DE69914231D1 - Neuartige Ester abgeleitet von substituierten Phenyl-Zyklohexyl-Verbindungen - Google Patents

Neuartige Ester abgeleitet von substituierten Phenyl-Zyklohexyl-Verbindungen

Info

Publication number
DE69914231D1
DE69914231D1 DE69914231T DE69914231T DE69914231D1 DE 69914231 D1 DE69914231 D1 DE 69914231D1 DE 69914231 T DE69914231 T DE 69914231T DE 69914231 T DE69914231 T DE 69914231T DE 69914231 D1 DE69914231 D1 DE 69914231D1
Authority
DE
Germany
Prior art keywords
substituted phenyl
esters derived
novel esters
phenyl cyclohexyl
cyclohexyl compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69914231T
Other languages
English (en)
Other versions
DE69914231T2 (de
Inventor
Castillo Nieto Juan Carlos Del
Freixa Maria Chalaux
Clotet Joan Huguet
Mancini Marisabel Mourelle
Ramon Amat Elisabet De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Vita SA
Original Assignee
Laboratorios Vita SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Vita SA filed Critical Laboratorios Vita SA
Publication of DE69914231D1 publication Critical patent/DE69914231D1/de
Application granted granted Critical
Publication of DE69914231T2 publication Critical patent/DE69914231T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/40Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/44Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C219/30Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69914231T 1998-11-06 1999-11-04 Neuartige Ester abgeleitet von substituierten Phenyl-Zyklohexyl-Verbindungen Expired - Fee Related DE69914231T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009802329A ES2141688B1 (es) 1998-11-06 1998-11-06 Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos.
ES9802329 1998-11-06

Publications (2)

Publication Number Publication Date
DE69914231D1 true DE69914231D1 (de) 2004-02-19
DE69914231T2 DE69914231T2 (de) 2004-11-11

Family

ID=8305698

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69911235T Expired - Fee Related DE69911235T2 (de) 1998-11-06 1999-11-04 Neuartige ester abgeleitet von substituierten phenyl-cyclohexyl-verbindungen
DE69914231T Expired - Fee Related DE69914231T2 (de) 1998-11-06 1999-11-04 Neuartige Ester abgeleitet von substituierten Phenyl-Zyklohexyl-Verbindungen
DE69914229T Expired - Fee Related DE69914229T2 (de) 1998-11-06 1999-11-04 Neuartige Ester abgeleitet von substituierten Phenyl-Zyklohexyl-Verbindungen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69911235T Expired - Fee Related DE69911235T2 (de) 1998-11-06 1999-11-04 Neuartige ester abgeleitet von substituierten phenyl-cyclohexyl-verbindungen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69914229T Expired - Fee Related DE69914229T2 (de) 1998-11-06 1999-11-04 Neuartige Ester abgeleitet von substituierten Phenyl-Zyklohexyl-Verbindungen

Country Status (39)

Country Link
US (1) US6455585B1 (de)
EP (3) EP1127871B1 (de)
JP (1) JP2002529442A (de)
KR (1) KR100453613B1 (de)
CN (1) CN1176902C (de)
AP (1) AP1222A (de)
AT (3) ATE257837T1 (de)
AU (1) AU755681B2 (de)
BG (1) BG105556A (de)
BR (1) BR9915727A (de)
CA (1) CA2349245A1 (de)
CR (1) CR6368A (de)
CU (1) CU23006A3 (de)
CZ (1) CZ20011500A3 (de)
DE (3) DE69911235T2 (de)
DK (3) DK1219594T3 (de)
EA (1) EA003742B1 (de)
EE (1) EE200100246A (de)
ES (4) ES2141688B1 (de)
GE (1) GEP20033116B (de)
HR (1) HRP20010412B1 (de)
HU (1) HUP0104218A3 (de)
ID (1) ID29017A (de)
IL (1) IL142592A0 (de)
IS (1) IS5934A (de)
MA (1) MA26765A1 (de)
MX (1) MXPA01004432A (de)
NO (1) NO20012234D0 (de)
NZ (1) NZ511739A (de)
OA (1) OA11672A (de)
PL (1) PL347492A1 (de)
PT (3) PT1219623E (de)
SI (3) SI1219623T1 (de)
SK (1) SK284068B6 (de)
TR (3) TR200101160T2 (de)
UA (1) UA59477C2 (de)
WO (1) WO2000027799A1 (de)
YU (1) YU29601A (de)
ZA (1) ZA200104026B (de)

