TW570920B - 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders - Google Patents
4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders Download PDFInfo
- Publication number
- TW570920B TW570920B TW088121125A TW88121125A TW570920B TW 570920 B TW570920 B TW 570920B TW 088121125 A TW088121125 A TW 088121125A TW 88121125 A TW88121125 A TW 88121125A TW 570920 B TW570920 B TW 570920B
- Authority
- TW
- Taiwan
- Prior art keywords
- formula
- trans
- group
- melting point
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Otolaryngology (AREA)
- Hospice & Palliative Care (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98204411 | 1998-12-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
TW570920B true TW570920B (en) | 2004-01-11 |
Family
ID=8234539
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW088121125A TW570920B (en) | 1998-12-22 | 1999-12-03 | 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders |
Country Status (34)
Country | Link |
---|---|
US (2) | US6544997B1 (no) |
EP (1) | EP1140915B1 (no) |
JP (1) | JP4615725B2 (no) |
KR (1) | KR100633680B1 (no) |
CN (1) | CN1150190C (no) |
AR (1) | AR024240A1 (no) |
AT (1) | ATE297917T1 (no) |
AU (1) | AU770397B2 (no) |
BG (1) | BG64953B1 (no) |
BR (1) | BR9916491A (no) |
CA (1) | CA2355857C (no) |
CZ (1) | CZ300851B6 (no) |
DE (1) | DE69925865T2 (no) |
DK (1) | DK1140915T3 (no) |
EA (1) | EA003608B1 (no) |
EE (1) | EE200100335A (no) |
ES (1) | ES2245131T3 (no) |
HK (1) | HK1039114B (no) |
HR (1) | HRP20010445A2 (no) |
HU (1) | HUP0104838A3 (no) |
ID (1) | ID28953A (no) |
IL (1) | IL143858A (no) |
MY (1) | MY121852A (no) |
NO (1) | NO321324B1 (no) |
NZ (1) | NZ512871A (no) |
PL (1) | PL197409B1 (no) |
PT (1) | PT1140915E (no) |
SI (1) | SI1140915T1 (no) |
SK (1) | SK285829B6 (no) |
TR (1) | TR200101962T2 (no) |
TW (1) | TW570920B (no) |
UA (1) | UA71591C2 (no) |
WO (1) | WO2000037461A1 (no) |
ZA (1) | ZA200105135B (no) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1547593A4 (en) * | 2002-09-12 | 2009-12-23 | Nagase Chemtex Corp | MEDICINAL COMPOSITION |
EA009464B1 (ru) * | 2003-06-19 | 2007-12-28 | Янссен Фармацевтика Н.В. | Бензамиды 4-(аминометил)пиперидина, замещённого гидроксикарбонилфенилом, в качестве антагонистов 5нт-рецепторов |
EP2305254A1 (en) | 2003-06-19 | 2011-04-06 | Janssen Pharmaceutica NV | Aminosulfonyl substituted 4-(aminomethyl)-piperidine benzamides as 5HT4-antagonists for the treatment of gatrointestinal conditions |
EP1638961B1 (en) * | 2003-06-19 | 2009-11-18 | Janssen Pharmaceutica N.V. | Heterocyclic substituted 4-(aminomethyl)-piperidine benzamides as 5ht4-antagonists |
PT1638959E (pt) * | 2003-06-19 | 2007-12-12 | Janssen Pharmaceutica Nv | 4-(aminometil)piperidinobenzamidas antagonistas de 5ht4 |
JO2478B1 (en) * | 2003-06-19 | 2009-01-20 | جانسين فارماسوتيكا ان. في. | (Aminomethyl) -biperidine benzamides as 5 HT4 antagonists |
AP2184A (en) * | 2003-09-03 | 2010-12-02 | Pfizer | Benzimidazolone compounds having 5-HT4 receptor agonistic activity. |
US7964727B2 (en) * | 2003-11-24 | 2011-06-21 | Pfizer Inc. | Quinolonecarboxylic acid compounds having 5-HT4 receptor agonistic activity |
