TR200200416T2 - İkame edilmiş fenilusikloheksil bileşimlerinden elde edilmiş yeni esterler. - Google Patents
İkame edilmiş fenilusikloheksil bileşimlerinden elde edilmiş yeni esterler.Info
- Publication number
- TR200200416T2 TR200200416T2 TR2002/00416T TR200200416T TR200200416T2 TR 200200416 T2 TR200200416 T2 TR 200200416T2 TR 2002/00416 T TR2002/00416 T TR 2002/00416T TR 200200416 T TR200200416 T TR 200200416T TR 200200416 T2 TR200200416 T2 TR 200200416T2
- Authority
- TR
- Turkey
- Prior art keywords
- substituted
- esters derived
- new esters
- phenylcyclohexyl
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
- C07C219/30—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Tramadol' den elde edilen ikame fenil-sikloheksil bilesimlerinden elde edilen yeni esterler, bunlarin elde edilme islemi ve analjezik özelliklere sahip olan ilacin hazirlanmasinda bunlarin kullanimi. Genel formülün (I) bu yeni bilesenleri daha yüksek bir analjezik aktiviteye, daha az toksiteye ve daha uzun bir etkinlik zamanina sahiptir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009802329A ES2141688B1 (es) | 1998-11-06 | 1998-11-06 | Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos. |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200200416T2 true TR200200416T2 (tr) | 2003-01-21 |
Family
ID=8305698
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2002/00416T TR200200416T2 (tr) | 1998-11-06 | 1999-11-04 | İkame edilmiş fenilusikloheksil bileşimlerinden elde edilmiş yeni esterler. |
TR2002/00415T TR200200415T2 (tr) | 1998-11-06 | 1999-11-04 | İkame edilmiş fenilusikloheksil bileşimlerinden elde edilmiş yeni esterler. |
TR2001/01160T TR200101160T2 (tr) | 1998-11-06 | 1999-11-04 | İkame edilmiş fenilusikloheksil bileşimlerinden elde edilmiş yeni esterler. |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2002/00415T TR200200415T2 (tr) | 1998-11-06 | 1999-11-04 | İkame edilmiş fenilusikloheksil bileşimlerinden elde edilmiş yeni esterler. |
TR2001/01160T TR200101160T2 (tr) | 1998-11-06 | 1999-11-04 | İkame edilmiş fenilusikloheksil bileşimlerinden elde edilmiş yeni esterler. |
Country Status (39)
Country | Link |
---|---|
US (1) | US6455585B1 (tr) |
EP (3) | EP1219623B1 (tr) |
JP (1) | JP2002529442A (tr) |
KR (1) | KR100453613B1 (tr) |
CN (1) | CN1176902C (tr) |
AP (1) | AP1222A (tr) |
AT (3) | ATE257817T1 (tr) |
AU (1) | AU755681B2 (tr) |
BG (1) | BG105556A (tr) |
BR (1) | BR9915727A (tr) |
CA (1) | CA2349245A1 (tr) |
CR (1) | CR6368A (tr) |
CU (1) | CU23006A3 (tr) |
CZ (1) | CZ20011500A3 (tr) |
DE (3) | DE69914229T2 (tr) |
DK (3) | DK1219594T3 (tr) |
EA (1) | EA003742B1 (tr) |
EE (1) | EE200100246A (tr) |
ES (4) | ES2141688B1 (tr) |
GE (1) | GEP20033116B (tr) |
HR (1) | HRP20010412B1 (tr) |
HU (1) | HUP0104218A3 (tr) |
ID (1) | ID29017A (tr) |
IL (1) | IL142592A0 (tr) |
IS (1) | IS5934A (tr) |
MA (1) | MA26765A1 (tr) |
MX (1) | MXPA01004432A (tr) |
NO (1) | NO20012234L (tr) |
NZ (1) | NZ511739A (tr) |
OA (1) | OA11672A (tr) |
PL (1) | PL347492A1 (tr) |
PT (3) | PT1127871E (tr) |
