TWI311580B - Biomedical devices containing internal wetting agents - Google Patents

Description

1311580 A7 B7 V. Description of invention (Related patents apply to this patent application statement 暮 — — 击 击 536 536 536 536 536 536 536 536 536 536 536 536 536 536 536 536 536 536 536 536 536 536 536 536 536 536 536 536 536 536 536 536 536 536 536 536 536 536 BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a manufacturing method and use containing an inner w*, and the like. In the second half of the second year, contact lenses have been used as commercial products for improved visual use. No: Γ glasses are made of hard materials, so they are more or less uncomfortable for users. Modern water gels, and especially 矽 〈 土 土 土 土 _ _ _ _ _ _ _ _ _ 土 土 土 土 土 土 土 土 土 土 土 土 土 土Weishui hydrogel is the polymer network of the city's water expansion, and the water-based lens provides good comfort to the W-speaker (four). But there are some users who have uncomfortable experience when collecting lenses. And the excessive eye is like the product (4). Ministry of Economic Affairs, Intellectual Property Bureau, employee consumption cooperative printing and sediment and lens table society (4) and «surface and egg = lipid and mucin and eye_hydrophilic surface interaction. Some people have tried to alleviate this problem by coating the surface of the money with the hydrophilic coating (such as electropolymer coating). Uncoated contact lenses with low surface deposits have not been disclosed. It has been revealed that (4) the hydrophilic agent (or preparation) and the human body containing the macromolecule in the reaction mixture, H, not all of the macromolecules containing #oxygen burned and the pro--3- paper scale applicable to the China National Standard (CNS) A4 specification ( 210x297 Ministry of Economic Affairs Intellectual Property Bureau Staff Consumer Cooperative Printed 1311580 A7 B7 V. INSTRUCTIONS (2) Waterborne Polymer Compatibility. It has also been revealed that by adding a polymerizable surfactant to a monomer mixture used to form an object To modify the surface of a polymeric object. However, it is not possible to improve the in-vivo wetness and reduce surface deposits. Polyvinylpyrrolidone (PVP) or poly-2-ethyl-2-carbazole It is added to a hydrogel composition to form an interpenetrating network that exhibits a low degree of friction, a low rate of dehydration, and a high degree of biodegradability. However, the disclosed hydrogel The formulation is a conventional hydrogel and does not reveal how to combine hydrophobic components (such as octagonal monomers) without losing monomer compatibility. Although incorporating high molecular weight polymers such as internal wetting agents in decane Hydrogels It is possible in the film, but such a polymer is difficult to dissolve in the reaction mixture containing oxime <· ν alkane. To dissolve these humectants, a cesium alkane giant or other prepolymer must be used. The oxoxane macro or prepolymer must be prepared in a separate step and then mixed with the remaining ingredients of the decane hydrogel formulation. This additional step (or steps) adds to the cost of making such lenses. Ingredients and time. Furthermore, these methods have failed in the manufacture of an ophthalmic device that is sufficiently moistened to use as a contactless contact lens. Therefore, it is advantageous to find a giant axane that does not require the use of Body % other prepolymers, and suitable for lens formulations for delayed wear without surface treatment. SUMMARY OF THE INVENTION The present invention relates to a wet alkane hydrogel comprising, substantially comprising or comprising at least one High molecular weight hydrophilic polymer and up to -4- paper scales applicable to China National Standard (CNS) A4 specification (210x297 mm)

Printed by the Ministry of Economic Affairs, Intellectual Property Office, Staff and Consumer Cooperatives 1311580 Αν B7 V. INSTRUCTIONS (3) The reaction mixture of a monomer containing a hydroxyl-functional azide. The invention further relates to a biomedical device formed by a reaction mixture comprising, consisting essentially of or comprising a high molecular weight hydrophilic polymer and an effective amount of a hydroxyl-functionalized decane-containing monomer. The invention further relates to a method of preparing a biomedical device comprising, consisting essentially of or comprising mixing a high molecular weight hydrophilic polymer and an effective amount of a hydroxyl-functionalized decane-containing monomer to form a transparent solution And curing the solution. The invention further relates to a method of preparation comprising, consisting essentially of or comprising the steps of: (a) mixing a high molecular weight hydrophilic polymer and an effective amount of a hydroxyl-functionalized decane-containing monomer and (b) curing The product of step (a) to form a biomedical device. The invention further relates to a method of preparation comprising, consisting essentially of or comprising the steps of: (a) mixing a high molecular weight hydrophilic polymer and an effective amount of a hydroxyl-functionalized siloxane containing monomer and (b) The product of step (a) is cured at or below the minimum temperature to form a moist biomedical device. The present invention relates to a method for improving the wettability of a substrate formed by a reaction mixture, comprising, consisting essentially of or comprising adding at least one high molecular weight hydrophilic polymer and an effective amount of at least one compatible monomer It is formed into the reaction mixture. The present invention relates to a method for improving the wettability of an ophthalmic device formed from a reaction mixture, comprising, substantially comprising or comprising adding at least one -5-Q of the paper size applicable to the Chinese National Standard (CNS) A4 specification (210x297) MM)

Turn I I I I η

1311580 A7 B7 V. DESCRIPTION OF THE INVENTION (Draft) Seeding a hydrophilic polymer of the southern stalk stem and a monomer of a quantity of functionalized oxoxane to the reaction mixture and v containing a hydroxyl group, the invention is more related to The reaction mixture comprises, consists essentially of, or comprises at least one of: an ophthalmic monomer, and a contact angle sufficient to provide the apparatus prior to functionalizing the helium at less than about 70 or less than about 60. _; about 8 〇, water-based polymer. High molecular weight 覩 The present invention is more related to the invention comprising, consisting essentially of, or comprising at least one monomer comprising c' and sufficient to provide the device with a surface-free treatment After the tear film collapse time is at least about 7 seconds, the tear film collapse time of ACUVUH® contact lenses is used in ancient polymers. In the case of a fluorescein-containing contact lens, there is virtually no surface deposition. ',..., the surface of the clarification of the details of the Ministry of Economic Affairs, the Intellectual Property Bureau, the employee consumption cooperative printing has now surprisingly found that 'bio-medical devices without surface modification, especially with special in vivo or clinical moistness (4) The device - may comprise - an effective amount of a high molecular weight hydrophilic polymer and - an effective amount: the base-functionally cut monomer is prepared in a (four) feed gel formulation. The so-called special wetness, the apparent dynamic contact angle is reduced by at least about ig% ', compared with similar formulations of any hydrophilic polymer, at least about, in some specific cases at least about . In the present invention -6- This paper scale applies the Chinese National Standard (CNS) A4 specification (2ΤΓχ297 public "57 !311580 A7

It is not necessary to make a surface enamel to provide clinical moistness. The ^^ must be composed of at least one kind of hydroxy-containing oxyxy The formation of giants. As used herein, "^A, a biolinguistic device, is intended to be used in animal tissues or in liquids, and is used in human tissues or fluids, and such devices. Examples include, but are not limited to, a guide tube, a graft (10), and an ophthalmic device such as an intraocular lens and a contact lens.

The biomedical device is an eye-shaped lens B, especially a contact lens, and most particularly, the invisible Mt manufactured by I-oxygenation. As used herein, the terms "lens," and "opial device" refer to devices that are present on or in the eye of the eye. These devices provide optical correction, injury, and drug delivery. , diagnostic function, cosmetic enhancement or effect or a combination of such specialties. The term lenses include, but are not limited to, soft contact lenses, hard contact lenses, intraocular lenses, outer lens lenses, eyeball inserts, and optical inserts. Property Bureau Staff Consumer Cooperative Printed As used herein, the term "monomer," is a type that contains less than one chelating group and an average molecular weight of less than about 2 Daltons (based on A compound as determined by gel permeation chromatography refractive index detection. Thus 'monomers (including dimers and in some cases oligomeric plates) include oligomers made from more than one monomeric unit. As used herein, the phrase "without surface treatment" means that the outer surface of the device of the present invention is not separately treated to improve the wettability of the device. The process of the present invention includes plasma treatment, grafting. , coating, etc. However, coatings other than improved wetness are provided (such as, but not limited to, anti--7 - this paper scale applies to China National Standard (CNS) A4 specification (210x297 public)! 311580 A7 -- -- B7 V. INSTRUCTION DESCRIPTION (6) Microbial coatings can be applied to the apparatus of the present invention. Various molecular weight ranges are disclosed herein. For compounds having a discontinuous molecular structure, as reported herein The molecular weight is based on the formula and is reported in grams per mole. In the case of polymers, the molecular weight (number average) is determined by gel permeation chromatography refractive index detection and reported in Dalton. , or by dynamic viscosity measurement (as described in the Encyclopedia of Polymer Science and Engineering 'N-vinylamine polymer.., 2nd edition, Book No. I98.257, John Wiley & Sons Limited In the company And the K-value is reported. Polymer 詈 Hydrophilic Polymer Economics Department Intellectual Property Bureau Employee Consumption Cooperative Printed # When used herein, "high molecular weight hydrophilic polymer, refers to the weight average molecular weight Not less than about 100,000 Daltons, wherein the substance, once combined with the alkane hydrogel formulation, increases the wettability of the cured Shiyan oxygen hydrogel. Preferably, the high molecular weight hydrophilic polymers have a weight average molecular weight of from greater than about 150,000 to about 2,000, more preferably from about 300,000 to about 1,800,000 Daltons, most preferably from about 300,000 to about 1,800,000 Daltons. 500,000 to about 1,500,000 Daltons. In addition, the molecular weight of the hydrophilic polymer of the present invention can also be expressed by the kappa value, which is based on dynamic viscosity measurement (as described in the Polymer Science and Engineering Encyclopedia 'Ν-vinylamine polymer, 2nd edition dry Edition, Vol. 17, pp. 198-257 - John Wiley & Sons, Inc.) When expressed in this manner, the hydrophilic monomer has a K- greater than about 46, preferably between about 46 and 150. value. High molecular weight hydrophilic polymerization 2 -8- This paper scale is applicable to China National Standard (CNS) A4 specification (210x297 mm) A7 1311580 Invention Description (7) The formula of the device is 'used enough to provide contact lenses in no less, in use During the maintenance period, substantially no surface deposits are maintained. The use period of the combined type includes at least about 8 hours, preferably several days in a row, purely :::: down, hours or longer. Substantially no surface deposits, when viewed with a xenon lamp, at least about 7〇%, preferably at least about 80%, and especially preferably 9%% of the lenses that are worn in the patient population, after wearing After time. , 4 τ was rated as no or slight deposition. = propylene glycol molecular weight hydrophilic polymer comprises from about 1 to about 15 weight percent of from about 3 to about 15 percent, most preferably from about 5 to about 12 percent, based on the total weight of all of the reaction components. Examples of hydrophilic polymers in the @knife include, but are not limited to, polydecylamine, poly-indolizine Uiv imine, poly-g (iv) and functionalized polyamine, polylactone, Ministry of Economic Affairs, Intellectual Property Office, employee consumption cooperative, printed poly a ruthenium imine, a polyendammine, such as a copolymerization of DMA with a less molar amount of a hydroxy functional monomer (such as HEMA), and then a base of the formed copolymer and a material comprising a polymerizable group ( DMA functionalization of DMA or N-vinylpyrrolidone and glycidyl methacrylate prepared by DMA functionalization of hydroxy or methacrylic acid methacrylate Polymers can also be used. Methyl methacrylate glycidol can be ring-opened to form a diol, which can be used in a mixed system with other pro-polymers to increase the high molecular weight hydrophilic polymer, containing a thiol group.忐 矽 矽 矽 单体 单体 及 及 及 及 及 及 及 及 及 较佳 较佳 较佳 较佳 较佳 较佳 较佳 较佳 较佳 较佳 较佳 较佳 较佳 较佳 较佳 较佳 较佳 较佳 较佳 较佳 较佳 较佳 较佳 较佳 较佳 较佳 较佳 较佳 较佳 较佳 较佳Cyclic guanamine or cyclic quinone imine. Hydrophilic polymers in polymers include, but are not limited to, poly-N-vinylpyrrolidone, poly-N---. Paper-9-1311580 A7 _________B7 V. Description of invention (s) Ethylene-2_hexahydropyridone, poly -N-ethylene-2-caprolactam, poly-N-vinyl-3-mercapto-2-caprolactam, poly-N_ethylene_3_mercaptohexahydropyridone, poly-N-ethylene _4·methyl_2_hexahydropyridone, poly_N_ethylene_4_mercapto-2·caprolactam, poly-N-ethylene_3_ethyl-2-pyrrolidone and polyethylene -4,5-Dimethyl-2-pyrrolidone, polyvinylimidazole, poly-N_N_didecyl acrylamide, polyvinyl alcohol, polyacrylic acid, polyethylene oxide, polyethyl 2 oxazolidine, heparin Polysaccharides, polysaccharides, mixtures and copolymers thereof (including block tables which are randomly 'branched, multi-bonded, comb-shaped or star-shaped)' are preferably poly-N-vinylpyrrolidone (PVP). Copolymers can also be used, such as graft copolymers of PVP. The Ministry of Economics, the Ministry of Finance, the Bureau of Fisheries, and the Consumers' Association for the Production of Waterborne Polymers provide the improved moisture content of the medical device of the present invention, especially the improved in vivo moistness. It is not intended to be subject to any salty high molecular weight hydrophilic polymer being a hydrogen bond acceptor, in which water is hydrogen bonded to water' thus effectively becoming more hydrophilic. The lack of water helps the hydrophilic polymer to be combined in the reaction mixture. In addition to the specially designated high molecular weight water-wet compound, it is expected that any high molecular weight hydrophilic polymer material will be rich, provided that the hydrophilic polymer (4) does not substantially consist of when the polymer is added to the Shixi = gel formulation. The phase of the reaction is separated and (9) imparts a wetness to the formed cured polymer. In the lower = specific example, the preferred high molecular weight hydrophilic polymer is preferably at the processing temperature = in the conversion. The manufacturing method of making money or cutting the thin coffee is a workmanship, so they are simple and the county is low. In these specific examples, a water-soluble high molecular weight hydrophilic polymer at a degree of addition is preferred.

(Invention) (9) As used herein, "human, _ is a species containing at least one type of monomer having a ping = base = energy fossil," (based on gel permeation chromatography: The sub-amount is less than about 3 〇〇 湾 〇〇 ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; 湾 湾 湾 湾 湾 湾 湾 湾 湾 湾 湾 湾 湾 湾 湾 湾 湾 湾 湾 湾 湾 湾The modified pro- and pro-forms are compatible with the polymer. Therefore, in the preferred embodiment, the second house: the sex is extremely effective. Because: the monomer contains at least one interesting group; And the oxygen 乂-s·, 圏 圏 圏 较 较 较 较 较 较 较 较 较 较 较 较 较 较 较 较 较 较 较 较 较 含 含 含 含 含 含 含 含 含 含 含 含 含 含 含 含 含 含 含 含 含 含Percentage. It is important that the ratio of the & 〇Η to f is the basis of the _ _ functionalization oxime oxy-type can provide the desired degree of compatibility _ high, official::==:: _ The ability of the object is very poor, leading to the early body in the hydrophilic polymerization of some of the specific examples, (4) 〇Γ incompatible. Therefore, in a certain to about (4) the door; ^ ratio is less than about 15:1, Good between about Μ U·1 In some specific examples, the primary secondary alcohol has an improved m❹ technology; ^ the functionalized Wei... the secondary drive will depend on the polymer to achieve the desired enthalpy, which is better than the hydrophilic polymer. Examples of monomers that contain hydrophilic and functional cleavage and cleavage of the brothel include the formula! and η of the single |_ -11- The paper ruler (four) is related to the ^^ 1311580

R1 R2 R-R6-C-R8-Si-R3 R5 R4 R1 R2 R2 R7_R6.i_R8_^_'j]n_R8_^ R5 R4 ^ ^

II wherein: n is an integer between 3 and 35, preferably between 4 and 25. R1 i hydrogen, Cw alkyl; 'R2, R\ and R4 are independently Cm alkyl, three Ci 6 alkyl decyloxy, phenyl, naphthyl, substituted C, .6 alkyl, substituted phenyl or substituted naphthyl, Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printed in the yard base substituent a member selected from the group consisting of a group consisting of a group consisting of a group consisting of a group consisting of a group of C, -6 alkyl groups, c, -6 alkoxides, amidino groups, halogens, hydroxyl groups, carboxyl groups, Cu alkylcarbonyl groups, and formazan. And wherein the aromatic substituent is selected from one or more of the group consisting of c16, an oxygen group, a C6 group, a C..6 alkoxy group, a guanamine group, a dentate group, a ruthenium group, a ruthenium group, a C!6 A member of a group consisting of a carbonyl group and a formamidine, R5 is a hydroxyl group, an alkyl group containing one or more hydroxyl groups; or (CH2 (CR9 -12- Ι.) This paper scale applies to the Chinese National Standard (CNS) A4 Specifications (210 297 297 public) Ministry of Economic Affairs Intellectual Property Bureau Staff Consumer Cooperative Printed 1311580 Αν B7 V. Invention Description (11) R'OXVR11, where y is 1 to 5, preferably 1 to 3, and X is 1 to 100 Integer, preferably 2 to 90 Preferably, R9-Rn are independently selected from H, an alkyl group having up to 10 carbon atoms, and an alkyl group up to 10 carbon atoms substituted with at least one polar functional group, and R6 is included up to 20 a divalent group of carbon atoms; R7 is a monovalent group of radicals capable of undergoing free radical and/or cationic polymerization and containing up to 20 carbon atoms; -1' R8 is a divalent group containing up to 20 carbon atoms or The trivalent group. The reaction mixture of the present invention may comprise more than one monomer containing a hydroxy-functional oxoxane. For monofunctional hydroxy-functional oxane-containing monomers, R1 is preferred. Is -hydrogen and preferably R2, R3 and R4 are Cy alkyl and three CN6 alkyl anthracene, preferably methyl and trimethyldecyloxy. In terms of polyfunctionality (difunctional or more) R^R4 independently comprises an ethylenically unsaturated polymerizable group, particularly preferably an acrylate group, a styryl group, a Cu alkyl acrylate group, a acrylamide, a CN6 alkyl acrylamide, a ruthenium-ruthenium> Alkene decylamine, N-ethylene thin amine, C2-I2 dilute group, C2-12 dilute phenyl group, C2-I2 dilute base group or 匸2-6 phenylene group Ci alkyl group Preferably, R5 is hydroxy, -CH2OH or CH2CHOHCH2OH, and _ is preferably hydroxy. Preferably, R6 is a divalent Cm alkyl group, a CN6 alkyloxy group, a CN6 alkyloxy Cw alkyl group, a phenylene group, a naphthalene group, C, _12 cycloalkyl, alkoxycarbonyl, decylamino, carboxy, CN6 alkylcarbonyl, carbonyl, Q.6 alkoxy, substituted CN6 alkyl, substituted CN6 alkyloxy, substituted -13- This paper size applies to China National Standard (CNS) A4 specification (210 X 297 mm)

