SU1031408A3 - Способ получени производных цефалоспорина или их солей с основани ми или их кислотно-аддитивных солей - Google Patents

Способ получени производных цефалоспорина или их солей с основани ми или их кислотно-аддитивных солей Download PDF

Info

Publication number
SU1031408A3
SU1031408A3 SU803219703A SU3219703A SU1031408A3 SU 1031408 A3 SU1031408 A3 SU 1031408A3 SU 803219703 A SU803219703 A SU 803219703A SU 3219703 A SU3219703 A SU 3219703A SU 1031408 A3 SU1031408 A3 SU 1031408A3
Authority
SU
USSR - Soviet Union
Prior art keywords
product
solution
reaction
nmr spectrum
mixture
Prior art date
Application number
SU803219703A
Other languages
English (en)
Russian (ru)
Inventor
Анри Жюнг Фредерик
Original Assignee
Иси Фарма (Фирма)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Иси Фарма (Фирма) filed Critical Иси Фарма (Фирма)
Application granted granted Critical
Publication of SU1031408A3 publication Critical patent/SU1031408A3/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/68—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Laminated Bodies (AREA)
  • Table Devices Or Equipment (AREA)
SU803219703A 1979-12-24 1980-12-23 Способ получени производных цефалоспорина или их солей с основани ми или их кислотно-аддитивных солей SU1031408A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7931616A FR2472574A1 (fr) 1979-12-24 1979-12-24 Derives de cephalosporine et composition pharmaceutique les contenant

Publications (1)

Publication Number Publication Date
SU1031408A3 true SU1031408A3 (ru) 1983-07-23

Family

ID=9233132

Family Applications (2)

Application Number Title Priority Date Filing Date
SU803219703A SU1031408A3 (ru) 1979-12-24 1980-12-23 Способ получени производных цефалоспорина или их солей с основани ми или их кислотно-аддитивных солей
SU813274748A SU1077573A3 (ru) 1979-12-24 1981-04-24 Способ получени производных цефалоспорина или их фармацевтически приемлемых солей с основани ми или кислотами

Family Applications After (1)

Application Number Title Priority Date Filing Date
SU813274748A SU1077573A3 (ru) 1979-12-24 1981-04-24 Способ получени производных цефалоспорина или их фармацевтически приемлемых солей с основани ми или кислотами

Country Status (27)