SI (3) | SI1127871T1 (tr) |
SK (1) | SK284068B6 (tr) |
TR (3) | TR200200416T2 (tr) |
UA (1) | UA59477C2 (tr) |
WO (1) | WO2000027799A1 (tr) |
YU (1) | YU29601A (tr) |
ZA (1) | ZA200104026B (tr) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2160534B1 (es) * | 1999-12-30 | 2002-04-16 | Vita Invest Sa | Nuevos esteres derivados de (rr,ss)-2-hidroxibenzoato de 3-(2-dimetilaminometil-1-hidroxiciclohexil) fenilo. |
DE10049483A1 (de) * | 2000-09-29 | 2002-05-02 | Gruenenthal Gmbh | Substituierte 1-Aminobutan-3-ol-Derivate |
US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
WO2004026291A1 (fr) * | 2002-08-28 | 2004-04-01 | Shuyi Zhang | Formulations orales d'ibuprofene et de tramadol, methodes de preparation de ces dernieres |
EP1908460A1 (de) | 2002-11-22 | 2008-04-09 | Grünenthal GmbH | Verwendung von (1R,2R)-3-(2-Dimethylaminomethyl-cyclohexyl)-phenol zur Behandlung von Entzündungsschmerz |
US20040248979A1 (en) * | 2003-06-03 | 2004-12-09 | Dynogen Pharmaceuticals, Inc. | Method of treating lower urinary tract disorders |
DE102004032051A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
US8075872B2 (en) | 2003-08-06 | 2011-12-13 | Gruenenthal Gmbh | Abuse-proofed dosage form |
DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
DE102004034619A1 (de) * | 2004-07-16 | 2006-02-23 | Grünenthal GmbH | Substituierte Aminoverbindungen als 5-HT/NA Uptakehemmer |
DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
DE102007011485A1 (de) | 2007-03-07 | 2008-09-11 | Grünenthal GmbH | Darreichungsform mit erschwertem Missbrauch |
RU2493830C2 (ru) | 2008-01-25 | 2013-09-27 | Грюненталь Гмбх | Лекарственная форма |
RU2508092C2 (ru) | 2008-05-09 | 2014-02-27 | Грюненталь Гмбх | Способ получения твердой лекарственной формы, в частности таблетки для фармацевтического применения, и способ получения прекурсора твердой лекарственной формы, в частности таблетки |
BR112012001244A2 (pt) | 2009-07-22 | 2020-12-08 | Gruünenthal Gmbh | Forma de dosagem resitente à adulteração, seu processo de produção, e embalagem contendo tal forma |
US10080721B2 (en) | 2009-07-22 | 2018-09-25 | Gruenenthal Gmbh | Hot-melt extruded pharmaceutical dosage form |
EP2383255A1 (en) * | 2010-04-28 | 2011-11-02 | Lacer, S.A. | New compounds, synthesis and use thereof in the treatment of pain |
NZ607392A (en) | 2010-09-02 | 2015-03-27 | Gruenenthal Chemie | Tamper resistant dosage form comprising inorganic salt |
AU2011297892B2 (en) | 2010-09-02 | 2014-05-29 | Grunenthal Gmbh | Tamper resistant dosage form comprising an anionic polymer |
WO2012100423A1 (en) * | 2011-01-27 | 2012-08-02 | Eli Lilly And Company | Analgesic compounds, methods, and formulations |
EP2530072A1 (en) | 2011-06-03 | 2012-12-05 | Lacer, S.A. | New compounds, synthesis and use thereof in the treatment of pain |
US10702485B2 (en) | 2011-07-09 | 2020-07-07 | Syntrix Biosystems Inc. | Compositions and methods for overcoming resistance to tramadol |
CA2839126A1 (en) | 2011-07-29 | 2013-02-07 | Grunenthal Gmbh | Tamper-resistant tablet providing immediate drug release |
