DE69838025D1 - Chinazolinone die farnesyltransferase hemmen - Google Patents

Chinazolinone die farnesyltransferase hemmen

Info

Publication number
DE69838025D1
DE69838025D1 DE69838025T DE69838025T DE69838025D1 DE 69838025 D1 DE69838025 D1 DE 69838025D1 DE 69838025 T DE69838025 T DE 69838025T DE 69838025 T DE69838025 T DE 69838025T DE 69838025 D1 DE69838025 D1 DE 69838025D1
Authority
DE
Germany
Prior art keywords
chinazolinone
hemmen
farnesyltransferase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69838025T
Other languages
English (en)
Other versions
DE69838025T2 (de
Inventor
Patrick Rene Janssen Angibaud
Marc Gaston Janss Venet
Eddy Jean Freyne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP97201259 priority Critical
Priority to EP97201259 priority
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Priority to PCT/EP1998/002357 priority patent/WO1998049157A1/en
Publication of DE69838025D1 publication Critical patent/DE69838025D1/de
Application granted granted Critical
Publication of DE69838025T2 publication Critical patent/DE69838025T2/de
Anticipated expiration legal-status Critical
Application status is Expired - Lifetime legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/78Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80Oxygen atoms
    • C07D239/82Oxygen atoms with an aryl radical attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
DE69838025T 1997-04-25 1998-04-17 Chinazolinone die farnesyltransferase hemmen Expired - Lifetime DE69838025T2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP97201259 1997-04-25
EP97201259 1997-04-25
PCT/EP1998/002357 WO1998049157A1 (en) 1997-04-25 1998-04-17 Farnesyltransferase inhibiting quinazolinones

Publications (2)

Publication Number Publication Date
DE69838025D1 true DE69838025D1 (de) 2007-08-16
DE69838025T2 DE69838025T2 (de) 2008-05-08

Family

ID=8228267

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69838025T Expired - Lifetime DE69838025T2 (de) 1997-04-25 1998-04-17 Chinazolinone die farnesyltransferase hemmen

Country Status (22)