Country Link
US (1) US4463173A (enExample)
EP (1) EP0031708B1 (enExample)
JP (1) JPS56158787A (enExample)
AT (1) ATE7918T1 (enExample)
AU (1) AU544374B2 (enExample)
CA (1) CA1175805A (enExample)
CS (1) CS226025B2 (enExample)
DD (1) DD155520A5 (enExample)
DE (1) DE3068273D1 (enExample)
DK (1) DK552480A (enExample)
ES (2) ES8201167A1 (enExample)
FI (1) FI803817L (enExample)
FR (1) FR2472574A1 (enExample)
GR (1) GR71920B (enExample)
HU (1) HU186289B (enExample)
IL (1) IL61775A (enExample)
MW (1) MW5380A1 (enExample)
NO (1) NO803903L (enExample)
NZ (1) NZ195731A (enExample)
PH (1) PH21662A (enExample)
PL (2) PL133508B1 (enExample)
PT (1) PT72265B (enExample)
SU (2) SU1031408A3 (enExample)
YU (2) YU324680A (enExample)
ZA (1) ZA807710B (enExample)
ZM (1) ZM11380A1 (enExample)
ZW (1) ZW31280A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2496666A1 (fr) * 1980-12-22 1982-06-25 Ici Pharma Nouveaux derives de cephalosporine et composition pharmaceutique les contenant
FR2496665A1 (fr) * 1980-12-23 1982-06-25 Ici Pharma Nouveaux derives de penicilline et composition pharmaceutique les contenant
ZA824094B (en) * 1981-06-19 1983-07-27 Ici Plc A process for the manufacture of cephalosporin derivative
EP0071370A3 (en) * 1981-07-23 1984-05-16 Ici Pharma Cephalosporin derivatives, process for their preparation and pharmaceutical compositions containing them
US4504478A (en) * 1981-09-18 1985-03-12 Imperial Chemical Industries Plc Cephalosporin-1-oxide derivatives
EP0082648A3 (en) * 1981-12-21 1984-09-26 Imperial Chemical Industries Plc Cephalosporin derivatives
JPS59110695A (ja) * 1982-12-16 1984-06-26 Asahi Chem Ind Co Ltd 経口用セフアロスポリン
GR78718B (enExample) * 1983-01-31 1984-09-27 Ici Pharma
US4855420A (en) * 1983-06-03 1989-08-08 Ici Pharma Cephalosporin derivatives
GB8316589D0 (en) * 1983-06-17 1983-07-20 Ici Plc Crystalline salts
US4547573A (en) * 1983-12-02 1985-10-15 Ici Pharma Process for preparing cephalosporin derivatives
DK429986A (da) * 1985-09-09 1987-03-10 Otsuka Pharma Co Ltd 2-oxa-isocephemforbindelser
US4760140A (en) * 1986-10-20 1988-07-26 American Cyanamid Company 3-substituted-7-[5-substituted-2-thiazolyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylic acid, diphenylmethyl esters
US6476220B2 (en) * 2000-11-27 2002-11-05 Aurobindo Pharma Limited Process for the preparation of furaca
US20030135041A1 (en) 2002-01-04 2003-07-17 Orchid Chemicals & Pharmaceuticals Limited, India Synthesis of ceftiofur intermediate
CA2737694C (en) * 2008-09-26 2013-07-02 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
US9920014B2 (en) * 2013-09-19 2018-03-20 The Florida International University Board Of Trustees Selective inhibition of bacterial topoisomerase I

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2430375A1 (de) * 1973-06-26 1975-03-20 Leo Pharm Prod Ltd 7-amino-delta hoch 3 -cephem-4-carbonsaeure-derivate
US4358447A (en) * 1979-04-27 1982-11-09 Merck & Co., Inc. 7-N-Heterocyclyl cephalosporins
EP0018595B1 (en) * 1979-04-27 1986-08-20 Merck & Co. Inc. 7-n-heterocyclyl cephalosporins, a process for preparing and a pharmaceutical composition comprising the same
US4255424A (en) * 1979-04-27 1981-03-10 Merck & Co., Inc. 7-N-Heterocyclyl 1-oxa, 1-aza, and 1-carbadethiacephalosporins
US4282219A (en) * 1979-08-01 1981-08-04 Merck & Co., Inc. 7-N-Heterocyclyl cephalosporins and antibiotic pharmaceutical compositions containing them

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
1. Патент FR 2421907 кл. С 07 р 501/36, опублик. 02.11.79. 2. Патент ОНА 3917587, кл. 260-243 С, опублик. 1975. *

