ATE336242T1 - Verwendung von gaboxadol zur behandlung von premenstruelle störung, postnatal depression oder postmenopausal-bedingte-dysphorische störung - Google Patents

Verwendung von gaboxadol zur behandlung von premenstruelle störung, postnatal depression oder postmenopausal-bedingte-dysphorische störung

Info

Publication number
ATE336242T1
ATE336242T1 AT01996378T AT01996378T ATE336242T1 AT E336242 T1 ATE336242 T1 AT E336242T1 AT 01996378 T AT01996378 T AT 01996378T AT 01996378 T AT01996378 T AT 01996378T AT E336242 T1 ATE336242 T1 AT E336242T1
Authority
AT
Austria
Prior art keywords
disorder
gaboxadol
postmenopausal
postnatal depression
dysphoric
Prior art date
Application number
AT01996378T
Other languages
English (en)
Inventor
Bjarke Ebert
Andersen Peter Hongaard
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8159857&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE336242(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Application granted granted Critical
Publication of ATE336242T1 publication Critical patent/ATE336242T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
AT01996378T 2000-11-20 2001-11-20 Verwendung von gaboxadol zur behandlung von premenstruelle störung, postnatal depression oder postmenopausal-bedingte-dysphorische störung ATE336242T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200001743 2000-11-20

Publications (1)

Publication Number Publication Date
ATE336242T1 true ATE336242T1 (de) 2006-09-15

Family

ID=8159857

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01996378T ATE336242T1 (de) 2000-11-20 2001-11-20 Verwendung von gaboxadol zur behandlung von premenstruelle störung, postnatal depression oder postmenopausal-bedingte-dysphorische störung

Country Status (34)

