CN1067687C - 生长激素促分泌素的多晶型物 - Google Patents

生长激素促分泌素的多晶型物 Download PDF

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Publication number
CN1067687C
CN1067687C CN96199328A CN96199328A CN1067687C CN 1067687 C CN1067687 C CN 1067687C CN 96199328 A CN96199328 A CN 96199328A CN 96199328 A CN96199328 A CN 96199328A CN 1067687 C CN1067687 C CN 1067687C
Authority
CN
China
Prior art keywords
spiral shell
ethyl
growth hormone
amino
carbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN96199328A
Other languages
English (en)
Chinese (zh)
Other versions
CN1205703A (zh
Inventor
J·P·德拉佩
D·C·杜波斯特
M·J·考夫曼
J·A·麦考莱
J·L·范德里拉
R·J·瓦索罗纳
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603361.8A external-priority patent/GB9603361D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of CN1205703A publication Critical patent/CN1205703A/zh
Application granted granted Critical
Publication of CN1067687C publication Critical patent/CN1067687C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Fodder In General (AREA)
  • Steroid Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN96199328A 1995-10-27 1996-10-23 生长激素促分泌素的多晶型物 Expired - Lifetime CN1067687C (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US590095P 1995-10-27 1995-10-27
US60/005,900 1995-10-27
GBGB9603361.8A GB9603361D0 (en) 1996-02-16 1996-02-16 Polymorphic forms of a growth hormone secretagogue
GB9603361.8 1996-02-16
PCT/US1996/016955 WO1997015574A1 (en) 1995-10-27 1996-10-23 Polymorphic forms of a growth hormone secretagogue

Publications (2)

Publication Number Publication Date
CN1205703A CN1205703A (zh) 1999-01-20
CN1067687C true CN1067687C (zh) 2001-06-27

Family

ID=26308741

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96199328A Expired - Lifetime CN1067687C (zh) 1995-10-27 1996-10-23 生长激素促分泌素的多晶型物

Country Status (22)

Country Link
EP (1) EP1019402A1 (pt)
JP (1) JP3204266B2 (pt)
KR (1) KR19990067098A (pt)
CN (1) CN1067687C (pt)
AU (1) AU707946B2 (pt)
BG (1) BG102476A (pt)
BR (1) BR9611229A (pt)
CA (1) CA2235371A1 (pt)
CO (1) CO4770956A1 (pt)
CZ (1) CZ128098A3 (pt)
EA (1) EA000528B1 (pt)
EE (1) EE9800147A (pt)
HK (1) HK1017894A1 (pt)
HU (1) HUP9902208A3 (pt)
IS (1) IS4721A (pt)
NO (1) NO310556B1 (pt)
NZ (1) NZ321370A (pt)
PL (1) PL327511A1 (pt)
SK (1) SK51398A3 (pt)
TR (1) TR199800726T2 (pt)
WO (1) WO1997015574A1 (pt)
YU (1) YU56696A (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6046333A (en) * 1996-10-25 2000-04-04 Merck & Co., Inc. Convergent process for the preparation of a growth hormone secretagogue
US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
US20170121385A1 (en) 2015-10-28 2017-05-04 Oxeia Biopharmaceuticals, Inc. Methods of treating neurodegenerative conditions

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994013696A1 (en) * 1992-12-11 1994-06-23 Merck & Co., Inc. Spiro piperidines and homologs which promote release of growth hormone

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994013696A1 (en) * 1992-12-11 1994-06-23 Merck & Co., Inc. Spiro piperidines and homologs which promote release of growth hormone

Also Published As

Publication number Publication date
NO981867D0 (no) 1998-04-24
NZ321370A (en) 1999-11-29
JP3204266B2 (ja) 2001-09-04
EP1019402A1 (en) 2000-07-19
MX9803351A (es) 1998-09-30
NO981867L (no) 1998-06-29
TR199800726T2 (xx) 1998-08-21
AU707946B2 (en) 1999-07-22
BR9611229A (pt) 1999-05-25
CN1205703A (zh) 1999-01-20
KR19990067098A (ko) 1999-08-16
WO1997015574A1 (en) 1997-05-01
EE9800147A (et) 1998-12-15
AU7468696A (en) 1997-05-15
HUP9902208A2 (hu) 1999-10-28
HK1017894A1 (en) 1999-12-03
NO310556B1 (no) 2001-07-23
SK51398A3 (en) 1998-12-02
CO4770956A1 (es) 1999-04-30
IS4721A (is) 1998-04-21
JPH10512295A (ja) 1998-11-24
EA000528B1 (ru) 1999-10-28
EA199800335A1 (ru) 1998-12-24
CZ128098A3 (cs) 1998-09-16
CA2235371A1 (en) 1997-05-01
HUP9902208A3 (en) 2001-05-28
BG102476A (en) 1999-04-30
YU56696A (sh) 1999-09-27
PL327511A1 (en) 1998-12-21

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
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C56 Change in the name or address of the patentee

Owner name: MERCK & CO. INC.

Free format text: FORMER NAME OR ADDRESS: MERCK + CO., INC.

CP03 Change of name, title or address

Address after: New jersey, USA

Patentee after: MERCK & Co.,Inc.

Address before: New jersey, USA

Patentee before: MERCK & Co.,Inc.

C56 Change in the name or address of the patentee
CP01 Change in the name or title of a patent holder

Address after: New jersey, USA

Patentee after: MERCK SHARP & DOHME Corp.

Address before: New jersey, USA

Patentee before: MERCK & Co.,Inc.

ASS Succession or assignment of patent right

Owner name: SCHERING CORP (US)

Free format text: FORMER OWNER: MSD CORP.

Effective date: 20121108

C41 Transfer of patent application or patent right or utility model
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Owner name: MSD CORP.

Free format text: FORMER NAME: SCHERING CORP (US)

CP01 Change in the name or title of a patent holder

Address after: New jersey, USA

Patentee after: MERCK SHARP & DOHME Corp.

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Patentee before: SCHERING Corp.

TR01 Transfer of patent right

Effective date of registration: 20121108

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Patentee after: SCHERING Corp.

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CX01 Expiry of patent term

Granted publication date: 20010627

EXPY Termination of patent right or utility model