1311580 A7 B7 Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printed i r-y V. Invention description (12)

Cu alkyl group-based Ck alkyl, substituted alkyl, substituted naphthalene, substituted CV12 cycloalkyl, wherein one or more selected from Ck alkoxycarbonyl, Cl-6 alkyl, CN6 A member of a group consisting of an alkoxy group, a decylamino group, a hydroxyl group, a hydroxyl group, a carboxyl group, a Cm alkylcarbonyl group, and an anthracene. Particularly preferred R6 is a divalent fluorenyl group (anthracene group). Preferably, R7 comprises a radical-reactive group such as acrylate, styryl, vinyl-ethylene ether, itaconate group, Cu alkyl acrylate group, and eneamine, Ck-based propylene. Indoleamine, N-vinyl indoleamine di N-vinylamine, C2-12 alkenyl, C2-12 alkenylphenyl, C2-12 alkenylnaphthalenyl or C2-6 decylphenyl Cw alkyl or a cationic A reactive group such as a vinyl ether or an epoxidized group. Tejia R7 is a methacrylate. R8 is a divalent C.6 alkyl group, a Cw alkyloxy group, a C1-6 alkyloxy group, a phenyl group, a phenyl group, a naphthyl group, a phenyl 2 cycloalkyl group, a c16 alkoxycarbonyl group, a decylamino group, a carboxyl group. , Cm alkylcarbonyl, carbonyl, Cl 6 alkoxy, substituted C "6 alkyl, substituted Cu alkyloxy, substituted c 丨 6 alkyloxy C, · 6 alkyl, Substituted, substituted naphthalene, substituted Cm2 cycloalkyl, selected from - or a plurality of Ci 6 alkoxycarbonyl, Cm alkyl, Cw alkoxy, decyl, halogen, a member of the k group consisting of a hydroxyl group, a complex group, a 6-alkylcarbonyl group and a formazan group. Particularly preferred R8 is a c-histyloxy Ck alkyl group. A particularly good formula [containing a thiol-functionalized fossil Examples of the body are: acrylic acid, 2-methyl-, 2-yl-based, ΗΗι, 3,3,3 tetramethyl-[(三甲笑甲石院)oxy] bis(oxyalkyl)]propoxy (4) (also known as ^ mercaptopropenyloxy-2-p-propyloxy)propyl bis(trimethylsulphonyl)methyl-14- _ This paper scale applies to China National Standard (CNS) A4 Specifications (210x297 -------- _

1311580 Λ7 B7 V. INSTRUCTIONS (η 〇 〇-Si(CH3)3 Φ - CH3 丨丨 OH 6

Si(CH3)3 The above compound, (3-methacryloxy-2-hydroxypropyloxy)propylbis(tridecylmethoxy)methyl decane is formed from an epoxide, which is produced. An 80:20 mixture of the above compound and (2-mercaptopropoxy-3-hydroxypropyloxy)propylbis(trimethyldecyloxy)methylnonane. In some embodiments of the invention, it is preferred to have some amount of a hydroxyl group present, preferably greater than about 10% by weight and particularly preferably at least about 20% by weight. Other suitable hydroxyl-functionalized alkoxylated monomers include (3-mercaptopropoxy-2-hydroxypropyloxy)propyl bis(tridecyloxy)methylnonane 〇p^Si (CH3)3 丨丨OH Ο

Si(CH3)3 bis-3-mercaptopropenyloxy-2-hydroxypropyloxypropylpolydidecyloxane

Ministry of Economic Affairs, Intellectual Property Bureau, Staff Consumer Cooperative, Printing Methyl Propenyloxy-2-(2-hydroxyethoxy)propyloxy)propyl bis (Thirteen-15) - This paper scale applies to China National Standard (CNS) A4 Specifications (210x297 mm) 1311580 A7 B7 V. Description of invention (Η基石夕氧) methyl Shi Xia

Si, ^ ^OH I η - Si-

Ν,Ν,Ν',Ν'-tetrakis(3-mercaptopropenyloxy-2-hydroxypropyl)_〇〇,〇)_bis-3_aminopropyl-polydidecyloxane. The reaction product of glycidyl methacrylate with an amine functional polythioxanthine can also be used as a monomer having a hydroxyl group-functional oxime. Other hydroxy-functional oxane-containing monomers include those described in U.S. Patent No. 5,994,488, the disclosure of U.S. Pat. Nos. 6, s. Monomers in 4,139,513 and 4,139,692. These and any other patents or applications cited herein are hereby incorporated by reference. Other structures of suitable hydroxy-functional azide-containing monomers include those similarly described in Pro. ACS Div. Polym. Mat. Sci. Eng., April 13-17, 1997, p. 42 and having The following structure: 裴 线 经济 经济 经济 经济 经济 经济 智慧 OR OR OR

OR .16- This paper scale applies to China National Standard (CNS) A4 specification (210x297 mm) Ministry of Economic Affairs Intellectual Property Bureau Staff Consumer Cooperative Printed 1311580 Λ7 B7 V. Invention Description (15) where η = 1-50 and R independent The ground layer comprises hydrazine or a polymerizable unsaturated group, wherein at least one R comprises a polymerizable group and at least one R (preferably 3-8 R) comprises hydrazine. Further suitable hydroxy-functionalized decane-containing monomers are disclosed in U.S. Patent No. 4,235,985. These components can be removed from the monomer containing the hydroxy-functional oxane by known methods such as liquid chromatography, evaporation, recrystallization or extraction - or they can be formed with care The reaction conditions and reaction ratios are selected to avoid. Suitable monofunctional hydroxy-functionalized decane monomers are commercially available from Gelest Corporation (Morrisville, ΡΑ). Suitable polyfunctional trans-functionalized oxosiloxane monomers are commercially available from Gelest Corporation (Morrisville, PA) or can be made using the procedures described in 5,994,488 and 5,962,548. Suitable PEG type hydroxy-functionalized decane monomers can be made using the procedure described in PCT/JP02/02231. While monomers containing hydroxy-functional oxane have been found to be particularly suitable for providing compatible polymers for biomedical devices, particularly ophthalmic devices, any monomer containing a functionalized oxane (which when polymerized or It can be used when it is formed into a final object that is compatible with the selected hydrophilic component. Suitable hydroxy-functionalized oxoxane monomers can be selected using the following monomer compatibility tests. In this test, a mono-3-mercapto oxypropyl terminal, a mono-butyl terminal polydimethyl methoxy oxane (mPDMS molecular weight 800-1000) and a monomer to be tested each 1 gram and 1 The 3,7-dimethyl-3-octanol was mixed together at about 20 °C. 12 parts by weight of K-90 PVP and 60 parts by weight -17- This paper size is applicable to China National Standard (CNS) A4 specification (210 X297 mm)

Ministry of Economic Affairs, Intellectual Property Bureau, Staff Consumption Cooperative Printing, Printing 1311580 Αν B7 V. Mixture of DMA of Invention (16) was added dropwise to the hydrophobic component solution with stirring until the solution remained turbid after stirring for 3 minutes. The mass of the blend of PVP and DMA added was determined in grams and recorded as the monomer compatibility index. Any monomer having a hydroxyl-functionalized oxoxane having greater than 0.2 grams, particularly preferably greater than about 0.7 grams, and most preferably greater than about 1.5 grams, will be suitable for use in the present invention. The "concentration amount" or "compatibilization effective amount" of the hydroxy-functionalized siloxane-containing monomer of the present invention is the amount required to compatibilize or dissolve the high molecular weight hydrophilic polymer. - the amount of functional oxime-oxygenated monomer will depend, in part, on the amount of hydrophilic polymer used, but more trans-functionalized siloxane-containing monomers are required and at higher concentrations The hydrophilic polymer is compatible. The effective amount of the hydroxyl-functionalized oxane-containing monomer in the polymer formulation comprises from about 5% by weight, based on the weight percent of the reaction component, to from about 90%, preferably. From about 10% to about 80%, optimally from about 20% to about 50%. In addition to the high molecular weight hydrophilic polymer of the present invention and the hydroxyl-functionalized alkoxylated monomer, other hydrophilic and hydrophobic monomers , a crosslinking agent, an additive, a diluent, a polymerization initiator can be used to prepare the biomedical device of the present invention. In addition to the high molecular weight hydrophilic polymer and the monomer containing a hydroxyl functionalized siloxane, the hydrogel formulation can be Including monomers containing other siloxanes, hydrophilic monomers and crosslinkers The biomedical device of the present invention is provided. The monomer containing other oxane is related to other siloxane containing monomers, and is described in U.S. Patent No. 4,711, -18- U l. This paper scale applies to China National Standard (CNS) A4 specification. (210x297 mm)

1311580

The guanamine product of 943, the vinyl carbamic acid m-acid lysate described in U.S. Patent No. 5,070', and the oxidative disintegration contained in U.S. Patent No. M2M45 are (IV), and the patents mentioned therein The case and other full-time jobs described in this booklet are for reference. In particular, 3-methylpropoxy bis(dimethyl oxa oxy) tartan (TRIS), monofluorenyl allyoxypropyl terminated polydidecyl fluorene, poly Methyl methoxy oxane, 3-mercapto propyleneoxypropyl bis(trimethyl decyloxy) decyl decane, 1 decyl propyleneoxy propyl pentamethyldioxane, and combinations thereof, particularly Used as other oxosiloxane-containing monomers of the present invention. The monomer containing other oxane may be present in an amount of from about 0 to about 75% by weight, particularly preferably from about 5 to about 6 Torr, and most preferably from about 10 and about 40% by weight. Hydrophilic Monomers Ministry of Economic Affairs Intellectual Property Office Staff Consumer Cooperative Printed In addition, the reactive components of the present invention may also include any hydrophilic monomer used to prepare conventional hydrogels. For example, a monomer containing an acrylic acid group ((3) cadaverine (3) COX ' wherein R is hydrogen or Ci-6 alkyl group and X is ruthenium or osmium) or ethylene group (-OCH 2 ) can be used. Examples of other pro-permanent monomers include n,n-dimethylpropenylamine, 2-ethylidene decyl acrylate, monomethylpropionate, 2-aminoethyl fluorenyl Acrylamide, polyethylidene ethyl acetophenone glyceride, methacrylic acid, acrylic acid, N-vinylpyrazine. Nitrite, N-ethylene-N-mercaptoacetamide, N-ethylene-N-ethylacetamide, hydrazine, ethyl ethane acetamide, and combinations thereof. -19-134 This paper scale applies to China National Standard (CNS) A4 specification (210x297 mm) Ministry of Economic Affairs Intellectual Property Bureau Staff Consumption Cooperative Printed 1311580 - B7 V. Invention Description (18) In addition to the other hydrophilic monomers mentioned above A polyoxyethylene polyol having one or more terminal hydroxyl groups substituted by a functional group containing a polymerizable double bond can be used. Examples include polyethylene glycol (as disclosed in U.S. Patent No. 5,484,863); ethoxylated alkyl glucosides (as disclosed in U.S. Patent Nos. 5,690,953, 5,304,584): and ethoxylated biphenol A, such as It is disclosed in U.S. Patent No. 5,565,539, which is incorporated by reference to the end of one or more molar equivalents (e.g., isocyanate S-ethyl ethyl methacrylate), a y_n. Reaction with acrylic acid anhydride, mercaptopropene hydrazine chloride, ethylene benzoquinone chloride, etc. to produce a polyethylidene polyol having one or more terminally polymerizable olefin groups through a linking moiety, such as an amino phthalate , urea or ester group, bonded to the polyethylidene polyol. Still other examples include the hydrophilic vinyl carbonate or vinyl urethane monomers described in U.S. Patent No. 5,070,215, the hydrophilic oxazolone monomers described in U.S. Patent 4,910,277, the disclosure of which is incorporated herein by reference. Reference herein) and polydextrose. Preferred other hydrophilic monomers are hydrazine, hydrazine-dimethyl decylamine (DMA), 2-hydroxyethyl decyl acrylate (fluorene), glyceryl methacrylate, 2-hydroxyethyl decyl propylene hydride. Amine, N-vinylpyrrolidone (NVP), polyethylidene monomethacrylate, methacrylic acid, acrylic acid, and combinations thereof, are particularly preferred as hydrophilic monomers comprising DMA. Other hydrophilic monomers may be present in an amount from about 0 to about 70% by weight, particularly preferably from about 5 to about 60, most preferably from about 10 and about 50% by weight. Crosslinker -20- This paper scale applies to China National Standard (CNS) A4 specification (210x297 mm)

A7 1311580 V. INSTRUCTIONS (l9) Printed by the Intellectual Property Office of the Ministry of Economic Affairs, the Consumer Cooperatives. Suitable crosslinkers are compounds with two or more polymerizable functional groups. The cross-linking agent can be hydrophilic or sparse, and in some specific examples of this correction, 'hydrophilic and hydrophobic--aged t have been found to provide improved optical clarity (compared to CSI thin lenses) Reduced haze) of Shixia oxygenated hydrogel. Examples of suitable hydrophilic crosslinking agents include compounds having two or more polymerizable functional groups and hydrophilic functional groups such as polyethers, captanamines or transradical groups. Specific examples include (tetraethyl glycol dimethacrylate), TrEGDMA (tri-ethyl glycol dimercapto acrylate), ethylene glycol dimercapto acrylate (EGDMA), ethyl Monoamine dimercaptopropenylamine, dimercapto glyceride and combinations thereof. Examples of suitable hydrophobic crosslinking agents include polyfunctional hydroxy-functionalized decane-containing monomers, polyfunctional polyethers - polymethyl oxalate oxime copolymers, and combinations thereof, and the like. . Special hydrophobic i crosslinkers include propyleneoxypropyl terminated polydimethyl oxime (n=10 or 20) (acPDMS), hydroxy acrylate functionalized oxime, giant methacrylate Propyl terminal PDMS, butanediol dimethyl endoate, divinylbenzene, 1,3-bis(3-methylpropoxypropyl)tetrakis(trimethylsuccinyloxy)-a Burn and its special composition. Preferred crosslinking agents include TEGDMA, EGDMA, acPDMS, and combinations thereof. The hydrophilic crosslinking agent is usually used in an amount of from about 0 to about 2% by weight, preferably from about 5% to about 2% by weight, and the hydrophobic crosslinking agent is usually used in an amount of from about 5% to about 5% by weight. The molar % indicates that it is from about 〇·〇1 to about 〇.2 mmol/g of the reaction component, preferably from about 0.02 to about 0.1% by weight, particularly preferably from 3 to about 0.6 mmol/g. -21- This paper scale applies to China National Standard (CNS) A4 specification (210x297 mm) A7 1311580 V. Description of invention (20) Increasing the concentration of crosslinker in the final polymer has been found to reduce haze. The concentration of the binder is increased by about 0.15 millimoles per gram of the reaction component above the 'modulus increase is above the above-mentioned desired level (greater than about 9 pounds per square inch). Therefore, in the present invention, the composition and amount of the crosslinking agent It is selected to provide a crosslinker concentration in the reaction mixture between about 〇.〇1 and about 莫1 4 mol/g of crosslinker. Other ingredients or additives well known in the art can also be Additives include, but are not limited to, ultraviolet absorbing compounds and monomers, reactive dyes, antimicrobial compounds, pigments, photochromic agents, excipients, and combinations thereof, etc. Other ingredients include oxygen permeable components such as A monomer containing a carbon-carbon triple bond and a fluorine-containing monomer well-known in the general scouring process, including a fluorine-containing (meth)acrylic acid ester. The ester preferably includes, for example, a fluorine-containing (fluorenyl)acrylic acid C2-C12 alkane. Ester (such as 2,2,2-trisylethyl) Acrylate, 2,2,2,2,,2,,21_hexafluoroisopropyl(indenyl)acrylate, 2,2,3,3,4,4,4-heptafluorobutyl (曱) Acrylate, 2,2,3,3'4'4'5'5,6,6,7,7,8,8,8-pentadecafluorooctyl (methyl)propionate, 2 , 2,3,3,4,4,5,5,6,6,7,7,8,8,9,9-hexadecafluorodecyl (meth)acrylic acid vinegar, etc. Consumer Cooperatives Print Diluent — The reactive components (hydroxy-functionalized alkoxylated monomers, hydrophilic polymers, parent binders, and other ingredients) are often lacking in water and selectively in at least one diluent Mix and react in the presence of (4) __ kinds of reaction mixture. The type and amount of diluent used also affect the polymer formed and -22- This paper scale applies to China National Standard (CNS) A4 specification (210 X 297 mm) Ministry of Economic Affairs Intellectual Property Bureau Staff Consumer Cooperative Printed 1311580 Λ7 B7 V. INSTRUCTIONS (21) Characteristics of objects. The haze and wetness of the final object can be selected by using a relatively hydrophobic thinner and/or lowering The concentration of the diluent used is improved. As mentioned above, increase The hydrophobicity of the release agent may also allow for poorly compatible ingredients (as determined by compatibility testing) to be processed to form a compatible polymer and object. However, when the diluent becomes more hydrophobic, then The processing steps that require the replacement of the diluent with water will necessitate the use of solvents rather than water. This may undesirably increase the complexity and cost of the manufacturing process - therefore, it is very important to have the necessary degree of processing convenience. A diluent is provided which provides the desired compatibility with the ingredients. The diluents useful in the preparation of the devices of the present invention include ethers, esters, hydrocarbons, alkyl i radicals, decanes, guanamines, alcohols, and the like. Composition. Indoleamines and alcohols are preferred diluents, while secondary and tertiary alcohols are preferred alcohol diluents. Examples of the ether which can be used as the diluent of the present invention include tetrahydrofuran, tripropylene glycol methyl, dipropylene glycol methyl bond, ethylene di-n-butyl ether, diethylene glycol n-butyl ether, diethylene glycol, decyl ether, Ethylene glycol phenyl ether, propylene glycol oxime ether, propylene glycol oxime ether acetate, dipropylene glycol oxime ether acetic acid g, propylene glycol n-propyl ether, dipropylene glycol n-propyl ray, tripropylene glycol n-butyl ether, propylene glycol phenyl ether, dipropylene glycol diterpene Ether, polyethylene glycol, polypropylene glycol and mixtures thereof. Examples of the ester which can be used in the present invention include ethyl acetate, butyl acetate, amyl acetate, decyl lactate, ethyl lactate, iso-propyl lactic acid. Examples of the alkyl halide which can be used as the diluent of the present invention include dichlorodecane. Examples of the decane which can be used as the diluent of the present invention include octadecylcyclotetraoxane. Examples of the alcohol which can be used as the diluent of the present invention include those having the following formula -23- The paper size is applicable to the Chinese National Standard (CNS) A4 specification (210 x 297 mm).

