IL142592A0 - New esters derived from substituted phenyl-cyclohexyl compounds - Google Patents

New esters derived from substituted phenyl-cyclohexyl compounds

Info

Publication number
IL142592A0
IL142592A0 IL14259299A IL14259299A IL142592A0 IL 142592 A0 IL142592 A0 IL 142592A0 IL 14259299 A IL14259299 A IL 14259299A IL 14259299 A IL14259299 A IL 14259299A IL 142592 A0 IL142592 A0 IL 142592A0
Authority
IL
Israel
Prior art keywords
substituted phenyl
esters derived
new esters
cyclohexyl compounds
cyclohexyl
Prior art date
Application number
IL14259299A
Other languages
English (en)
Original Assignee
Vita Invest Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vita Invest Sa filed Critical Vita Invest Sa
Publication of IL142592A0 publication Critical patent/IL142592A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/40Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/44Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C219/30Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL14259299A 1998-11-06 1999-11-04 New esters derived from substituted phenyl-cyclohexyl compounds IL142592A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009802329A ES2141688B1 (es) 1998-11-06 1998-11-06 Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos.
PCT/ES1999/000352 WO2000027799A1 (es) 1998-11-06 1999-11-04 Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos

Publications (1)

Publication Number Publication Date
IL142592A0 true IL142592A0 (en) 2002-03-10

Family

ID=8305698

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14259299A IL142592A0 (en) 1998-11-06 1999-11-04 New esters derived from substituted phenyl-cyclohexyl compounds

Country Status (39)

Country Link
US (1) US6455585B1 (xx)
EP (3) EP1219594B1 (xx)
JP (1) JP2002529442A (xx)
KR (1) KR100453613B1 (xx)
CN (1) CN1176902C (xx)
AP (1) AP1222A (xx)
AT (3) ATE249418T1 (xx)
AU (1) AU755681B2 (xx)
BG (1) BG105556A (xx)
BR (1) BR9915727A (xx)
CA (1) CA2349245A1 (xx)
CR (1) CR6368A (xx)
CU (1) CU23006A3 (xx)
CZ (1) CZ20011500A3 (xx)
DE (3) DE69911235T2 (xx)
DK (3) DK1127871T3 (xx)
EA (1) EA003742B1 (xx)
EE (1) EE200100246A (xx)
ES (4) ES2141688B1 (xx)
GE (1) GEP20033116B (xx)
HR (1) HRP20010412B1 (xx)
HU (1) HUP0104218A3 (xx)
ID (1) ID29017A (xx)
IL (1) IL142592A0 (xx)
IS (1) IS5934A (xx)
MA (1) MA26765A1 (xx)
MX (1) MXPA01004432A (xx)
NO (1) NO20012234D0 (xx)
NZ (1) NZ511739A (xx)
OA (1) OA11672A (xx)
PL (1) PL347492A1 (xx)
PT (3) PT1219594E (xx)
SI (3) SI1127871T1 (xx)
SK (1) SK284068B6 (xx)
TR (3) TR200200415T2 (xx)
UA (1) UA59477C2 (xx)
WO (1) WO2000027799A1 (xx)
YU (1) YU29601A (xx)
ZA (1) ZA200104026B (xx)

Families Citing this family (39)

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ES2160534B1 (es) * 1999-12-30 2002-04-16 Vita Invest Sa Nuevos esteres derivados de (rr,ss)-2-hidroxibenzoato de 3-(2-dimetilaminometil-1-hidroxiciclohexil) fenilo.
DE10049483A1 (de) * 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte 1-Aminobutan-3-ol-Derivate
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
WO2004026291A1 (fr) * 2002-08-28 2004-04-01 Shuyi Zhang Formulations orales d'ibuprofene et de tramadol, methodes de preparation de ces dernieres
PT1562567T (pt) 2002-11-22 2017-08-24 Gruenenthal Gmbh Combinação de analgésicos selecionados e inibidores da cox-ii
US20040248979A1 (en) * 2003-06-03 2004-12-09 Dynogen Pharmaceuticals, Inc. Method of treating lower urinary tract disorders
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
DE102004032051A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102004034619A1 (de) * 2004-07-16 2006-02-23 Grünenthal GmbH Substituierte Aminoverbindungen als 5-HT/NA Uptakehemmer
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
EP2249811A1 (en) 2008-01-25 2010-11-17 Grünenthal GmbH Pharmaceutical dosage form
CA2723438C (en) 2008-05-09 2016-10-11 Gruenenthal Gmbh Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step
WO2011009602A1 (en) 2009-07-22 2011-01-27 Grünenthal GmbH Hot-melt extruded controlled release dosage form
BR112012001244A2 (pt) 2009-07-22 2020-12-08 Gruünenthal Gmbh Forma de dosagem resitente à adulteração, seu processo de produção, e embalagem contendo tal forma
EP2383255A1 (en) * 2010-04-28 2011-11-02 Lacer, S.A. New compounds, synthesis and use thereof in the treatment of pain
RU2604676C2 (ru) 2010-09-02 2016-12-10 Грюненталь Гмбх Устойчивая к разрушению лекарственная форма, содержащая неорганическую соль
AR082862A1 (es) 2010-09-02 2013-01-16 Gruenenthal Gmbh Forma de dosificacion resistente a alteracion que comprende un polimero anionico
WO2012100423A1 (en) 2011-01-27 2012-08-02 Eli Lilly And Company Analgesic compounds, methods, and formulations
EP2530072A1 (en) 2011-06-03 2012-12-05 Lacer, S.A. New compounds, synthesis and use thereof in the treatment of pain
US10702485B2 (en) 2011-07-09 2020-07-07 Syntrix Biosystems Inc. Compositions and methods for overcoming resistance to tramadol
PT2736497T (pt) 2011-07-29 2017-11-30 Gruenenthal Gmbh Comprimido resistente a adulteração proporcionando libertação imediata de fármaco
BR112014002022A2 (pt) 2011-07-29 2017-02-21 Gruenenthal Gmbh comprimido resistente à violação proporcionando liberação de fármaco imediata
CA2864949A1 (en) 2012-02-28 2013-09-06 Grunenthal Gmbh Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
ES2692944T3 (es) 2012-04-18 2018-12-05 Grünenthal GmbH Forma de dosificación farmacéutica resistente a la manipulación y resistente a la descarga rápida de la dosis
WO2013168005A2 (en) * 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of restless leg syndrome and fibromyalgia
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
MX2015016254A (es) 2013-05-29 2016-04-20 Gruenenthal Gmbh Forma de dosificacion resistente al uso indebido con perfil de liberacion bimodal.
MX371432B (es) 2013-05-29 2020-01-30 Gruenenthal Gmbh Forma de dosificacion resistente al uso indebido que contiene una o mas particulas.
US10624862B2 (en) 2013-07-12 2020-04-21 Grünenthal GmbH Tamper-resistant dosage form containing ethylene-vinyl acetate polymer
CN105934241B (zh) 2013-11-26 2020-06-05 格吕伦塔尔有限公司 通过低温研磨制备粉末状药物组合物
WO2015173195A1 (en) 2014-05-12 2015-11-19 Grünenthal GmbH Tamper resistant immediate release capsule formulation comprising tapentadol
CN107889459A (zh) 2015-04-24 2018-04-06 格吕伦塔尔有限公司 具有立即释放和对溶剂萃取的抗性的抗篡改剂型
US10842750B2 (en) 2015-09-10 2020-11-24 Grünenthal GmbH Protecting oral overdose with abuse deterrent immediate release formulations

