SU1436875A3 - Способ получени производных силибинина - Google Patents

Способ получени производных силибинина Download PDF

Info

Publication number
SU1436875A3
SU1436875A3 SU853985401A SU3985401A SU1436875A3 SU 1436875 A3 SU1436875 A3 SU 1436875A3 SU 853985401 A SU853985401 A SU 853985401A SU 3985401 A SU3985401 A SU 3985401A SU 1436875 A3 SU1436875 A3 SU 1436875A3
Authority
SU
USSR - Soviet Union
Prior art keywords
silibinin
animals
ethyl acetate
burns
ethanol
Prior art date
Application number
SU853985401A
Other languages
English (en)
Russian (ru)
Inventor
Браатц Райнхард
Герлер Клаус
Хальбах Гюнтер
Зойке Хартвиг
Шмидт Карлхайнц
Original Assignee
Др.Мадаус Унд Ко (Фирма)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Др.Мадаус Унд Ко (Фирма) filed Critical Др.Мадаус Унд Ко (Фирма)
Application granted granted Critical
Publication of SU1436875A3 publication Critical patent/SU1436875A3/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Silicon Compounds (AREA)
SU853985401A 1984-11-22 1985-11-21 Способ получени производных силибинина SU1436875A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843442639 DE3442639A1 (de) 1984-11-22 1984-11-22 Flavolignanderivate, verfahren zu deren herstellung und arzneimittel, die diese verbindungen enthalten

Publications (1)

Publication Number Publication Date
SU1436875A3 true SU1436875A3 (ru) 1988-11-07

Family

ID=6250903

Family Applications (1)

Application Number Title Priority Date Filing Date
SU853985401A SU1436875A3 (ru) 1984-11-22 1985-11-21 Способ получени производных силибинина

Country Status (29)

Country Link
JP (1) JPS61143377A (enrdf_load_stackoverflow)
KR (1) KR870001020B1 (enrdf_load_stackoverflow)
AR (1) AR240931A1 (enrdf_load_stackoverflow)
AT (1) AT393268B (enrdf_load_stackoverflow)
BE (1) BE903693A (enrdf_load_stackoverflow)
CA (1) CA1337124C (enrdf_load_stackoverflow)
CH (1) CH659473A5 (enrdf_load_stackoverflow)
CS (1) CS273610B2 (enrdf_load_stackoverflow)
DD (1) DD259191A1 (enrdf_load_stackoverflow)
DE (1) DE3442639A1 (enrdf_load_stackoverflow)
DK (1) DK164865C (enrdf_load_stackoverflow)
EG (1) EG19424A (enrdf_load_stackoverflow)
ES (1) ES8609311A1 (enrdf_load_stackoverflow)
FI (1) FI84064C (enrdf_load_stackoverflow)
FR (1) FR2573427B1 (enrdf_load_stackoverflow)
GB (1) GB2167414B (enrdf_load_stackoverflow)
HU (1) HU195503B (enrdf_load_stackoverflow)
IE (1) IE58791B1 (enrdf_load_stackoverflow)
IT (1) IT1190426B (enrdf_load_stackoverflow)
LU (1) LU86163A1 (enrdf_load_stackoverflow)
MX (1) MX168415B (enrdf_load_stackoverflow)
NL (1) NL192387C (enrdf_load_stackoverflow)
NO (1) NO160205C (enrdf_load_stackoverflow)
PL (1) PL146890B1 (enrdf_load_stackoverflow)
PT (1) PT81532B (enrdf_load_stackoverflow)
SE (1) SE465676B (enrdf_load_stackoverflow)
SU (1) SU1436875A3 (enrdf_load_stackoverflow)
YU (1) YU43689B (enrdf_load_stackoverflow)
ZA (1) ZA858951B (enrdf_load_stackoverflow)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8716918D0 (en) * 1987-07-17 1987-08-26 Inverni Della Beffa Spa Soluble derivatives of silybin
US5262439A (en) * 1992-04-30 1993-11-16 The Regents Of The University Of California Soluble analogs of probucol
CN101137639B (zh) * 2005-03-11 2012-05-23 霍华德弗洛里生理医学实验研究所 类黄酮化合物及其用途
ES2374117T3 (es) * 2007-11-15 2012-02-13 Madaus Gmbh Componente de silibinina para el tratamiento de la hepatitis.
RU2482844C2 (ru) * 2007-11-15 2013-05-27 Мадаус Гмбх Силибининовый компонент для лечения гепатита
AU2010247716B2 (en) * 2009-05-14 2015-11-05 Madaus Gmbh Amorphous silibinin for the treatment of viral hepatitis
EP3409280B1 (en) 2012-07-05 2021-04-14 Nutramax Laboratories, Inc. Compositions comprising a sulforaphane and milk thistle extract or powder
CN103193768B (zh) * 2013-02-22 2016-03-30 西安安健药业有限公司 治疗肝病的水飞蓟宾二偏琥珀酸酯异构体
CN103113359B (zh) * 2013-02-22 2016-01-06 西安安健药业有限公司 水飞蓟宾二偏琥珀酸酯及其药用盐
CN103172622B (zh) * 2013-02-22 2015-11-04 西安安健药业有限公司 水飞蓟宾二偏琥珀酸酯的活性异构体

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1963318A1 (de) * 1969-12-17 1971-06-24 Schwabe Willmar Gmbh & Co Silybinhalbester der Bernsteinsaeure und der Phthalsaeure,ihre Salze mit pharmakologisch vertraglichen Basen,Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Arzneipraeparaten