1311580

V. Description of the invention (

R

C-OH wherein R, R and R" are independently selected from H, a linear, branched, or cyclic monovalent alkyl group having from j to 1 carbon, which may optionally be substituted by one or more Shouting, m--aryl, amine, decylamine, alkene, alkyne, carboxylic acid, alcohol, brewing, (4) groups are substituted, or R, R > R" either or both can be combined Or a plurality of cyclic structures such as an alkyl group having 1 to 10 carbon atoms which may be substituted as described above, provided that no more than one of R, R, or R" is hydrazine. The particles R, R' and R" are independently selected from fluorene or unsubstituted linear, branched, or cyclic monovalent alkyl groups having from 1 to: carbon. More preferably R, IT and γ are independently selected from fluorene or unsubstituted direct bonds, branches, or cyclic monovalent groups having from i to 7 carbons. In some embodiments, preferred diluents have a total carbon number of 4 or more, particularly preferably 5 or more, because the higher the molecular weight diluent, the lower the volatility and the lower the secret. When one of # R, r, and r" is Η, the structure forms a secondary alcohol. When R, r, and r are not - Η, the structure forms a tertiary alcohol. The tertiary alcohol is preferred over the secondary alcohol. The agent is preferably inert and when the total number of carbons is 5 or less, the water is replaced. Examples of secondary alcohols that are useful for the purpose include 2-butanol, 2-propanol, methanol, cyclohexanol, cyclopentanol and decyl alcohol, 2-pentanol, 3-pentanol, 2_ ^ Alcohol, 3-hexanol, 3-methyl-2-butanol, 2-heptanol,: octanol, 2-sterol' -24- The paper size _ 111 ® Home (CNS) A4 (21G X 297 ^57 13 π 580

V. Description of the invention (23 2-nonanol, 3-octanol, hypotenol, etc. Examples of useful tertiary alcohols include *He Leyi alcohol, third brewing, 2-methyl-2_e Alcohol, -pentane and methylhexanol, 2-methyl-2-ol wide" two; methyl-3-butanol, methylcyclopropanol, monoheptanol, hydrazine: octyl 2-methyl-2 Sterol, 3-C, η-methyl I decyl alcohol, • 4′^-yl-3-hexanol, 3-methyl-3-heptanol, 4-mercapto-4-heptanol, 3-methyl- 3-octanol, 4 and 4 m. K-methyl-4-octanol, 3-methyl-3-nonanol~ 4-methyl-4-nonanol, 3-methyl-Q-li, " Octanol, 3-ethyl-3-hexanol, 3-mercapto-3-heptanol, 4-ethyl-4-glyoxime. ^. Antiallergic, 4-propyl-4-heptanol, 4 _isopropyl_4_heptanol, 2,4-dimethyl-2-pentanol, j-1 methyl hydrazine, 1-ethylcyclopentanol, 1-ethyl i-pentanol, 3 -hydroxy_3_methyl-3-mercapto-1-butene, 4-hydroxy-4-methyl-1-indenyl-2-propanol, 2-methoxy-2-methyl-2- Propanol, 2,3,4-dimethyl-3-pentanol, 3,7--methyl, ffy'-methyl-3-octanol, 2-phenyl-2-butanol, 2-mercapto -1-phenyl-2-propanol and 3-ethyl-3-butanol, etc. single alcohol or two or more A mixture of the above alcohols or two or more alcohols according to the above structure can be used as a diluent for the production of the polymer of the present invention. In one embodiment, the preferred alcohol diluent is a grade t having at least * charcoal. And tertiary alcohols. More preferred alcohol diluents include tert-butanol, third pentanol: 2: butanol, 2-methyl-2, pentanol, 2,3-dimercapto-2-butanol, !_曱基_ 3-pentanol, 3-ethyl_3_pentanol, 3,7-dimethyl_3_octanol. ~ The current best diluent is hexanol, heptanol, octanol , sterol, sterol, tert-butanol, 3-methyl-3-pentanol, isopropanol, third pentanol, lactic acid ethyl acetate, methyl lactate, isopropyl lactate, 3 dimethyl _3^Dimethylmethaneamine, dimethylacetamide, dimethylpropanamine, N-methylpyridin-25- ordering line 1 t Ministry of Economic Affairs Intellectual Property Bureau employees consumption cooperatives printed paper scale applicable China National Standard (CNS) A4 Specification (7f〇χ 297 public) Α7 !31158〇五, invention description (24) rancidinone and mixtures thereof. Other diluents which can be used in the present invention are described in the US patent Case 6,020,445, which is incorporated herein as a reference In one embodiment of the invention, the diluent is water-soluble under processing conditions and is readily washable by water from the lens in a short period of time. Suitable water-soluble diluents include Κethoxy 2 _propanol, 1-mercapto-2-propanol 'third, sterol, tripropylene glycol methyl ether, isopropanol, 1-methyl-2-pyrrolidone, 'team-mercaptopropane SI amine, lactic acid Ethyl vinegar, dipropyl ketone, bismuth oxime, methyl ether and mixtures thereof. The use of a water-reducible diluent allows the horizontal molding process to be carried out using only water or an aqueous solution containing water as a substantial component. In one embodiment, the diluent is typically present in an amount of less than about 5% by weight of the reaction mixture and preferably less than about 4,000%, more preferably between about 10 and about 3%. ·- Strict! · The diluent can also contain other ingredients, such as excipients. A suitable release agent is i to bath and help the lens to deblocking. The Ministry of Economic Affairs, Intellectual Property Bureau, Consumer Cooperatives, printing polymerization initiators include compounds such as lauryl peroxide, benzoquinone pervaporate, isopropyl carbonate, azobisisobutyl carbonitrile, etc. Lower free radicals are produced, as well as photoinitiator systems such as & hydroxy = oxime, oxime ethoxybenzoin, acetophenone, acetamyl oxidized scale, and: amine plus diketone, mixtures thereof, and the like. The description of the photoinitiator is based on the cyclohexyl ketone, 2-carbyl-2-methylphenyl-propyl-(tetra), bis((dimethoxybenzophenone)-2,4-4 -trimethylpentyloxyphosphonium _BAP0), bis(2,4,6-trimethylbenzylidene)-stupyloxy (1st _ 819) ' 2,4,6_trimethyl fresh base II Phenylphosphine oxide and dimethyl benzophenone diphenylphosphine oxide, benzoin A and camphor and ^ -26- This paper scale applies to China National Standard (CNS) A4 specifications (21〇χ297 public Chu)- ~~ ~—— _ A7 1311580 V. DESCRIPTION OF THE INVENTION (25) A composition of 4-(N,N-didecylamino)benzoate. Commercially available visible light initiator systems include Irgacure 819, Irgacure 1700, Irgacure 1800, Irgacure 819, Irgacure 1850 (all from Steam Batt Chemicals) and Lucirin TPO Initiator (available from BASF). Commercially available UV photoinitiators include Darocur 1173 and Darocur 2959 (Steam Bart Chemicals). The initiator is used in the reaction mixture in an amount effective to effect photopolymerization of the mixture, e.g., from 1 to about 2 parts by weight per 1 part of the reaction monomer. The polymerization of the reaction mixture can be initiated by suitably selecting heat or visible light or ultraviolet light or other methods depending on the polymerization initiator used. Alternatively, the priming can be carried out using, for example, an electron beam, without a photoinitiator. However, when a photoinitiator is used, preferred initiators are 1-nonylcyclohexylbenzophenone and bis(2,6-dimethoxybenzylidene)-2,4-4-trimethylpentene. A composition of phosphine oxide (DMBAPO), and the preferred method of polymerization initiation is visible light. Most preferred is bis(2,4,6-trimethylphenylhydrazinyl)-phenylphosphine oxide (Irgacure 819®). The present invention further comprises, consists of, and substantially comprises a formulation of the following shown as a hydrocele, a biomedical device, an ophthalmic device, and a contact lens: The Ministry of Economic Affairs, the Intellectual Property Office, the employee's consumption cooperation, the weight of the printed product ------- lHMWHP SCM HM ~ l5"90 -------- 1-15,3-15 or 5-12 0 0 ~~~~~~~~~~ 10-80 -- __1 1-15,3-15 or 5-12 0 〇~~- 20-50 ----- 1-15, 3-15 or 5-12 0 0 '~~ 5-90 1 1-15, 3 -15 or 5-12 0-80, 5-60 or 0-70, ^60^ ΤίδΟ --*--two 10-40 10-50 1-15,3-15 or 5-12 0-80, 5 -60 or 〇-70,5^60^~ -27- The paper scale is suitable for money (4) Household standard (CNS) A4 specification (210x297 mm) 1311580 A7 B7 V. Invention description (26: 10-40 10-50 20 -50 1-15,3-15 or 5-12 0-80,5-60 or 10-40 0-70, 5-60 or 10-50 HFSCM is a hydroxyl-functionalized alkane-containing monomer HMWHP The high molecular weight hydrophilic polymer SCM is a oxosiloxane-containing monomer HM which is a hydrophilic monomer or more by weight based on all the reaction components. Therefore, the present invention includes the components listed in the table (which describes 9 〇値可. The composition of energy Perfluoroalkane hydrogels, biomedical devices, ophthalmic devices, and contact lenses. Each of the above ranges begins with the word "about." The combination of the foregoing ranges is presented, provided that the ingredients listed are The other ingredients are added up to 100% by weight. The preferred range of the combined methoxyxane-containing monomer (hydroxy-functionalized decane and other oxo-containing monomers) is from about 5 to 99 weight percent of the reaction component. More preferably, it is from about 15 to 90 weight percent, most preferably from about 25 to about 80 weight percent. The preferred range of the hydroxyl-functionalized alkane-containing monomer is from about 5 to about 90 weight percent, preferably from about 10 to about 10 weight percent. 80, and most preferably from about 20 to about 50 weight percent. The preferred range of hydrophilic monomer is from about 0 to about 70 weight percent of the reaction component, particularly preferably from about 5 to about 60 weight percent, most preferably from about 10 to about 50 percent. The weight percent. high molecular weight hydrophilic "green polymer" preferably ranges from about 1 to about 15 weight percent, particularly preferably from about 3 to about 15 weight percent, most preferably from about 5 to about 12 weight percent. All about weight percent is based on The total weight of the reaction components is the standard. Preferably, the range is from about 0 to about 70 weight percent, based on the weight of all ingredients in the reaction mixture, particularly preferably from about 0 to about 50 weight percent, more preferably from about 0 to -28 - the paper scale applies to the Chinese National Standard (CNS) A4. Specifications (210 X 297 mm) Ordering line #Ministry of Economics Intellectual Property Bureau Staff Consumer Cooperatives Printing A7 B7 311580 V. Invention Description (27 about 40 weight percent and in some specific examples, the best is between about 10 to about Between 30 weight percent. The amount of diluent required will vary depending on the nature and relative amount of the reaction components. In a preferred embodiment, the reaction component comprises 2-acrylic acid, 2-methyl-, 2-hydroxy-3-[3-[l,3,3,3-tetradecyl-1-[(trimethyl)曱矽alkyl)oxy]dioxaxyalkyl]propoxy]propyl ester "SiGMA" (~28% by weight of the reaction component); (8OO-tOO0 MW monomethacryloxypropyl terminal single-positive -butyl terminated polydioxanoxane "mPDMS" (~31% by weight); hydrazine, hydrazine-dimethyl methacrylamide "DMA" (~24% by weight); 2-hydroxyethyl methacrylic acid Ester "HEMA" (~6% by weight); tetraethylene glycol dimercapto acrylate "TEGDMA" (~1.5% by weight); polyvinylpyrrolidone "K-90.PVP" (~7% by weight); The amount contains a small amount of additives and a photoinitiator. The polymerization is preferably diluted at about 23% (by weight of the combined monomer and diluent blend) of 3,7-dimercapto-3-octanol. In other preferred embodiments, the reaction components include those shown in the table below. All amounts begin with the word "about." SiGMA 30 30 mPDMS 23 18 DMA 31 31 HEMA 7.5 9 EGDMA 0.75 0.8 PVP 6 6 -29- This paper scale applies to China National Standard (CNS) A4 specification (210x297 mm) 1311580 A7 B7 V. Invention Description (28 The polymerization of the above formula is preferably in the third - Pentanol is carried out as a diluent, comprising about 29% by weight of uncured reaction mixing process. The biomedical device of the present invention utilizes a high molecular weight hydrophilic polymer, a monomer of 3 hydroxy-functionalized decane. , plus one or more of the following: a monomer containing other oxoxane, a hydrophilic monomer, an additive ("reaction component"), and a diluent ("reaction mixture"), mixed with a polymerization initiator, and The product is cured under suitable conditions to form a product which can then be opened/formed into a suitable shape by lathe, cutting. In addition, the reaction mixture can be subsequently solidified into a suitable object in one, and the Ministry of Economy, Intellectual Property Office, Staff Consumer Cooperatives In the manufacture of contact lenses, various methods of treating the reaction mixture are known, including spin casting and electrostatic casting. Rotary casting is disclosed in U.S. Patent 3 4, M29 and 3, 660, 545, and the electrostatic casting method is disclosed in 4, 113, 224 and 4, 197. A preferred method of making a contact lens comprising the polymer of the present invention is molding Wei Cai gel, which is rotary and precise. Controlling the final shape of the hydrated lens. In this way, the anti-Kujia people are placed in a mold towel with the shape of the final desired 11 oo- _ (ie, ^ ^ ^ ΛΚ α ) = 丄 to produce a polymer / _ in the shape of the final desired product. Thereafter, the polymer/diluent mixture is treated with a solvent to remove the dilute coffee, and finally it is replaced with water to produce a helium-oxygen boiling water gel having a final size/shape which is quite similar to the original molding.聚聚-30- This paper scale is applicable to China National Standard (CNS) A4 specification (2丨〇X 297 public recovery)!311580 V. Invention description (29 compound/diluent object size and shape. This method can be Used to shape glasses and further steps are described in U.S. Patent No. 4,495=Hid=, 336, 4,889,664 and 5, 〇39 459, and this article is used for μ-curing, and the invention is characterized by a solid-state hydrogel formulation. Into the dampness of the material. Now the wealth of Wei Qianjiao = can be used to select the curing conditions that provide a moist eye device (especially a _ = lens). The knee time is the crosslinked polymer During the opening of the network, the viscosity of the curing reaction mixture is close to infinity, and the mixture becomes non-liquid. The degree of conversion of the gel point system is independent of the reaction conditions, so it can be used as the reaction rate. The indicator of the present For the compound, the gel time can be used to determine the curing conditions of a and the desired spread. Therefore, in the process of the present invention = the reaction mixture is in the improved thirst of the device to be used, or Good enough to wet the gel time or above to cure 'has to be hydrophilic coating or surface treatment ("minimum gel time,"). 1 no land 'improved wetness is forward dynamic contact angle compared to no In the formulation of high scores ^ good compound, 'reduced at least the job. The longer the gel, the better = because they improve the wetness and increase the processing flexibility. The θ1 gel time varies according to the different times. The hydrogel formula varies. Solid effect gel (4). For example, the indifference of the _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ - ^ 1311580 A7 ___ B7 V. Description of invention (for polymerization) or temperature (initiating extraction and attack energy in terms of thermal polymerization (whether by choosing a more effective initiator or range of irradiation, or by borrowing - ° 4 The stronger absorption of the bow hair styling agent in the selected range Reduce the gel time. (5) '... The type and concentration of the diluent are also known as the second gel time known to those skilled in the art. The minimum gel time can be selected by selecting a specific formula, changing one of the above factors and measuring I1 gel time and contact angle are determined. The minimum gel time is above the point where the formed lens is usually wet. Below the minimum gel time, the lens is usually not wet. Just a contact lens and t, "usually wet "Shows less than about 80° for the lens" is preferably less than 70. And preferably less than about 6 〇. Before entering the dynamic contact angle, or the contact lens shows that the tear film collapse time is equal to or better than ACUVUE® lens. Those familiar with the technology will understand the above-mentioned, the minimum gel time can be a range, taking into account the statistical variation of the experiment. In certain embodiments utilizing visible light illumination, a minimum gel time of at least about 30 seconds, preferably at least about 35 seconds, and especially preferably greater than about 4 seconds, has been found to be advantageous. The Intellectual Property Office of the Ministry of Economic Affairs, the Consumers' Cooperatives, prints the mold containing the reaction mixture to ionized or actinic radiation, such as electron beam, X-ray, UV or visible light, that is, having a wave 丨5(] to about 800 奈Preferably, the light source is UV or visible light having a wavelength of from about 250 to about 700 nm. Suitable sources of radiation include UV lamps and daylight. The UV absorbing compounds are included in In a specific example of the composition (for example, as a UV blocker), curing is performed by means of UV irradiation (such as by means of visible light or heat) -32- This paper scale is applicable to the Chinese National Standard (CNS) A4 specification ( 210x297 mm) [311580 A7 B7 V. Description of invention (31 Ministry of Economic Affairs Intellectual Property Office employee consumption cooperative printing. In a preferred embodiment, the radiation source is selected from low-intensity UVA (about 315-about 400 奈m), UVB (about 280 to about 315) or visible light (about 400 to about 450 nm). In another preferred embodiment, the reaction mixture comprises a UV absorbing compound which is cured by visible light and low strength. This article When used, the "low strength" means between about 0.1 milliwatts per square centimeter to about 6 milliwatts per square centimeter, preferably between about 0.2 milliwatts per square centimeter and 3 milliwatts per square centimeter. The time is very long, usually above about 1 minute, preferably from about 1 to about 60 minutes, more preferably between about 1 and about 30 minutes. This slow, low strength cure provides a display of sustained in vivo resistance to protein deposition. The key to compatible ophthalmic devices. The curing time of the reaction mixture is also important. When the temperature increases above room temperature, the haze of the formed polymer decreases. The effective temperature to reduce haze includes the formation of fog of the lens. The temperature is reduced by at least about 20% compared to lenses of the same composition made at 25 ° C. Thus, suitable curing temperatures include those greater than about 25 ° C, preferably those between about 25 ° C. And those between 70 ° C, especially those between about 40 ° C and 70 ° C. The exact setting of curing conditions (temperature, strength and time) will depend on the composition of the selected lens material and For those who are familiar with the technology, it is undecided to refer to this teaching. Within a certain range, curing can be carried out in one or more curing zones. The curing time must be sufficient to form a polymer network from the reaction mixture. The polymer network formed is expanded with a diluent and the shape of the cavity. This paper scale applies to China National Standard (CNS) A4 specification (210 X 297 mm). Ordering line 1311580 A7