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1199764B (de) * 1963-04-02 1965-09-02 Gruenenthal Chemie Verfahren zur Herstellung von basisch substituierten Phenolaethern
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
DE19525137C2 (de) * 1995-07-11 2003-02-27 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe
DE19609847A1 (de) * 1996-03-13 1997-09-18 Gruenenthal Gmbh Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe

Also Published As

Publication number Publication date
AU1047300A (en) 2000-05-29
EP1219594A1 (en) 2002-07-03
EP1219623B1 (en) 2004-01-14
CN1325377A (zh) 2001-12-05
ES2207298T3 (es) 2004-05-16
MXPA01004432A (es) 2002-09-18
CN1176902C (zh) 2004-11-24
HUP0104218A3 (en) 2002-11-28
TR200200416T2 (tr) 2003-01-21
HRP20010412B1 (en) 2004-04-30
SK284068B6 (sk) 2004-09-08
ZA200104026B (en) 2002-05-17
ATE249418T1 (de) 2003-09-15
JP2002529442A (ja) 2002-09-10
PT1127871E (pt) 2003-12-31
PL347492A1 (en) 2002-04-08
PT1219594E (pt) 2004-04-30
BR9915727A (pt) 2001-09-04
DE69914231T2 (de) 2004-11-11
BG105556A (en) 2001-12-29
EP1219623A1 (en) 2002-07-03
KR100453613B1 (ko) 2004-10-20
SI1127871T1 (en) 2004-02-29
IS5934A (is) 2001-05-03
TR200101160T2 (tr) 2002-01-21
WO2000027799A1 (es) 2000-05-18
EP1127871B1 (en) 2003-09-10
CU23006A3 (es) 2004-12-17
EA200100476A1 (ru) 2002-02-28
AP1222A (en) 2003-11-06
CR6368A (es) 2002-04-08
CA2349245A1 (en) 2000-05-18
US6455585B1 (en) 2002-09-24
DE69914229T2 (de) 2004-12-09
HUP0104218A2 (hu) 2002-03-28
HRP20010412A2 (en) 2002-12-31
DE69911235D1 (de) 2003-10-16
TR200200415T2 (tr) 2002-06-21
DE69914229D1 (de) 2004-02-19
SI1219623T1 (en) 2004-06-30
ES2213731T3 (es) 2004-09-01
EA003742B1 (ru) 2003-08-28
UA59477C2 (uk) 2003-09-15
NO20012234L (no) 2001-05-04
ATE257837T1 (de) 2004-01-15
ATE257817T1 (de) 2004-01-15
ES2141688B1 (es) 2001-02-01
MA26765A1 (fr) 2004-12-20
AU755681B2 (en) 2002-12-19
SI1219594T1 (en) 2004-06-30
NO20012234D0 (no) 2001-05-04
EP1127871A1 (en) 2001-08-29
DE69914231D1 (de) 2004-02-19
DE69911235T2 (de) 2004-07-01
ES2213732T3 (es) 2004-09-01
KR20010080942A (ko) 2001-08-25
SK5842001A3 (en) 2001-12-03
PT1219623E (pt) 2004-04-30
ID29017A (id) 2001-07-26
EP1219594B1 (en) 2004-01-14
ES2141688A1 (es) 2000-05-16
GEP20033116B (en) 2003-11-25
DK1219623T3 (da) 2004-04-19
EE200100246A (et) 2002-12-16
CZ20011500A3 (cs) 2001-09-12
DK1219594T3 (da) 2004-04-19
DK1127871T3 (da) 2003-11-24
OA11672A (en) 2005-01-12
YU29601A (sh) 2003-04-30
NZ511739A (en) 2002-11-26

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