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Патент DE № 1923082, кл.12 q 24, опублик. 1974. Вьшоженна за вка DE № 3225688, кл. С 07 D 407/02, опублик,02.02.84. Вейганд-Хильгентаг, Методы экспе ;-: римента в органической химии Хими . . *

Also Published As

Publication number Publication date
FI854535A7 (fi) 1986-05-23
PL146890B1 (en) 1989-03-31
SE465676B (sv) 1991-10-14
ZA858951B (en) 1986-08-27
NL192387C (nl) 1997-07-04
YU178685A (en) 1988-02-29
HUT40114A (en) 1986-11-28
FR2573427B1 (fr) 1989-03-10
IE852808L (en) 1986-05-22
DE3442639A1 (de) 1986-05-22
MX168415B (es) 1993-05-24
SE8505487D0 (sv) 1985-11-20
JPS61143377A (ja) 1986-07-01
AT393268B (de) 1991-09-25
FI84064C (fi) 1991-10-10
CA1337124C (en) 1995-09-26
LU86163A1 (de) 1986-03-24
NO160205C (no) 1989-03-22
FR2573427A1 (fr) 1986-05-23
EG19424A (en) 1995-02-28
AR240931A2 (es) 1991-03-27
NL192387B (nl) 1997-03-03
FI854535A0 (fi) 1985-11-18
ES8609311A1 (es) 1986-09-01
FI84064B (fi) 1991-06-28
PT81532B (pt) 1987-11-11
NL8503171A (nl) 1986-06-16
HU195503B (en) 1988-05-30
GB2167414A (en) 1986-05-29
DK537785A (da) 1986-05-23
NO854655L (no) 1986-05-23
PL256374A1 (en) 1986-12-02
GB8528226D0 (en) 1985-12-18
CS273610B2 (en) 1991-03-12
DE3442639C2 (enrdf_load_stackoverflow) 1989-08-10
DK537785D0 (da) 1985-11-21
BE903693A (fr) 1986-05-22
PT81532A (de) 1985-12-01
IE58791B1 (en) 1993-11-17
DK164865C (da) 1993-01-18
DK164865B (da) 1992-08-31
ES549116A0 (es) 1986-09-01
DD259191A1 (de) 1988-08-17
SE8505487L (sv) 1986-05-23
JPH0432073B2 (enrdf_load_stackoverflow) 1992-05-28
IT1190426B (it) 1988-02-16
GB2167414B (en) 1989-01-11
CS837885A2 (en) 1990-08-14
YU43689B (en) 1989-10-31
AR240931A1 (es) 1991-03-27
IT8522932A0 (it) 1985-11-21
KR870001020B1 (ko) 1987-05-23
CH659473A5 (de) 1987-01-30
ATA337185A (de) 1991-02-15
KR860004056A (ko) 1986-06-16
NO160205B (no) 1988-12-12

Similar Documents

Publication Publication Date Title
SU1436875A3 (ru) Способ получени производных силибинина
KR19990014987A (ko) 항암, 기관분화유도, 암세포전이 혈관형성억제, 항산화 및숙취해소 작용을 하는 옻나무 추출물, 이의 제조방법 및 이를 포함하는 조성물
RU2217130C2 (ru) Смесь первичных жирных кислот, получаемых из сахарно-тростникового воска
CA2372223A1 (en) Use of phyllanthus for targeted stimulation of the immune system
RU2383537C2 (ru) Применение тризамещенных бензопиранонов
CH629793A5 (fr) Procede de preparation de nouveaux derives de l'oxepane.
CN114173775A (zh) 防风草内酯的药物组合物及其用途
IE50062B1 (en) Pharmaceutical compositions containing climbing ivy extracts
JP3418724B2 (ja) セスキテルペノイド化合物及びそれを含む医薬
JP2004244367A (ja) リグノフェノール系誘導体を含有する哺乳動物細胞保護剤
RU2270686C2 (ru) Способ получения гепатопротекторного и гипохолестеринемического средства
SU740250A1 (ru) Способ получени нарингина
WO2001082941A1 (en) Composition for treatment of b-type hepatitis and liver cirrhosis
WO1991009595A1 (en) Anti-viral compositions
RU2178709C2 (ru) Способ получения вещества, обладающего иммуномодулирующей активностью
JP2734136B2 (ja) オクタデセン酸誘導体及びこれを有効成分とする子宮頚癌細胞の殺細胞剤
JP4010714B2 (ja) イリドイド誘導体とこれを有効成分とする抗炎症剤並びに自己免疫疾患剤
SI8511786A8 (sl) Postopek za pripravo derivatov silibinina
JPH11349526A (ja) 新規化合物又はその薬理上許容される塩並びにそれらを有効成分とする抗酸化剤
Yamaguchi et al. Toxic Substances in Cancer VI. Effect on the Movement of Paramecium of the Extract of Gastric Carcinoma Tissue (2 nd Report)
CN108047239A (zh) 一种化合物、制备方法及其在制备预防/治疗自身免疫性疾病药物中的应用
CN108084156A (zh) 一种化合物及其医药用途
FR2526789A2 (fr) Nouveaux derives d'acides phenyl aliphatique carboxyliques, procede pour leur preparation et leur application comme medicaments
WO2004113319A1 (ja) 新規クロメン化合物
HK1081195A1 (en) Compounds and mixture or compositions from mycelia of antrodia camphorata and use thereof