^ Do 15] After the Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printed place, used for lens formula ^ removed from the money. Unfortunately, it is difficult to release from the lens mold. Yuan Cheng" tablets, even, and agents) will be dried up with a kind of * agent (such as organic solution, removed in the lens holding tool of the present invention). The compound is added to the anti (four) ^ ' at least a low molecular weight hydrophilic poly' object, which is formed into an aqueous solution of a desired surfactant by using an ageing substance =: substantially containing or containing a small amount of a polymer, which can be any and silky Low molecular weight hydrophilic but its molecular weight is 4 2 molecular weight polymer defined structure, the coffee == hydrophilic polymer can help the lens release 40 000 Dalton. This technology is better, preferably lower At about 2 〇, the specialization of _ ' π f will know the aforementioned molecular group A ^ and a certain amount of material having a molecular weight higher than a specific average will be as long as the average molecular weight is within a specific range. Preferably, Low eight; Xia Hydrophilic compound ride from water soluble polyamine, (four) E knife _ = and their mixture and especially good poly-B (four) bite, polyethylene glycol B = ethyl-2- ten sitting Lin (available from Polymer Chemical Innovation, Dinga (10), AZ), poly(methyl acrylate), poly (1 lactic acid), poly Indoleamine, polyhexene, polyhexyl vinegar diol 1 ethyl alcohol, poly(tetrakisylmethyl methacrylate), poly(acrylic acid), poly(1-mercapto glycerol glycerin), poly ( 2_Baiyi 2, etc. Lin), poly(2-light propyl methacrylate), poly(2_ethylene:bipyridine, telluride), polyacrylamide, polydecyl propylene Indoleamine and mixtures thereof, and the like.

-34- Ben·Zhang scale applies Chinese National Standard (CMS) A4 specification (21〇 X 297 mm)

1311580 A7 B7 V. INSTRUCTIONS (33) The low molecular weight hydrophilic polymer can be used in an amount of up to about 20% by weight based on the total weight of the reaction components, particularly preferably between about 5 and about 20% by weight. Suitable surfactants include betaines, amine oxides, combinations thereof, and the like. Examples of suitable surfactants include TWEEN® (ICI), DOE 120 (Amerchol/Union Carbide), and the like. The surface can be used in an amount up to about 10,000', preferably between about 25 and about 1500 ppm and more preferably between about 100 ppm and about 1200 ppm. Suitable excipients are low molecular weight and include 丨_methyl_4_hexahydropyridone, 3-fosfos-1,2-propanediol, tetrahydro-2H-pentan-4-ol, glycerol formaldehyde, B _4·oxy-1-hexahydropyridinecarboxylate, 13-dimercapto-3,4,5,6-tetrahydro 2 (iH)-pyrimidinone and 1_(2-hydroxyethyl)_2- Pyrrolidone. The lens obtained from the reaction mixture having no low molecular weight hydrophilic polymer can be deintercalated in an aqueous solution containing at least one organic solvent. The organic solvent is hydrophobic but miscible with water. Suitable alcohols, ethers, etc., especially primary alcohols, and particularly preferred are isopropanol, DPMa, τρΜ DPM, decyl alcohol, ethanol, propanol, and mixtures thereof, which are suitable for the Ministry of Economics. The Intellectual Property Office staff consumption cooperative prints a suitable debonding temperature range from about room temperature to about 1 〇〇. Hey, between the 70C and 95°C, the higher temperature provides a faster point to go. Mixing (such as sound waves) can also be used to reduce the silk connection time. The method known in the art, such as vacuum nozzles, can also be removed from the lens. The mold is used. -35- This paper size applies to the Chinese National Standard (CNS) A4 specification (21〇χ 297 mm A7). B7 [311580 V. INSTRUCTIONS (34 Distillation/Hydration of Diluent Basically, after curing the reaction mixture, the formed polymer is treated with a solvent to remove the diluent (if used), unreacted components, and vice Products, etc., and hydrate the polymer to form a hydrogel. In addition, depending on the solubility characteristics of the components of the hydrogel, the solvent used initially may be ethanol, methanol, isopropanol, TPM, DPM, PEGs, PPGs, glycerin. , a mixture thereof, or a mixture of one or more of the organic liquid and water, followed by extraction with pure water (or physiological saline). The organic liquid can also be used as a "pre-wetting". After removal of the back curve by the lens, the lens can be briefly infiltrated (for up to about 30 minutes, preferably between about 5 and about 30 minutes) in an organic liquid or a mixture of an organic liquid and water. After infiltration, the Γν lens can be further hydrated with a water extraction solvent. In some embodiments, a preferred method uses an extraction solvent that is primarily water (preferably greater than 90% water, and particularly preferably greater than 97% water). Other ingredients may include salts such as sodium hydride, sodium borate boric acid, DPM, hydrazine, ethanol or isopropanol. The lenses are typically released from the mold by the mold, optionally with agitation or continuous flow of solvent extraction onto the lens. The process can be carried out at a temperature of from about 2 to about 121 ° C, preferably from about 20 to about 98 ° C. This process can be carried out under high pressure, especially when the use temperature exceeds about 100 ° C, but is more typical The ground is carried out under atmospheric pressure. It is also possible to stick the lens in a solution (for example, containing some excipients) and then transfer them to another solution (such as the final packaging solution), but the lens can also be removed. Adhere to the same solution packaged by them. Use this extraction solvent -36- This paper size applies to China National Standard (CNS) A4 specification (210 X 297 mm) Gutter Ministry of Economic Affairs Intellectual Property Bureau employees Co., Ltd. Printing A7 1311580 V. Invention Description (35) The lens can be carried out for about 30 seconds to about 3 days, preferably between about 5 and about % minutes. The selected hydration solution can additionally contain a small amount of additives. Such as surfactants. Suitable surface activity · including nonionic surfactants such as betaines and amine oxides. Special surfactants include TWEEN 80 (available from Amerchol), DOE 120 (available from joint stone anemia) Company), Plur〇nics, thiol cellulose, a mixture thereof f, and which may be between about 0.01% by weight and about 5% by weight (based on the use) The total weight of the hydration solution is accurate) is added. In one embodiment, the lens can be hydrated using a "gradual reduction," wherein the bath is gradually replaced during the hydration process. Suitable "gradual reduction" methods have at least two steps 'where a percentage of the solvent is replaced by water After the hydration of the polymer, the Shixi oxygen-fired hydrogel preferably comprises from about 1G to about 6G by weight of water, more preferably from about 2 〇 to about 55 weight percent, based on the total weight of the yoke oxygenated hydrogel. The water is preferably from about 25 to about 5% by weight of water. Further details of the manufacture of the diarrhea-hydrogel contact lens are described in U.S. Patent Nos. 4,495,313, 4, 680, 336, 4, 889, 664 and 5, 039, 459, incorporated herein by reference. The Ministry of Intellectual Property's employee consumption cooperative prints the cured ophthalmic device of the present invention without exhibiting a coating, which means that the living body is excellent in the body. The raw &amp; biomedical device is an ophthalmic device," Dyeability can be measured by measuring the amount of surface deposits of the lens (which is commonly referred to as "lipid deposits,") during wear. The surface and surface deposits of the mirror are determined as follows: The film was placed in the human eye and evaluated with a slit lamp after being worn for 3 minutes and a week. During the evaluation period, the patient was asked to blink several times and “make the difference between sediment and -37- this paper size applies to China. Country (2 丨〇χϋ - - 1311580 A7 B7 V. Invention Description (π: ----- Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printed on the back surface of the debris. The front and back surface sediments are said Tolerance is separate (ie, gel-like bumps) or thin. The front surface deposits give a bright reflection and the back surface deposits no. During the eye or push-up test, the deposit can be trapped with the back surface. The money is different. The sediment will move and the debris on the back surface will remain static. Based on the percentage of the affected lens surface, the sediment will be classified into five categories: none (about 1%), slightly ( From about i to about 5%), slight (about 6% to about 15%), _zhong Geng (about 16% to about 25%) and serious (greater than about 25%), the difference between 1% in each category is considered to be Clinically significant. The ophthalmic device of the present invention also exhibits low haze, good wettability, and modulus. The sheet is placed in a physiological saline solution in a transparent chamber on a black background, with a fiber optic lamp underneath, perpendicular to the lens chamber 66. The image of the lens is captured by the camera from above. Background-subtraction The scattered light image is quantified by integrating the center 丨〇 millimeter of the lens, and then compared to a CSI Thin Lens® of one-1.00 diopter (which is used, 3⁄4, set at a haze value of 100), no lens setting The value of haze is hum. The degree of wetness is determined by using a linoleic acid buffered saline solution, using a Wilhelmy balance to measure the dynamic contact angle or DCA (essentially at 231). When the sample is immersed or pulled out of saline solution The wetting force between the lens surface and the borate buffered saline was measured using a Wilhelmy microbalance. Use the following equation: F = 2ypcos0 or a = cos·1 ( ργ2γρ ) where F is the wetting force, γ is the surface tension of the probe liquid, and ρ is the meniscus -38- This paper scale applies to the Chinese national standard ( CNS) A4 size (210x297 mm) Setting line # A7 1311580 B7 V. Description of invention (37) The periphery of the sample and θ is the contact angle. Basically, the two contact angles were obtained by the ~hybridization test to obtain the advancing contact angle and the receding contact angle. Advance I @gastric system was obtained from the section of the fishery test' where the sample was immersed in the probe g# and these values are reported herein. The 1 0 4 jgj lenses of each composition were measured and reported as an average. Printed by the Ministry of Economic Affairs, Intellectual Property Bureau, Staff Consumer Cooperatives However, DCA is usually not a good indicator of wetness in the eye. Pre-Lens Tear Film Non-Invasive-Sexual Crash Time (PLTF-NIBUT) is a measure of in vivo or "clinical" lens wetness. The PLTF-NIBUT is measured using a slit lamp and a Keeler Tearscope Plus for non-invasive observation of the tear film. The elapsed time between the opening of the eye after blinking and the appearance of the first dark spot in the tear film on the anterior surface of the contact lens was recorded as ΡυΓΡ-ΝΙΒυΤ. The PLTF-NIBUT was placed in the eye and was measured for 30-minutes after one week. Three measurements were taken at each time interval and averaged to one reading. The PLTF-NIBUT measures two eyes, first right eye and then left eye. The mobility system uses the "push up" test to measure the patient's eye at the initial gaze position. The push-up test is to use a gentle upward pointing of the lower eyelid to push the lens. Determine the resistance of the lens to upward movement and rank according to the following levels: 1 (excessive 'unacceptable movement'), 2 (medium but acceptable movement) '3 (moderate movement)' 4 (minimum, but acceptable Move), j (insufficient, unacceptable movement). The lenses of the present invention exhibit at least about 3 mins per square inch, preferably between about 30 and about 90 pounds per square inch, and more preferably between about 40 and about 70 pieces per square inch. The modulus is measured by a crosshead equipped with a fixed-speed mobile tension tester that is lowered to the load compartment of the initial gauge height. -39- This paper scale applies to the China National Standard (CNS) A4 specification γ21〇χ297 '' 1311580 A7 B7 V. INSTRUCTIONS (π: Quantities. Suitable testing machines include Instron Model 1122. Dog bone samples with 0.522 inch length, 0.276 inch "ear" width and 0.213 inch neck width are mounted on the fixture and The elongation was measured at a constant speed of 2 吋/min until the fracture was measured. The initial gauge length (Lo) of the sample and the fracture length (Lf) of the sample were measured. Twelve samples of each composition were measured and the average value was recorded. The number is measured as the initial linear portion of the deer force/strain curve. The contact lens prepared by the present invention has a 〇2Dk value of about 40 and about 3 barrer (by polarography) Measured. Place the lens on the sensor and cover it with a mesh support. Expose the lens to a humidified 2.1% 〇2 atmosphere. Use a 4 mm diameter gold step and a silver The polar anode oxygen sensor of the ring anode measures the diffusion through the lens Oxygen. Control values are those measured by contact lenses for this product. The Balafilcon A lens from Bausch &amp; Lomb gives a measurement of about 79 bar, and the Etafilcon lens gives about 20 to 25 bar. Measurement of the ear (1 bar = cubic centimeter gas X cm ^ 2 ) / (cubic centimeters of polymer x seconds X cm mercury column)). Printed by the Intellectual Property Office of the Ministry of Economic Affairs, the Consumer Cooperatives. The gel time is determined by the following methods. The photopolymerization reaction was monitored by an ATS StressTech galvanometer equipped with a photocuring auxiliary device consisting of a temperature-controlled battery having a quartz substrate and an aluminum top plate, and a radiation delivery system equipped with a band pass filter. A light shot from a Novacure Mercury lamp with an aperture and a computer-controlled shutter is transmitted via a liquid light guide to the quartz plate of the galvanometer. The filter is a 420 nm (20 nm FWHM) bandpass filter that simulates the light emitted by the TL03 bulb. Radiation intensity (by the IL1400A radiation on the surface of the quartz window -40 - This paper scale applies to the Chinese National Standard (CNS) A4 specification (210x297 public Chu) A7 1311580 V. Invention description (39) '-meter, using XRL140A sensor It is determined by the aperture to control 0.02 watts/cm 2 of soil. The temperature is controlled at 45 ± 〇 _i ° c. After the degassing reaction mixture of about 1 cfe is placed on the bottom plate of the ammeter, the top plate of the 25 mm straight handle is lowered to 5 〇〇 ± 〇 mm above the bottom plate, and maintained there until the reaction reaches the gel. So far. Allow the sample to reach thermal equilibrium (~4 minutes, measured by steady-state shear viscosity leveling) before the light circle starts and the reaction begins. The sample chamber was purged with nitrogen at a rate of 4 G0 scxm between the time the sample reached thermal equilibrium. During the reaction, the current meter continuously monitors the strain due to the applied dynamic stress (rapid vibration mode). The time segments of less than one complete cycle are used to calculate the strain under the applied programmed stress. The computer calculates the dynamic shear mode (G,), the loss modulus (G"), and the viscosity (v*) as a function of the exposure time ^ with the ^ reaction, and the shear mode is increased from <丨Pa to &gt;〇 Mpa, while the Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printed tan 5 (= G" / G,) decreased from near infinity to less than 1. For the test conducted in this paper, the gel time is tan δ equals The time under GG is the point of GG.) At G, it reaches 1〇〇 (after the gel point, it is short-lived ^, moving to the top plate, so that the gap between the top plate and the bottom plate can follow the reaction list. The bulk mixture changes during shrinkage during curing. It should be understood that all of the above tests have inherent test errors of a certain amount. As the results reported herein are not considered to be an absolute number, the numbers are based on the accuracy of the particular test. The following examples are included to illustrate the invention. These examples are not intended to limit the invention. They are merely intended to suggest a method of practicing the invention. Those skilled in the field of spectacles and other experts Other -41- paper rulers for implementing the present invention can be found Applicable—China Country~^^^〇x-297 Public Love 1--- 1311580 A7 B7 V. Inventive Note (40) Method, but these methods are considered to be within the scope of the present invention. The abbreviation is used in the following examples: SiGMA 2_acrylic acid, 2·indolyl-, 2-hydroxy-3-[3-[l,3,3,3-tetramethyl-1-system Methyl decyl)oxy]dioxaxyalkyl]propoxy]propyl DMA, N,N-dimercaptopropenylamine

HEMA mPDMS Ministry of Economic Affairs Intellectual Property Office Staff Consumer Cooperative Printed 5 ---1·*- 2-Ethyl Mercapto Acrylic Acid 800-1000 Molecular Weight (Mn) Monomethacryloxypropyl Terminal Single-Positive - Butyl terminal polydimethyl methoxy oxane 2-(2'-hydroxy-5-mercapto hydroxyethyl phenyl)_2H_ benzotriazole 1:1 (by weight) 1-hydroxycyclohexylbenzene a blend of ketone and bis(2,6-dimethoxyanthracenyl)-2,4-4-tridecylpentylphosphine oxide poly(N-vinylpyrrolidone) (κ value 90) The reaction product of the blue hydrazine reactive blue No. 4 and hydrazine, as described in Example 4 of U.S. Patent No. 5,944,853, isopropyl alcohol D30 3,7-dimethyl-3-octanol mPDMS-OH -(3-Methylpropoxy-2-hydroxypropyloxy)propyl terminal, mono-butyl terminal polydimethyl methoxy olefin (MW 1100) TEGDMA tetraethylene glycol dimercapto acrylate - 42-

Norbtoc CGI 1850

PVP This paper scale applies to China National Standard (CNS) A4 specification (210x297 mm) 埤 Ordering line 1311580 A7 B7 V. Invention description (4!

