CN114728967A - 作为jak抑制剂的三并杂环类化合物及其应用 - Google Patents

作为jak抑制剂的三并杂环类化合物及其应用 Download PDF

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Publication number
CN114728967A
CN114728967A CN202080076696.XA CN202080076696A CN114728967A CN 114728967 A CN114728967 A CN 114728967A CN 202080076696 A CN202080076696 A CN 202080076696A CN 114728967 A CN114728967 A CN 114728967A
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China
Prior art keywords
alkyl
compound
independently
radical
reaction
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Pending
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CN202080076696.XA
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English (en)
Inventor
毛魏魏
李文龙
韦昌青
钱文远
胡国平
黎健
陈曙辉
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Chia Tai Tianqing Pharmaceutical Group Co Ltd
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Chia Tai Tianqing Pharmaceutical Group Co Ltd
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Publication of CN114728967A publication Critical patent/CN114728967A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

一种作为JAK抑制剂的三并杂环类化合物，以及在制备治疗JAK1或/和JAK2相关疾病的药物中的应用。具体涉及式(Ⅰ')所示化合物或其药学上可接受的盐。

Description

PCT国内申请，说明书已公开。

Claims (20)

  1. PCT国内申请，权利要求书已公开。
CN202080076696.XA 2019-11-27 2020-11-27 作为jak抑制剂的三并杂环类化合物及其应用 Pending CN114728967A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201911180309 2019-11-27
CN2019111803092 2019-11-27
CN202010501267 2020-06-04
CN2020105012674 2020-06-04
PCT/CN2020/132426 WO2021104488A1 (zh) 2019-11-27 2020-11-27 作为jak抑制剂的三并杂环类化合物及其应用

Publications (1)

Publication Number Publication Date
CN114728967A true CN114728967A (zh) 2022-07-08

Family

ID=76129134

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080076696.XA Pending CN114728967A (zh) 2019-11-27 2020-11-27 作为jak抑制剂的三并杂环类化合物及其应用

Country Status (11)

Country Link
US (1) US20230017539A1 (zh)
EP (1) EP4067356A4 (zh)
JP (1) JP2023503482A (zh)
KR (1) KR20220107018A (zh)
CN (1) CN114728967A (zh)
AU (1) AU2020390378A1 (zh)
BR (1) BR112022010181A2 (zh)
CA (1) CA3162572A1 (zh)
IL (1) IL293153A (zh)
MX (1) MX2022006333A (zh)
WO (1) WO2021104488A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117586285A (zh) * 2024-01-19 2024-02-23 英矽智能科技(上海)有限公司 三并环类化合物

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115124526B (zh) * 2020-12-04 2024-01-30 广州嘉越医药科技有限公司 一种吡咯并嘧啶类化合物中间体及其制备方法
CN117295739A (zh) * 2021-05-26 2023-12-26 正大天晴药业集团股份有限公司 三并杂环类化合物的结晶和盐及其应用
AU2021479662A1 (en) * 2021-12-21 2024-02-29 Yiyou Biotech (Shanghai) Co., Ltd. Pyrido ring compound, preparation method therefor, intermediate, composition, and application

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011086053A1 (en) * 2010-01-12 2011-07-21 F. Hoffmann-La Roche Ag Tricyclic heterocyclic compounds, compositions and methods of use thereof
WO2013007765A1 (en) * 2011-07-13 2013-01-17 F. Hoffmann-La Roche Ag Fused tricyclic compounds for use as inhibitors of janus kinases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011086053A1 (en) * 2010-01-12 2011-07-21 F. Hoffmann-La Roche Ag Tricyclic heterocyclic compounds, compositions and methods of use thereof
WO2013007765A1 (en) * 2011-07-13 2013-01-17 F. Hoffmann-La Roche Ag Fused tricyclic compounds for use as inhibitors of janus kinases

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117586285A (zh) * 2024-01-19 2024-02-23 英矽智能科技(上海)有限公司 三并环类化合物
CN117586285B (zh) * 2024-01-19 2024-04-05 英矽智能科技(上海)有限公司 三并环类化合物

Also Published As

Publication number Publication date
AU2020390378A1 (en) 2022-06-09
BR112022010181A2 (pt) 2022-10-11
JP2023503482A (ja) 2023-01-30
KR20220107018A (ko) 2022-08-01
WO2021104488A1 (zh) 2021-06-03
US20230017539A1 (en) 2023-01-19
MX2022006333A (es) 2022-06-22
EP4067356A4 (en) 2024-03-27
CA3162572A1 (en) 2021-06-03
IL293153A (en) 2022-07-01
EP4067356A1 (en) 2022-10-05

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