SK7682003A3 - GABA enhancers in the treatment of diseases relating to reduced neurosteroid activity - Google Patents
GABA enhancers in the treatment of diseases relating to reduced neurosteroid activity Download PDFInfo
- Publication number
- SK7682003A3 SK7682003A3 SK768-2003A SK7682003A SK7682003A3 SK 7682003 A3 SK7682003 A3 SK 7682003A3 SK 7682003 A SK7682003 A SK 7682003A SK 7682003 A3 SK7682003 A3 SK 7682003A3
- Authority
- SK
- Slovakia
- Prior art keywords
- gaba
- neurosteroid
- compound
- disorder
- disease
- Prior art date
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
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- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/22—Anxiolytics
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200001743 | 2000-11-20 | ||
| PCT/DK2001/000773 WO2002040009A1 (en) | 2000-11-20 | 2001-11-20 | Gaba enhancers in the treatment of diseases relating to reduced neurosteroid activity |
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| SK7682003A3 true SK7682003A3 (en) | 2003-10-07 |
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| SK768-2003A SK7682003A3 (en) | 2000-11-20 | 2001-11-20 | GABA enhancers in the treatment of diseases relating to reduced neurosteroid activity |
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| US (2) | US20040024038A1 (de) |
| EP (1) | EP1337247B1 (de) |
| JP (1) | JP4152186B2 (de) |
| KR (1) | KR100865651B1 (de) |
| CN (1) | CN1318027C (de) |
| AR (1) | AR031473A1 (de) |
| AT (1) | ATE336242T1 (de) |
| AU (2) | AU2351402A (de) |
| BG (1) | BG107909A (de) |
| BR (1) | BR0115668A (de) |
| CA (1) | CA2429220C (de) |
| CY (1) | CY1106209T1 (de) |
| CZ (1) | CZ20031383A3 (de) |
| DE (1) | DE60122368T2 (de) |
| DK (1) | DK1337247T3 (de) |
| EA (1) | EA007287B1 (de) |
| ES (1) | ES2266308T3 (de) |
| HK (1) | HK1075010A1 (de) |
| HR (1) | HRP20030404A2 (de) |
| HU (1) | HUP0400505A3 (de) |
| IL (1) | IL155587A0 (de) |
| IS (1) | IS2427B (de) |
| ME (1) | MEP6408A (de) |
| MX (1) | MXPA03004349A (de) |
| NO (1) | NO20032271L (de) |
| NZ (1) | NZ525520A (de) |
| PL (1) | PL361051A1 (de) |
| PT (1) | PT1337247E (de) |
| SI (1) | SI1337247T1 (de) |
| SK (1) | SK7682003A3 (de) |
| UA (1) | UA77403C2 (de) |
| WO (1) | WO2002040009A1 (de) |
| YU (1) | YU39003A (de) |
| ZA (1) | ZA200303289B (de) |
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| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| PL205881B1 (pl) * | 2001-11-26 | 2010-06-30 | Finzelberg Gmbh & Co Kg | Stabilny preparat z ekstraktu imbirowego i sposób jego wytwarzania, preparat galenowy oraz zastosowanie stabilizowanego preparatu z ekstraktu imbirowego |
| PL1641456T3 (pl) * | 2003-06-25 | 2010-08-31 | H Lundbeck As | Gaboksadol do leczenia depresji i innych zaburzeń afektywnych |
| GB0402118D0 (en) | 2004-01-30 | 2004-03-03 | Merck Sharp & Dohme | Polymorphic forms of a GABAA agonist |
| MXPA06015196A (es) * | 2004-06-29 | 2007-03-15 | Lundbeck & Co As H | Tratamiento del dolor neuropatico, la fibromialgia o la artritis reumatoide. |
| WO2006012563A2 (en) * | 2004-07-23 | 2006-02-02 | The Regents Of The University Of California | Method for the treatment and diagnosis of certain psychiatric disorders related to the menstrual cycle |
| GB0417558D0 (en) * | 2004-08-06 | 2004-09-08 | Merck Sharp & Dohme | Novel combination therapy |
| EP2292222A1 (de) | 2005-01-28 | 2011-03-09 | H. Lundbeck A/S | Polymorphe Formen eines GABAA-Agonisten |
| US20070122507A1 (en) * | 2005-05-26 | 2007-05-31 | Palu Afa K | Histone deacetylase and tumor necrosis factor converting enzyme inhibition |
| US8856289B2 (en) * | 2006-12-29 | 2014-10-07 | Prodea Systems, Inc. | Subscription management of applications and services provided through user premises gateway devices |
| WO2008141112A1 (en) * | 2007-05-09 | 2008-11-20 | Cenerx Biopharma, Inc. | Methods of treating rett syndrome |
| CN101585862B (zh) * | 2008-05-20 | 2014-12-17 | 梅克芳股份公司 | 甾族化合物 |