TrEGDMA triethylene glycol dimercapto acrylate TRIS 3-methyl propylene oxypropyl tris(trimethyl 7 oxy) sulphuric acid MPD 3-mercapto propylene oxy propyl (pentamethoxy propylene oxide) MBM 3_Methacryloxypropyltris(trimethyldecyloxy)methylhydrazine

AcPDMS Triglide CGI 819 Bi-3-methylpropenyloxy-2-hydroxypropyloxypropylpolydimethyloxane - Tripropylene glycol methyl ether bis(2,4,6-trimethylbenzhydryl) _Phenylphosphine oxide PVP low molecular weight poly(N-vinylpyrrolidone) (κ value π) In the examples, the 'strength system was measured using an X 1400 Α radiometer using an XRL 140A perceptron. EXAMPLES 1-10 The reaction components and diluents (D30) listed in Table 1 are printed at about 23 C for at least about 3 hours at a trade association of the Intellectual Property Office of the Ministry of Economic Affairs. All ingredients are dissolved. The reaction component is reported as a weight percent of all reactive components and the diluent is the weight percent of the final reaction mixture. The reaction mixture was placed in a thermoplastic contact lens mold (Topas® Ethylene and Raw Ice: Copolymer of Phenene, available from Ticona Polymers) and utilized a Phillips tl 20W/03T fluorescent bulb at 45 ° C at N2 The irradiation is about 20 minutes. Open the mold, remove the lens from a 50:50 (by weight) solution of IPA and H20 and soak it in IPA for about 15 hours at room temperature to remove residual thinner -43- This paper scale applies to China National Standard (CNS) A4 size (210x297 mm) A7 1311580 B7 V. INSTRUCTIONS (42) Release and monomer, put it in deionized water for about 30 minutes, then equilibrate in borate buffered saline for at least 24 hours, and Autoclaved at 122 ° C for 30 minutes. The characteristics of the formed lens are shown in Table 1. Printed by the Intellectual Property Office of the Ministry of Economic Affairs, the Consumers' Cooperatives-44- This paper scale applies the Chinese National Standard (CNS) A4 specification (210x297 mm) 1311580 V. Invention Description (43) A7 Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printing Table 1 Example # 1 2 3 4 5 6 7 8 9 10 Composition SiGMA 28 30 28.6 28 31 32 29 39.4 20 68 PVP (K90) 7 10 7.1 7 7 7 6 6.7 3 7 DMA 23.5 17 24.5 23.5 20 20 24 16.4 37 22 MPDMS 31 32 0 31 31 34 31 29.8 15 0 TRIS 0 0 0 0 0 0 0 0 15 0 HEMA 6 6 6.1 6 6.5 3 5.5 2.9 8 0 Norblo.c 2 2 0 2.0 2 2 2 1.9 0 0 CGI 1850 0.98 1 1.02 1 1 1 1 1 1 0 TEGDMA 1.5 2 1.02 1.5 1.5 1 1.5 1.9 0 2 TrEGDMA 0 0 0 0 0 0 0 0 1 0 Blue HEMA 0.02 0 0 0 0 0 0 0 0 0 mPDMS-OH - 0 0 31.6 0 0 0 0 0 0 0 Darocur 1173 0 0 0 0 0 0 0 0 0 1 D30 % 23 26 17 23 23 29 32 28 17 27 Characteristic %EWC' 36 33 39 40 36 37 39 25 48 29 Modulus ( Broken/square inch) 68 78 112 61 67 50 66 92 43 173 % elongation 301 250 147 294 281 308 245 258 364 283 DCA2 (forward) 62 55 58 64 72 65 61 55 92 72 (Edge Correction) 103 111 101 131 110 132 106 140 64 76 1. Balance the water content. -45- This paper size is applicable to China National Standard (CNS) A4 specification (210x297 mm). A7 1311580 V. INSTRUCTIONS (44) 2. Dynamic contact angle, measured by Wilhehny balance with physiological boric acid buffered saline. 3. Oxygen permeability, edge correction, measured in Barre. The results of Examples 1-10 show that the components of the reaction mixture and their amounts are substantially variable while still providing uncoated lenses having superior mechanical properties and wettability balance. The contact angle (DCA) of Example 9 may be too high to form a clinically wet lens&apos; and the modulus may be lower than would be expected for a lens that provides mechanical strength. Example 9 contained the lowest concentration of SiGMA (20%). Since SiGMA has been reduced, less pvp can be added to the formulation while still providing a compatible reaction mixture. Thus, these examples show that SiGMA is effective in compatibilizing PVP, and that when sufficient SiG·A PW is present, lenses with desired wettability and other mechanical properties can be produced without any form of surface modification. . Example 11 Printing by the Ministry of Economic Affairs, Intellectual Property Office, Staff Consumer Cooperatives Remanufactured lenses with the formulation of Example 1, but did not control the curing strength. Mechanical strength is reported in Table 2 below. These lenses were evaluated clinically using ACUVUE® 2 lenses as a control group. The lens was worn by six patients in a daily wear mode (unloaded at night) for one week. In the first week, the PLTF-NIBUT was 3.6 (±3_0) seconds compared to 5.8 (2.5 seconds) for ACUVUE® 2 lenses. For the 50% § test and 1% control lens, the front surface deposition was rated as nothing. The mobility of the test and control group lenses is acceptable. -46- ; ΰ ; This paper scale applies to China National Standard (CNS) A4 specification (210 X 297 mm) Α7 !311580 V. Invention description (45) f Example 12 Repeat Example 11 but reduce the curing strength to 1.0 Milliwatts per square centimeter. Mechanical strength is reported in Table 2 below. These lenses were clinically evaluated using ACUYUE® 2 lenses as a control group. The lens was worn by 15 patients in a daily wear mode (unloaded at night) for one week. In the first week, the PLTF-NIBUT was 8.2 (±1·7) seconds compared to 6.9 (±1·5) seconds for the ACUVUE®2 lens. For all patients wearing the test and control group lenses, the anterior surface deposition was rated as nothing. The mobility of the test and control group lenses is acceptable. Table 2 _^Example # 1 11 12 %EWC ------- 36 36 36 'Modulus (pounds/flats - inches) 68 74 87 Uijfe degrees 301 315 223 -^dca 62 77 56 L_Dk 103 1 127 102 Ministry of Economic Affairs Intellectual Property Office Employees Consumption Cooperatives Printing Generally, the mechanical properties of Examples 1, 11 and 12 have consistent results for multiple operations of the same material. However, the clinical results of Example 丨丨 (uncontrolled cure strength) and 12 (low controlled compression strength) were substantially different. The wettability (measured by PLTF-NIBUT) of one of the Example 11 was lower than that of the AcuVUE® 2 lens (3.6 to 5.8), and half of the lenses had a higher surface deposition degree. The mirror of Example 12 (controlled low-intensity cure) exhibited a significantly improved wetness in the eye's measured better than ACUVUE® 2 lenses (8.2 pairs of -47-1G2 paper scales applicable to China National Standard (CNS) A4 specifications ( 210x297 mm) 1311580 Λ7 B7 V. Description of invention (46) 6.9) and no surface deposition. Thus, the use of low, controlled cure provides an uncoated lens having the same or in many cases better wetness in the eye as conventional hydrogel lenses. EXAMPLES 13-17 The reaction mixture of the monomers described in Table 3 and containing low or no hydroxyl-functionalized alkoxylated monomers (SiGMA in these examples) was mixed and stirred stably for 16 hours at room temperature. . Even after 16 hours, the reaction mixture was turbid and partially had a sink. Therefore, such reaction mixtures cannot be used to make lenses. Table 3 Example # 13 14 15 16 17 Composition SiGMA 0 0 0 10 20 PVP ( K90 ) 12 12 10 8.0 8.0 DMA 10 10 8.3 19 19 MPDMS 37 37 30.8 35 28 TRIS 14 14 11.7 17 14 HEMA 25 25 37.5 8.0 8.0 TEGDMA 1.0 1.0 0.83 2.0 2.0 Darocur 1173 1.0 1.0 0.83 1.0 1.0 D30 % 23 31 31 27 A 27 Ministry of Economic Affairs Intellectual Property Office Staff Consumer Cooperative Printed Examples 13 to 15 show no hydroxy-functionalized alkane-containing singles The reaction mixture of the body (SiGMA or mPDMS-OH) is incompatible and is not suitable for the manufacture of contact lenses. Examples 16 and 17 show hydroxyl-containing---48- This paper scale applies to China National Standard (CNS) A4 specification (210 X 297 mm) 1311580 A7 V. Invention Description (B7 Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printing = oxy-fired monomer less than about 2 G weight percent is sufficient to compatibilize significant = molecular weight PVP. However, compared to the implementation of 17 to Example 9, a small amount of high molecular weight PVP (3 wt%) can still be A compatible reaction mixture is formed. 18-25 A solution containing 1.00 gram of D30, 1.00 gram of mPDMS and gram of TMs is placed in a small glass vial (Example 19). When the compound is about 20 to 23 When the magnetic stirrer was used for rapid mixing, a solution containing 12 parts by weight of PVP (K90) and 6 parts of DMA was added dropwise until the solution remained turbid after stirring for 3 minutes. The added dm^ The mass of the a/pvp blend was determined to be grams and reported as the "monomer compatibility index." Using SiGMA (Example 18), MBM (Example λ 20), MPD (Example 21), acPDMS (where η = ι〇) (Example 22), acPDMS (where η = 20) (Example 23), iSiGMA-3Me (Example 24) and TR IS2-HOEOP2 (Example 25) was repeated as a test oxirane monomer in place of TRIS. -49- This paper scale applies to China National Standard (CNS) A4 specification (210 X 297 mm) 1311580 Λ7 B7 , invention description (abbreviated) Table 4 Example # Test oxime-containing monomer monomer compatibility index Si: OH 18 SiGMA 1.8 3:1 19 TRIS 0.07 4:0 20 MBM 0.09 3:0 21 MPD 0.05 2 :0 22 acPDMS (n= 10)* 1.9 11:2 23 acPDMS (n=20)* 1 21:2 24 · ISiMAA-3Me 0.15 4:0 25 TRIS2-HOEOP2 0.11 3:2 26 MPDMS-OH 0.64 ~11 :1 The structure of acPDMS, iSiGMA-3Me and TRIS2-HOEOP2 is as follows: acPDMS (η average 10 or 20) Printed by the Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative

-50- This paper size is applicable to China National Standard (CNS) A4 specification (210x297 mm) A7 1311580 V. Invention description (4〇iSiMAA3-Me 〇/°Me The results shown in Table 4 show siGMA, acpDMs (and 20) and mPDMs_〇H are easier to combine than another oxo-containing monomer; the diluent is further blended with a mixture of 7 oxy-fired monomers and high molecular weight polymer (PVP). A compatible high-molecular-weight hydrophilic polymer with a compatibility index of greater than about 0.5, such as PVP ^ Example 27-35, 'Industrial Intelligence Intellectual Property Bureau employee consumption cooperative printing use example 1 The reaction mixture was formulated to make lenses. A plastic contact lens mold (manufactured by a copolymer of ethylene and norbornene obtained from Topas® from Ticona Polymers) was stored in nitrogen (&lt; 5% 〇 2) overnight. Each mold was dosed into 75 microliters of the reaction mixture. The mold was closed and the lens was cured using the time and curing strength shown in Table 5. The mirror mixture was formed by irradiating the monomer mixture with a visible light fluorescent lamp. Cured at 45 ° C. Strength is used The variable aperture (baUast) or filter is changed in two steps of varying intensity and curing time. The time in step 2 is selected to provide the same total irradiation energy (about 83 〇mJ/cm 2 ) for each sample. The IPA/Water 60:40 mixture will release the finished lens. The mirror-51-ibb paper size is applicable to the Chinese National Standard (CNS) A4 specification (210x297 mm) 1311580

The tablets were transferred to a small can containing 1 g of isopropyl alcohol (IPA). Replace IPA for 1 hour every 2 hours. At the end of about 1 hour, remove 50% of IPA and replace with deionized water. Turn the canister for 2 minutes. After the deduction of the minute, remove 5% of the IPA and replace it with deionized water and turn the canister for 20 minutes. Transfer the lens to the packaging solution, rotate for 2 () minutes, and then test. 'Example# Table Step 1 Strength (milliwatts/cm 2 ) Step 1 Time (minutes: seconds) --- Step 2 Strength (milliwatts/cm 2 ) Step 2 Time (minutes: seconds) Advancing contact angle 6:55 5.5 1:28 51 + 1 2:46 —1 — 5.5 2:21 55 ± 2 11:03 ------- Π5.5 0:35 55 ± 1 6:30 ------- - 5.5 0:35 50 ± 1 1:37 ~~ 5.5 2:21 55 + 1 4:04 ------ 5.5 1:28 54 ±2 2:52 —--— 5.5 1:28 62 ± 6 4:36 --------- 5.5 0:35 76 ± 9 1:09 ----- 5.5 0:35 78 ±6 The contact angles of the examples 27 to 32 are not significantly different, indicating low The cure strength of step 1 at about 2 milliwatts per square centimeter provides an improved system for this lens formulation' regardless of the cure time of the step. However, those skilled in the art will recognize that the shorter cure times of step 1 (such as those used in Examples 28 and 31) allow for a shorter overall cure cycle. In addition, it should be noted that even the contact angle_amount of Examples 3 to 3 is higher than that of Example-52- This paper size is applicable to China - 27_ 28 29 30· 31 32 33 34 35 1. u_ \J_ 1.7 1.7 2.4 2.4 2.4 Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printing [311580 A7 B7 V. Inventions (51 27-32, the lenses of Examples 33-35 can still provide ideal intraocular moistness. Examples 36-41 Example 1 The reaction components of Example 1 were mixed with 25% or 40% D3O as a diluent. The resulting reaction mixture was loaded into a plastic contact lens mold (from ethylene and from Topas® from Ticona Polymers). The copolymer of norbornene was made and cured in a glove box and under nitrogen at a strength of about 2.5 mW/cm 2 , about 30 minutes, and the temperature shown in Table 6 below. According to 1, the lens, hydration and autoclaving were removed from the mold. After hydration, the haze value of the lens was measured. The results are shown in Table 6, which shows that the haze was lowered at a higher temperature. Reduced concentration of thinner and reduced haze Ministry of Finance, Intellectual Property Bureau, Staff and Consumers Cooperatives, Printed Table 6 Example # %D30 Temperature (°C) % Haze DCA(°) 36 25 25 3〇(6) 99 37 25 50-55 12(2) 100 38 25 60-65 14(0.2) 59 39 40 25 50(10) 68 40 40 50-55 40(9) 72 - 41 40 60-65 32(1) 66 + Haze (standard deviation) The results of Table 6 show By increasing the curing temperature, the haze is reduced by about 20% (Example 41 vs. Example 39) and up to about 65% (Example 37 vs. Example 36). The diluent concentration is reduced from 40 to 25%, and the haze is lowered. -53- This paper size is applicable to China National Standard (CNS) A4 specification (210 X 297 mm) [311580 A7 B7 V. Description of invention (52 between approximately 40 and 75%. Examples 42-47 Using Example 1 Procedures The lenses were made from the formulation shown in Table 7. The cure time was 30 minutes at 25 ° C and the strength was about 2.5 mW/cm 2 . The percent haze was measured and reported in Table 8. Ministry of Economic Affairs Intellectual Property Office Staff Cooperatives Printed Table 7 Example # 42 43 44 45 46 47 SiGMA 28.0 28.0 28.0 28.0 28.0 28.0 mPDMS 31.0 31.0 28.0 28.0 28.0 28.0 acPDMS (n=10) 0.0 0.0 4.0 4.0 4.0 4.0 DMA 23.5 23.5 23.5 23.5 24.0 24.0 HEMA 6.0 6.0 5.0 5.0 6.0 6.0 TEGDMA 1.5 1.5 1.5 1.5 0.0 0.0 Norbloc 2.0 2.0 2.0 2.0 2.0 2.0 PVP (K-90) 7.0 7.0 7.0 7.0 7.0 7.0 CGI 1850 1.0 1.0 1.0 1.0 1.0 1.0 D30 25.0 40 25.0 40.0 25.0 40.0 Characteristic haze 30 50 7.3 14 26 25 Modulus (pounds per square inch) 74 56 148 104 74 NT elongation (%) 326 395 188 251 312 NT EWC (%) 38 41 33 35 38 39 Comparison of the results of the same amount of diluent and TEGDMA or acPDMS (Examples 42 and 46 and Examples 43 and 47) shows that -54- gutter paper size applies to China National Standard (CNS) A4 specification (210x297 mm) 1311580 A7 B7 V. INSTRUCTIONS (") acPDMS is an effective cross-linking agent and provides lenses with characteristics comparable to those used as crosslinkers with TEGDMA. Examples 44 and 45 comprise two crosslinkers. The haze of these examples is substantially reduced compared to lenses made from either crosslinker. However, modulus and elongation are negatively affected (probably because the amount of crosslinker is too large). Examples 48-54 A counter-mix was made using the formulation shown in Table 8 with the indicated diluent. The reaction mixture was placed in a thermoplastic contact lens mold and irradiated with a Philips TL 20W/03T fluorescent bulb at 45 ° C, 0.8 mW/cm 2 for about 32 minutes. The mold was opened and the lens was released in deionized water at 95 ° C for 20 minutes. The lenses were placed in a boric acid buffered saline solution for 60 minutes and autoclaved at 122 ° C for 30 minutes. The characteristics of the formed lens are shown in Table 9. Ministry of Economic Affairs Intellectual Property Office Staff Consumer Cooperatives Printed Table 8 Example # 48 49 50 51 52 53 54 Composition SiGMA 30 30 30 33 34 25 20 PVP 6 6 6 6 7 6 Flying DMA 31 31 31 30 30 31 31 MPDMS 19 22 23.5 16.5 19 25 28 AcPDMS (n=10) 2 0 0 3 0 0 0 HEMA 9.85 8.5 6.95 9 6 10.5 12.5 Norbloc 1.5 1.5 1.5 2 1.5 1.5 1.5 -55- This paper scale applies to the Chinese National Standard (CNS) A4 specification ( 210x297 mm) 1311580 A7 B7 V. Inventive Note (Μ) CGI819 0.23 0.23 0.25 0.48 0 0.23 0.23 CGI 1850 0 0 0 0 1 0 0 EGDMA 0.4 0.75 0.8 0 0 0.75 0.75 TEGDMA 0 0 0 0 1.5 0 0 Blue HEMA 0.02 0.02 0 0 0 0.02 0.02 % Thinner ^ 40 40 27.3 39.4 25.9 40 40 Thinner Composition AABCDAA Characteristics EWC (%) 45 45 47 49 47 49 50 DCA (Forward) 52(2) 51(7) 74 (10) 108 75(6) 47(2) 56 (ID Modulus (pounds per square inch - 吋) 91 77 69 55 49 63 67 Elongation NT 232 167 275 254 110 124 Dk Bar) 54 60 78 44 87 59 60 Dilution Agent (parts by weight): A = 72_5% third-pentanol and 27.5PVP (Mw = 2500) B = third-sterol