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ES2160534B1 (es) * 1999-12-30 2002-04-16 Vita Invest Sa Nuevos esteres derivados de (rr,ss)-2-hidroxibenzoato de 3-(2-dimetilaminometil-1-hidroxiciclohexil) fenilo.
DE10049483A1 (de) * 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte 1-Aminobutan-3-ol-Derivate
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
WO2004026291A1 (fr) * 2002-08-28 2004-04-01 Shuyi Zhang Formulations orales d'ibuprofene et de tramadol, methodes de preparation de ces dernieres
ES2819854T3 (es) 2002-11-22 2021-04-19 Gruenenthal Gmbh Uso de (1R,2R)-3-(3-dimetilamino-1-etil-2-metil-propil)-fenol para tratar el dolor inflamatorio
US20040248979A1 (en) * 2003-06-03 2004-12-09 Dynogen Pharmaceuticals, Inc. Method of treating lower urinary tract disorders
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE102004032051A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102004034619A1 (de) * 2004-07-16 2006-02-23 Grünenthal GmbH Substituierte Aminoverbindungen als 5-HT/NA Uptakehemmer
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
US8383152B2 (en) 2008-01-25 2013-02-26 Gruenenthal Gmbh Pharmaceutical dosage form
HUE030803T2 (en) 2008-05-09 2017-06-28 Gruenenthal Gmbh Process for the preparation of an intermediate powder formulation and a final solid dosage form using a spraying step \ t
AR077420A1 (es) 2009-07-22 2011-08-24 Gruenenthal Gmbh Forma de dosificacion resistente a la manipulacion para opiaceos sensibles a la oxidacion
EP2456427B1 (de) 2009-07-22 2015-03-04 Grünenthal GmbH Heißschmelzextrudierte retardierte pharmazeutische Darreichungsform
EP2383255A1 (de) * 2010-04-28 2011-11-02 Lacer, S.A. Neue Verbindungen, deren Synthese und Verwendung bei der Schmerzbehandlung
JP5933553B2 (ja) 2010-09-02 2016-06-15 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング アニオン性ポリマーを含む不正使用抵抗性剤形
ES2486791T3 (es) 2010-09-02 2014-08-19 Grünenthal GmbH Forma de dosificación resistente a la manipulación que comprende una sal inorgánica
WO2012100423A1 (en) * 2011-01-27 2012-08-02 Eli Lilly And Company Analgesic compounds, methods, and formulations
EP2530072A1 (de) 2011-06-03 2012-12-05 Lacer, S.A. Neue Verbindungen, deren Synthese und Verwendung bei der Schmerzbehandlung
US10702485B2 (en) 2011-07-09 2020-07-07 Syntrix Biosystems Inc. Compositions and methods for overcoming resistance to tramadol
LT2736495T (lt) 2011-07-29 2017-11-10 Grünenthal GmbH Sugadinimui atspari tabletė, pasižyminti greitu vaisto atpalaidavimu
RS56527B1 (sr) 2011-07-29 2018-02-28 Gruenenthal Gmbh Tableta za trenutno oslobađanje leka rezistentna na zloupotrebu
CA2864949A1 (en) 2012-02-28 2013-09-06 Grunenthal Gmbh Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
EP2838512B1 (de) 2012-04-18 2018-08-22 Grünenthal GmbH Fälschungssichere und dose dumping sichere pharmazeutische darreichungsform
US9339484B2 (en) * 2012-05-10 2016-05-17 Cellix Bio Private Limited Compositions and methods for the treatment of restless leg syndrome and fibromyalgia
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
JP6466417B2 (ja) 2013-05-29 2019-02-06 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 二峰性放出プロファイルを有する改変防止(tamper−resistant)剤形
MX371432B (es) 2013-05-29 2020-01-30 Gruenenthal Gmbh Forma de dosificacion resistente al uso indebido que contiene una o mas particulas.
MX368846B (es) 2013-07-12 2019-10-18 Gruenenthal Gmbh Forma de dosificación resistente a la alteración que contiene polímero de acetato de etilen-vinilo.
EP3073994A1 (de) 2013-11-26 2016-10-05 Grünenthal GmbH Herstellung einer pulverförmigen pharmazeutischen zusammensetzung mittels kryogenen mahlens
EP3142646A1 (de) 2014-05-12 2017-03-22 Grünenthal GmbH Manipulationssichere kapselformulierung mit tapentadol mit unmittelbarer freisetzung
EA035434B1 (ru) 2015-04-24 2020-06-15 Грюненталь Гмбх Защищенная от применения не по назначению лекарственная форма с немедленным высвобождением и устойчивостью к экстракции растворителями
JP2018526414A (ja) 2015-09-10 2018-09-13 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 乱用抑止性の即放性製剤を用いた経口過剰摂取に対する保護

