SI1219594T1 - New esters derived from substituted phenyl-cyclohexyl compounds - Google Patents

New esters derived from substituted phenyl-cyclohexyl compounds

Info

Publication number
SI1219594T1
SI1219594T1 SI9930540T SI9930540T SI1219594T1 SI 1219594 T1 SI1219594 T1 SI 1219594T1 SI 9930540 T SI9930540 T SI 9930540T SI 9930540 T SI9930540 T SI 9930540T SI 1219594 T1 SI1219594 T1 SI 1219594T1
Authority
SI
Slovenia
Prior art keywords
substituted phenyl
esters derived
new esters
cyclohexyl compounds
cyclohexyl
Prior art date
Application number
SI9930540T
Other languages
English (en)
Slovenian (sl)
Inventor
Castillo Nieto Juan Carlos Del
Freixa Maria Chalaux
Clotet Joan Huguet
Mancini Marisabel Mourelle
Ramon Amat Elisabet De
Original Assignee
Laboratorios Vita, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Vita, S.A. filed Critical Laboratorios Vita, S.A.
Publication of SI1219594T1 publication Critical patent/SI1219594T1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/40Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/44Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C219/30Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SI9930540T 1998-11-06 1999-11-04 New esters derived from substituted phenyl-cyclohexyl compounds SI1219594T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009802329A ES2141688B1 (es) 1998-11-06 1998-11-06 Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos.
PCT/ES1999/000352 WO2000027799A1 (es) 1998-11-06 1999-11-04 Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos

Publications (1)

Publication Number Publication Date
SI1219594T1 true SI1219594T1 (en) 2004-06-30

Family

ID=8305698

Family Applications (3)

Application Number Title Priority Date Filing Date
SI9930450T SI1127871T1 (en) 1998-11-06 1999-11-04 New esters derived from substituted phenyl-cyclohexyl compounds
SI9930541T SI1219623T1 (en) 1998-11-06 1999-11-04 New esters derived from substituted phenyl-cyclohexyl compounds
SI9930540T SI1219594T1 (en) 1998-11-06 1999-11-04 New esters derived from substituted phenyl-cyclohexyl compounds

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SI9930450T SI1127871T1 (en) 1998-11-06 1999-11-04 New esters derived from substituted phenyl-cyclohexyl compounds
SI9930541T SI1219623T1 (en) 1998-11-06 1999-11-04 New esters derived from substituted phenyl-cyclohexyl compounds

Country Status (39)

Country Link
US (1) US6455585B1 (xx)
EP (3) EP1219594B1 (xx)
JP (1) JP2002529442A (xx)
KR (1) KR100453613B1 (xx)
CN (1) CN1176902C (xx)
AP (1) AP1222A (xx)
AT (3) ATE257837T1 (xx)
AU (1) AU755681B2 (xx)
BG (1) BG105556A (xx)
BR (1) BR9915727A (xx)
CA (1) CA2349245A1 (xx)
CR (1) CR6368A (xx)
CU (1) CU23006A3 (xx)
CZ (1) CZ20011500A3 (xx)
DE (3) DE69914229T2 (xx)
DK (3) DK1219594T3 (xx)
EA (1) EA003742B1 (xx)
EE (1) EE200100246A (xx)
ES (4) ES2141688B1 (xx)
GE (1) GEP20033116B (xx)
HR (1) HRP20010412B1 (xx)
HU (1) HUP0104218A3 (xx)
ID (1) ID29017A (xx)
IL (1) IL142592A0 (xx)
IS (1) IS5934A (xx)
MA (1) MA26765A1 (xx)
MX (1) MXPA01004432A (xx)
NO (1) NO20012234L (xx)
NZ (1) NZ511739A (xx)
OA (1) OA11672A (xx)
PL (1) PL347492A1 (xx)
PT (3) PT1219594E (xx)
SI (3) SI1127871T1 (xx)
SK (1) SK284068B6 (xx)
TR (3) TR200101160T2 (xx)
UA (1) UA59477C2 (xx)
WO (1) WO2000027799A1 (xx)
YU (1) YU29601A (xx)
ZA (1) ZA200104026B (xx)

