BR9611229A - Forma polimórfica do composto metanossulfonato de n-[1(r)-[(1,2-di-hidro-1-metanossulfonil espiro [3h-indol-3,4'-piperdin]1'il) carbonil]-2-(fenilmetil-oxi) etil]-2 amino-2 metilpropanamida composição faracêutica - Google Patents

Forma polimórfica do composto metanossulfonato de n-[1(r)-[(1,2-di-hidro-1-metanossulfonil espiro [3h-indol-3,4'-piperdin]1'il) carbonil]-2-(fenilmetil-oxi) etil]-2 amino-2 metilpropanamida composição faracêutica

Info

Publication number
BR9611229A
BR9611229A BR9611229A BR9611229A BR9611229A BR 9611229 A BR9611229 A BR 9611229A BR 9611229 A BR9611229 A BR 9611229A BR 9611229 A BR9611229 A BR 9611229A BR 9611229 A BR9611229 A BR 9611229A
Authority
BR
Brazil
Prior art keywords
piperdin
methylpropanamide
phenylmethyl
indol
dihydro
Prior art date
Application number
BR9611229A
Other languages
English (en)
Inventor
Jerome P Draper
David C Dubost
Michael J Kaufman
James A Mccauley
Jennifer L Vandrilla
Richard J Varsolona
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603361.8A external-priority patent/GB9603361D0/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of BR9611229A publication Critical patent/BR9611229A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
BR9611229A 1995-10-27 1996-10-23 Forma polimórfica do composto metanossulfonato de n-[1(r)-[(1,2-di-hidro-1-metanossulfonil espiro [3h-indol-3,4'-piperdin]1'il) carbonil]-2-(fenilmetil-oxi) etil]-2 amino-2 metilpropanamida composição faracêutica BR9611229A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US590095P 1995-10-27 1995-10-27
GBGB9603361.8A GB9603361D0 (en) 1996-02-16 1996-02-16 Polymorphic forms of a growth hormone secretagogue
PCT/US1996/016955 WO1997015574A1 (en) 1995-10-27 1996-10-23 Polymorphic forms of a growth hormone secretagogue

Publications (1)

Publication Number Publication Date
BR9611229A true BR9611229A (pt) 1999-05-25

Family

ID=26308741

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9611229A BR9611229A (pt) 1995-10-27 1996-10-23 Forma polimórfica do composto metanossulfonato de n-[1(r)-[(1,2-di-hidro-1-metanossulfonil espiro [3h-indol-3,4'-piperdin]1'il) carbonil]-2-(fenilmetil-oxi) etil]-2 amino-2 metilpropanamida composição faracêutica

Country Status (22)

Country Link
EP (1) EP1019402A1 (pt)
JP (1) JP3204266B2 (pt)
KR (1) KR19990067098A (pt)
CN (1) CN1067687C (pt)
AU (1) AU707946B2 (pt)
BG (1) BG102476A (pt)
BR (1) BR9611229A (pt)
CA (1) CA2235371A1 (pt)
CO (1) CO4770956A1 (pt)
CZ (1) CZ128098A3 (pt)
EA (1) EA000528B1 (pt)
EE (1) EE9800147A (pt)
HK (1) HK1017894A1 (pt)
HU (1) HUP9902208A3 (pt)
IS (1) IS4721A (pt)
NO (1) NO310556B1 (pt)
NZ (1) NZ321370A (pt)
PL (1) PL327511A1 (pt)
SK (1) SK51398A3 (pt)
TR (1) TR199800726T2 (pt)
WO (1) WO1997015574A1 (pt)
YU (1) YU56696A (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6046333A (en) * 1996-10-25 2000-04-04 Merck & Co., Inc. Convergent process for the preparation of a growth hormone secretagogue
US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
WO2017075535A1 (en) 2015-10-28 2017-05-04 Oxeia Biopharmaceuticals, Inc. Methods of treating neurodegenerative conditions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK282166B6 (sk) * 1992-12-11 2001-11-06 Merck & Co., Inc. Spiropiperidínové deriváty, spôsob ich výroby a farmaceutický prostriedok s ich obsahom

Also Published As

Publication number Publication date
CO4770956A1 (es) 1999-04-30
AU7468696A (en) 1997-05-15
KR19990067098A (ko) 1999-08-16
HUP9902208A2 (hu) 1999-10-28
EA000528B1 (ru) 1999-10-28
CN1067687C (zh) 2001-06-27
NO981867L (no) 1998-06-29
YU56696A (sh) 1999-09-27
BG102476A (en) 1999-04-30
WO1997015574A1 (en) 1997-05-01
HK1017894A1 (en) 1999-12-03
EA199800335A1 (ru) 1998-12-24
CA2235371A1 (en) 1997-05-01
JP3204266B2 (ja) 2001-09-04
HUP9902208A3 (en) 2001-05-28
NZ321370A (en) 1999-11-29
SK51398A3 (en) 1998-12-02
NO310556B1 (no) 2001-07-23
AU707946B2 (en) 1999-07-22
TR199800726T2 (xx) 1998-08-21
JPH10512295A (ja) 1998-11-24
IS4721A (is) 1998-04-21
PL327511A1 (en) 1998-12-21
EE9800147A (et) 1998-12-15
MX9803351A (es) 1998-09-30
NO981867D0 (no) 1998-04-24
CN1205703A (zh) 1999-01-20
CZ128098A3 (cs) 1998-09-16
EP1019402A1 (en) 2000-07-19

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFERIMENTO DO PRESENTE PEDIDO, UMA VEZ QUE O MESMO NAO ATENDE AOS REQUISITO NOVIDADE ( ART. 8O C/C ART. 11 DA LPI ) E ATIVIDADE INVENTIVA ( ART. 8O C/C ART. 13 DA LPI )

B25D Requested change of name of applicant approved

Owner name: MERCK SHARP AND DOHME CORP. (US)

Free format text: NOME ALTERADO DE: MERCK AND CO., INC.

B12B Appeal against refusal [chapter 12.2 patent gazette]
B25A Requested transfer of rights approved

Owner name: SCHERING CORPORATION (US)

B25D Requested change of name of applicant approved

Owner name: MERCK SHARP AND DOHME CORP. (US)

B25G Requested change of headquarter approved

Owner name: MERCK SHARP AND DOHME CORP. (US)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]
B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]