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DE1199764B (de) * 1963-04-02 1965-09-02 Gruenenthal Chemie Verfahren zur Herstellung von basisch substituierten Phenolaethern
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
DE19525137C2 (de) * 1995-07-11 2003-02-27 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe
DE19609847A1 (de) * 1996-03-13 1997-09-18 Gruenenthal Gmbh Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe

Also Published As

Publication number Publication date
HRP20010412B1 (en) 2004-04-30
CU23006A3 (es) 2004-12-17
IS5934A (is) 2001-05-03
HRP20010412A2 (en) 2002-12-31
TR200200416T2 (tr) 2003-01-21
BR9915727A (pt) 2001-09-04
NZ511739A (en) 2002-11-26
DK1127871T3 (da) 2003-11-24
HUP0104218A2 (hu) 2002-03-28
ZA200104026B (en) 2002-05-17
YU29601A (sh) 2003-04-30
NO20012234L (no) 2001-05-04
TR200200415T2 (tr) 2002-06-21
SK5842001A3 (en) 2001-12-03
TR200101160T2 (tr) 2002-01-21
EP1127871A1 (de) 2001-08-29
ES2213731T3 (es) 2004-09-01
EP1219623A1 (de) 2002-07-03
PT1219623E (pt) 2004-04-30
DE69914231T2 (de) 2004-11-11
ATE257817T1 (de) 2004-01-15
GEP20033116B (en) 2003-11-25
UA59477C2 (uk) 2003-09-15
EP1127871B1 (de) 2003-09-10
PT1127871E (pt) 2003-12-31
NO20012234D0 (no) 2001-05-04
DE69911235D1 (de) 2003-10-16
DE69914229D1 (de) 2004-02-19
ES2213732T3 (es) 2004-09-01
AP1222A (en) 2003-11-06
CA2349245A1 (en) 2000-05-18
HUP0104218A3 (en) 2002-11-28
DE69911235T2 (de) 2004-07-01
EP1219623B1 (de) 2004-01-14
EA200100476A1 (ru) 2002-02-28
EP1219594B1 (de) 2004-01-14
PT1219594E (pt) 2004-04-30
CR6368A (es) 2002-04-08
DE69914229T2 (de) 2004-12-09
AU1047300A (en) 2000-05-29
AU755681B2 (en) 2002-12-19
JP2002529442A (ja) 2002-09-10
BG105556A (en) 2001-12-29
US6455585B1 (en) 2002-09-24
ES2141688B1 (es) 2001-02-01
IL142592A0 (en) 2002-03-10
EP1219594A1 (de) 2002-07-03
ID29017A (id) 2001-07-26
CN1325377A (zh) 2001-12-05
DK1219594T3 (da) 2004-04-19
CN1176902C (zh) 2004-11-24
SI1219623T1 (en) 2004-06-30
ATE257837T1 (de) 2004-01-15
KR100453613B1 (ko) 2004-10-20
ATE249418T1 (de) 2003-09-15
WO2000027799A1 (es) 2000-05-18
MXPA01004432A (es) 2002-09-18
SK284068B6 (sk) 2004-09-08
ES2141688A1 (es) 2000-05-16
CZ20011500A3 (cs) 2001-09-12
KR20010080942A (ko) 2001-08-25
DK1219623T3 (da) 2004-04-19
EE200100246A (et) 2002-12-16
EA003742B1 (ru) 2003-08-28
SI1219594T1 (en) 2004-06-30
SI1127871T1 (en) 2004-02-29
PL347492A1 (en) 2002-04-08
ES2207298T3 (es) 2004-05-16
OA11672A (en) 2005-01-12
MA26765A1 (fr) 2004-12-20

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