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DE10049483A1 (de) * 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte 1-Aminobutan-3-ol-Derivate
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
WO2004026291A1 (fr) * 2002-08-28 2004-04-01 Shuyi Zhang Formulations orales d'ibuprofene et de tramadol, methodes de preparation de ces dernieres
EP1685829B1 (de) 2002-11-22 2008-04-09 Grünenthal GmbH Verwendung von (1RS,3RS,6RS)-6-dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexan-1,3-diol zur Behandlung von Entzündungsschmerz
US20040248979A1 (en) * 2003-06-03 2004-12-09 Dynogen Pharmaceuticals, Inc. Method of treating lower urinary tract disorders
DE102004032051A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102004034619A1 (de) * 2004-07-16 2006-02-23 Grünenthal GmbH Substituierte Aminoverbindungen als 5-HT/NA Uptakehemmer
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
TWI454288B (zh) 2008-01-25 2014-10-01 Gruenenthal Chemie 藥物劑型
PT2273983T (pt) 2008-05-09 2016-10-28 Gruenenthal Gmbh Processo para a preparação de uma formulação em pó intermediária e uma forma de dosagem sólida final sob utilização de uma etapa de congelamento por atomização
ES2560210T3 (es) 2009-07-22 2016-02-17 Grünenthal GmbH Forma de dosificación resistente a la manipulación para opiádes sensibles a la oxidación
CN102573805A (zh) 2009-07-22 2012-07-11 格吕伦塔尔有限公司 热熔挤出的控制释放剂型
EP2383255A1 (en) 2010-04-28 2011-11-02 Lacer, S.A. New compounds, synthesis and use thereof in the treatment of pain
TWI516286B (zh) 2010-09-02 2016-01-11 歌林達股份有限公司 含陰離子聚合物之抗破碎劑型
RU2604676C2 (ru) 2010-09-02 2016-12-10 Грюненталь Гмбх Устойчивая к разрушению лекарственная форма, содержащая неорганическую соль
WO2012100423A1 (en) 2011-01-27 2012-08-02 Eli Lilly And Company Analgesic compounds, methods, and formulations
EP2530072A1 (en) 2011-06-03 2012-12-05 Lacer, S.A. New compounds, synthesis and use thereof in the treatment of pain
US10702485B2 (en) 2011-07-09 2020-07-07 Syntrix Biosystems Inc. Compositions and methods for overcoming resistance to tramadol
CN103857386A (zh) 2011-07-29 2014-06-11 格吕伦塔尔有限公司 提供药物立即释放的抗破碎片剂
LT2736495T (lt) 2011-07-29 2017-11-10 Grünenthal GmbH Sugadinimui atspari tabletė, pasižyminti greitu vaisto atpalaidavimu
JP6117249B2 (ja) 2012-02-28 2017-04-19 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 薬理学的に活性な化合物および陰イオン性ポリマーを含むタンパーレジスタント剤形
CA2868142A1 (en) 2012-04-18 2013-10-24 Grunenthal Gmbh Tamper resistant and dose-dumping resistant pharmaceutical dosage form
US9339484B2 (en) * 2012-05-10 2016-05-17 Cellix Bio Private Limited Compositions and methods for the treatment of restless leg syndrome and fibromyalgia
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
JP6445537B2 (ja) 2013-05-29 2018-12-26 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 1個または複数の粒子を含有する改変防止(tamper−resistant)剤形
US9737490B2 (en) 2013-05-29 2017-08-22 Grünenthal GmbH Tamper resistant dosage form with bimodal release profile
CN105682643B (zh) 2013-07-12 2019-12-13 格吕伦塔尔有限公司 含有乙烯-醋酸乙烯酯聚合物的防篡改剂型
AU2014356581C1 (en) 2013-11-26 2020-05-28 Grunenthal Gmbh Preparation of a powdery pharmaceutical composition by means of cryo-milling
EP3142646A1 (en) 2014-05-12 2017-03-22 Grünenthal GmbH Tamper resistant immediate release capsule formulation comprising tapentadol
CN107889459A (zh) 2015-04-24 2018-04-06 格吕伦塔尔有限公司 具有立即释放和对溶剂萃取的抗性的抗篡改剂型
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DE1199764B (de) * 1963-04-02 1965-09-02 Gruenenthal Chemie Verfahren zur Herstellung von basisch substituierten Phenolaethern
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
DE19525137C2 (de) * 1995-07-11 2003-02-27 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe
DE19609847A1 (de) * 1996-03-13 1997-09-18 Gruenenthal Gmbh Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe

Also Published As

Publication number Publication date
EA003742B1 (ru) 2003-08-28
ES2141688A1 (es) 2000-05-16
AU1047300A (en) 2000-05-29
EP1219623A1 (en) 2002-07-03
DE69914229T2 (de) 2004-12-09
ES2213732T3 (es) 2004-09-01
JP2002529442A (ja) 2002-09-10
CN1325377A (zh) 2001-12-05
BG105556A (en) 2001-12-29
PL347492A1 (en) 2002-04-08
CN1176902C (zh) 2004-11-24
TR200200415T2 (tr) 2002-06-21
DK1219623T3 (da) 2004-04-19
EE200100246A (et) 2002-12-16
SI1127871T1 (en) 2004-02-29
SK284068B6 (sk) 2004-09-08
DE69911235T2 (de) 2004-07-01
DK1219594T3 (da) 2004-04-19
OA11672A (en) 2005-01-12
AP1222A (en) 2003-11-06
ZA200104026B (en) 2002-05-17
ES2207298T3 (es) 2004-05-16
HUP0104218A2 (hu) 2002-03-28
WO2000027799A1 (es) 2000-05-18
DK1127871T3 (da) 2003-11-24
TR200101160T2 (tr) 2002-01-21
DE69914231T2 (de) 2004-11-11
EA200100476A1 (ru) 2002-02-28
DE69914231D1 (de) 2004-02-19
US6455585B1 (en) 2002-09-24
AU755681B2 (en) 2002-12-19
IS5934A (is) 2001-05-03
EP1127871B1 (en) 2003-09-10
KR20010080942A (ko) 2001-08-25
EP1219594B1 (en) 2004-01-14
CU23006A3 (es) 2004-12-17
IL142592A0 (en) 2002-03-10
PT1219623E (pt) 2004-04-30
DE69914229D1 (de) 2004-02-19
ATE257837T1 (de) 2004-01-15
NO20012234D0 (no) 2001-05-04
PT1127871E (pt) 2003-12-31
CZ20011500A3 (cs) 2001-09-12
EP1219594A1 (en) 2002-07-03
SI1219623T1 (en) 2004-06-30
EP1219623B1 (en) 2004-01-14
YU29601A (sh) 2003-04-30
NZ511739A (en) 2002-11-26
UA59477C2 (uk) 2003-09-15
CR6368A (es) 2002-04-08
ES2141688B1 (es) 2001-02-01
HRP20010412A2 (en) 2002-12-31
PT1219594E (pt) 2004-04-30
ID29017A (id) 2001-07-26
ATE249418T1 (de) 2003-09-15
SK5842001A3 (en) 2001-12-03
BR9915727A (pt) 2001-09-04
HRP20010412B1 (en) 2004-04-30
HUP0104218A3 (en) 2002-11-28
ATE257817T1 (de) 2004-01-15
MXPA01004432A (es) 2002-09-18
DE69911235D1 (de) 2003-10-16
TR200200416T2 (tr) 2003-01-21
NO20012234L (no) 2001-05-04
EP1127871A1 (en) 2001-08-29
GEP20033116B (en) 2003-11-25
KR100453613B1 (ko) 2004-10-20
MA26765A1 (fr) 2004-12-20
ES2213731T3 (es) 2004-09-01
CA2349245A1 (en) 2000-05-18

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