ES8201167A1 - Procedimiento para la obtencion de derivados de cefalospori-nas - Google Patents

Procedimiento para la obtencion de derivados de cefalospori-nas

Info

Publication number
ES8201167A1
ES8201167A1 ES498157A ES498157A ES8201167A1 ES 8201167 A1 ES8201167 A1 ES 8201167A1 ES 498157 A ES498157 A ES 498157A ES 498157 A ES498157 A ES 498157A ES 8201167 A1 ES8201167 A1 ES 8201167A1
Authority
ES
Spain
Prior art keywords
6alkyl
hydroxy
aromatic
carboxy
cyano
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES498157A
Other languages
English (en)
Other versions
ES498157A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca SAS
Original Assignee
ICI Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ICI Pharma SA filed Critical ICI Pharma SA
Publication of ES498157A0 publication Critical patent/ES498157A0/es
Publication of ES8201167A1 publication Critical patent/ES8201167A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/68—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Laminated Bodies (AREA)
  • Table Devices Or Equipment (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE CEFALOSPORINA Y DE SUS SALES DE ADICON DE ACIDO O DE ADICION DE BASES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R1 ES UN RADICAL C93 DE LAS DEFALOSPORINAS ANTIBACTERIANAS CONOCIDAS; R2 ES UN RADICAL CARBOXI O HETEROCICLICO CON HIDROGENO ACIDO, ! R3 Y A PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA DESPROTECCION DE COMPUESTOS DE FORMULA (I) QUE TIENEN GRUPOS PROTECTORES EN LUGAR DE ATOMOS (S) DE HIDROGENO ACIDO (S), SIGUIENDO METODOS CONVENCIONALES, Y A CONTINUACION TRATAMIENTO DEL PRODUCTO OBTENIDO CON UN ACIDO O UNA BASE FISIOLOGICAMENTE COMPATIBLES, SEGUN QUE DICHO PRODUCTO TENGA RESTOS ACIDOS O BASICOS. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIBACTERIANA.
ES498157A 1979-12-24 1980-12-24 Procedimiento para la obtencion de derivados de cefalospori-nas Expired ES8201167A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7931616A FR2472574A1 (fr) 1979-12-24 1979-12-24 Derives de cephalosporine et composition pharmaceutique les contenant

Publications (2)

Publication Number Publication Date
ES498157A0 ES498157A0 (es) 1981-12-01
ES8201167A1 true ES8201167A1 (es) 1981-12-01

Family

ID=9233132

Family Applications (2)

Application Number Title Priority Date Filing Date
ES498157A Expired ES8201167A1 (es) 1979-12-24 1980-12-24 Procedimiento para la obtencion de derivados de cefalospori-nas
ES502352A Granted ES502352A0 (es) 1979-12-24 1981-05-20 Procedimiento para la obtencion de derivados de cefalospori-nas

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES502352A Granted ES502352A0 (es) 1979-12-24 1981-05-20 Procedimiento para la obtencion de derivados de cefalospori-nas

Country Status (27)

