) 2000-06-20
KR20000034800A (ko) 2000-06-26
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BR9900828A (pt) 2000-05-23
US5998498A (en) 1999-12-07
EP0940693A3 (en) 2000-10-11
EP0940693A2 (en) 1999-09-08
EP1560043B1 (en) 2008-06-18
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HK1078937A1 (en) 2006-03-24
CA2264083A1 (en) 1999-09-02

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