TW200533348A (en) * | 2004-02-18 | 2005-10-16 | Theravance Inc | Indazole-carboxamide compounds as 5-ht4 receptor agonists |
US8309575B2 (en) | 2004-04-07 | 2012-11-13 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
TWI351282B (en) * | 2004-04-07 | 2011-11-01 | Theravance Inc | Quinolinone-carboxamide compounds as 5-ht4 recepto |
US7728006B2 (en) * | 2004-04-07 | 2010-06-01 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
EP1758891A2 (en) | 2004-06-15 | 2007-03-07 | Pfizer Japan Inc. | Benzimidazolone carboxylic acid derivatives |
US20060035890A1 (en) * | 2004-08-10 | 2006-02-16 | Amit Banerjee | Compounds and methods for the treatment of ubiquitin conjugating disorders |
JP5042028B2 (ja) * | 2004-11-05 | 2012-10-03 | セラヴァンス, インコーポレーテッド | キノリノン−カルボキサミド化合物 |
JP5086091B2 (ja) * | 2004-11-05 | 2012-11-28 | セラヴァンス, インコーポレーテッド | 5−ht4受容体アゴニスト化合物 |
JP5159317B2 (ja) * | 2004-12-22 | 2013-03-06 | セラヴァンス, インコーポレーテッド | インダゾール−カルボキサミド化合物 |
WO2006094063A1 (en) * | 2005-03-02 | 2006-09-08 | Theravance, Inc. | Quinolinone compounds as 5-ht4 receptor agonists |
US9101160B2 (en) | 2005-11-23 | 2015-08-11 | The Coca-Cola Company | Condiments with high-potency sweetener |
US8017168B2 (en) | 2006-11-02 | 2011-09-13 | The Coca-Cola Company | High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith |
US8377968B2 (en) | 2008-06-02 | 2013-02-19 | Zalicus Pharmaceuticals, Ltd. | N-piperidinyl acetamide derivatives as calcium channel blockers |
US10208023B2 (en) | 2013-03-01 | 2019-02-19 | Mark G. DeGiacomo | Heterocyclic inhibitors of the sodium channel |
US20180305334A1 (en) * | 2015-10-14 | 2018-10-25 | Aquinnah Pharmaceuticals, Inc. | Compounds, compositions and methods of use against stress granules |
US20220241258A1 (en) | 2019-07-11 | 2022-08-04 | Praxis Precision Medicines, Inc. | Formulations of t-type calcium channel modulators and methods of use thereof |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ225152A (en) * | 1987-07-17 | 1990-04-26 | Janssen Pharmaceutica Nv | Heterocyclically substituted piperidinyl benzamides as pharmaceuticals |
CA1317940C (en) * | 1987-09-25 | 1993-05-18 | Georges H. P. Van Daele | Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides |
US5374637A (en) * | 1989-03-22 | 1994-12-20 | Janssen Pharmaceutica N.V. | N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives |
NZ243993A (en) | 1991-08-20 | 1994-10-26 | Smithkline Beecham Plc | Pharmaceutical compositions having 5-ht4 receptor antagonist activity and selected compounds having such activity |
JP3294611B2 (ja) * | 1991-09-12 | 2002-06-24 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | 5−ht4レセプター・アンタゴニスト |
CA2105072C (en) * | 1992-01-23 | 1998-07-28 | Hiroshi Nagase | Morphinan derivative and its pharmaceutical applications |
AU667874B2 (en) * | 1992-02-06 | 1996-04-18 | Smithkline Beecham Plc | Benzopyran, benzothiopyran and benzofuran derivatives as 5-HT4 antagonists |
GB9219163D0 (en) | 1992-09-10 | 1992-10-28 | Smithkline Beecham Plc | Pharmaceuticals |