C= 15/38/38% TMP/2M2P/PVP (Mw = 2500) D = 57/43 2M2P/TMP Ministry of Economic Affairs Intellectual Property Office Staff Consumer Cooperative Printed NT - Not tested Therefore, Examples 48 and 51 show that they contain hydrophilic Formulation of EGDMA or TEGDMA and hydrophobic crosslinker (acPDMS) provides a hydroxane hydrogel composition that exhibits a superior balance of properties including good water content, moderate Dk, wettability, modulus and elongation. . -56- This paper size is suitable for the towel _ 彳 J iJ ^ CNS) A4 regulation f (21G tearing public love 1311580 A7 B7 V, invention description (55 Example 55 clinical evaluation of the lens of Example 48. By 18 patients Daily wear mode (night unloading) wears the lens for one week. In the first week, the PLTF-NIBUT is 8·4 (±2·9) seconds, compared to 7.0 for the ACUVUE® 2 lens. 1.3) Seconds. For 97% of patients with test lenses, the opaque deposition of the anterior surface was rated as insignificant, compared with 89% in the control group. The mobility of the lenses in the test and control groups was acceptable. - Example 56 Clinical evaluation of the lens of Example 49. The lens was worn by 18 patients in a daily wear mode (unloaded at night) for one week. In the first week, ?1^忾1^1 ugly 11 Ding is 8.4 (±2.9) seconds, compared to 8.0; \〇] £@2 lenses are 7.0 (±1.3) seconds. For 95% of patients with test lenses, the front surface discontinuous deposition is The rating was no, and the control group was 89%. The mobility of the test and control group lenses was acceptable. Example 57 Clinical evaluation The lenses of Example 51 were worn daily by 13 patients. Mode (night dismount) wears the lens for one week. In the second week, PL·ΓF-NIBUT is 4.3 (±1.9) seconds compared to 9.6 (±2,1) seconds for ACUVUE® 2 lenses. For 70% of patients with test lenses, the degree of discontinuous deposition on the anterior surface was rated as insignificant, compared with 92% in the control group. The mobility of the lenses in the test and control groups was acceptable. Therefore, at the contact angle Measured values (108° of Example 51 vs. 52° of Example 48) and y-57- This paper scale applies to China National Standard (CNS) A4 specification (210 X 297 mm). Consumer Cooperatives Printed 1311580 A7 V. INSTRUCTIONS (56) The clinical wetness measured by PLTF-NIBUT (the sec of Example sl vs. W seconds of Example 48) is used in Examples 9-60. The components of the column (expressed in parts by weight) and the following procedure for the manufacture of a helium oxide hydrogel lens. The ingredients are mixed in a small tank to form a reaction mixture. The small can containing the reaction mixture is placed in a car T_v, two exchanges ± rainbow Press on the press roll and roll overnight. =,, one = placed in - vacuum dryer and applied vacuum == gas backfill dryer. In the - glove box, add about: gram::: lens material to τ〇ρΑρ (this ί of 浠 and borneol): concave and blow before the cavity ;; glasses. The mold is closed with a polypropylene to the convex bottom curved mold. Polymerization, and light-induced by using visible light of 5 watts/cm 2 produced by a 20 watt TL_035 disc. Curing at 45 ° C for 25 minutes.徭, the bucket fork ^ 'After 45, open the abutment. Under the conditions shown in Table H), the amount of TWeen is used to print the Uquasonic 75D type knife in a sonic bath containing deionized water. The lens removal time is shown in Table 1G. The lens is transparent and is suitable for the shape of the eye. -58- The paper size is applicable to the Chinese National Standard (CNS) A4 specification (210x297). 1311580 A7 B7 V. (57) Table 9 Example 58 Example 59 Example 60 Example 61 SiGMA 3.05 3.2 3.2 3.0 mPDMS 1.7 1.7 1.7 1.7 DMA 3.2 3.0 3.1 3.2 PVP 0.6 0.6 0.6 0.6 HEMA 1.0 0.8 0.8 1.0 TEGDMA 0.2 0.4 0.3 0.2 Norblock 0.15 0.2 0.2 0.2 CGI 1850 0.1 0.1 0.3 0.3 Triglide 1.5 1.5 1.5 2M2P 2.5 2.5 2.5 2.5 PVP Low Molecular Weight 0.5 1.5 1.5 0.5 Binding Table 10 Example # Formulation Example # [Tween] (ppm) Temperature fc) Deblocking time (minutes) 62 58 850 75 10 63 58 10,000 70 10-15 64 58 0 75 20-22 65 58 850 22 10-15 66 59 850 85 3 67 60 850 85 6 68 61 850 75 T8 Example 69 will be implemented at 65 ° C Example 66 The lens of Example 59 was further hydrated in deionized water for 20 minutes. Then the lens was transferred to -59- This paper scale was applicable to China National Standard (CNS) A4 specification (210x297 mm). Ministry of Economy, Intellectual Property Bureau, Staff Consumption Cooperative Printed A7 1311580 B7 V. INSTRUCTIONS (5 in boric acid buffered saline solution to equilibrate for at least 24 hours. The lens is transparent and suitable for contact lenses. The lens has a water content of 43%, 87 lbs. The square inch modulus, 175% elongation and 61 bar Dk. The lens was found to have a 57 degree forward contact angle. This shows that the lens surface is substantially free of leachable hydrophobic material. Example 70 At 75t, the front curved concave portion of the lens mold from Example 61 was placed in a sonic bath (Aquasonic Model 75D) containing about 5% DOE-120 in deionized water. The lens was placed in the frame within 18 minutes. Sticky. Lu. Example 71 (Using an organic solvent) The front curved concave portion of the lens mold of Example 61 was placed in a sonic bath containing about 1% 2-propanol in deionized water at about 75 °C. (Aquasonic 75D type). The lens was removed from the frame within 15 minutes. When Tween was used as an additive (Example 68), the deblocking time was 18 minutes. Therefore, this example shows that an organic solvent can also be used to debond a lens comprising a low molecular weight hydrophilic polymer. __ Example 72 (without low molecular weight PVP). The decane hydrogel lens was made using the formulation and procedure of Example 58, but without any low molecular weight PVP. The following procedure was used to debond the lens. At about 65 ° C, the front concave concave portion of the lens mold is placed to contain about -60- the paper size applies to the Chinese National Standard (CNS) A4 specification (210 X 297 mm). Co-operative printing A7 1311580 B7 V. INSTRUCTIONS (59) 850 ppm Tween in a sonic bath in deionized water (Aquasonic 75D). The lens is not released from the mold. Under a similar debonding condition (Examples 62-850 ppm Tween and 75 ° C), the formulation containing the low molecular weight hydrophilic polymer (Example 58 formulation) had a deblocking time of 10 minutes. Thus, this example shows that deblocking cannot be accomplished in water only in formulations that do not include low molecular weight hydrophilic polymers in the formulation. Example 73 The front curved concave portion of the lens mold of Example 72 was placed in a sonic bath (Aquasonic Model 75D) containing about 1% 2-propanol organic solvent in deionized water at about 75 °C. in. The lens is drilled from the frame in 20 to 25 minutes. Therefore, the lens of the present invention which does not contain a low molecular weight hydrophilic polymer can be drilled by using an aqueous solution containing an organic solvent. Examples 74-76 Ministry of Economic Affairs Intellectual Property Office Staff Consumer Cooperative Printed Formulations and lenses according to Example 49, but varying the amount of photoinitiator (0.23, 0.38 or 0.5% by weight), at Philippe at 45 °C The TL 20W/03T fluorescent bulb (which closely matches the spectral output of the visible light used to determine the gel time) was cured with a 2.0 mW/cm 2 irradiation. The contact angles of the formed lenses are shown in Table 11. -61- This paper size is applicable to China National Standard (CNS) A4 specification (210 X 297 mm) 1311580 A7 B7 V. Invention description (60) Table 11 Example #% by weight Advance DCA Gel time (seconds) 74 0.23 59(4) 65 75 0.38 62(6) 57 76 0.5 80(7) 51 Example 77-79 % The gel time of the formulation of Example 1 was measured at 45 ° C at 1.0, 2.5 and 5.0 mm/cm 2 . The results are shown in Table 12. Table 12 Example # Strength (milliwatts / cm ^ 2) Gel time (seconds) 77 1 52 78 2.5 38 79 5 34 5 Line Ministry of Economic Affairs Intellectual Property Office Staff Consumer Cooperatives Print Examples 74 to 76 and 77 to 79 As a result, it was revealed that the gel time was increased and the wettability was improved as compared with Examples 27 to 35. Therefore, the gel point, in conjunction with the good contact angle, can be used to determine the appropriate curing conditions for a given polymer formulation and photoinitiator system. Examples 79-83 Using the reactive components shown in Table 14 and 29% (based on all reactive components and diluents) of third-pentanol as diluent and 11% PVP 2,500 (based on reactive components) ) to manufacture reaction mix-62- This paper scale applies to China National Standard (CNS) A4 specification (210x297 mm) A7 B7 Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative print 1311580 V. Invention description (6i object. In order to be 100% of the reaction components, the reaction mixture was placed in a thermoplastic contact lens mold and irradiated with a Philips TL 20W/03T fluorescent bulb at 60 ° C under nitrogen for about 30 mW/cm 2 . Minutes. The mold was opened and released in deionized water for 15 minutes at 95 ° C. The lens was then placed in a salt buffered saline solution for 60 minutes and autoclaved at 122 ° C for 30 minutes. The characteristics are shown in Table 13 〇' - Table 13 Example # 79 80 81 82 83 Composition SiGMA 30 30 30 30 30 PVP 0 1 3 6 8 DMA 37 36 34 31 29 MPDMS 22 22 22 22 22 HEMA 8.5 8.5 8.5 8.5 8.5 Norbloc 1.5 1 1.5 1.5 1.5 1.5 CGI 8 19 0.25 0.25 0.25 0.25 0.25 EGDMA 0.75 0.75 0.75 0.75 0.75 Characteristic DCA (forward) 122(8) 112(6) 66(13) 58(8) 54(3) Haze 18(4) 11(1) 13(1) 14( 2) 12(1) Table 12 shows that the addition of PVP significantly reduces the contact angle. As low as 1%, the dynamic contact angle is reduced by about 10% and as low as 3%, the dynamic contact angle is reduced by about 50%. Example 84-86 -63- Bonding paper The scale applies to China National Standard (CNS) A4 specification (2丨〇χ297 public Chu) A7 Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative print 1311580 V. Invention description (ω) Use the ingredients listed in Table 14 and the following procedures to manufacture oxygen Alkane hydrogel lenses: The reactive components are mixed with a diluent in a small pot at room temperature. A small can containing the reaction mixture is placed on a one-cylinder press roll and rolled overnight. The vacuum dryer was used to remove oxygen by applying vacuum for 40 minutes. The dryer was backfilled with nitrogen. In a glove box, about '0.10 grams of degassed lens material was added to the TOPAS® cavity before the concave surface and nitrogen was blown to form a contact lens. The mold is closed with a polypropylene convex bottom curved mold. Polymerization was carried out under nitrogen, and by using the generated fluorescence of 20 watts with phosphorus TL-03 1.0 mW / cm2 of visible light to be initiated. After curing at 45 t for 15 minutes, the mold was opened. The front concave portion of the lens mold was placed in deionized water at 95-100 °C. The lens debonding time is shown in Table 14. The lens is transparent and is a suitable shape for the contact lens. Table 14 Example # 84 85 86 Composition SiGMA 30 30 30 PVP 6 6 6 DMA 31 31 31 MPDMS 21 21 21 AcPDMS (n=10) 0 0 0 HEMA 9.25 9.25 9.25 Norbloc 1.5 1.5 1.5 CGI 819 0.25 0.25 0.25 CGI 1850 0 0 0 -64- This paper size is applicable to China National Standard (CNS) A4 specification (210x297 mm) 1311580 A7 ____B7 V. Invention description (")

EGDMA 1.0 1.0 1.0 TEGDMA 0 0 0 Blue HEMA 0 0 0 40.0 40.0 40.0 Thinner Composition Ε FG DCA (Forward) 53(3) 55(3) 56(9) Haze 丄.,~~-- 15(3) 22(2) 16(2) Debonding. Connecting time (minutes) — 3 5 8 Thinner (parts by weight of diluent): E = 62.5% third-pentanol and 37.5% PVP (MW = 2500) F = 62: 5% tri-pentanol and 37.5% 1,3-dimercapto-3,4,5,6-tetrahydro-2(out)-pyrimidinone G = '62, S% third - Pentanol and 37.5% ethyl-4-oxo-1-hexahydropyridine carboxylate Thus 'Examples 84-86 show that many excipients can be used to improve deblocking. EXAMPLES Reaction mixtures were prepared using the reactive components shown in Table 15 and 42% (based on all-reactive components and diluents) of third-pentanol as a diluent. The reaction mixture was placed in a thermoplastic contact lens mold and irradiated with Phillips TL 20W/03T fluorescent bulb at 50 C and helium for about 30 minutes at 〇 8 mW/cm 2 . Open the mold and release it at room temperature-65- This paper size is applicable to China^&quot;Si(CNS)A4 specification (21G X 297 mm) 1311580 A7 B7 V. Invention description (64) The lens is in deionized water after 15 minute. The lenses were then placed in a borate buffered saline solution for 60 minutes and autoclaved at 122 °C for 30 minutes. The characteristics of forming the lens are shown in Table 12. Table 12 Example # 87 Ingredient SiGMA 0 PVP 7 DMA 25 MPDMS 48.6 AcPDMS 5 HEMA 12.25 Norbloc 1.5 CGI 819 0.25 TEGDMA 0.4 Customs Department of Intellectual Property Office Consumer Cooperation Duplicate Example 88 mPDMS-OH (for example 3) Preparation of 96 g of Gelest MCR-E11 (mono-(2,3-epoxypropyl)-propyl ether terminal polydimethyl methoxy oxane (1000 MW)), 11.6 g methacrylic acid, 0.10 g Triethylamine and 0.02 g of hydroquinone monoterpene ether were heated to 140 ° C with a bubble machine and stirred for 2.5 hours. The product was extracted with saturated aqueous NaHC03 and CH2C12. The CH2C12 layer was dried over Na.sub.2SO.sub.4 and evaporated. HPLC/MS is consistent with the desired structure. -66- This paper size applies to China National Standard (CNS) A4 specification (210x297 mm) 1311580 A7 B7 Eighty-eight 10-15 Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printing 5, invention description (65 0

OH ·6 This paper scale applies to China National Standard (CNS) A4 specification (210x297 mm)

Claims (1)

131158011^ This month, the scope of the patent application 2. 3. 4. 5. 6. Patent application No. 91120935 ^ -r ^ ^.R?C Patent Appln. No.91120935 Correction 5 innocent praise please #利范围Chinese Annex 1 (3, 1n-chinese - Rncl (τττ) (Represented on November 19, 2008) (Submitted on November 19, 2008) A biomedical device consisting of a high molecular weight hydrophilic polymer and effective The biomedical device of the first aspect of the invention, wherein the hydroxy-functionalized oxane-containing monomer is 5% by weight. The biomedical device device according to claim 1 is a xenon-fired hydrogel contact lens. The biomedical device according to claim 1 of the patent scope contains 15% of a high molecular weight hydrophilic polymer. In the biomedical device of claim 2, the effective amount of the hydroxyl-functionalized azide-containing monomer is ι〇% 80%. According to the biomedical device of claim 1, the butyl group contains a hydroxyl group. ·The functionalized siloxane monomer is Or η ς: R1 r2 r7-R6-C-R8-Si-R3 R5 heart. 4 Among them, the package to the middle of the elimination of 68- the paper size of the standard (CNS) A4 specifications (210 x 297 public Love) A8 B8 C8 D8 311580 VI. Patent Application R1 R2 R2 R5 R7- R6- C - R8- Si- [OSi]n- R8-C - R6- R7 II where: n is between 3 and 3 5 Integer integer; R1 is hydrogen, Cu alkyl; R2, R3 and R4 are each independently Cw alkyl, tri Cw alkyl decyloxy, phenyl, naphthyl, substituted Cu alkyl, substituted benzene a substituted or substituted fluorenyl group, wherein the alkyl substituent is selected from one or more selected from the group consisting of Cw alkoxycarbonyl, Cw alkyl, Ci-6 alkoxy, arylamino, 1,3-hydroxy, hydroxy, carboxy, Cw alkane a member of a group consisting of a carbonyl group and a hydrazine, wherein the aromatic substituent is selected from one or more selected from the group consisting of Cw alkoxycarbonyl, Ch6 alkyl, c1-6 alkoxy, amidino, halogen, A member of a group consisting of a hydroxyl group, a carboxyl group, a Cw alkylcarbonyl group, and a formazan, and the Ministry of Economic Affairs Intellectual Property Office employee consumption cooperative prints R as a base group, a base containing one or more warp groups; or (CH2 ( CR9 R10) 〇)) x)-R&quot;, where y is from 1 to 5, and X is an integer from 1 to 100; W-R11 is independently selected from fluorene, an alkyl group having up to 1 carbon atom, and up to 1 〇 An alkyl group substituted with at least one polar functional group, -69- This paper scale applies to the Chinese National Standard (CNS) A4 specification (210x297 mm) n R is a divalent group containing up to 20 carbon atoms; R can undergo free radical and/or cationic polymerization and contains a monovalent group of up to 20 carbon atoms; _ ^ inclusion up to 2 〇 A divalent or trivalent group of carbon atoms. According to the biomedical device with 6 patent applications, y is 1 to 3. 8. A biomedical device according to item 6 of the patent application, wherein X is 2 to 90. 9. According to the biomedical device with 8 patent applications, x is 10 to 25. 10. The biomedical device according to the scope of patent application ,i, wherein the single system of 忒3 hydroxy-functional oxirane is selected from the group consisting of 2-acrylic acid, 2-mercapto-2-_2 via JI [3_[u, 3 ,3_tetradecyl]heptamethylmethylmethylalkyl)oxy]dimethoxyalkyl]propoxy]propyl, (3-f-propenyloxy-2-hydroxypropyloxy)propyl (Trimethyl decyloxy) decane, (2-methyl propyleneoxy _3 hydroxypropyloxy) propylene Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printed clothing tris (trimethyl decyloxy) A a group consisting of decane and mixtures thereof. 11. The biomedical device according to claim 10, wherein an effective amount of the hydroxyl-functionalized alkane-containing monomer is from 20% to 50%. 12. According to the biomedical device of the scope of patent application, further comprising 10% to 40% of other monomers containing other oxane, -70- 1311580 bis---. Bureau employees' consumption cooperatives printed 50% hydrophilic single-water-based monomer. Up to 15% high molecular weight pro According to the patent application scope w ^ 闺 12 12 biomedical devices, Α 灭 为 - - 。 soft soft contact lenses. 14. According to the patent application scope of the first person ~ Α 固 Gudi 1 biomedical device, which is έ 基 _ g 芑 芑 芑 芑 夕 夕 氧 & & μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ μ The early body has a monomer larger than °. 5. 15. According to the scope of the patent application, the biomedical device of the first paragraph, and the hydrophilic polymer of the knife is a poly-I-B. A method of preparing a biomedical device comprising mixing a sub-amount of a hydrophilic polymer and an effective amount of a monomer containing a polyfunctional siloxane to form an embroidering solution. The seed oxy-hydrogel is formed from a reverse mixture comprising a high molecular weight hydrophilic polymer and an effective amount of a monomer comprising a hydroxy-functional oxoxane. 18. The invention according to claim 17 of the present invention, wherein the hydrophilic polymer is selected from the group consisting of polyamines, polylactones, polyamidiamines, polyendammines, and functionalized polyamines. a group of functionalized polylactones, functionalized polyimines, functionalized polyendammines, and mixtures thereof. 19. The decane hydrogel according to item 17 of the patent application, wherein the hydrophilic single system is selected from the group consisting of poly-indole vinylpyrrolidone, poly-fluorene-ethylene-2-hexahydropyridone, poly_ Ν_Ethylene_2_内内 16. 17. -71 This paper size applies to China National Standard (CNS) A4 specification (210x297 mm) 1311580 VI. Patent application scope A8 B8 C8 D8 Water-ethylene _3-methyl-2-caprolactam Ministry of Economic Affairs Intellectual Property Bureau Staff Consumer Cooperative Printed clothing 3-methyl-2-hexahydropyridone, poly_ N_ethylene_4_methyl_2_hexahydro^疋嗣承-N-ethylene _4_methyl_2_hexylamine, poly-ethylene-3-ethyl_2-吼 slightly bite _ and poly_N_ethyl _4,5_ dimethyl ^ each bite _, polyethyl (tetra) saliva, poly _N_N_ bis f-propyl (tetra), inflammatory vinyl alcohol, polyacrylic acid, polyethylene oxide, poly 2 Ethyl (4), heparin polysaccharide, polysaccharide, mixtures thereof and copolymers. 20. The oxime oxygen-fired hydrogel according to claim 17, wherein the hydrophilic polymer comprises poly-N-vinyl ketone. 21 · According to the scope of application of the patent, the date number π dry solid 17th alkane hydrogel, containing high molecular weight hydrophilic monomers of 3 1 to 15. 22. A high molecular weight hydrophilic monomer in an amount of from 3 to 15% by weight based on the oxime hydrogel of the scope of the patent application. 23. A high molecular weight hydrophilic monomer comprising from 5 to 12% by weight of a hydroxane hydrogel according to the scope of the patent application 1*c spear. 24. According to the 17th article of the patent application scope, the Φ poet ^ Gan Yi's W-based alkane hydrogel, the compound S can be oxidized and the monomer is the formula I or η R1 R2 R6'9~ R8*~Si-R3R5 ^ -72 This paper scale is suitable for the standard _ home standard (CNS) A4 specifications (2 hearts 297 Αδ Β8 C8 D8 1311580 VI. Patent application scope R 6R 5 -1 RICIR - 8 R - R2lsi-^4 [0 2 .'-4 RISIR I 8 R 1 - 5 RICIR - 6 RII where: η is between 3 and An integer between 35; R is chloro, Ci.6 alkyl; R2, R3 and R4 are, independently of each other, Cw alkyl, tri Cw alkyl decyloxy, phenyl, naphthyl, substituted Cu alkyl, a substituted phenyl or substituted naphthyl group, wherein the alkyl substituent is selected from one or more selected from the group consisting of Cw alkoxycarbonyl, Cw alkyl, CN6 alkoxy, decylamine, hydroxyl, hydroxy, carboxy, a member of a group consisting of Cw alkylcarbonyl and formamidine, and wherein the aromatic substituent is selected from one or more of (^_6 anthracene, Cl-6, alkoxy, aramidyl) , a group consisting of a group consisting of a hydroxyl group, a hydroxyl group, a carboxyl group, a Cw alkylcarbonyl group and a hydrazine. The Ministry of Economic Affairs, the Intellectual Property Office, the employee consumption cooperative, prints R5 as a radical, and contains one or more bases. Or (CH2(CR9 R10)yO)x)-Rn ' where y is 1 to 5, X is an integer from 1 to 100; R9-R&quot; is independently selected from Η, up to 1 〇 Until alkyl atoms up to 10 carbon atoms and substituted with at least one of the polar functional group, 73- A8 B8 C8 D8 Ministry of Economic Affairs Intellectual Property Bureau Staff Consumer Cooperative Printed 1311580 VI. The patent application range is from C 3 to a divalent group of carbon atoms up to 2 carbon atoms; ' R is a free radical and / or cation A monovalent group which polymerizes and contains up to 20 carbon atoms; R is a divalent or trivalent group containing up to 20 carbon atoms. The root shot is patented _24 item 垸 - hydrogel, where y is 1 to 3. 26. Root shots require a money gel of item 24 of the patent range, where X is 2 to 90. 2 Enter the stone gel according to item 26 according to the towel, where X is 10 to 25. 28. A hydrogel according to the item 17 of the patent specification, wherein the hydroxy-functionalized alkane-containing monomer of the effective 1 is from 20% to 50%. 29. The invention according to claim 24, wherein the single system of 忒3 hydroxy-functional siloxane is selected from the group consisting of L acryl, 2-methyl-2-hydroxy-hydrazine, ^ 3_Tetramethyl-small [(trimethylcarbinyl)oxy]dioxaxyalkyl]propoxy]propyl ester, (3-decylpropenyloxy-2-hydroxypropyloxy)propyl a group consisting of (trimethyldecyloxy)decane, (2-methylpropenyloxy-3-hydroxypropyloxy)propyltris(trimethyldecyloxy)methylnonane, and mixtures thereof in. 30. A decane hydrogel according to item 17 of the patent application, further comprising at least one monomer containing other oxane. —------ Ί上 This paper scale turns t Lin (21G X 297 public) 1311580 B8 C8 I &quot; D8 VI. Scope of Application for Patent - 3L Radiation Requesting Patent (4) 3Q ♦ Oxygen boiling water coagulation, wherein the single system containing other oxane is selected from 3 - methacryloxy A decylamine analog of a tris(trimethyldecyloxy)decane; a hydrazine I alkylvinylamine f-ester analog, a decyl alkane ethylene carbonate, a hydrazine, and a hydrazine-containing monomer And oligomers. 32. The oxyhydrogenated hydrogel according to item 5% of the patent application, wherein the single system containing other oxane is selected from the group consisting of 3-methacryloxypropyltris(trimethyldecyloxy)decane. Monomethyl propyloxypropyl terminal polydimethyl methoxy oxane, polydimethyl methoxy oxane, 3-methyl propylene oxy propyl bis (trimethyl sulphate ) methyl sulphur A group consisting of acryloxypropylpentamethyl pentoxide and its composition. 33. A Xixi oxygen-fired hydrogel according to the third aspect of the patent application, wherein the monomer containing other oxoxane is present in an amount of from 0 to 80% by weight. 34. According to the decane hydrogel of the third paragraph of the scope of the patent application, the Ministry of Economic Affairs, the Intellectual Property Office, the employee's consumption cooperation, the printing of the monomer containing other oxoxane in the amount of 5 to 6 〇% by weight presence. 35. The invention according to claim 3, wherein the other alkoxysilane-containing monomer is present in an amount of from 1 to 4% by weight. 36. Further comprising at least one hydrophilic monomer according to the Si Xizhuo hydrogel of claim 17 of the patent application. ___ -75- Ϊ Paper scale applicable to China National Standard (CNS) A4 Specification: X297 - 311580 VI. Application for patent A8 B8 C8 D8 Scope 37 • A paraxane hydrogel according to Article 36 of the patent application scope, at least one of which The hydrophilic monomer comprises at least one acrylic group, ethyl fluorenyl group or a combination thereof. 38 4 39. The alkane hydrogel according to claim 37, wherein the acrylic group has the formula CH2=CRCOX, wherein R is hydrogen or Cl-6 alkyl and X is deuterium or N. The alkane hydrogel according to claim 36, wherein the at least one hydrophilic single system is selected from the group consisting of ruthenium, ν-dimercaptopropenylamine, 2-hydroxyethyl methacrylate, and monodecyl. Glyceryl acrylate, 2-hydroxyethyl decyl acrylamide, polyethyl methacrylate, methacrylic acid, acrylic acid, hydrazine-vinyl pyrrolidone, hydrazine-ethylene-hydrazine-methyl acetamide, Ν_乙蝉_ethylacetamide, Ν-ethylene-Ν-ethylformamide, Ν_vinylamine, hydrophilic ethylene carbonate monomer, vinyl phthalate monomer, hydrophilic 呤A group consisting of oxazolone monomer, polydextrose, copolymers and compositions thereof. The Ministry of Economic Affairs, the Intellectual Property Office, and the Employees' Cooperatives Co., Ltd. 4, which is based on the patent application 帛36, wherein the at least one hydrophilic monomer comprises at least one of having one or more polymerizable doubles. The functional group of the bond is substituted with the terminal hydroxyl group to form an ethyl alcohol. 41. The alkane hydrogel of claim 4, wherein the at least one hydrophilic single system is selected from the group consisting of polyethylene glycol, /ethoxylated alkyl glycoside, and having one or more -76- This paper scale applies to China National Standard (CNS) A4 specification (210x297 mm) Αδ Β8 C8 D8 circumference 1311580 —— / ', apply for a patent in the m group. 42. The alkane hydrogel according to claim 36, wherein the at least one hydrophilic single system is selected from the group consisting of hydrazine, hydrazine-dimercaptopropene, 2-hydroxyethyl methacrylate, Group of methacrylic acid glycerin, 2_ mercaptoethyl methacrylamide, N-vinylpyrrole I extended ethyl monomethacrylic acid glycerin, thioglycolic acid, acrylic acid and the like In the group. 43. The alkane hydrogel of claim 36, wherein at least one of the hydrophilic monomers comprises n,n-dimercaptopropeneamine. 44. A decane hydrogel according to item % of the patent application, wherein the at least one hydrophilic single system is present in an amount of from 0 to 70% by weight. 45. A decane hydrogel according to item 5% of the patent application, wherein the at least one hydrophilic single system is present in an amount of from 5 to 60% by weight. 46. According to the scope of patent application No. 30, Shixia Oxygen Hydrogel is printed by Xiahai Department of Intellectual Property Bureau employee consumption cooperative. At least one hydrophilic single system exists in the amount of 丨〇 to weight%. 47. The oxime oxygen-fired hydrogel according to claim 17 which comprises 1 to 15% by weight of a high molecular weight hydrophilic polymer and 5 to 90% by weight of a monomer having a hydroxy-functional siloxane. . Vanadium according to the scope of application of the scope of the 17th oxime oxygenated hydrogel, its 匕 33 to 15% by weight of high molecular weight hydrophilic polymer and -77- private paper scale applicable to national standard (CNS) A4 specifications ( 21〇X 297 mm) ΐ3Π58〇, Shenqing Patent Α8 Β8 C8 D8 Range 1 ο $49 Cabinet 8 〇% by weight of hydroxyl-functionalized oxy-burning monomer. The alkane hydrogel according to claim 17 of the patent application, which is 5 to 12% by weight of a high molecular weight hydrophilic polymer and 5 to 50% by weight of a monomer having a hydroxyl group-functionalized alkane. 2. The alkane hydrogel according to item η of the patent application, further comprising 0 to 8% by weight of at least one other halogen-containing monomer. 51. The helium a hydrogel of claim 17 of the patent application scope further comprises from 0 to 70% by weight of at least one hydrophilic body. Dry 52. = a decane hydrogel according to claim 50 of the patent application, comprising 5 to 6 重量% of the at least one other oxo-containing monomer. 53_ = a decane hydrogel according to claim 50 of the patent application, comprising 10 to 40% by weight of the at least one other oxene-containing monomer. Ministry of Economic Affairs Intellectual Property Office Employees Consumption Cooperative Printed Clothing 54. The decane hydrogel according to claim 51 of the patent application contains 5 to 60% by weight of the at least one hydrophilic monomer. 55. The alkane hydrogel according to item 51 of the patent application, comprising 10 to 5 % by weight of the at least one hydrophilic monomer. 56. A hydroxane hydrogel according to item 17 of the scope of the patent application, comprising δ 1/6 to 15% of the South molecule 1 hydrophilic polymer; from 9% to 9% by weight of the hydroxyl-functionalized oxirane Monomer; 5 to 6 重量% of other siloxane-containing monomers and 5 to 60% by weight -78- This paper scale applies to Chinese National Standard (CNS) A4 (210 χ 297 gong) hydrophilic monomer . 57.: According to the second: the scope of the scope of the 17th oxygen oximeter hydrogel, package 22, 1, molecular weight hydrophilic polymer; 3 hydroxy-functionalized oxirane to 〇 5 to :; % by weight of other monomers containing a sulphuric oxide and 2% by weight of a hydrophilic monomer. 58. According to the patent scope of the patent, the 17th inch of the dry silicone hydrogel, from 3 〇 to 12% of high molecular weight hydrophilic polymer; 20 to 5% by weight of the containing ketone _ a monomer having a functional oxoquinone; 5 to 6 重量% by weight of other anthracene-containing monomer and 50 to 60% by weight of a hydrophilic monomer. The invention provides a high-molecular-weight hydrophilic polymer of 5' to 12% according to the nth item of the patent application scope; 20 to 5% by weight of the hydroxy-functionalized oxime-burning monomer; 〇 to 4% by weight of other monomers containing a ceramsite and 1 〇 to 5% by weight of a hydrophilic monomer. 6〇. According to the scope of the patent application, 7 tS + τ ^ 寸 〜 尊 尊 尊 尊 国 国 17 17 17 17 17 17 17 17 尊 尊 尊 尊 尊 尊 , , , , , , , , , , , , , , , , , , . 61. The yoke oxygen hydrogel according to claim 17, wherein the hydrophilic polymer comprises at least one annular portion along a skeleton portion of the hydrophilic polymer. 62_ According to the patent application scope nth, the Xiyang oxygenated hydrogel, wherein the 5 HAI hydrophilic polymer is selected from the group consisting of cyclic guanamine, cyclic -79-131158 〇, patent application range A8 B8 C8 D8 A group consisting of amines and combinations thereof. An ophthalmic device which comprises a hydroxane hydrogel according to item 17 of the patent application. 64. The ophthalmic device according to application No. 63 of the patent application further contains less than 70. Enter the dynamic contact angle before. 65. The ophthalmic device according to application No. 63 of the patent application further contains less than 60. Enter the dynamic contact angle before. 66. The ophthalmic device of claim 63, further comprising a tear film collapse time of at least 7 seconds and an oxygen permeability of at least 50 bar after wearing for about one week. 7. An ophthalmic device according to claim 64, further comprising a modulus of less than 90 psi. 68. The ophthalmic device according to claim 64, further comprising a water content of between 10 and 60%. 69. The ophthalmic device according to claim 64, further comprising a water content of between 20 and 55%. Ministry of Economic Affairs, Intellectual Property Bureau, Staff and Consumer Cooperatives, Printing and Printing Co., Ltd. 7〇. According to the eye treatment of Article 64 of the patent application, the step further includes a water content between 25 and 40%. 71. The ophthalmic device of claim 66, wherein the tear film collapse time is at least 7 seconds after 7 days of wearing. 