SMT201600317B - Derivati sostituti dell'acido 1,2,3,4- tetraidrociclopenta[b]indol-3-il acetico utili nel trattamento di disturbi autoimmuni e infiammatori - Google Patents

Derivati sostituti dell'acido 1,2,3,4- tetraidrociclopenta[b]indol-3-il acetico utili nel trattamento di disturbi autoimmuni e infiammatori

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Publication number
SMT201600317B
SMT201600317B SM201600317T SM201600317T SMT201600317B SM T201600317 B SMT201600317 B SM T201600317B SM 201600317 T SM201600317 T SM 201600317T SM 201600317 T SM201600317 T SM 201600317T SM T201600317 B SMT201600317 B SM T201600317B
Authority
SM
San Marino
Prior art keywords
tetraidrocyclopental
indol
autoimmune
acid
treatment
Prior art date
Application number
SM201600317T
Other languages
English (en)
Italian (it)
Inventor
Robert M Jones
Daniel J Buzard
Sangdon Han
Juerg Lehmann
Brett Ullman
Jeanne V Moody
Xiuwen Zhu
Scott Stirn
Sun Hee Kim
Original Assignee
Arena Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arena Pharm Inc filed Critical Arena Pharm Inc
Publication of SMT201600317B publication Critical patent/SMT201600317B/it

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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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SM201600317T 2008-07-23 2016-09-14 Derivati sostituti dell'acido 1,2,3,4- tetraidrociclopenta[b]indol-3-il acetico utili nel trattamento di disturbi autoimmuni e infiammatori SMT201600317B (it)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13567208P 2008-07-23 2008-07-23
US20937409P 2009-03-06 2009-03-06
PCT/US2009/004265 WO2010011316A1 (en) 2008-07-23 2009-07-22 SUBSTITUTED 1,2,3,4- TETRAHYDROCYCLOPENTA[b]INDOL-3-YL) ACETIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS

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SMT201600317B true SMT201600317B (it) 2016-11-10

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