HUP0400505A2 - Gaba-receptorra ható vegyületek alkalmazása csökkent neuroszteroid aktivitás kezelésére alkalmas gyógyászati készítmények előállítására - Google Patents

Gaba-receptorra ható vegyületek alkalmazása csökkent neuroszteroid aktivitás kezelésére alkalmas gyógyászati készítmények előállítására

Info

Publication number
HUP0400505A2
HUP0400505A2 HU0400505A HUP0400505A HUP0400505A2 HU P0400505 A2 HUP0400505 A2 HU P0400505A2 HU 0400505 A HU0400505 A HU 0400505A HU P0400505 A HUP0400505 A HU P0400505A HU P0400505 A2 HUP0400505 A2 HU P0400505A2
Authority
HU
Hungary
Prior art keywords
gaba
neurosteroid
decrease
compound
compounds
Prior art date
Application number
HU0400505A
Other languages
English (en)
Inventor
Bjarke Ebert
Peter Hongaard Andersen
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8159857&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0400505(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of HUP0400505A2 publication Critical patent/HUP0400505A2/hu
Publication of HUP0400505A3 publication Critical patent/HUP0400505A3/hu

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

A találmány A találmány nemszteroid vegyületek - amelyek GABA-agonisták, GABA felvételét gátló vegyületek vagy GABA típusúaktivitást fokozó vegyületek - alkalmazására vonatkozik csökkentneuroszteroid aktivitással kapcsolatos rendellenességek kezelésérealkalmas gyógyászati készítmények előállítására. A nemszteroidvegyület lehet egy nemalloszterikus GABA agonista, a alegységettartalmazó GABA-komplexek iránt affinitást mutató vegyület, GABAújrafelvételt gátló vegyület vagy GABA-típusú aktivitást fokozóvegyület. A találmány szerinti alkalmazásnál a megbetegedés aneuroszteroid-szint változásából, így például a neuroszteroid-szintcsökkenéséből, közelebbről a neuroszteroid-szint visszatérő periodikuscsökkenéséből, a neuroszteroidszint rendkívüli csökkenéséből vagyneuroszteroid-szint korral összefüggő csökkenéséből adódik. Amegbetegedés lehet például premenstruális rendellenesség, szülés utánidepresszió vagy poszt-menopauzálisan jelentkező ideges nyugtalanság. Ó
HU0400505A 2000-11-20 2001-11-20 Use of gaba receptor compounds for preparation of pharmaceutical compositions available for treating reduced neurosteroid activity HUP0400505A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200001743 2000-11-20
PCT/DK2001/000773 WO2002040009A1 (en) 2000-11-20 2001-11-20 Gaba enhancers in the treatment of diseases relating to reduced neurosteroid activity

Publications (2)

Publication Number Publication Date
HUP0400505A2 true HUP0400505A2 (hu) 2004-07-28
HUP0400505A3 HUP0400505A3 (en) 2008-08-28

Family

ID=8159857

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0400505A HUP0400505A3 (en) 2000-11-20 2001-11-20 Use of gaba receptor compounds for preparation of pharmaceutical compositions available for treating reduced neurosteroid activity

Country Status (34)

Country Link
US (2) US20040024038A1 (hu)
EP (1) EP1337247B1 (hu)
JP (1) JP4152186B2 (hu)
KR (1) KR100865651B1 (hu)
CN (1) CN1318027C (hu)
AR (1) AR031473A1 (hu)
AT (1) ATE336242T1 (hu)
AU (2) AU2002223514B2 (hu)
BG (1) BG107909A (hu)
BR (1) BR0115668A (hu)
CA (1) CA2429220C (hu)
CY (1) CY1106209T1 (hu)
CZ (1) CZ20031383A3 (hu)
DE (1) DE60122368T2 (hu)
DK (1) DK1337247T3 (hu)
EA (1) EA007287B1 (hu)
ES (1) ES2266308T3 (hu)
HK (1) HK1075010A1 (hu)
HR (1) HRP20030404A2 (hu)
HU (1) HUP0400505A3 (hu)
IL (1) IL155587A0 (hu)
IS (1) IS2427B (hu)
ME (1) MEP6408A (hu)
MX (1) MXPA03004349A (hu)
NO (1) NO20032271L (hu)
NZ (1) NZ525520A (hu)
PL (1) PL361051A1 (hu)
PT (1) PT1337247E (hu)
SI (1) SI1337247T1 (hu)
SK (1) SK7682003A3 (hu)
UA (1) UA77403C2 (hu)
WO (1) WO2002040009A1 (hu)
YU (1) YU39003A (hu)
ZA (1) ZA200303289B (hu)

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PT1641456E (pt) * 2003-06-25 2010-06-01 Lundbeck & Co As H Gaboxadol para o tratamento de depressão e outros distúrbios afectivos
GB0402118D0 (en) 2004-01-30 2004-03-03 Merck Sharp & Dohme Polymorphic forms of a GABAA agonist
CN1976700A (zh) * 2004-06-29 2007-06-06 H.隆德贝克有限公司 神经性疼痛、纤维肌痛或类风湿关节炎的治疗
WO2006012563A2 (en) * 2004-07-23 2006-02-02 The Regents Of The University Of California Method for the treatment and diagnosis of certain psychiatric disorders related to the menstrual cycle
GB0417558D0 (en) * 2004-08-06 2004-09-08 Merck Sharp & Dohme Novel combination therapy
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KR102049526B1 (ko) * 2018-06-05 2019-11-27 충남대학교산학협력단 Gaba를 유효성분으로 하는 항결핵 약학 조성물
WO2020061410A1 (en) 2018-09-20 2020-03-26 Ovid Therapeutics Inc. Use of gaboxadol for the treatment of tourette syndrome, tics and stuttering
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MX2021007224A (es) 2018-12-17 2021-09-23 Ovid Therapeutics Inc Uso de gaboxadol para el tratamiento del trastorno del sue?o vigilia que no es de 24 horas.
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KR20220114572A (ko) 2019-12-18 2022-08-17 오비드 테라퓨틱스 인크. 1p36 결실 증후군의 치료적 치료를 위한 가복사돌
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Also Published As

Publication number Publication date
BR0115668A (pt) 2003-09-02
KR100865651B1 (ko) 2008-10-29
IS6803A (is) 2003-04-30
AU2002223514B2 (en) 2006-11-30
SI1337247T1 (sl) 2006-12-31
EP1337247A1 (en) 2003-08-27
NO20032271D0 (no) 2003-05-20
DK1337247T3 (da) 2006-12-04
US20040024038A1 (en) 2004-02-05
EA007287B1 (ru) 2006-08-25
ES2266308T3 (es) 2007-03-01
IL155587A0 (en) 2003-11-23
HUP0400505A3 (en) 2008-08-28
JP2004513921A (ja) 2004-05-13
SK7682003A3 (en) 2003-10-07
EP1337247B1 (en) 2006-08-16
IS2427B (is) 2008-10-15
KR20030065517A (ko) 2003-08-06
CN1592616A (zh) 2005-03-09
CY1106209T1 (el) 2011-06-08
US20090143435A1 (en) 2009-06-04
WO2002040009A1 (en) 2002-05-23
HRP20030404A2 (en) 2005-04-30
CA2429220C (en) 2009-09-15
ZA200303289B (en) 2005-07-27
AR031473A1 (es) 2003-09-24
YU39003A (sh) 2006-05-25
DE60122368T2 (de) 2007-08-09
ATE336242T1 (de) 2006-09-15
CA2429220A1 (en) 2002-05-23
CN1318027C (zh) 2007-05-30
EA200300594A1 (ru) 2003-10-30
PL361051A1 (en) 2004-09-20
PT1337247E (pt) 2006-11-30
BG107909A (bg) 2004-08-31
AU2351402A (en) 2002-05-27
NO20032271L (no) 2003-05-20
MEP6408A (xx) 2010-02-10
DE60122368D1 (de) 2006-09-28
UA77403C2 (en) 2006-12-15
JP4152186B2 (ja) 2008-09-17
MXPA03004349A (es) 2003-08-19
CZ20031383A3 (cs) 2003-08-13
HK1075010A1 (en) 2005-12-02
NZ525520A (en) 2005-04-29

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