DE60135904D1 - Arzneien zur behandlung von nervenerkrankungen - Google Patents
Arzneien zur behandlung von nervenerkrankungenInfo
- Publication number
- DE60135904D1 DE60135904D1 DE60135904T DE60135904T DE60135904D1 DE 60135904 D1 DE60135904 D1 DE 60135904D1 DE 60135904 T DE60135904 T DE 60135904T DE 60135904 T DE60135904 T DE 60135904T DE 60135904 D1 DE60135904 D1 DE 60135904D1
- Authority
- DE
- Germany
- Prior art keywords
- growth factor
- nerve growth
- factor production
- enhancing
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 201000010099 disease Diseases 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 title 1
- 210000005036 nerve Anatomy 0.000 title 1
- 230000014537 nerve growth factor production Effects 0.000 abstract 9
- 230000002708 enhancing effect Effects 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 3
- 235000013361 beverage Nutrition 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 239000003623 enhancer Substances 0.000 abstract 2
- 230000000069 prophylactic effect Effects 0.000 abstract 2
- 229940124597 therapeutic agent Drugs 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/121—Heterocyclic compounds containing oxygen or sulfur as hetero atom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/12—Acetic acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicinal Preparation (AREA)
- Fodder In General (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000019208 | 2000-01-27 | ||
JP2000019331 | 2000-01-27 | ||
JP2000254683 | 2000-08-24 | ||
JP2000308519 | 2000-10-06 | ||
PCT/JP2001/000513 WO2001054682A1 (fr) | 2000-01-27 | 2001-01-26 | Medicaments |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60135904D1 true DE60135904D1 (de) | 2008-11-06 |
Family
ID=27480961
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60135904T Expired - Fee Related DE60135904D1 (de) | 2000-01-27 | 2001-01-26 | Arzneien zur behandlung von nervenerkrankungen |
Country Status (10)
Country | Link |
---|---|
US (1) | US7268160B2 (de) |
EP (1) | EP1254658B1 (de) |
JP (1) | JP4249926B2 (de) |
KR (2) | KR100711537B1 (de) |
CN (1) | CN100346776C (de) |
AT (1) | ATE409028T1 (de) |
AU (1) | AU2001228825A1 (de) |
DE (1) | DE60135904D1 (de) |
TW (1) | TWI255181B (de) |
WO (1) | WO2001054682A1 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1127572A3 (de) * | 2000-02-25 | 2003-05-02 | Basf Aktiengesellschaft | Verwendung von Flavonen zur Behandlung von Cyclooxygenase-2 ermittelten Krankheiten |
KR20020089440A (ko) * | 2000-04-11 | 2002-11-29 | 다카라 바이오 가부시키가이샤 | 치료제 |
FR2841784B1 (fr) | 2002-07-08 | 2007-03-02 | Composition a base de derives de 1,3-diphenylprop-2en-1-one substitues, preparation et utilisations | |
FR2841900B1 (fr) | 2002-07-08 | 2007-03-02 | Genfit S A | Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations |
EP1574506A4 (de) | 2002-10-01 | 2007-05-30 | Takara Bio Inc | Heilmittel |
AU2003277630A1 (en) * | 2002-11-12 | 2004-06-03 | Takara Bio Inc. | Agent for improving learning and memorizing abilities |
US20070092551A1 (en) * | 2003-05-02 | 2007-04-26 | Takara Bio Inc. | Therapeutic agent |
KR20060121273A (ko) * | 2003-12-05 | 2006-11-28 | 다카라 바이오 가부시키가이샤 | 치료제 |
JPWO2005074906A1 (ja) * | 2004-02-06 | 2008-01-10 | タカラバイオ株式会社 | 治療剤 |
EP1883453A1 (de) * | 2005-05-26 | 2008-02-06 | Council Of Scientific And Industrial Research | Pharmazeutische zusammensetzung mit eignung bei der behandlung von hepatozellulärem karzinom |
JP2007230946A (ja) * | 2006-03-02 | 2007-09-13 | Nagase & Co Ltd | 神経突起伸長剤 |
JP4912708B2 (ja) * | 2006-03-24 | 2012-04-11 | 三井農林株式会社 | 新規物質tmr |
WO2009013168A1 (en) * | 2007-07-25 | 2009-01-29 | Symrise Gmbh & Co. Kg | 3-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)-1-propanone and its use as antioxidant |