72. A method of forming a biomedical device comprising the steps of (4) mixing a reactive component comprising at least one high molecular weight hydrophilic polymer and an effective amount of at least one hydroxyl-functionalized siloxane containing monomer and (b) curing The product of the step (&amp;) to form a biological one... The Chinese standard (cns) A4 specification d tear public 1311580 Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printed A8 B8 C8 D8 Scope six, apply for patent Medical device. 73. The method according to claim 72, wherein the biological 74 drop-out device comprises an ophthalmic device. The method of claim 73, wherein the ophthalmic coating is a decane hydrogel contact lens. 75. The method according to claim 73, wherein the reaction-generating fraction is mixed in the presence of a diluent to form a reaction mixture. 76. The method of claim 75, wherein the diluent is selected from the group consisting of ethers, esters, alkanes, halogenated alkanes, decane, shellfish, amines, alcohols, and mixtures thereof In the group. 77. The method of claim 75, wherein the diluent is selected from the group consisting of guanamines, alcohols, and mixtures thereof. 78. The method of claim 5, wherein the diluent is selected from the group consisting of secondary and tertiary alcohols and mixtures thereof. '' 79. According to the method of claim 75, wherein the agent is selected from the group consisting of tetrahydrofuran, ethyl acetate, methyl lactate: lactam isopropyl ester, vinyl chloride, octamethylcyclotetraoxane: brewing Amine, dimethylacetamide, dimethylpropanamine: a flavonone, a mixture thereof, and any of the foregoing and at least two mixtures. 81 - This paper scale applies to China National Standard (CNS) A4 specification (210x297 mm) 1311580 A8 B8 C8 D8 VI. Patent application scope 80_ According to the patent application scope, the 77th agent contains at least one of having at least 81 _ according to the scope of the patent application, the agent contains at least one of which has at least 82. According to the scope of the patent application, the 75th agent is inert and easy Replace with water. 83. A method of selecting at least one alcohol, alcohol, 2-butanol, 2-methyl term according to the scope of the patent application, wherein the alcohol having 5 carbon atoms is diluted. A method of diluting an alcohol having 6 carbon atoms. The method of the item, wherein the method of diluting the product, wherein the dilution is free of third butanol, third pentanol, 2,3-dimethyl-2, Ding, Ministry of Economic Affairs, Intellectual Property Bureau, employee consumption, co-operative printing of alcohol, A group consisting of 3-methyl-3-pentanol, 3-ethyl-3-butanol, 3,7-dimethyl 3-octanol, and mixtures thereof. 84. The method according to claim 75, wherein the agent is selected from the group consisting of hexanol, heptanol, octanol, decyl alcohol, decyl alcohol, tributyl alcohol, 3-methylpentanol, isopropanol, and third pentane. Ethyl alkylate, decyl lactate, isopropyl lactate, 3,7-dimethyl octanol, dimethyl decylamine, dimethyl acetamide, dimethyl hydrazine, hydrazine-methyl pyrrolidine The ketones and their mixtures are grouped into groups. 85. According to the method of the 75th patent of Shenqing Patent, and the medium and the agent are free of 1-ethoxy-2-propanol, ketone, propanol, tri-pentanol and tripropylene glycol methyl ether. A group consisting of isopropanol, keto-2-pyrrolidone, ethyl lactate, hydrazine, hydrazine-dimercaptopropionamide, dioxopropanol, and mixtures thereof. 86. According to the method of applying for the scope of patents, item 75, Boss/, 肀 稀 第 - 82 82 82 82 82 82 82 82 82 82 82 82 82 82 82 82 82 82 82 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本 本13 11580, Patent Application A8 B8 C8 D8 The agent is present in an amount of less than 50% by weight, based on the reaction mixture. I. The method according to claim 76, wherein the dilution month J is present in an amount of less than 40% by weight, based on the reaction mixture. 88. The method of claim 75, wherein the diluent is present in an amount between 1 and 3% by weight, based on the reaction mixture. 89. The method of claim 75, wherein the diluent is water soluble under processing conditions and the method further comprises (c) removing the lens and (d) water from a mold in which the lens is cured. The lens wherein steps (c) and (d) are carried out in an aqueous solution containing water as a substantial component. 9. The method of claim 75, wherein the reaction mixture further comprises at least one initiator. 91. The method of claim 90, wherein the curing is performed by heat, exposure to radiation, or a combination thereof. The Ministry of Economic Affairs, Intellectual Property Office, Employees' Cooperatives, Printing and Garment 92. The method of claim 9 wherein the curing is by irradiation with ionizing and/or actinic light and comprising at least one photoinitiator. The initiator is carried out. The method according to claim 92, wherein the radiation comprises light having a wavelength of 200 to 500 nm and the initiator is selected from the group consisting of an aromatic α-hydroxy ketone, an alkoxy benzoin, acetophenone, Ethyl phosphine oxide, a mixture of a third amine and a second, -83 - This paper scale applies to the Chinese National Standard (CNS) A4 specification (210 297 297 mm) B8 C8 D8 1311580, the scope of patent application and its mixture In the group consisting of. 94. The method of claim 92, wherein the initiator is selected from the group consisting of 1-hydroxycyclohexyl benzophenone, 2-hydroxy-2-indolyl-1-phenyl-propan-1-one, and bis (2) ,6-dimethoxybenzylidene)_2,4- 4-dimethylpentylphosphine oxide, bis(2,4,6-trimercaptobenzylidene l-phenylphosphine oxide, 2,4 ,6-trimethylbenzyldiphenylphosphine oxide and 2,4,6-trimethylbenzimidyldiphenylphosphine oxide, benzoin methyl ester, camphorquinone and ethyl 4_(N,N_dioxin The method of claim 9, wherein the initiator is present in the reaction in an amount effective to initiate polymerization of the reaction mixture. 96. The method of claim 9 wherein the initiator is present in the reaction mixture in an amount of from 1 to 2 weight percent based on the reactive component. The method of item 92, wherein the curing is carried out by visible light irradiation. The Intellectual Property Department of the Ministry of Economic Affairs and the Consumer Cooperatives print 98. According to the scope of the patent application No. 9 The method wherein the initiator comprises 1-hydroxycyclohexyl benzophenone, bis(2,6-dimethoxyphenylphenyl)-2,4-4-dimethylpentyl phosphine oxide, and mixtures thereof. According to the method of claim 98, wherein the initiator comprises bis(2,6-dimethoxyphenylhydrazinyl)-2, cardiotrimethylpentylphosphine oxide. According to the scope of the patent application 帛99 The method, wherein the -84- 1311580 B8 C8 ___D8____, the sizing of the sizing component comprises at least one uv absorbing compound. 101. The method according to claim 97, wherein the curing step is between 0.1 And the curing strength between 6 mW / cm ^ 2. 1 〇 2 · according to the method of claim 97, wherein the curing step is between 0.2 mW / cm ^ 2 to 3 mW / cm ^ 2 The method of claim 101, wherein the curing step further comprises a curing time of at least 1 minute. 104. The method according to claim 1, wherein the curing Step further includes The curing time between i and 60 minutes. The method of claim 101, wherein the curing step further comprises a curing time between 丨 and 30 minutes. 106. According to the scope of the patent application. The method of claim 3, wherein the curing step is carried out at a temperature greater than 25. (: at a temperature of 107. 107. According to the method of claim 103, wherein the curing economics department intellectual property bureau employee consumption cooperative printing step is It is carried out at a temperature between 25 ° C and 70X:. 108. The method of claim 103, wherein the curing step is between 40. (: and 7 (the temperature between TC. 109. According to the method of claim 75, where the anti-waste, -85- this paper scale applies to the Chinese National Standard (CNS) A4 specification (210 X 297 public)麓) — [311580 Patent Application A8 B8 C8 D8 The mixture is cured in a mold and the method is advanced::: The step of removing the device from the mold by using the device. ~ no. According to the application of the patent (4) (10) The method further comprises at least: a medium-reacting reactant. 7 liters of low-knife summer hydrophilic polymerization hi. According to the method of the patent scope 帛110, the amount of hydrophilic polymer has less than 4 〇, _: : The average molecular weight of the target. The number of the current number 112. According to the method of the patent (4) 11G of the towel, (1) The amount of the hydrophilic polymer has an average molecular weight of less than 20, the color of the binocular of the coffee. The number of buckets (1). The method of claim 110, wherein the low-partition hydrophilic polymer is selected from the group consisting of water-soluble polyamines, amides, and polyethylene glycols, and mixtures thereof. A method of applying for a patent scope of 110, wherein The low-part f-weight hydrophilic polymer is selected from the group consisting of poly-vinylpyrrolidone, and ethyl alcohol, polyethyl 2-carbazole, and mixtures thereof. 'Ministry of Commerce, Intellectual Property Office, Staff Consumption Cooperative The method of claim 11, wherein the low molecular weight 1E hydrophilic polymer is present in an amount of up to 20% by weight based on the reaction mixture. 116. According to the scope of claim 11 The method wherein the low molecular weight hydrophilic polymer is present in an amount of 5 and 20% by weight based on the reaction mixture. The paper scale is suitable for the standard (CNS) A4 specification (10) 297 297 public Chu 1311580, Patent Application No. B8 C8 D8 i _ The method according to claim 109, wherein the borax is carried out using an aqueous solution. 118. The method of claim 1, wherein the aqueous solution further comprises at least one The method of claim 118, wherein the surfactant comprises at least one nonionic surfactant. The method of claim lls, wherein the surfactant comprises TWEEN® or DOE 120. 121. The method according to claim 118, wherein the surfactant is present in an amount up to 10,000 ppm. The method of claim 118, wherein the surface/tongue agent is present in an amount between 500 ppm and 1500 ppm. 123. The method of claim 118, wherein the surfactant is There is a presence between 1〇〇 and 12〇〇ppm. The method of claim 1, wherein the aqueous solution comprises at least one organic solvent. Person ^ Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printing clothing 125. According to the method of claim 1, paragraph 1, which is between room temperature and 1 〇〇. (: between the temperatures I, 126_ according to the method of claim 1, paragraph 1, wherein the I connection is carried out at a temperature between 70t and 95 ° C. 4 to drill 127. According to the scope of patent application The method of item 1〇9, the connection is carried out by stirring. °Hai-dry-87 This paper scale is applicable to China National Standard (CNS) A4 specification (210 297 mm) '—^ 1311580 VI. Patent application scope A8 B8 C8 D8 Ministry of Economic Affairs Intellectual Property Bureau Employees Consumption Cooperatives Printed 128·=Please refer to the method of Section 109 of the patent, wherein the disturbance contains sound waves. 129. ^ A method of forming a wettable biomedical device, comprising two: (a The combination comprises a high molecular weight hydrophilic polymer and a reaction comprising a (four) functionalized calcined monomer and (b) at a small gel time or a curing step (a) The product is formed into a wettable biomedical device. 130. The device is an ophthalmic lens according to the method of claim 129 of the patent application. 131. The method according to claim 129, wherein the device is Contact lenses. 132. According to the application The method of claim 131, wherein the wetness comprises a dynamic contact angle of 70 or less. 133. The method according to claim 131, wherein the humidity comprises a 00 or lower advance dynamic 134. The method of claim 131, wherein the humidity comprises a tear film collapse time of at least 7 seconds. 135. The method of claim 13 wherein the counter component further comprises at least An initiator according to the method of claim 135, wherein the solid is carried out by irradiation and the concentration of the initiator and the curing time of the gel. 137. According to the method of claim 135, wherein the initiator is used in an amount of up to 1% based on all reactive components - 88 sheets of paper are applicable to the Chinese National Standard (CNS) A4 specification ( 210 X 297 mm) Αδ Β8 C8 D8 Patent application scope [311580 exists. 138. The method of claim 1, wherein the initiating agent is present in a quantity of less than 5% 5%. &lt;Use 139_: According to the method of claim 136, wherein the curing is performed under the intensity of less than 5 watts/cm 2 . The method of claim 帛 (9), wherein the gel time is at least 30 seconds. 14 = The method of claim 129, wherein the gel time is at least 35 seconds. 142. An ophthalmic device comprising at least one monomer having a hydroxyl-functionalized hydrazine emulsion and - sufficient to provide the device having less than 80 without surface treatment. A high molecular weight hydrophilic polymer that has previously been used in dynamic contact angles. Ministry of Economic Affairs, Intellectual Property Office, Staff Consumer Cooperative, 143. An ophthalmic device comprising at least one hydroxyl-functionalized xenon-burning monomer and one sufficient to provide the device with at least a forward dynamic contact angle without surface treatment. A high molecular weight hydrophilic polymer disposed at least 10% lower than the dynamic contact angle prior to the ophthalmic device without the hydrophilic polymer. 144_ An ophthalmic device comprising at least one hydroxyl-functionalized xenon-burning monomer and one sufficient to provide the device with a tear film collapse day after being worn for at least 7 seconds in a day without surface treatment Amount of south molecular weight hydrophilic polymer. -89- Wood paper scale suitable for financial standards (CNS) A4 specifications (21G x 297 A8 B8 C8 D8 [311580 VI. Patent application scope 145. According to the patent application scope 142 items of ophthalmic devices, which The device is a decane hydrogel contact lens. Λ Η 6. The ophthalmic device according to the scope of the patent application 帛ΐ42, wherein the single system containing the ketone-functional fossil oxime is used to compatibilize the effective amount: 147 The ophthalmic device according to the scope of the patent application 142, wherein the single system containing hydroxyl-functionalized alkane is present in an amount of from 5% to _%. 148. According to the scope of the patent application 帛 142 An ophthalmic device comprising 1 to 15% of a high molecular weight hydrophilic polymer. Η9. According to the ophthalmic device of claim 142, further comprising at least one of 〇 to 80 重量150. The ophthalmic device according to claim 142, further comprising 〇 to 70% by weight of at least one hydrophilic monomer. 151. The ophthalmic device according to claim 142 of the patent application, comprising an economic department Intellectual Property Bureau employee consumption cooperative printed 1 ^ to 15% a hydrophilic polymer; 5 to 90% by weight of a monomer containing a hydroxyl group-functionalized alkane; 〇 to 80% by weight of a monomer containing another oxime and a hydrophilicity of 〇 to 7% by weight 152. The ophthalmic device according to item 42 of the patent application, further comprising a haze value below 100. 153. The ophthalmic device according to item 42 of the patent application, further comprising a haze of less than 50 154. According to the 56th item of the patent application, the -90- paper scale applies to the Chinese National Standard (CNS) A4 specification (21〇χ297 mm) 1311580 B8 C8 VI. ~ &quot;一~'~ The monomer containing hydroxyl-functionalized alkoxysilane contains 2-propanoid acid, 2-methyl-, 2-di-methyl-methyl [[tridecylfluorenyl)oxy (dioxaoxyalkyl)propoxy]propyl ester, «Hei hydrophilic polymer comprises polyvinylpyrrolidone; the monomer containing other alkoxysilanes comprises a single monomethacryloxypropyl terminal' a polybutyl methoxide of the n-butyl terminal and the hydrophilic monomer comprising 2-carbylethyl methacrylate and N,N-dimethylpropane 155. The alkane hydrogel according to claim 54 of the patent application, which comprises 28% by weight of 2-acrylic acid, 2-mercapto-, 2-hydroxy-3_[3-[1,3,3 , 3-tetramethyl_1_[(trimethyldecyl)oxy] diazepine]propoxy]propyl ester, 31% by weight of monomethyl propyloxypropyl terminal - n-butyl terminal polydimethyl methoxy oxane; 24% by weight of n, N-dimercapto acrylamide; 6% by weight of 2-hydroxyethyl methacrylate; ι. 5 wt% Tetraethylene glycol dimethyl acrylate; 7% by weight of polyvinylpyrrolidine and up to 1% by weight of the photoinitiator reaction product. Printed by the Intellectual Property Office of the Ministry of Economic Affairs, Employees' Consortium 156. According to the scope of application No. 54 of the patent application, it consists of 30% by weight of 2-acrylic acid, 2-methyl-, 2-hydroxy-3. -[3-[1,3,3,3-Tetramethyl-1_[(trimethylmethylalkyl)oxy]dioxaxyalkyl]propoxy]propyl ester, 23% by weight of monomethyl a mono-n-butyl terminated polydioxanoxane terminated by a propyleneoxypropyl group; 31% by weight of N,N-dimethylpropenylamine; 7.5% by weight of 2-hydroxyethylmethacrylic acid Ester; 〇·75% by weight of 4-91 - This paper scale applies to China National Standard (CNS) A4 specification (210 X297 public hair) 1311580 B8 __JD8____ VI. Patent application scope - ~ Ethylene dimethacrylate; % by weight of polyvinylpyrrolidone and up to 1% by weight of photoinitiator. 157. A hydroxane hydrogel according to claim 154 of the patent application, comprising 30% by weight of 2-acrylic acid, 2-mercapto... 2_hydroxy_3_[3_[1,3,3,3-tetramethyl 1-[(Trimethyldecyl)oxy]dioxaxyalkyl]propoxy]propyl ester, 18% by weight of monomethacryloxypropyl terminated mono-n-butyl terminal Polydimethyl oxazepine; 31% by weight of N,N-dimethyl acrylamide; 9% by weight of 2-hydroxyethyl methacrylate; 8% by weight of tetraethylene glycol dimethyl Acrylate; 6% by weight of polyvinylpyrrolidine _ and less than 1% by weight of photoinitiator. 158. A method of improving the wettability of an ophthalmic device formed from a reaction mixture comprising mixing at least one high molecular weight hydrophilic polymer and an effective amount of at least one hydroxyl-containing functionalized oxoxane monomer to the In the reaction mixture. 159. The method of claim 1 , wherein the compatibilizing monomer has a compatibility index greater than 0.5. Printed by the Ministry of Economic Affairs, the Ministry of Finance, and the Consumers' Union. 16 _ According to the method of claim 158, wherein the compatibilizing monomer has a compatibility index greater than 1. 161. The method of claim 158, wherein the compatibilizing monomer has a Si to 0H ratio of less than 15:1. 16Z. The method according to claim 158, wherein the compatibilizing monomer has a Si to 〇H ratio of from 1:1 to 1〇:1. 163. According to the method of claim 1, the wet paper size applies to the Chinese National Standard (CNS) A4 specification (210x297 public interest) Ministry of Economic Affairs Intellectual Property Office Staff Consumer Cooperative Printed Α δ 1311580 cs _D8_ VI. Application The patented range contains a contact angle of 80° or less. 3 9 This paper scale applies to China National Standard (CNS) A4 specification (210 X 297 mm)