MX9306311A (es) | 1992-10-13 | 1994-04-29 | Smithkline Beecham Plc | Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen |
AU5150393A (en) | 1992-10-13 | 1994-05-09 | Smithkline Beecham Plc | Heterocyclic -esters or -amides used as 5-ht4 receptor antagonists |
NZ257545A (en) | 1992-11-05 | 1997-01-29 | Smithkline Beecham Plc | Heterocyclic (especially piperidine) derivatives and pharmaceutical compositions |
GB9301660D0 (en) * | 1993-01-28 | 1993-03-17 | Smithkline Beecham Plc | Pharmaceuticals |
GB9312348D0 (en) | 1993-06-16 | 1993-07-28 | Smithkline Beecham Plc | Pharmaceuticals |
ES2103675B1 (es) * | 1995-01-10 | 1998-07-01 | Almirall Lab | Nuevas piperidinas sustituidas. |
IT1275903B1 (it) | 1995-03-14 | 1997-10-24 | Boehringer Ingelheim Italia | Esteri e ammidi della 1,4-piperidina disostituita |
GB9507882D0 (en) | 1995-04-18 | 1995-05-31 | Pharmacia Spa | Substituted dihydrobenzofuran derivatives as 5-ht4 agonists |
ATE250931T1 (de) * | 1996-02-15 | 2003-10-15 | Janssen Pharmaceutica Nv | Verwendung von 5-ht4 antagonisten zur überwindung der gastrointestinalen beschädigung, die durch inhibitoren der serotonin-wiederaufnahme hervorgerufen werden |
TW445263B (en) * | 1996-02-29 | 2001-07-11 | Janssen Pharmaceutica Nv | Novel esters of 1,4-disubstituted piperidine derivatives |
TW402591B (en) * | 1997-07-11 | 2000-08-21 | Janssen Pharmaceutica Nv | Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives |
DE69935600T2 (de) * | 1998-09-10 | 2007-12-06 | F. Hoffmann-La Roche Ag | Dihydrobenzodioxincarbonsäureamid- und ketonderivate als 5-ht4-rezeptorantagonisten |
DE10217868A1 (de) * | 2002-04-22 | 2003-10-30 | Jomed N V | Ballon-Katheter |
-
1999
- 1999-12-03 TW TW088121125A patent/TW570920B/zh not_active IP Right Cessation
- 1999-12-14 BR BR9916491-4A patent/BR9916491A/pt not_active Application Discontinuation
- 1999-12-14 US US09/857,905 patent/US6544997B1/en not_active Expired - Lifetime
- 1999-12-14 EA EA200100710A patent/EA003608B1/ru not_active IP Right Cessation
- 1999-12-14 EE EEP200100335A patent/EE200100335A/xx unknown
- 1999-12-14 CZ CZ20012117A patent/CZ300851B6/cs not_active IP Right Cessation
- 1999-12-14 ES ES99967956T patent/ES2245131T3/es not_active Expired - Lifetime
- 1999-12-14 JP JP2000589532A patent/JP4615725B2/ja not_active Expired - Fee Related
- 1999-12-14 DE DE69925865T patent/DE69925865T2/de not_active Expired - Lifetime
- 1999-12-14 KR KR1020017005055A patent/KR100633680B1/ko not_active IP Right Cessation
- 1999-12-14 ID IDW00200101336A patent/ID28953A/id unknown
- 1999-12-14 CA CA002355857A patent/CA2355857C/en not_active Expired - Fee Related
- 1999-12-14 AU AU24328/00A patent/AU770397B2/en not_active Ceased
- 1999-12-14 PL PL348417A patent/PL197409B1/pl unknown
- 1999-12-14 HU HU0104838A patent/HUP0104838A3/hu unknown
- 1999-12-14 WO PCT/EP1999/010064 patent/WO2000037461A1/en active IP Right Grant
- 1999-12-14 PT PT99967956T patent/PT1140915E/pt unknown
- 1999-12-14 SI SI9930822T patent/SI1140915T1/sl unknown
- 1999-12-14 UA UA2001064399A patent/UA71591C2/uk unknown
- 1999-12-14 NZ NZ512871A patent/NZ512871A/xx unknown