Country Link
US (1) US4463173A (es)
EP (1) EP0031708B1 (es)
JP (1) JPS56158787A (es)
AT (1) ATE7918T1 (es)
AU (1) AU544374B2 (es)
CA (1) CA1175805A (es)
CS (1) CS226025B2 (es)
DD (1) DD155520A5 (es)
DE (1) DE3068273D1 (es)
DK (1) DK552480A (es)
ES (2) ES8201167A1 (es)
FI (1) FI803817L (es)
FR (1) FR2472574A1 (es)
GR (1) GR71920B (es)
HU (1) HU186289B (es)
IL (1) IL61775A (es)
MW (1) MW5380A1 (es)
NO (1) NO803903L (es)
NZ (1) NZ195731A (es)
PH (1) PH21662A (es)
PL (2) PL133508B1 (es)
PT (1) PT72265B (es)
SU (2) SU1031408A3 (es)
YU (2) YU324680A (es)
ZA (1) ZA807710B (es)
ZM (1) ZM11380A1 (es)
ZW (1) ZW31280A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2496666A1 (fr) * 1980-12-22 1982-06-25 Ici Pharma Nouveaux derives de cephalosporine et composition pharmaceutique les contenant
FR2496665A1 (fr) * 1980-12-23 1982-06-25 Ici Pharma Nouveaux derives de penicilline et composition pharmaceutique les contenant
ZA824094B (en) * 1981-06-19 1983-07-27 Ici Plc A process for the manufacture of cephalosporin derivative
EP0071370A3 (en) * 1981-07-23 1984-05-16 Ici Pharma Cephalosporin derivatives, process for their preparation and pharmaceutical compositions containing them
US4504478A (en) * 1981-09-18 1985-03-12 Imperial Chemical Industries Plc Cephalosporin-1-oxide derivatives
EP0082648A3 (en) * 1981-12-21 1984-09-26 Imperial Chemical Industries Plc Cephalosporin derivatives
JPS59110695A (ja) * 1982-12-16 1984-06-26 Asahi Chem Ind Co Ltd 経口用セフアロスポリン
GR78718B (es) * 1983-01-31 1984-09-27 Ici Pharma
US4855420A (en) * 1983-06-03 1989-08-08 Ici Pharma Cephalosporin derivatives
GB8316589D0 (en) * 1983-06-17 1983-07-20 Ici Plc Crystalline salts
US4547573A (en) * 1983-12-02 1985-10-15 Ici Pharma Process for preparing cephalosporin derivatives
AU583419B2 (en) * 1985-09-09 1989-04-27 Higuchi, Yoshinari 2-oxa-isocephem compounds, compositions containing same and processes for preparing same
US4760140A (en) * 1986-10-20 1988-07-26 American Cyanamid Company 3-substituted-7-[5-substituted-2-thiazolyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylic acid, diphenylmethyl esters
US6476220B2 (en) * 2000-11-27 2002-11-05 Aurobindo Pharma Limited Process for the preparation of furaca
US20030135041A1 (en) 2002-01-04 2003-07-17 Orchid Chemicals & Pharmaceuticals Limited, India Synthesis of ceftiofur intermediate
AU2009296820B2 (en) * 2008-09-26 2014-03-20 Merck Sharp & Dohme Llc Novel cyclic benzimidazole derivatives useful anti-diabetic agents
US9920014B2 (en) * 2013-09-19 2018-03-20 The Florida International University Board Of Trustees Selective inhibition of bacterial topoisomerase I

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2430375A1 (de) * 1973-06-26 1975-03-20 Leo Pharm Prod Ltd 7-amino-delta hoch 3 -cephem-4-carbonsaeure-derivate
US4255424A (en) * 1979-04-27 1981-03-10 Merck & Co., Inc. 7-N-Heterocyclyl 1-oxa, 1-aza, and 1-carbadethiacephalosporins
US4358447A (en) * 1979-04-27 1982-11-09 Merck & Co., Inc. 7-N-Heterocyclyl cephalosporins
DE3071707D1 (en) * 1979-04-27 1986-09-25 Merck & Co Inc 7-n-heterocyclyl cephalosporins, a process for preparing and a pharmaceutical composition comprising the same
US4282219A (en) * 1979-08-01 1981-08-04 Merck & Co., Inc. 7-N-Heterocyclyl cephalosporins and antibiotic pharmaceutical compositions containing them

Also Published As

Publication number Publication date
NZ195731A (en) 1984-04-27
FR2472574A1 (fr) 1981-07-03
PL228757A1 (es) 1982-01-04
SU1031408A3 (ru) 1983-07-23
ES8204438A1 (es) 1982-05-01
AU544374B2 (en) 1985-05-23
DD155520A5 (de) 1982-06-16
JPH0320398B2 (es) 1991-03-19
FI803817L (fi) 1981-06-25
AU6513480A (en) 1981-07-02
EP0031708B1 (en) 1984-06-13
PL133508B1 (en) 1985-06-29
CA1175805A (en) 1984-10-09
NO803903L (no) 1981-06-25
SU1077573A3 (ru) 1984-02-29
EP0031708A3 (en) 1982-02-24
ES502352A0 (es) 1982-05-01
ES498157A0 (es) 1981-12-01
PH21662A (en) 1988-01-13
HU186289B (en) 1985-07-29
ATE7918T1 (de) 1984-06-15
YU292682A (en) 1983-06-30
EP0031708A2 (en) 1981-07-08
MW5380A1 (en) 1982-09-08
ZA807710B (en) 1981-11-25
CS226025B2 (en) 1984-03-19
DE3068273D1 (en) 1984-07-19
PL232847A1 (es) 1982-03-29
ZW31280A1 (en) 1981-09-29
JPS56158787A (en) 1981-12-07
US4463173A (en) 1984-07-31
ZM11380A1 (en) 1982-10-21
IL61775A (en) 1984-08-31
IL61775A0 (en) 1981-01-30
GR71920B (es) 1983-08-17
PT72265B (en) 1981-11-05
YU324680A (en) 1983-04-30
PL132587B1 (en) 1985-03-30
PT72265A (en) 1981-01-01
DK552480A (da) 1981-06-25

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