| WO2012173634A1 (en) * | 2011-06-16 | 2012-12-20 | Solace Lifesciences, Inc. | Systems and methods for balancing and maintaining the health of the human autonomic nervous system |
| RU2496496C1 (ru) * | 2012-10-04 | 2013-10-27 | Исаак Григорьевич Гитлин | Фармацевтическая композиция, обладающая гамк-ергической активностью |
| EP4233861A3 (de) * | 2016-08-11 | 2023-10-11 | Ovid Therapeutics, Inc. | Zusammensetzungen zur behandlung von essentiellem tremor |
| US20180338959A1 (en) * | 2017-05-24 | 2018-11-29 | Ovid Therapeutics Inc. | Treatment of depressive disorders |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| KR102049522B1 (ko) * | 2018-06-05 | 2019-11-27 | 충남대학교산학협력단 | Gaba를 유효성분으로 하는 살모넬라 감염질환의 예방 및 치료용 조성물 |
| KR102049526B1 (ko) * | 2018-06-05 | 2019-11-27 | 충남대학교산학협력단 | Gaba를 유효성분으로 하는 항결핵 약학 조성물 |
| MX2021003302A (es) | 2018-09-20 | 2021-05-13 | Ovid Therapeutics Inc | Uso de gaboxadol para el tratamiento del sindrome de tourette, los tics y la tartamudez. |
| KR20210110585A (ko) | 2018-11-21 | 2021-09-08 | 썰테고 테라퓨틱스 아이엔씨. | 자살의 위험을 감소시키고 우울증의 신속한 완화를 위한 가복사돌 |
| KR20210105387A (ko) | 2018-12-17 | 2021-08-26 | 오비드 테라퓨틱스 인크. | 비-24 시간 수면-각성 장애의 치료를 위한 가복사돌의 사용 |
| CA3138008A1 (en) | 2019-04-17 | 2020-10-22 | Compass Pathfinder Limited | Methods of treating neurocognitive disorders, chronic pain and reducing inflammation |
| AU2020405060A1 (en) | 2019-12-18 | 2022-06-09 | Ovid Therapeutics Inc. | Gaboxadol for therapeutic treatment of 1p36 deletion syndrome |
| EP4153549A2 (de) | 2020-05-20 | 2023-03-29 | Certego Therapeutics Inc. | Ringdeuteriertes gaboxadol und seine verwendung zur behandlung von psychiatrischen erkrankungen |
| CN114404437A (zh) * | 2022-03-15 | 2022-04-29 | 山东中医药大学 | 没食子酰芍药苷在制备gabaa受体抑制剂中的应用 |
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|---|---|---|---|---|
| US4362731A (en) * | 1980-09-01 | 1982-12-07 | Sandoz Ltd. | Myotonolytic use of 4,5,6,7-tetrahydroisoxazolo [5,4-c] pyridin-3-ol and derivatives thereof |
| US5120723A (en) * | 1987-08-25 | 1992-06-09 | University Of Southern California | Method, compositions, and compounds for modulating brain excitability |
| CA2118938A1 (en) * | 1991-09-13 | 1993-04-01 | Kelvin W. Gee | Novel gabaa receptor with steroid binding sites |
| US5206415A (en) * | 1991-12-20 | 1993-04-27 | Washington University | Tricyclic steroid analogs |
| CZ300694A3 (en) * | 1993-12-02 | 1996-05-15 | Akzo Nobel Nv | Substituted 2beta-morpholinandrostane derivatives, process of their preparation, their use for preparing pharmaceutical preparations and pharmaceutical compositions containing thereof |
| GEP20002033B (en) * | 1994-11-23 | 2000-04-10 | Cocensys Inc Us | Androstane and Pregnane Series Compounds for Allosteric Modulation of GABA Receptor |
| US5776959A (en) * | 1995-06-05 | 1998-07-07 | Washington University | Anticonvulsant and anxiolytic lactam and thiolactam derivatives |
| GEP20012530B (en) * | 1995-06-06 | 2001-09-25 | Cocensys Inc | Neuroactive Steroids of the Androstane and Pregnane Series |
| IT1290003B1 (it) * | 1997-03-03 | 1998-10-19 | Angelini Ricerche Spa | Uso di pivagabina per preparare composizioni farmaceutiche |
| GB9801208D0 (en) * | 1998-01-21 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
| BR9912291A (pt) * | 1998-07-22 | 2001-04-17 | Akzo Nobel Nv | Derivado de alfa-aminoácido fenil éster, composição farmacêutica, e, uso de um derivado de alfa-aminoácido fenil éster. |
| IL149575A0 (en) * | 1999-12-08 | 2002-11-10 | Warner Lambert Co | Method for the stereoselective synthesis of cyclic amino acids |
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- 2001-11-20 EP EP01996378A patent/EP1337247B1/de not_active Expired - Lifetime
- 2001-11-20 CA CA002429220A patent/CA2429220C/en not_active Expired - Fee Related
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- 2001-11-20 AT AT01996378T patent/ATE336242T1/de active
- 2001-11-20 AU AU2002223514A patent/AU2002223514B2/en not_active Ceased
- 2001-11-20 WO PCT/DK2001/000773 patent/WO2002040009A1/en active IP Right Grant
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