AR087360A1 (es) | 2011-07-29 | 2014-03-19 | Gruenenthal Gmbh | Tableta a prueba de manipulacion que proporciona liberacion de farmaco inmediato |
WO2013127831A1 (en) | 2012-02-28 | 2013-09-06 | Grünenthal GmbH | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
LT2838512T (lt) | 2012-04-18 | 2018-11-12 | GrĆ¼nenthal GmbH | Pažeidimui atspari ir dozės atpalaidavimo nuokrypiui atspari farmacinė vaisto forma |
WO2013168005A2 (en) * | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of restless leg syndrome and fibromyalgia |
US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
CA2907950A1 (en) | 2013-05-29 | 2014-12-04 | Grunenthal Gmbh | Tamper-resistant dosage form containing one or more particles |
EP3003283A1 (en) | 2013-05-29 | 2016-04-13 | Grünenthal GmbH | Tamper resistant dosage form with bimodal release profile |
BR112016000194A8 (pt) | 2013-07-12 | 2019-12-31 | Gruenenthal Gmbh | forma de dosagem resistente à violação contendo o polímero de acetato de etileno-vinila |
CN105934241B (zh) | 2013-11-26 | 2020-06-05 | 格吕伦塔尔有限公司 | 通过低温研磨制备粉末状药物组合物 |
MX2016014738A (es) | 2014-05-12 | 2017-03-06 | Gruenenthal Gmbh | Formulacion en capsula de liberacion inmediata resistente a alteraciones que comprende tapentadol. |
MX2017013637A (es) | 2015-04-24 | 2018-03-08 | Gruenenthal Gmbh | Forma de dosificacion resistente a alteraciones con liberacion inmediata y resistencia contra la extraccion por solventes. |
WO2017042325A1 (en) | 2015-09-10 | 2017-03-16 | Grünenthal GmbH | Protecting oral overdose with abuse deterrent immediate release formulations |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1199764B (de) * | 1963-04-02 | 1965-09-02 | Gruenenthal Chemie | Verfahren zur Herstellung von basisch substituierten Phenolaethern |
US3652589A (en) * | 1967-07-27 | 1972-03-28 | Gruenenthal Chemie | 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols |
DE19525137C2 (de) * | 1995-07-11 | 2003-02-27 | Gruenenthal Gmbh | 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe |
DE19609847A1 (de) * | 1996-03-13 | 1997-09-18 | Gruenenthal Gmbh | Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe |
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1998
- 1998-11-06 ES ES009802329A patent/ES2141688B1/es not_active Expired - Fee Related
-
1999
- 1999-04-11 UA UA2001063799A patent/UA59477C2/uk unknown
- 1999-11-04 GE GEAP19995930A patent/GEP20033116B/en unknown
- 1999-11-04 ID IDW00200101215A patent/ID29017A/id unknown
- 1999-11-04 OA OA1200100111A patent/OA11672A/en unknown
- 1999-11-04 WO PCT/ES1999/000352 patent/WO2000027799A1/es not_active Application Discontinuation
- 1999-11-04 EE EEP200100246A patent/EE200100246A/xx unknown
- 1999-11-04 EP EP02075837A patent/EP1219623B1/en not_active Expired - Lifetime
- 1999-11-04 AT AT02075838T patent/ATE257817T1/de not_active IP Right Cessation
- 1999-11-04 ES ES02075837T patent/ES2213731T3/es not_active Expired - Lifetime
- 1999-11-04 PT PT99953994T patent/PT1127871E/pt unknown
- 1999-11-04 AT AT02075837T patent/ATE257837T1/de not_active IP Right Cessation