Country Link
US (2) US20040024038A1 (de)
EP (1) EP1337247B1 (de)
JP (1) JP4152186B2 (de)
KR (1) KR100865651B1 (de)
CN (1) CN1318027C (de)
AR (1) AR031473A1 (de)
AT (1) ATE336242T1 (de)
AU (2) AU2002223514B2 (de)
BG (1) BG107909A (de)
BR (1) BR0115668A (de)
CA (1) CA2429220C (de)
CY (1) CY1106209T1 (de)
CZ (1) CZ20031383A3 (de)
DE (1) DE60122368T2 (de)
DK (1) DK1337247T3 (de)
EA (1) EA007287B1 (de)
ES (1) ES2266308T3 (de)
HK (1) HK1075010A1 (de)
HR (1) HRP20030404A2 (de)
HU (1) HUP0400505A3 (de)
IL (1) IL155587A0 (de)
IS (1) IS2427B (de)
ME (1) MEP6408A (de)
MX (1) MXPA03004349A (de)
NO (1) NO20032271D0 (de)
NZ (1) NZ525520A (de)
PL (1) PL361051A1 (de)
PT (1) PT1337247E (de)
SI (1) SI1337247T1 (de)
SK (1) SK7682003A3 (de)
UA (1) UA77403C2 (de)
WO (1) WO2002040009A1 (de)
YU (1) YU39003A (de)
ZA (1) ZA200303289B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
DE50214447D1 (de) * 2001-11-26 2010-07-01 Finzelberg Gmbh & Co Kg Ingwer-extraktzubereitung
ES2341004T3 (es) * 2003-06-25 2010-06-14 H. Lundbeck A/S Gaboxadol para tratar la depresion y otros trastornos afectivos.
GB0402118D0 (en) 2004-01-30 2004-03-03 Merck Sharp & Dohme Polymorphic forms of a GABAA agonist
EA200700102A1 (ru) * 2004-06-29 2007-06-29 Х.Лундбекк А/С Лечение невропатической боли, фибромиалгии или ревматоидного артрита
WO2006012563A2 (en) * 2004-07-23 2006-02-02 The Regents Of The University Of California Method for the treatment and diagnosis of certain psychiatric disorders related to the menstrual cycle
GB0417558D0 (en) * 2004-08-06 2004-09-08 Merck Sharp & Dohme Novel combination therapy
US8022084B2 (en) 2005-01-28 2011-09-20 H. Lundbeck A/S Polymorphic forms of a GABAA agonist
US20070122507A1 (en) * 2005-05-26 2007-05-31 Palu Afa K Histone deacetylase and tumor necrosis factor converting enzyme inhibition
WO2008085207A2 (en) * 2006-12-29 2008-07-17 Prodea Systems, Inc. Multi-services application gateway
WO2008141112A1 (en) * 2007-05-09 2008-11-20 Cenerx Biopharma, Inc. Methods of treating rett syndrome
CN101585862B (zh) * 2008-05-20 2014-12-17 梅克芳股份公司 甾族化合物
WO2012173634A1 (en) * 2011-06-16 2012-12-20 Solace Lifesciences, Inc. Systems and methods for balancing and maintaining the health of the human autonomic nervous system
RU2496496C1 (ru) * 2012-10-04 2013-10-27 Исаак Григорьевич Гитлин Фармацевтическая композиция, обладающая гамк-ергической активностью
KR102518846B1 (ko) * 2016-08-11 2023-04-05 오비드 테라퓨틱스 인크. 간질 장애의 치료를 위한 방법 및 조성물
US20180338959A1 (en) * 2017-05-24 2018-11-29 Ovid Therapeutics Inc. Treatment of depressive disorders
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
KR102049522B1 (ko) * 2018-06-05 2019-11-27 충남대학교산학협력단 Gaba를 유효성분으로 하는 살모넬라 감염질환의 예방 및 치료용 조성물
KR102049526B1 (ko) * 2018-06-05 2019-11-27 충남대학교산학협력단 Gaba를 유효성분으로 하는 항결핵 약학 조성물
MX2021003302A (es) 2018-09-20 2021-05-13 Ovid Therapeutics Inc Uso de gaboxadol para el tratamiento del sindrome de tourette, los tics y la tartamudez.
EP3883566A4 (de) 2018-11-21 2022-09-07 Certego Therapeutics Inc. Gaboxadol zur verringerung des risikos von suizid und zur schnellen linderung von depressionen
CA3123876A1 (en) 2018-12-17 2020-06-25 Ovid Therapeutics Inc. Use of gaboxadol for the treatment of non-24 hour sleep-wake disorder
WO2020212952A1 (en) 2019-04-17 2020-10-22 Compass Pathfinder Limited Treatment of depression and other various disorders with psilocybin
EP4051272A4 (de) 2019-12-18 2023-01-04 Ovid Therapeutics Inc. Gaboxadol zur therapeutischen behandlung von 1p36-deletionssyndrom
CA3182508A1 (en) 2020-05-20 2021-11-25 Certego Therapeutics Inc. Ring deuterated gaboxadol and its use for the treatment of psychiatric disorders
CN114404437A (zh) * 2022-03-15 2022-04-29 山东中医药大学 没食子酰芍药苷在制备gabaa受体抑制剂中的应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4362731A (en) * 1980-09-01 1982-12-07 Sandoz Ltd. Myotonolytic use of 4,5,6,7-tetrahydroisoxazolo [5,4-c] pyridin-3-ol and derivatives thereof
US5120723A (en) * 1987-08-25 1992-06-09 University Of Southern California Method, compositions, and compounds for modulating brain excitability
WO1993005786A1 (en) * 1991-09-13 1993-04-01 Cocensys, Inc. Novel gabaa receptor with steroid binding sites
US5206415A (en) * 1991-12-20 1993-04-27 Washington University Tricyclic steroid analogs
CZ300694A3 (en) * 1993-12-02 1996-05-15 Akzo Nobel Nv Substituted 2beta-morpholinandrostane derivatives, process of their preparation, their use for preparing pharmaceutical preparations and pharmaceutical compositions containing thereof
CN1171114A (zh) * 1994-11-23 1998-01-21 科斯赛斯公司 用于γ-氨基丁酸受体的变构调节的雄甾烷和孕甾烷组系
US5776959A (en) * 1995-06-05 1998-07-07 Washington University Anticonvulsant and anxiolytic lactam and thiolactam derivatives
ES2235187T3 (es) * 1995-06-06 2005-07-01 Euro-Celtique S.A. Esteroides neuroactivos de las series del androstano y el pregnano.
IT1290003B1 (it) * 1997-03-03 1998-10-19 Angelini Ricerche Spa Uso di pivagabina per preparare composizioni farmaceutiche
GB9801208D0 (en) * 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
TR200100166T2 (tr) * 1998-07-22 2001-05-21 Akzo Nobel N.L. alfa-amino asit fenil ester türevleri
HUP0203812A3 (en) * 1999-12-08 2004-12-28 Warner Lambert Co Method for the stereoselective synthesis of cyclic amino acids

