TW200829594A - Phosphoinositide 3-kinase inhibitor compounds and methods of use - Google Patents
Phosphoinositide 3-kinase inhibitor compounds and methods of use Download PDFInfo
- Publication number
- TW200829594A TW200829594A TW096146408A TW96146408A TW200829594A TW 200829594 A TW200829594 A TW 200829594A TW 096146408 A TW096146408 A TW 096146408A TW 96146408 A TW96146408 A TW 96146408A TW 200829594 A TW200829594 A TW 200829594A
- Authority
- TW
- Taiwan
- Prior art keywords
- pyrimidin
- methyl
- amine
- phenyl
- pyrimidine
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87342206P | 2006-12-07 | 2006-12-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
TW200829594A true TW200829594A (en) | 2008-07-16 |
Family
ID=39403189
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW096146408A TW200829594A (en) | 2006-12-07 | 2007-12-05 | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
Country Status (19)
Families Citing this family (80)
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JP4862654B2 (ja) | 2004-10-08 | 2012-01-25 | アステラス製薬株式会社 | 芳香環縮合ピリミジン誘導体 |
GB0423653D0 (en) * | 2004-10-25 | 2004-11-24 | Piramed Ltd | Pharmaceutical compounds |
TWI498332B (zh) * | 2006-04-26 | 2015-09-01 | Hoffmann La Roche | 作為pi3k抑制劑之嘧啶衍生物及相關製備方法、醫藥組合物、用途、套組及產物 |
RU2008141356A (ru) | 2006-04-26 | 2010-06-10 | Ф. Хоффманн-Ля Рош Аг (Ch) | Производные пиримидина в качестве ингибиторов фосфатидилинозитол-3-киназы (pi3k) |
PT2024372E (pt) | 2006-04-26 | 2010-09-16 | Hoffmann La Roche | Derivado de tieno[3,2-d]pirimidina útil como inibidor de pi3k |
TW200801012A (en) | 2006-04-26 | 2008-01-01 | Piramed Ltd | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
GB0608820D0 (en) | 2006-05-04 | 2006-06-14 | Piramed Ltd | Pharmaceutical compounds |
JP5284977B2 (ja) | 2006-12-07 | 2013-09-11 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | ホスホイノシチド3−キナーゼ阻害剤化合物及び使用方法 |
-
2007
- 2007-12-05 CA CA2671845A patent/CA2671845C/en not_active Expired - Fee Related
- 2007-12-05 AR ARP070105448A patent/AR064154A1/es unknown
- 2007-12-05 CN CN200780051049.8A patent/CN101675053B/zh active Active
- 2007-12-05 ZA ZA200904531A patent/ZA200904531B/xx unknown
- 2007-12-05 RU RU2009125916/04A patent/RU2470936C2/ru not_active IP Right Cessation
- 2007-12-05 EP EP07865255.9A patent/EP2114950B1/en active Active
- 2007-12-05 AU AU2007333243A patent/AU2007333243B2/en not_active Ceased
- 2007-12-05 PE PE2007001727A patent/PE20081353A1/es not_active Application Discontinuation
- 2007-12-05 CL CL200703523A patent/CL2007003523A1/es unknown
- 2007-12-05 WO PCT/US2007/086533 patent/WO2008073785A2/en active Application Filing
- 2007-12-05 TW TW096146408A patent/TW200829594A/zh unknown
- 2007-12-05 KR KR1020097014132A patent/KR101507182B1/ko active IP Right Grant
- 2007-12-05 MX MX2009005925A patent/MX2009005925A/es active IP Right Grant
- 2007-12-05 JP JP2009540457A patent/JP5500990B2/ja active Active
- 2007-12-05 BR BRPI0717907-3A2A patent/BRPI0717907A2/pt not_active Application Discontinuation
- 2007-12-05 US US11/951,189 patent/US9487533B2/en active Active
- 2007-12-05 ES ES07865255T patent/ES2571028T3/es active Active
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2009
- 2009-06-04 IL IL199151A patent/IL199151A/en not_active IP Right Cessation
- 2009-07-06 NO NO20092565A patent/NO342697B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
BRPI0717907A2 (pt) | 2013-11-05 |
CA2671845C (en) | 2015-03-24 |
KR20090106508A (ko) | 2009-10-09 |
AR064154A1 (es) | 2009-03-18 |
CA2671845A1 (en) | 2008-06-19 |
PE20081353A1 (es) | 2008-11-12 |
ZA200904531B (en) | 2010-09-29 |
IL199151A0 (en) | 2010-03-28 |
NO20092565L (no) | 2009-09-07 |
CN101675053B (zh) | 2014-03-12 |
JP2010512337A (ja) | 2010-04-22 |
EP2114950B1 (en) | 2016-03-09 |
WO2008073785A3 (en) | 2008-08-28 |
CN101675053A (zh) | 2010-03-17 |
RU2009125916A (ru) | 2011-01-20 |
NO342697B1 (no) | 2018-07-09 |
WO2008073785A2 (en) | 2008-06-19 |
ES2571028T3 (es) | 2016-05-23 |
EP2114950A2 (en) | 2009-11-11 |
US20080269210A1 (en) | 2008-10-30 |
AU2007333243A1 (en) | 2008-06-19 |
RU2470936C2 (ru) | 2012-12-27 |
JP5500990B2 (ja) | 2014-05-21 |
KR101507182B1 (ko) | 2015-03-30 |
AU2007333243B2 (en) | 2013-03-14 |
US9487533B2 (en) | 2016-11-08 |
IL199151A (en) | 2017-01-31 |
CL2007003523A1 (es) | 2008-08-22 |
MX2009005925A (es) | 2009-08-12 |
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