Country Link
US (2) US6177432B1 (de)
EP (1) EP0977750B1 (de)
JP (1) JP4308919B2 (de)
KR (1) KR100520401B1 (de)
CN (1) CN1094937C (de)
AT (1) AT366250T (de)
AU (1) AU738628B2 (de)
BR (1) BR9809398A (de)
CA (1) CA2288140C (de)
CZ (1) CZ296959B6 (de)
DE (1) DE69838025T2 (de)
ES (1) ES2289783T3 (de)
HU (1) HU0001122A3 (de)
IL (1) IL130363A (de)
NO (1) NO317576B1 (de)
NZ (1) NZ336233A (de)
PL (1) PL190944B1 (de)
RU (1) RU2205831C2 (de)
SK (1) SK146199A3 (de)
TR (1) TR199902606T2 (de)
WO (1) WO1998049157A1 (de)
ZA (1) ZA9803504B (de)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100520401B1 (ko) * 1997-04-25 2005-10-12 얀센 파마슈티카 엔.브이. 파네실 트랜스퍼라제 억제작용을 갖는 퀴나졸리논
JP4491136B2 (ja) 1998-07-06 2010-06-30 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプJanssen Pharmaceutica Naamloze Vennootschap 関節症を治療するためのファルネシルタンパク質トランスフェラーゼ阻害剤
US6284755B1 (en) 1998-12-08 2001-09-04 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
WO2000034239A2 (en) 1998-12-08 2000-06-15 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
ID29241A (id) * 1998-12-23 2001-08-16 Janssen Pharmaceutica Nv Turunan-turunan kinolin teranelasi-1,2
AU3372601A (en) * 2000-02-04 2001-08-14 Janssen Pharmaceutica Nv Farnesyl protein transferase inhibitors for treating breast cancer
DE60130976T2 (de) 2000-02-24 2008-07-17 Janssen Pharmaceutica N.V. Dosierschema enthaldend farnesyl protein transferase inhibitoren für die behandlung von krebs
JP2003525239A (ja) * 2000-02-29 2003-08-26 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ タキサン化合物とのファルネシルタンパク質トランスフェラーゼ阻害剤の組み合わせ剤
CA2397448A1 (en) * 2000-02-29 2001-09-07 Janssen Pharmaceutica N.V. Farnesyl protein transferase inhibitor combinations with further anti-cancer agents
AU3927501A (en) * 2000-02-29 2001-09-12 Janssen Pharmaceutica Nv Farnesyl protein transferase inhibitor combinations with anti-tumor podophyllotoxin derivatives
EP1261356A2 (de) * 2000-02-29 2002-12-04 Janssen Pharmaceutica N.V. Kombination von farnesyl proteintransferase inhibitoren mit einer platin-koordinationsverbindung
EP1267872A2 (de) * 2000-02-29 2003-01-02 Janssen Pharmaceutica N.V. Kombination von farnesyl proteintransferase inhibitoren mit antitumor wirksamen anthracyclinderivaten
WO2001064217A2 (en) * 2000-02-29 2001-09-07 Janssen Pharmaceutica N.V. Combinations of a farnesyl protein transferase inhibitor with nitrogen mustard or nitrosourea alkylating agents
AU5616601A (en) * 2000-02-29 2001-09-12 Janssen Pharmaceutica Nv Farnesyl protein transferase inhibitor combinations with anti-tumor nucleoside derivatives
EP1267929A2 (de) * 2000-02-29 2003-01-02 Janssen Pharmaceutica N.V. Kombination von farnesyl-protein-transferase-inhibitor mit her2-antikorper
EP1261341A2 (de) * 2000-02-29 2002-12-04 Janssen Pharmaceutica N.V. Kombination von farnesyl proteintransferase inhibitoren mit camptothecin-derivaten
CA2397694A1 (en) * 2000-02-29 2001-09-07 Janssen Pharmaceutica Inc. Farnesyl protein transferase inhibitor combinations
CA2397475A1 (en) * 2000-02-29 2001-09-07 Janssen Pharmaceutica N.V. Farnesyl protein transferase inhibitor combinations with vinca alkaloids
JO2361B1 (en) * 2000-06-22 2006-12-12 جانسين فارماسيوتيكا ان. في Farnesyl transferase inhibiting 1-2 annelated quinoline enantiomer
ES2261476T3 (es) * 2000-09-25 2006-11-16 Janssen Pharmaceutica N.V. Derivados de quinolina y quinazolina que inhiben la farnesil-tranferasa como inhibidores de farnesil-tranferasa.
AU9382901A (en) 2000-09-25 2002-04-02 Janssen Pharmaceutica Nv Farnesyl transferase inhibiting 6-((substituted phenyl)methyl)-quinoline and quinazoline derivatives
JP4974439B2 (ja) * 2000-09-25 2012-07-11 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプJanssen Pharmaceutica Naamloze Vennootschap ファルネシルトランスフェラーゼを阻害する6−ヘテロシクリルメチルキノリノン誘導体
EP1322650B1 (de) 2000-09-25 2008-09-24 Janssen Pharmaceutica N.V. Farnesyl transferase-hemmende 6-heterocyclylmethyl-chinolin und chinazol-derivate
EP1339709B1 (de) * 2000-11-21 2009-06-24 Janssen Pharmaceutica N.V. Farnesyltransferase hemmende benzoheterocyclische derivate
AU1831102A (en) * 2000-11-28 2002-06-11 Janssen Pharmaceutica Nv Farnesyl protein transferase inhibitors for the treatment of inflammatory bowel disease
WO2002051835A1 (en) * 2000-12-27 2002-07-04 Janssen Pharmaceutica N.V. Farnesyl transferase inhibiting 4-substituted quinoline and quinazoline derivatives
ES2318000T3 (es) * 2001-02-15 2009-05-01 Janssen Pharmaceutica Nv Combinaciones de inhibidores de la farnesil-protein-transferasa con agentes antiestrogenos.
AU2002253101B2 (en) 2001-03-12 2007-08-09 Janssen Pharmaceutica N.V. Process for the preparation of imidazole compounds
US20020177575A1 (en) * 2001-05-04 2002-11-28 Ward Wakeland Identification of farnesyl-protein transferase as a target for systemic lupus erythematosus therapies
US7408063B2 (en) 2001-12-19 2008-08-05 Janssen Pharmaceutica, N.V. 1,8-annelated quinoline derivatives substituted with carbon-linked triazoles as farnesyl transferase inhibitors
FR2837201A1 (fr) * 2002-03-18 2003-09-19 Servier Lab Nouveaux composes derives de la quinazoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA2478813C (en) 2002-03-22 2011-10-18 Janssen Pharmaceutica N.V. Benzylimidazolyl substituted 2-quinoline and quinazoline derivatives for use as farnesyl transferase inhibitors
WO2003087101A1 (en) 2002-04-15 2003-10-23 Janssen Pharmaceutica N.V. Farnesyl transferase inhibiting tricyclic quinazoline derivatives substituted with carbon-linked imidazoles or triazoles
US20030125268A1 (en) * 2002-08-28 2003-07-03 Rybak Mary Ellen Margaret Farnesyl protein transferase inhibitor combinations with anti-tumor anthracycline derivatives
WO2005089518A2 (en) * 2004-03-18 2005-09-29 The Brigham And Women's Hospital, Inc. Uch-l1 expression and cancer therapy
EP1744751A4 (de) * 2004-03-18 2010-03-10 Brigham & Womens Hospital Verfahren zur behandlung von synucleinopathien
CA2559282A1 (en) * 2004-03-18 2005-09-29 Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies
CA2559221A1 (en) * 2004-03-18 2005-09-29 Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies
US20070293539A1 (en) * 2004-03-18 2007-12-20 Lansbury Peter T Methods for the treatment of synucleinopathies
WO2005089515A2 (en) * 2004-03-18 2005-09-29 The Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies
EP1655289A1 (de) * 2004-11-04 2006-05-10 Embl Quinazoline Derivate, Prozess zu deren Herstellung , deren Verwendung als Antimitotika sowie diese beinhaltende pharmazeutische Zusammensetzunegen
ES2403060T3 (es) 2004-11-05 2013-05-13 Janssen Pharmaceutica Nv Uso terapéutico de inhibidores de la farnesiltransferasa y métodos de control de la eficacia de los mismos.
US20060194821A1 (en) * 2005-02-18 2006-08-31 The Brigham And Women's Hospital, Inc. Compounds inhibiting the aggregation of superoxide dismutase-1
BRPI0609962A2 (pt) 2005-04-19 2011-10-11 Smithkline Beechman Cork Ltd composição farmacêutica oral, e, método para tratar um distúrbio em um mamìfero
US20060281788A1 (en) 2005-06-10 2006-12-14 Baumann Christian A Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor
WO2007075923A2 (en) 2005-12-23 2007-07-05 Link Medicine Corporation Treatment of synucleinopathies
US8697716B2 (en) 2006-04-20 2014-04-15 Janssen Pharmaceutica Nv Method of inhibiting C-KIT kinase
PL2021335T3 (pl) 2006-04-20 2011-10-31 Janssen Pharmaceutica Nv Związki heterocykliczne jako inhibitory kinazy C-FMS
ES2566772T3 (es) 2006-04-20 2016-04-15 Janssen Pharmaceutica, N.V. Inhibidores de la quinasa c-fms
CA2663161C (en) 2006-09-11 2014-10-28 N.V. Organon Quinazolinone and isoquinolinone acetamide derivatives
JO3240B1 (ar) 2007-10-17 2018-03-08 Janssen Pharmaceutica Nv c-fms مثبطات كيناز
US8232402B2 (en) * 2008-03-12 2012-07-31 Link Medicine Corporation Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
US7932036B1 (en) 2008-03-12 2011-04-26 Veridex, Llc Methods of determining acute myeloid leukemia response to treatment with farnesyltransferase
US20100331363A1 (en) * 2008-11-13 2010-12-30 Link Medicine Corporation Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
EP2370436A1 (de) * 2008-11-13 2011-10-05 Link Medicine Corporation Azachinolinonderivate und deren verwendungen
US20110060005A1 (en) * 2008-11-13 2011-03-10 Link Medicine Corporation Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
US8431576B2 (en) * 2009-06-25 2013-04-30 Alkermes Pharma Ireland Limited Heterocyclic compounds for the treatment of neurological and psychological disorders
AU2011282614B2 (en) 2010-07-28 2015-11-26 Veridex, Llc Methods of determining Acute Myeloid Leukemia response to treatment with farnesyltransferase inhibitors
JOP20180012A1 (ar) 2012-08-07 2019-01-30 Janssen Pharmaceutica Nv عملية السلفنة باستخدام نونافلوروبوتانيسولفونيل فلوريد
EP2882757B1 (de) 2012-08-07 2016-10-05 Janssen Pharmaceutica, N.V. Verfahren zur herstellung heterocyclischer esterderivate
CN103275085B (zh) * 2013-05-30 2015-04-08 温州大学 一种喹唑啉并喹唑啉酮化合物及其合成方法和用途
CN108371711A (zh) 2015-08-17 2018-08-07 库拉肿瘤学公司 使用法尼基转移酶抑制剂治疗癌症患者的方法
AR110031A1 (es) 2016-11-03 2019-02-13 Kura Oncology Inc Métodos de tratamiento de pacientes con cáncer con inhibidores de farnesiltransferasa
WO2019113269A1 (en) 2017-12-08 2019-06-13 Kura Oncology, Inc. Methods of treating cancer patients with farnesyltransferase inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2002864C (en) 1988-11-29 1999-11-16 Eddy J. E. Freyne (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives
EP0664128A4 (de) * 1992-10-07 1997-12-17 Sumitomo Pharma Pharmazeutisches mittel zur hemmung der tumornekrosefaktorproduktion.
TW321649B (de) * 1994-11-12 1997-12-01 Zeneca Ltd
KR100520401B1 (ko) * 1997-04-25 2005-10-12 얀센 파마슈티카 엔.브이. 파네실 트랜스퍼라제 억제작용을 갖는 퀴나졸리논