- 1999-11-04 CZ CZ20011500A patent/CZ20011500A3/cs unknown
- 1999-11-04 IL IL14259299A patent/IL142592A0/xx unknown
- 1999-11-04 HU HU0104218A patent/HUP0104218A3/hu unknown
- 1999-11-04 DE DE69914229T patent/DE69914229T2/de not_active Expired - Fee Related
- 1999-11-04 EA EA200100476A patent/EA003742B1/ru not_active IP Right Cessation
- 1999-11-04 BR BR9915727-6A patent/BR9915727A/pt not_active IP Right Cessation
- 1999-11-04 DK DK02075838T patent/DK1219594T3/da active
- 1999-11-04 KR KR10-2001-7005667A patent/KR100453613B1/ko not_active IP Right Cessation
- 1999-11-04 EP EP99953994A patent/EP1127871B1/en not_active Expired - Lifetime
- 1999-11-04 TR TR2002/00416T patent/TR200200416T2/tr unknown
- 1999-11-04 AP APAP/P/2001/002161A patent/AP1222A/en active
- 1999-11-04 MX MXPA01004432A patent/MXPA01004432A/es unknown
- 1999-11-04 EP EP02075838A patent/EP1219594B1/en not_active Expired - Lifetime
- 1999-11-04 PT PT02075837T patent/PT1219623E/pt unknown
- 1999-11-04 SK SK584-2001A patent/SK284068B6/sk unknown
- 1999-11-04 US US09/831,177 patent/US6455585B1/en not_active Expired - Fee Related
- 1999-11-04 NZ NZ511739A patent/NZ511739A/xx unknown
- 1999-11-04 DK DK02075837T patent/DK1219623T3/da active
- 1999-11-04 YU YU29601A patent/YU29601A/sh unknown
- 1999-11-04 SI SI9930450T patent/SI1127871T1/xx unknown
- 1999-11-04 CN CNB998129259A patent/CN1176902C/zh not_active Expired - Fee Related
- 1999-11-04 DE DE69911235T patent/DE69911235T2/de not_active Expired - Fee Related
- 1999-11-04 PT PT02075838T patent/PT1219594E/pt unknown
- 1999-11-04 DK DK99953994T patent/DK1127871T3/da active
- 1999-11-04 SI SI9930541T patent/SI1219623T1/xx unknown
- 1999-11-04 SI SI9930540T patent/SI1219594T1/xx unknown
- 1999-11-04 ES ES02075838T patent/ES2213732T3/es not_active Expired - Lifetime
- 1999-11-04 AT AT99953994T patent/ATE249418T1/de not_active IP Right Cessation
- 1999-11-04 TR TR2002/00415T patent/TR200200415T2/tr unknown
- 1999-11-04 DE DE69914231T patent/DE69914231T2/de not_active Expired - Fee Related
- 1999-11-04 JP JP2000580979A patent/JP2002529442A/ja active Pending
- 1999-11-04 AU AU10473/00A patent/AU755681B2/en not_active Ceased
- 1999-11-04 CA CA002349245A patent/CA2349245A1/en not_active Abandoned
- 1999-11-04 ES ES99953994T patent/ES2207298T3/es not_active Expired - Lifetime
- 1999-11-04 TR TR2001/01160T patent/TR200101160T2/tr unknown
- 1999-11-04 PL PL99347492A patent/PL347492A1/xx unknown
-
2001
- 2001-05-03 IS IS5934A patent/IS5934A/is unknown
- 2001-05-04 NO NO20012234A patent/NO20012234L/no unknown
- 2001-05-07 CU CU2001010920010109A patent/CU23006A3/es unknown
- 2001-05-16 CR CR6368A patent/CR6368A/es not_active Application Discontinuation
- 2001-05-17 ZA ZA200104026A patent/ZA200104026B/en unknown
- 2001-05-23 MA MA26211A patent/MA26765A1/fr unknown
- 2001-05-29 HR HR20010412A patent/HRP20010412B1/xx not_active IP Right Cessation
- 2001-06-01 BG BG105556A patent/BG105556A/xx unknown
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