SK51398A3 - Polymorphic forms of n-[1(r)-[(1,2-dihydro-1- -methanesulfonylspiro[3h-indole-3,4'-piperidin]-1'-yl)carbonyl]- -2-(phenylmethyloxy)ethyl]-2-amino-2-methyl-propanamide- -methanesulfonate, the preparation thereof, pharmaceutical composition containing them and their use - Google Patents

Polymorphic forms of n-[1(r)-[(1,2-dihydro-1- -methanesulfonylspiro[3h-indole-3,4'-piperidin]-1'-yl)carbonyl]- -2-(phenylmethyloxy)ethyl]-2-amino-2-methyl-propanamide- -methanesulfonate, the preparation thereof, pharmaceutical composition containing them and their use Download PDF

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Publication number
SK51398A3
SK51398A3 SK513-98A SK51398A SK51398A3 SK 51398 A3 SK51398 A3 SK 51398A3 SK 51398 A SK51398 A SK 51398A SK 51398 A3 SK51398 A3 SK 51398A3
Authority
SK
Slovakia
Prior art keywords
ethyl
amino
carbonyl
phenylmethyloxy
dihydro
Prior art date
Application number
SK513-98A
Other languages
English (en)
Slovak (sk)
Inventor
Jerome P Draper
David C Dubost
Michael J Kaufman
James A Mccauley
Jennifer L Vandrilla
Richard J Varsolona
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603361.8A external-priority patent/GB9603361D0/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of SK51398A3 publication Critical patent/SK51398A3/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Fodder In General (AREA)
  • Medicines Containing Plant Substances (AREA)
SK513-98A 1995-10-27 1996-10-23 Polymorphic forms of n-[1(r)-[(1,2-dihydro-1- -methanesulfonylspiro[3h-indole-3,4'-piperidin]-1'-yl)carbonyl]- -2-(phenylmethyloxy)ethyl]-2-amino-2-methyl-propanamide- -methanesulfonate, the preparation thereof, pharmaceutical composition containing them and their use SK51398A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US590095P 1995-10-27 1995-10-27
GBGB9603361.8A GB9603361D0 (en) 1996-02-16 1996-02-16 Polymorphic forms of a growth hormone secretagogue
PCT/US1996/016955 WO1997015574A1 (en) 1995-10-27 1996-10-23 Polymorphic forms of a growth hormone secretagogue

Publications (1)

Publication Number Publication Date
SK51398A3 true SK51398A3 (en) 1998-12-02

Family

ID=26308741

Family Applications (1)

Application Number Title Priority Date Filing Date
SK513-98A SK51398A3 (en) 1995-10-27 1996-10-23 Polymorphic forms of n-[1(r)-[(1,2-dihydro-1- -methanesulfonylspiro[3h-indole-3,4'-piperidin]-1'-yl)carbonyl]- -2-(phenylmethyloxy)ethyl]-2-amino-2-methyl-propanamide- -methanesulfonate, the preparation thereof, pharmaceutical composition containing them and their use

Country Status (22)

Country Link
EP (1) EP1019402A1 (ja)
JP (1) JP3204266B2 (ja)
KR (1) KR19990067098A (ja)
CN (1) CN1067687C (ja)
AU (1) AU707946B2 (ja)
BG (1) BG102476A (ja)
BR (1) BR9611229A (ja)
CA (1) CA2235371A1 (ja)
CO (1) CO4770956A1 (ja)
CZ (1) CZ128098A3 (ja)
EA (1) EA000528B1 (ja)
EE (1) EE9800147A (ja)
HK (1) HK1017894A1 (ja)
HU (1) HUP9902208A3 (ja)
IS (1) IS4721A (ja)
NO (1) NO310556B1 (ja)
NZ (1) NZ321370A (ja)
PL (1) PL327511A1 (ja)
SK (1) SK51398A3 (ja)
TR (1) TR199800726T2 (ja)
WO (1) WO1997015574A1 (ja)
YU (1) YU56696A (ja)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6046333A (en) * 1996-10-25 2000-04-04 Merck & Co., Inc. Convergent process for the preparation of a growth hormone secretagogue
US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
WO2017075535A1 (en) 2015-10-28 2017-05-04 Oxeia Biopharmaceuticals, Inc. Methods of treating neurodegenerative conditions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL176993B1 (pl) * 1992-12-11 1999-08-31 Merck & Co Inc Nowe związki spiropiperydynowe oraz sposób ich wytwarzania

Also Published As

Publication number Publication date
EA000528B1 (ru) 1999-10-28
BR9611229A (pt) 1999-05-25
CO4770956A1 (es) 1999-04-30
EP1019402A1 (en) 2000-07-19
AU707946B2 (en) 1999-07-22
BG102476A (en) 1999-04-30
IS4721A (is) 1998-04-21
NZ321370A (en) 1999-11-29
CN1067687C (zh) 2001-06-27
NO981867D0 (no) 1998-04-24
AU7468696A (en) 1997-05-15
CN1205703A (zh) 1999-01-20
NO310556B1 (no) 2001-07-23
NO981867L (no) 1998-06-29
HUP9902208A3 (en) 2001-05-28
TR199800726T2 (xx) 1998-08-21
HUP9902208A2 (hu) 1999-10-28
EE9800147A (et) 1998-12-15
KR19990067098A (ko) 1999-08-16
YU56696A (sh) 1999-09-27
HK1017894A1 (en) 1999-12-03
JP3204266B2 (ja) 2001-09-04
EA199800335A1 (ru) 1998-12-24
WO1997015574A1 (en) 1997-05-01
MX9803351A (es) 1998-09-30
CZ128098A3 (cs) 1998-09-16
CA2235371A1 (en) 1997-05-01
JPH10512295A (ja) 1998-11-24
PL327511A1 (en) 1998-12-21

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