TR199802269T2 - Endotelin reseptör antagonistleri olarak faydali indol türevleri. - Google Patents

Endotelin reseptör antagonistleri olarak faydali indol türevleri.

Info

Publication number
TR199802269T2
TR199802269T2 TR1998/02269T TR9802269T TR199802269T2 TR 199802269 T2 TR199802269 T2 TR 199802269T2 TR 1998/02269 T TR1998/02269 T TR 1998/02269T TR 9802269 T TR9802269 T TR 9802269T TR 199802269 T2 TR199802269 T2 TR 199802269T2
Authority
TR
Turkey
Prior art keywords
receptor antagonists
indole derivatives
endothelin receptor
derivatives useful
useful
Prior art date
Application number
TR1998/02269T
Other languages
English (en)
Inventor
James Rawson David
Neil Dack Kevin
Peter Dickinson Roger
James Kim
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of TR199802269T2 publication Critical patent/TR199802269T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Formül (I)'in bilesimleri ve onlarin farmasötik olarak kabul edilebilir türevleri restenosis, böbrek yetmezligi ve pulmonal hipertansiyonun tedavisinde faydalidir.
TR1998/02269T 1996-05-09 1997-04-11 Endotelin reseptör antagonistleri olarak faydali indol türevleri. TR199802269T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9609641.7A GB9609641D0 (en) 1996-05-09 1996-05-09 Compounds useful in therapy

Publications (1)

Publication Number Publication Date
TR199802269T2 true TR199802269T2 (tr) 2001-12-21

Family

ID=10793387

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1998/02269T TR199802269T2 (tr) 1996-05-09 1997-04-11 Endotelin reseptör antagonistleri olarak faydali indol türevleri.

Country Status (43)

Country Link
US (4) US6017945A (tr)
EP (1) EP0901470B1 (tr)
JP (1) JP3245179B2 (tr)
KR (1) KR100331217B1 (tr)
CN (1) CN1124262C (tr)
AP (1) AP830A (tr)
AR (1) AR007030A1 (tr)
AT (1) ATE263151T1 (tr)
AU (1) AU717849B2 (tr)
BG (1) BG102873A (tr)
BR (1) BR9709072A (tr)
CA (1) CA2253876A1 (tr)
CO (1) CO4650036A1 (tr)
CZ (1) CZ292928B6 (tr)
DE (1) DE69728392T2 (tr)
DK (1) DK0901470T3 (tr)
DZ (1) DZ2227A1 (tr)
EA (1) EA001471B1 (tr)
ES (1) ES2218675T3 (tr)
GB (1) GB9609641D0 (tr)
HK (1) HK1019149A1 (tr)
HN (1) HN1997000058A (tr)
HR (1) HRP970249B1 (tr)
HU (1) HUP9901245A3 (tr)
ID (1) ID16878A (tr)
IL (1) IL125903A0 (tr)
IS (1) IS1856B (tr)
MA (1) MA26428A1 (tr)
NO (1) NO312547B1 (tr)
NZ (1) NZ332640A (tr)
OA (1) OA10896A (tr)
PE (1) PE65098A1 (tr)
PL (1) PL329725A1 (tr)
PT (1) PT901470E (tr)
SI (1) SI0901470T1 (tr)
SK (1) SK150398A3 (tr)
TN (1) TNSN97078A1 (tr)
TR (1) TR199802269T2 (tr)
TW (1) TW491838B (tr)
UA (1) UA50767C2 (tr)
UY (1) UY24546A1 (tr)
WO (1) WO1997043260A1 (tr)
ZA (1) ZA973963B (tr)

