MX9803351A - Formas polimorficas de un secretagogo de hormona de crecimiento. - Google Patents
Formas polimorficas de un secretagogo de hormona de crecimiento.Info
- Publication number
- MX9803351A MX9803351A MX9803351A MX9803351A MX9803351A MX 9803351 A MX9803351 A MX 9803351A MX 9803351 A MX9803351 A MX 9803351A MX 9803351 A MX9803351 A MX 9803351A MX 9803351 A MX9803351 A MX 9803351A
- Authority
- MX
- Mexico
- Prior art keywords
- polymorphic forms
- growth hormone
- polymorphic
- methanesulfonylspiro
- phenylmethyloxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Fodder In General (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines Containing Plant Substances (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Esta invencion se refiere a formas polimorficas del compuesto metanosulfonato de N-[1(R)-[1,2-dihidro-metanosulfonil-espiro[3H-indo l-3,4'-piperidin]-1'il)-carbonil]-2-(fenilmetiloxi -etil]-2-amino-2-metilpropanamida, que es un secretagogo de hormona de crecimiento,util en animales productores de alimento para promover su crecimiento, volviendo así más eficiente la elaboracion de productos de carne comestible, y en los humanos, para tratar condiciones fisiologicas o médicas que se caracterizan por una deficiencia de la secrecion de la hormona de crecimiento, y para tratar condiciones médicas que mejoran por los efectos anabolicos de la hormona de crecimiento; las formas polimorficas presentes tienen ventajas sobre las demás formas conocidas de metanosulfonato de N-[1(R)-[1,2-dihidro-metanosulfonil-espiro[3H-indo l-3,4'-piperidin]-1'-il)-carbonil]-2-(fenilmetil-o xi)-etil]-2-amino-2-metilpropanamida, en términos de estabilidad termodinámica y adaptabilidad para su inclusion en formulaciones farmacéuticas; la presente invencion también se refiere a procedimientos para preparar estas formas polimorficas, formulaciones farmacéuticas que comprenden estas formas polimorficas como ingredientes activos y al uso de la forma polimorfica del compuesto y sus formulaciones en el tratamiento de ciertos trastornos.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US590095P | 1995-10-27 | 1995-10-27 | |
| US005900 | 1995-10-27 | ||
| GBGB9603361.8A GB9603361D0 (en) | 1996-02-16 | 1996-02-16 | Polymorphic forms of a growth hormone secretagogue |
| GB9603361.8 | 1996-02-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9803351A true MX9803351A (es) | 1998-09-30 |
| MXPA98003351A MXPA98003351A (es) | 1998-11-16 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| NZ321370A (en) | 1999-11-29 |
| PL327511A1 (en) | 1998-12-21 |
| NO981867L (no) | 1998-06-29 |
| CN1205703A (zh) | 1999-01-20 |
| EA000528B1 (ru) | 1999-10-28 |
| JP3204266B2 (ja) | 2001-09-04 |
| SK51398A3 (en) | 1998-12-02 |
| BR9611229A (pt) | 1999-05-25 |
| AU707946B2 (en) | 1999-07-22 |
| EP1019402A1 (en) | 2000-07-19 |
| YU56696A (sh) | 1999-09-27 |
| BG102476A (en) | 1999-04-30 |
| AU7468696A (en) | 1997-05-15 |
| EA199800335A1 (ru) | 1998-12-24 |
| CO4770956A1 (es) | 1999-04-30 |
| JPH10512295A (ja) | 1998-11-24 |
| NO310556B1 (no) | 2001-07-23 |
| NO981867D0 (no) | 1998-04-24 |
| CZ128098A3 (cs) | 1998-09-16 |
| CA2235371A1 (en) | 1997-05-01 |
| HK1017894A1 (en) | 1999-12-03 |
| EE9800147A (et) | 1998-12-15 |
| WO1997015574A1 (en) | 1997-05-01 |
| KR19990067098A (ko) | 1999-08-16 |
| HUP9902208A2 (hu) | 1999-10-28 |
| CN1067687C (zh) | 2001-06-27 |
| TR199800726T2 (xx) | 1998-08-21 |
| IS4721A (is) | 1998-04-21 |
| HUP9902208A3 (en) | 2001-05-28 |
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