Also Published As

Publication number Publication date
UA77403C2 (en) 2006-12-15
CN1592616A (zh) 2005-03-09
US20040024038A1 (en) 2004-02-05
EP1337247B1 (de) 2006-08-16
EA007287B1 (ru) 2006-08-25
SI1337247T1 (sl) 2006-12-31
AR031473A1 (es) 2003-09-24
CA2429220A1 (en) 2002-05-23
NO20032271L (no) 2003-05-20
HUP0400505A3 (en) 2008-08-28
DK1337247T3 (da) 2006-12-04
KR100865651B1 (ko) 2008-10-29
IS6803A (is) 2003-04-30
US20090143435A1 (en) 2009-06-04
MEP6408A (xx) 2010-02-10
IS2427B (is) 2008-10-15
CN1318027C (zh) 2007-05-30
AU2002223514B2 (en) 2006-11-30
EP1337247A1 (de) 2003-08-27
ES2266308T3 (es) 2007-03-01
HRP20030404A2 (en) 2005-04-30
BG107909A (bg) 2004-08-31
JP2004513921A (ja) 2004-05-13
WO2002040009A1 (en) 2002-05-23
BR0115668A (pt) 2003-09-02
YU39003A (sh) 2006-05-25
AU2351402A (en) 2002-05-27
ZA200303289B (en) 2005-07-27
NO20032271D0 (no) 2003-05-20
HK1075010A1 (en) 2005-12-02
CA2429220C (en) 2009-09-15
KR20030065517A (ko) 2003-08-06
PT1337247E (pt) 2006-11-30
IL155587A0 (en) 2003-11-23
DE60122368T2 (de) 2007-08-09
CY1106209T1 (el) 2011-06-08
DE60122368D1 (de) 2006-09-28
MXPA03004349A (es) 2003-08-19
PL361051A1 (en) 2004-09-20
EA200300594A1 (ru) 2003-10-30
SK7682003A3 (en) 2003-10-07
JP4152186B2 (ja) 2008-09-17
NZ525520A (en) 2005-04-29
HUP0400505A2 (hu) 2004-07-28
CZ20031383A3 (cs) 2003-08-13

Similar Documents

Publication Publication Date Title
ATE336242T1 (de) Verwendung von gaboxadol zur behandlung von premenstruelle störung, postnatal depression oder postmenopausal-bedingte-dysphorische störung
DE60114580D1 (de) Verwendung von cyanochinolinen zur behandlung oder inhibierung von dickdarmpolypen
ATE257013T1 (de) Verwendung von botulinum-toxin zur behandlung von diabetes
ATE513550T1 (de) Verwendung eines ibat-hemmers zur behandlung oder vorbeugung von verstopfung
DE69910781D1 (de) Behandlung zur beseitigung von gerüchen
ATE419856T1 (de) Verwendung von rimexolon zur behandlung von augentrockenheit
ATE456375T1 (de) Verwendung von botulinum toxin zur behandlung von neuralgischen schmerzen
ATE288748T1 (de) Verwendung von retigabin zur behandlung von neuropathischen schmerzen
ATE534379T1 (de) Neue verwendung von peptid-verbindungen zur behandlung von muskelschmerzen
DE60106229D1 (de) Uv-verstärktes silylierungsverfahren zur erhöhung des ätzwiderstands von dünnen resistschichten
DE10082139T1 (de) Zusammensetzung zur Behandlung von Reibungspaaren
ATE312587T1 (de) Zusammenseztungen und verfahren zur behandlung von haarausfall unter verwendung von c16-c20 aromatischen tetrahydro-prostaglandinen
DE60136477D1 (de) Retinoide zur behandlung von emphysem
ATE346614T1 (de) Vaginale zusammensetzung enthaltend lidocaine zur behandlung von gebärmutterrhythmusstörung
ATE338552T1 (de) Verwendungen von et743 zur behandlung von krebs
DE60130661D1 (de) Verwendung der 13-cis retinsäure zur behandlung von emphysemen
DE60101309D1 (de) Diacerein zur behandlung von psoriasis
ATE232378T1 (de) Reinigungspflaster zur verbesserung des hautzustandes
ATE390474T1 (de) Verwendung von polymerem material zur behandlung harter oberflächen
ATE493125T1 (de) Carbamatverbindungen zur behandlung von schmerz
DE50105735D1 (de) Chlorzoxazon zur behandlung von psoriasis
ATE209891T1 (de) Verwendung von 1-hydroxy-2-pyridonen zur behandlung der seborrhoischen dermatitis
DE60103503D1 (de) Verwendung von fsh zur behandlung von infertilität
DE60110748D1 (de) Behandlung von fluorkohlenstoff-beschickungen
ATE404203T1 (de) Verwendung von desoxypeganin zur behandlung der klinischen depression

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1337247

Country of ref document: EP