Also Published As

Publication number Publication date
NZ195731A (en) 1984-04-27
ES502352A0 (es) 1982-05-01
ZW31280A1 (en) 1981-09-29
IL61775A (en) 1984-08-31
NO803903L (no) 1981-06-25
HU186289B (en) 1985-07-29
AU6513480A (en) 1981-07-02
US4463173A (en) 1984-07-31
GR71920B (enExample) 1983-08-17
PL232847A1 (enExample) 1982-03-29
PL132587B1 (en) 1985-03-30
ES8204438A1 (es) 1982-05-01
ZA807710B (en) 1981-11-25
DK552480A (da) 1981-06-25
JPH0320398B2 (enExample) 1991-03-19
YU292682A (en) 1983-06-30
IL61775A0 (en) 1981-01-30
FI803817A7 (fi) 1981-06-25
EP0031708B1 (en) 1984-06-13
ATE7918T1 (de) 1984-06-15
FR2472574A1 (fr) 1981-07-03
PT72265B (en) 1981-11-05
FI803817L (fi) 1981-06-25
ZM11380A1 (en) 1982-10-21
SU1077573A3 (ru) 1984-02-29
AU544374B2 (en) 1985-05-23
JPS56158787A (en) 1981-12-07
PL133508B1 (en) 1985-06-29
PL228757A1 (enExample) 1982-01-04
CS226025B2 (en) 1984-03-19
EP0031708A3 (en) 1982-02-24
EP0031708A2 (en) 1981-07-08
ES498157A0 (es) 1981-12-01
YU324680A (en) 1983-04-30
MW5380A1 (en) 1982-09-08
PT72265A (en) 1981-01-01
DD155520A5 (de) 1982-06-16
PH21662A (en) 1988-01-13
DE3068273D1 (en) 1984-07-19
CA1175805A (en) 1984-10-09
ES8201167A1 (es) 1981-12-01

Similar Documents

Publication Publication Date Title
SU1031408A3 (ru) Способ получени производных цефалоспорина или их солей с основани ми или их кислотно-аддитивных солей
US3165531A (en) 13-substituted-6-deoxytetracyclines and process utilizing the same
SU1750420A3 (ru) Способ получени производных бензола
US4935507A (en) Crystalline 7-(2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4-carboxylic acid (syn isomer)
WO2019020102A1 (zh) 一种嘧啶酮并杂芳基类衍生物的制备方法及其中间体
BR112014012414B1 (pt) Processos para preparar 5-flúor-1h-pirazolopiridinas substituídas
CN105814053A (zh) 作为tnf活性调节剂的咪唑并吡啶衍生物
WO2023201802A1 (zh) 一种恩赛特韦的合成方法
SU676166A3 (ru) Способ получени цефалоспоринов или их солей
WO2023125896A1 (zh) 一种glp-1激动剂中间体及其制备方法及在医药中的用途
SU698532A3 (ru) Способ получени производных пиридо (1,2-а) пиримидина
SU847922A3 (ru) Способ получени - - -( -окси- -метил-НиКОТиНАМидО)- -( -ОКСифЕНил)АцЕТАМидО - -( -МЕТилТЕТРАзОл- -ил)ТиОМЕТил- -цЕфЕМ- -КАРбОНОВОй КиСлОТы
DE2730377A1 (de) 7-beta-(2-oxyimino-2-arylacetamido)- cephalosporine
EP0036636A1 (en) A method and intermediates for preparing 3,3'-azo-bis-(6-hydroxy benzoic acid)
JPH10512579A (ja) 新規の９Ｈ−ピリド［３，４−ｂ］インドール−誘導体
SU541429A3 (ru) Способ получени производных 3-алкил-4-сульфамоиланилина или их солей
SU799670A3 (ru) Способ получени производныхфузидОВОй КиСлОТы или EE СОлЕй
SU560530A3 (ru) Способ получени производных бис (бензамидо)бензойной кислоты
CN116730808A (zh) 头孢维星衍生物中间体的制备方法
SU541428A3 (ru) Способ получени простых гликолевых эфиров
DE2710490A1 (de) 7-acylamino-3-(5-sulfoalkyl-1,3,4- oxadiazol-2-ylthiomethyl)-3-cephem-4- carbonsaeuren, ihre salze, verfahren zu ihrer herstellung, zwischenprodukte und arzneimittel
JPS5826750B2 (ja) 新規なイミダゾ−ル誘導体
CN103936691A (zh) 一种制备2-氨基-5-取代-1,3,4-噻二唑的方法
CH630634A5 (de) Verfahren zur herstellung von 7-beta-(2-oxyimino-2-arylacetamido)-cephalosporine.
US4118491A (en) 7-Acyl-3-(sulfaminoalkyl substituted tetrazolylthiomethyl)cephalosporins, antibacterial compositions containing them and methods of treating bacterial infections with them