TR199902606T2 - Farnesil transferazi engelleyici kinazolinonlar. - Google Patents

Farnesil transferazi engelleyici kinazolinonlar.

Info

Publication number
TR199902606T2
TR199902606T2 TR1999/02606T TR9902606T TR199902606T2 TR 199902606 T2 TR199902606 T2 TR 199902606T2 TR 1999/02606 T TR1999/02606 T TR 1999/02606T TR 9902606 T TR9902606 T TR 9902606T TR 199902606 T2 TR199902606 T2 TR 199902606T2
Authority
TR
Turkey
Prior art keywords
farnesyl transferase
quinazolinones
transferase inhibitor
compounds
medicament
Prior art date
Application number
TR1999/02606T
Other languages
English (en)
Inventor
Rene Angibaud Patrick
Gaton Venet Marc
Jean Edgard Freyne Eddy
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of TR199902606T2 publication Critical patent/TR199902606T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms
    • C07D239/82—Oxygen atoms with an aryl radical attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Cosmetics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Bu bulus, farnesil transferazi engelleyici etkinlige sahip olan (I) formülünün bilesiklerine, bu bilesiklerin farmasötik açidan kabul edilebilir asit ilave tuzlarina ve bu bilesiklerin stereokimyasal açidan izomerik biçimlerine, bunlarin hazirlanmasina, bunlari ihtiva eden bilesimlere ve bunlarin bir tibbi madde olarak kullanimina iliskindir.
TR1999/02606T 1997-04-25 1998-04-17 Farnesil transferazi engelleyici kinazolinonlar. TR199902606T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97201259 1997-04-25

Publications (1)

Publication Number Publication Date
TR199902606T2 true TR199902606T2 (tr) 2000-07-21

Family

ID=8228267

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/02606T TR199902606T2 (tr) 1997-04-25 1998-04-17 Farnesil transferazi engelleyici kinazolinonlar.

Country Status (22)

Country Link
US (2) US6177432B1 (tr)
EP (1) EP0977750B1 (tr)
JP (1) JP4308919B2 (tr)
KR (1) KR100520401B1 (tr)
CN (1) CN1094937C (tr)
AT (1) ATE366250T1 (tr)
AU (1) AU738628B2 (tr)
BR (1) BR9809398A (tr)
CA (1) CA2288140C (tr)
CZ (1) CZ296959B6 (tr)
DE (1) DE69838025T2 (tr)
ES (1) ES2289783T3 (tr)
HU (1) HUP0001122A3 (tr)
IL (1) IL130363A (tr)
NO (1) NO317576B1 (tr)
NZ (1) NZ336233A (tr)
PL (1) PL190944B1 (tr)
RU (1) RU2205831C2 (tr)
SK (1) SK146199A3 (tr)
TR (1) TR199902606T2 (tr)
WO (1) WO1998049157A1 (tr)
ZA (1) ZA983504B (tr)

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WO2000034437A2 (en) 1998-12-08 2000-06-15 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
ES2200591T3 (es) 1998-12-23 2004-03-01 Janssen Pharmaceutica N.V. Derivados de 1,2-quinolina anelados.
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ATE323474T1 (de) * 2000-02-04 2006-05-15 Janssen Pharmaceutica Nv Farnesyl protein transferase inhibitoren zur behandlung von brustkrebs
DE60130976T2 (de) 2000-02-24 2008-07-17 Janssen Pharmaceutica N.V. Dosierschema enthaldend farnesyl protein transferase inhibitoren für die behandlung von krebs
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DE60118225T2 (de) * 2000-09-25 2007-05-03 Janssen Pharmaceutica N.V. Chinolin- und chinazolinderivate und deren verwendung als farnesyl transferase inhibitoren
ATE434615T1 (de) * 2000-11-21 2009-07-15 Janssen Pharmaceutica Nv Farnesyltransferase hemmende benzoheterocyclische derivate
AU2002218311A1 (en) * 2000-11-28 2002-06-11 Janssen Pharmaceutica N.V. Farnesyl protein transferase inhibitors for the treatment of inflammatory bowel disease
DE60117847T2 (de) * 2000-12-27 2006-11-16 Janssen Pharmaceutica N.V. Farnesyltransferase hemmende, in der 4-stellung substituierte chinolin- und chinazolinderivate
ATE415161T1 (de) * 2001-02-15 2008-12-15 Janssen Pharmaceutica Nv Farnesyl-protein-transferase hemmer in kombination mit antiöstrogenen
CN1246318C (zh) * 2001-03-12 2006-03-22 詹森药业有限公司 咪唑化合物的制备方法
US20020177575A1 (en) * 2001-05-04 2002-11-28 Ward Wakeland Identification of farnesyl-protein transferase as a target for systemic lupus erythematosus therapies
CA2469275C (en) * 2001-12-19 2011-09-06 Janssen Pharmaceutica N.V. 1,8-annelated quinoline derivatives substituted with carbon-linked triazoles as farnesyl transferase inhibitors
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Also Published As

Publication number Publication date
CA2288140C (en) 2007-04-03
KR20000069560A (ko) 2000-11-25
SK146199A3 (en) 2000-06-12
AU738628B2 (en) 2001-09-20
ATE366250T1 (de) 2007-07-15
BR9809398A (pt) 2000-06-13
CN1094937C (zh) 2002-11-27
RU2205831C2 (ru) 2003-06-10
PL336468A1 (en) 2000-06-19
PL190944B1 (pl) 2006-02-28
EP0977750A1 (en) 2000-02-09
IL130363A0 (en) 2000-06-01
DE69838025T2 (de) 2008-05-08
NZ336233A (en) 2001-01-26
HUP0001122A2 (hu) 2001-04-28
ZA983504B (en) 1999-10-25
IL130363A (en) 2002-08-14
JP4308919B2 (ja) 2009-08-05
CN1252800A (zh) 2000-05-10
US6358961B1 (en) 2002-03-19
CZ296959B6 (cs) 2006-08-16
AU7646098A (en) 1998-11-24
NO995169L (no) 1999-12-27
NO317576B1 (no) 2004-11-15
JP2001522364A (ja) 2001-11-13
CA2288140A1 (en) 1998-11-05
EP0977750B1 (en) 2007-07-04
DE69838025D1 (de) 2007-08-16
NO995169D0 (no) 1999-10-22
KR100520401B1 (ko) 2005-10-12
US6177432B1 (en) 2001-01-23
HUP0001122A3 (en) 2002-03-28
ES2289783T3 (es) 2008-02-01
WO1998049157A1 (en) 1998-11-05
CZ371799A3 (cs) 2000-02-16

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