- 1999-12-14 SK SK859-2001A patent/SK285829B6/sk not_active IP Right Cessation
- 1999-12-14 AT AT99967956T patent/ATE297917T1/de not_active IP Right Cessation
- 1999-12-14 IL IL14385899A patent/IL143858A/xx not_active IP Right Cessation
- 1999-12-14 TR TR2001/01962T patent/TR200101962T2/xx unknown
- 1999-12-14 CN CNB998147699A patent/CN1150190C/zh not_active Expired - Fee Related
- 1999-12-14 DK DK99967956T patent/DK1140915T3/da active
- 1999-12-14 EP EP99967956A patent/EP1140915B1/en not_active Expired - Lifetime
- 1999-12-17 MY MYPI99005534A patent/MY121852A/en unknown
- 1999-12-21 AR ARP990106644A patent/AR024240A1/es active IP Right Grant
-
2001
- 2001-06-07 BG BG105571A patent/BG64953B1/bg unknown
- 2001-06-08 NO NO20012858A patent/NO321324B1/no not_active IP Right Cessation
- 2001-06-14 HR HR20010445A patent/HRP20010445A2/hr not_active Application Discontinuation
- 2001-06-21 ZA ZA200105135A patent/ZA200105135B/en unknown
-
2002
- 2002-01-29 HK HK02100161.1A patent/HK1039114B/zh not_active IP Right Cessation
-
2003
- 2003-01-29 US US10/353,307 patent/US7205410B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TW570920B (en) | 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders | |
TW577886B (en) | (Benzofuran or benzopyran) derivatives having fundic relaxation properties | |
TW548103B (en) | Bicyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives | |
EP0720609B1 (en) | 3-(5-tetrazolyl-benzyl)amino-piperidine derivatives and antagonists of tachykinins | |
TW504510B (en) | 2,4-diaminopyrimidine derivatives | |
CN107286077A (zh) | 一种选择性的c-kit激酶抑制剂 | |
TW577887B (en) | Polymorphic form I of a tachykinin receptor antagonist | |
HU228128B1 (hu) | Tachikinin-receptor antagonista hatású 1-(1,2-diszubsztituált piperidinil)-4-szubsztituált piperidinszármazékok | |
CN103080087A (zh) | 哌啶衍生物及其用于治疗代谢紊乱的用途 | |
CN112341439A (zh) | 一种免疫调节剂 | |
CN101213187A (zh) | 作为rho-激酶抑制剂的异喹啉衍生物 | |
WO2013123824A1 (zh) | 聚乙二醇与纳洛酮的结合物及其药物组合物和应用 | |
CN112824398A (zh) | 一种免疫调节剂 | |
HU229766B1 (hu) | 1-(1,2-diszubsztituált piperidinil)-4-(kondenzált imidazolil)-piperidin-származékok | |
CN100537565C (zh) | 作为5ht4-拮抗剂的4-(氨甲基)-哌啶苯甲酰胺 | |
CN108884093A (zh) | 6,7,8,9-四氢-5H-吡啶并[2,3-d]氮杂*多巴胺D3配体 | |
EP1238970B1 (en) | Cycloamine ccr5 receptor antagonists | |
CN114728967A (zh) | 作为jak抑制剂的三并杂环类化合物及其应用 | |
WO2023205786A1 (en) | Didehydro-3'-deoxy-4'-ethynylthymidines and related compounds and their use in treating medical conditions | |
CN100516066C (zh) | 供治疗胃底松弛作用损伤的化合物 | |
TW200904449A (en) | Dibenzo[b,f][1,4]oxazapine compounds | |
HUT72740A (en) | Dimethylbenzofurans and dimethylbenzopyrans and they use for preparing pharmaceutical compositions having 5-ht3 antagonistic activity | |
JPH06507162A (ja) | 抗セロトニン類、それらの製造およびそれらを含有する薬物 | |
WO2021159372A1 (zh) | Jak抑制剂在制备治疗jak激酶相关疾病药物中的应用 | |
TWI289559B (en) | Aminoalkyl substituted (benzodioxan, benzofuran or benzopyran) derivatives |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
GD4A | Issue of patent certificate for granted invention patent | ||
MM4A | Annulment or lapse of patent due to non-payment of fees |