CN102697757B (zh) * | 2012-05-18 | 2014-06-04 | 广州军区广州总医院 | 对羟基苄叉丙酮在制备预防和/或治疗脑病药物中的应用 |
JP2017043572A (ja) * | 2015-08-28 | 2017-03-02 | 株式会社ファンケル | ヘリピロンaを有効成分とするbdnf産生促進剤 |
CN109651121B (zh) * | 2019-01-25 | 2021-11-26 | 陕西理工大学 | 一种Robtein的合成方法 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA945175A (en) * | 1970-11-16 | 1974-04-09 | Bunzo Nomiya | Benzalacetone or acetophenone amidinohydrazone derivatives and the production thereof |
FI874163A (fi) | 1986-09-26 | 1988-03-27 | Mitsui Toatsu Chemicals | Katekolderivat samt preparat innehaollande desamma foer haemmande och botande av regressiva sjukdomar i det centrala nervsystemet. |
JPS6442422A (en) | 1987-08-10 | 1989-02-14 | Tsumura & Co | Antiulcer agent |
KR890700117A (ko) | 1986-12-12 | 1989-03-02 | 쓰무라 아끼라 | 유효성분으로서 칼콘 유도체를 함유하는 항 궤양제 및 신규의 칼콘 유도체 |
US5234951A (en) | 1986-12-12 | 1993-08-10 | Tsumura Juntendo, Inc. | Anti-ulcer agent comprising chalcone derivative |
JPH01125320A (ja) | 1987-11-09 | 1989-05-17 | Tsumura & Co | テストステロン−5α−リダクターゼ阻害剤 |
JPH02104568A (ja) | 1988-06-22 | 1990-04-17 | Yoshitomi Pharmaceut Ind Ltd | 神経成長因子産生促進作用剤 |
JPH02187765A (ja) | 1989-01-14 | 1990-07-23 | Oki Electric Ind Co Ltd | コントラスト増強用の光脱色性層用材料およびそれを用いたパターン形成方法 |
JPH08768B2 (ja) * | 1989-08-24 | 1996-01-10 | 武田薬品工業株式会社 | 神経成長因子分泌誘導剤 |
JPH03122645A (ja) | 1989-10-05 | 1991-05-24 | Nippon Kanko Shikiso Kenkyusho:Kk | ホトレジスト用光吸収材料 |
JP2719042B2 (ja) | 1990-11-22 | 1998-02-25 | 三共株式会社 | 神経成長因子産生分泌促進剤 |
JPH07110812B2 (ja) | 1990-12-11 | 1995-11-29 | 財団法人喫煙科学研究財団 | 神経成長因子生合成促進剤 |
JPH0578384A (ja) | 1991-03-27 | 1993-03-30 | Taisho Pharmaceut Co Ltd | フラボノール誘導体 |
JPH0561220A (ja) | 1991-08-30 | 1993-03-12 | Ricoh Co Ltd | 電子写真感光体 |
JPH05246932A (ja) * | 1992-03-04 | 1993-09-24 | Nippon High Potsukusu:Kk | 3,4−ジヒドロキシカルコン誘導体 |
JPH07194355A (ja) * | 1993-12-28 | 1995-08-01 | Sanei Gen F F I Inc | エタノール製剤 |
JPH07285856A (ja) * | 1994-04-21 | 1995-10-31 | Hoechst Japan Ltd | 骨粗鬆症治療剤 |
JPH0827086A (ja) | 1994-07-22 | 1996-01-30 | Sagami Chem Res Center | N−アシル−n−置換シンナモイルエチレンジアミン誘導体 |
FR2747568B1 (fr) | 1996-04-17 | 1999-09-17 | Oreal | Utilisation d'au moins un inhibiteur de lipoxygenase et d'au moins un inhibiteur de cyclo-oxygenase pour modifier la pousse des poils et/ou des cheveux |
JPH10114649A (ja) * | 1996-10-15 | 1998-05-06 | Dokutaazu Kosumeteikusu:Kk | 津液改善剤及びそれを含有する経口投与用組成物 |
GB9712966D0 (en) | 1997-06-19 | 1997-08-27 | Indena Spa | Novel chalcones |
JPH11246398A (ja) * | 1998-03-02 | 1999-09-14 | Kyowa Hakko Kogyo Co Ltd | 生体内過酸化脂質増加に起因する疾患の予防または治療剤 |
EP0998939A1 (de) * | 1998-09-09 | 2000-05-10 | The School Of Pharmacy, University Of London | Chalcone Pflanzenextrakten zur Anwendung in der Therapie |
JP4171178B2 (ja) | 1999-02-19 | 2008-10-22 | タカラバイオ株式会社 | 治療剤 |
AU3837300A (en) * | 1999-04-15 | 2000-11-02 | Takara Shuzo Co., Ltd. | Remedies |
WO2001030335A2 (en) * | 1999-10-22 | 2001-05-03 | The Board Of Trustees Of The University Of Illinois | Pharmaceutical compositions useful in the prevention and treatment of beta-amyloid protein-induced disease |
-
2001
- 2001-01-26 CN CNB018073298A patent/CN100346776C/zh not_active Expired - Fee Related
- 2001-01-26 KR KR1020027009621A patent/KR100711537B1/ko not_active IP Right Cessation
- 2001-01-26 AU AU2001228825A patent/AU2001228825A1/en not_active Abandoned
- 2001-01-26 JP JP2001555660A patent/JP4249926B2/ja not_active Expired - Fee Related
- 2001-01-26 WO PCT/JP2001/000513 patent/WO2001054682A1/ja active IP Right Grant
- 2001-01-26 US US10/182,193 patent/US7268160B2/en not_active Expired - Fee Related
- 2001-01-26 AT AT01946787T patent/ATE409028T1/de not_active IP Right Cessation