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GB9722287D0 (en) 1997-10-22 1997-12-17 Pfizer Ltd Compounds useful in therapy
HU228964B1 (en) 1999-02-10 2013-07-29 Astrazeneca Ab Quinazoline derivatives as angiogenesis inhibitors, process for their preparation and medicaments containing them
GB0016162D0 (en) * 2000-06-30 2000-08-23 Cancer Res Campaign Tech Indole-3-acetic acid derivatives
US20050203166A1 (en) * 2000-06-30 2005-09-15 Cancer Research Technology Limited Indole-3-acetic acid derivatives
TWI224101B (en) 2001-06-20 2004-11-21 Wyeth Corp Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)
PT1397130E (pt) 2001-06-20 2007-11-13 Wyeth Corp Derivados ácidos de indole substituído como inibidores de inibidor 1 do activador de plasminogénio (pai-1)
AR037097A1 (es) 2001-10-05 2004-10-20 Novartis Ag Compuestos acilsulfonamidas, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento
DE60327550D1 (de) 2002-12-10 2009-06-18 Wyeth Corp Substituierte indoloxoacetylaminoessigsäurederivate als inhibitoren des plasminogenaktivatorinhibitors-1 (pai-1)
UA80453C2 (en) 2002-12-10 2007-09-25 Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1)
US7348351B2 (en) 2002-12-10 2008-03-25 Wyeth Substituted 3-alkyl and 3-arylalkyl 1H-indol-1yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
AU2003296324A1 (en) 2002-12-10 2004-06-30 Wyeth Aryl, aryloxy, and alkyloxy substituted 1h-indol-3-yl glyoxylic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
DK1569900T3 (da) 2002-12-10 2006-10-23 Wyeth Corp Substituerede 3-carbonyl-1-yl-eddikesyrederivater som inhibitorer af plasminogenaktivator-inhibitor-1 (PAI-1)
JP2007500253A (ja) * 2003-01-22 2007-01-11 イーライ リリー アンド カンパニー ステロイドホルモン核内受容体のインドール誘導体モジュレーター
US7446201B2 (en) 2003-09-25 2008-11-04 Wyeth Substituted heteroaryl benzofuran acids
US7351726B2 (en) 2003-09-25 2008-04-01 Wyeth Substituted oxadiazolidinediones
US7442805B2 (en) 2003-09-25 2008-10-28 Wyeth Substituted sulfonamide-indoles
US7342039B2 (en) 2003-09-25 2008-03-11 Wyeth Substituted indole oximes
US7420083B2 (en) 2003-09-25 2008-09-02 Wyeth Substituted aryloximes
US7582773B2 (en) 2003-09-25 2009-09-01 Wyeth Substituted phenyl indoles
US7268159B2 (en) 2003-09-25 2007-09-11 Wyeth Substituted indoles
US7411083B2 (en) 2003-09-25 2008-08-12 Wyeth Substituted acetic acid derivatives
US7163954B2 (en) 2003-09-25 2007-01-16 Wyeth Substituted naphthyl benzothiophene acids
US7265148B2 (en) 2003-09-25 2007-09-04 Wyeth Substituted pyrrole-indoles
US7141592B2 (en) 2003-09-25 2006-11-28 Wyeth Substituted oxadiazolidinediones
US7332521B2 (en) 2003-09-25 2008-02-19 Wyeth Substituted indoles
JP2005109006A (ja) * 2003-09-29 2005-04-21 Tdk Corp 高電圧貫通型コンデンサ及びマグネトロン
HN2004000536A (es) * 2003-12-16 2009-02-18 Wyeth Corp Un procediemiento de sintesis para la alquilacion reductiva de la posicon c-3 de indoles
BRPI0514544A (pt) 2004-08-23 2008-06-17 Wyeth Corp ácidos de oxazol-naftila como moduladores de inibidor tipo-1 de ativador de plasminogênio (pai-1)
US7683091B2 (en) 2005-08-17 2010-03-23 Wyeth Substituted indoles and methods of their use
CA2641952C (en) * 2006-04-13 2011-02-01 Actelion Pharmaceuticals Ltd Treatment of early stage idiopathic pulmonary fibrosis
DE102008030206A1 (de) 2008-06-25 2009-12-31 Bayer Schering Pharma Aktiengesellschaft 3-Cyanoalky- und 3-Hydroxyalkyl-Indole und ihre Verwendung
DE102008030207A1 (de) 2008-06-25 2009-12-31 Bayer Schering Pharma Aktiengesellschaft Substituierte 7-Sulfanylmethyl-, 7-Sulfinylmethyl- und 7-Sulfonylmethyl-Indole und ihre Verwendung
CN106674065A (zh) * 2016-12-07 2017-05-17 贵州大学 一种5‑卤代‑2‑烷氧基‑4‑甲苯磺酰氯制备方法
GB201817038D0 (en) * 2018-10-19 2018-12-05 Inflazome Ltd Novel processes
KR20210134689A (ko) 2019-02-27 2021-11-10 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 뇌 장애를 치료하기 위한 아제피노-인돌 및 다른 헤테로사이클

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GB9317096D0 (en) * 1993-08-17 1993-09-29 Pfizer Ltd Indoles

Also Published As

Publication number Publication date
CZ358298A3 (cs) 1999-08-11
IS4838A (is) 1998-08-28
HK1019149A1 (en) 2000-01-14
IL125903A0 (en) 1999-04-11
US6384070B2 (en) 2002-05-07
DZ2227A1 (fr) 2002-12-25
CZ292928B6 (cs) 2004-01-14
BR9709072A (pt) 1999-08-03
TW491838B (en) 2002-06-21
UY24546A1 (es) 2000-09-29
NO985225D0 (no) 1998-11-09
MA26428A1 (fr) 2004-12-20
AP830A (en) 2000-05-03
NO985225L (no) 1998-11-09
PE65098A1 (es) 1998-10-29
DE69728392T2 (de) 2005-01-13
US6136843A (en) 2000-10-24
IS1856B (is) 2003-02-21
CA2253876A1 (en) 1997-11-20
HN1997000058A (es) 1997-06-26
CN1216531A (zh) 1999-05-12
HUP9901245A2 (hu) 1999-08-30
OA10896A (en) 2001-10-11
AP9700982A0 (en) 1997-07-31
UA50767C2 (uk) 2002-11-15
EP0901470B1 (en) 2004-03-31
AR007030A1 (es) 1999-10-13
HRP970249A2 (en) 1998-06-30
ES2218675T3 (es) 2004-11-16
KR20000010879A (ko) 2000-02-25
US6017945A (en) 2000-01-25
NO312547B1 (no) 2002-05-27
JP3245179B2 (ja) 2002-01-07
ID16878A (id) 1997-11-20
US20010014677A1 (en) 2001-08-16
GB9609641D0 (en) 1996-07-10
ATE263151T1 (de) 2004-04-15
JPH11508285A (ja) 1999-07-21
KR100331217B1 (ko) 2002-05-09
PT901470E (pt) 2004-07-30
NZ332640A (en) 2001-03-30
DE69728392D1 (de) 2004-05-06
CN1124262C (zh) 2003-10-15
PL329725A1 (en) 1999-04-12
AU2697897A (en) 1997-12-05
WO1997043260A1 (en) 1997-11-20
SK150398A3 (en) 1999-03-12
HRP970249B1 (en) 2003-06-30
DK0901470T3 (da) 2004-07-12
SI0901470T1 (en) 2004-08-31
BG102873A (en) 1999-11-30
HUP9901245A3 (en) 2002-01-28
CO4650036A1 (es) 1998-09-03
EA199800908A1 (ru) 1999-06-24
EP0901470A1 (en) 1999-03-17
US6306852B1 (en) 2001-10-23
AU717849B2 (en) 2000-04-06
ZA973963B (en) 1998-11-09
TNSN97078A1 (fr) 2005-03-15
EA001471B1 (ru) 2001-04-23

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