Also Published As

Publication number Publication date
IL130363A (en) 2002-08-14
NO317576B1 (no) 2004-11-15
CA2288140A1 (en) 1998-11-05
HU0001122A3 (en) 2002-03-28
KR20000069560A (ko) 2000-11-25
AT366250T (de) 2007-07-15
NO995169L (no) 1999-12-27
PL336468A1 (en) 2000-06-19
WO1998049157A1 (en) 1998-11-05
US6177432B1 (en) 2001-01-23
BR9809398A (pt) 2000-06-13
JP4308919B2 (ja) 2009-08-05
RU2205831C2 (ru) 2003-06-10
PL190944B1 (xx) 2006-02-28
IL130363D0 (en) 2000-06-01
SK146199A3 (en) 2000-06-12
CZ371799A3 (cs) 2000-02-16
DE69838025T2 (de) 2008-05-08
AU7646098A (en) 1998-11-24
KR100520401B1 (ko) 2005-10-12
ZA9803504B (en) 1999-10-25
CA2288140C (en) 2007-04-03
ES2289783T3 (es) 2008-02-01
HU0001122A2 (hu) 2001-04-28
CN1094937C (zh) 2002-11-27
JP2001522364A (ja) 2001-11-13
NO995169D0 (no) 1999-10-22
US6358961B1 (en) 2002-03-19
EP0977750B1 (de) 2007-07-04
AU738628B2 (en) 2001-09-20
CN1252800A (zh) 2000-05-10
CZ296959B6 (cs) 2006-08-16
EP0977750A1 (de) 2000-02-09
TR199902606T2 (xx) 2000-07-21
NZ336233A (en) 2001-01-26

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