- 2001-01-26 KR KR1020067016718A patent/KR20060095786A/ko not_active Application Discontinuation
- 2001-01-26 DE DE60135904T patent/DE60135904D1/de not_active Expired - Fee Related
- 2001-01-26 EP EP01946787A patent/EP1254658B1/de not_active Expired - Lifetime
- 2001-01-29 TW TW090101645A patent/TWI255181B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU2001228825A1 (en) | 2001-08-07 |
EP1254658A1 (de) | 2002-11-06 |
WO2001054682A1 (fr) | 2001-08-02 |
CN1419448A (zh) | 2003-05-21 |
EP1254658B1 (de) | 2008-09-24 |
JP4249926B2 (ja) | 2009-04-08 |
KR20060095786A (ko) | 2006-09-01 |
KR20020073186A (ko) | 2002-09-19 |
ATE409028T1 (de) | 2008-10-15 |
TWI255181B (en) | 2006-05-21 |
CN100346776C (zh) | 2007-11-07 |
US20030144316A1 (en) | 2003-07-31 |
US7268160B2 (en) | 2007-09-11 |
EP1254658A4 (de) | 2003-06-18 |
KR100711537B1 (ko) | 2007-04-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60135904D1 (de) | Arzneien zur behandlung von nervenerkrankungen | |
ATE355374T1 (de) | Therapeutische agentien und methoden ihrer verwendung zur behandlung von amyloidogenen erkrankungen | |
ATE405564T1 (de) | 1h-imidazoä4,5-cüchinolinderivate zur behandlung von protein kinase-abhängigen krankheiten | |
EP1302542A4 (de) | Neues, physiologisch aktives peptid und dessen verwendung | |
WO2003099771A3 (en) | Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases | |
MXPA05006940A (es) | Formulaciones terapeuticas para el tratamiento de enfermedades relacionadas con beta - amiloide. | |
HUP0105027A2 (hu) | N-Heterociklusos vegyületek karbonsavszármazékai és karbonsav-izoszterei és alkalmazásuk | |
EA200100524A1 (ru) | Амиды антраниловой кислоты и их применение в качестве лекарственных средств | |
DE60222137D1 (de) | Zuckerderivate von hydromorphon, dihydromorphin und dihydroisomorphin, zusammensetzungen davon und verwendung zur vorbeugung und behandlung von schmerzen | |
ATE388951T1 (de) | Dpp-iv-inhibierende purin-derivative zur behandlung von diabetes | |
DE60126829D1 (de) | Kombination von drei Substanzen zur Vorbeugung und Behandlung von Arthritis | |
ATE412646T1 (de) | Zur behandlung von schmerzen geeignete therapeutische mittel | |
ATE367387T1 (de) | Verwendung von oxindolderivaten zur behandlung von mit demenz in zusammenhang stehenden krankheiten, alzheimer-krankheit und mit glycogensynthasekinase-3 assoziierten leiden | |
ATE439833T1 (de) | Pharmazeutische zubereitung enthaltend ein catechin, ascorbinsäure, prolin und lysin zur behandlung von neoplastischen krankheiten | |
AU2001266289A1 (en) | 2-arachidonylglycerol (2-ag) - an inhibitor of tumor necrosis factor -alfa and neuroprotector of brain in closed head injury | |
DE69521536D1 (de) | Zusammensetzungen die G-CSF und ein TNF-Bindungsprotein enthalten | |
ATE366107T1 (de) | Verwendung von sulfodehydroabietinsäure zur behandlung entzündlicher darmerkrankungen | |
ATE265851T1 (de) | Behandlung von erkrankungen, die vom cytokinwachstumsfaktor verursacht werden | |
ATE192923T1 (de) | Verwendung von boswelliasäure zur behandlung von hirntumoren | |
MXPA06007007A (es) | Derivados de prolina usados como ingredientes farmaceuticos activos para el tratamiento de tumores. | |
ATE285773T1 (de) | Pharmazeutische zusammensetzungen zur behandlung von neurologischen krankheiten | |
DE60306503D1 (de) | Statin-therapie zur verbesserung der aufrechterhaltung der kognitiven funktion | |
DE68916651D1 (de) | Heilmittel zur behandlung von toxoplasmose. | |
HUP0105412A2 (hu) | 3-Izoxazolidinon- és karboxi-alkil-hidroxámsav-származékok alkalmazása fertőzések kezelésére szolgáló gyógyszerkészítmények előállítására | |
ATE350034T1 (de) | Verwendung von epothilone zur behandlung hyperparathyreoidismus |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |