SK287618B6 - Vakcína obsahujúca aspoň jeden antigén a peptid a použitie tohto peptidu - Google Patents
Vakcína obsahujúca aspoň jeden antigén a peptid a použitie tohto peptidu Download PDFInfo
- Publication number
- SK287618B6 SK287618B6 SK575-2003A SK5752003A SK287618B6 SK 287618 B6 SK287618 B6 SK 287618B6 SK 5752003 A SK5752003 A SK 5752003A SK 287618 B6 SK287618 B6 SK 287618B6
- Authority
- SK
- Slovakia
- Prior art keywords
- peptide
- amino acid
- vaccine
- acid residues
- antigen
- Prior art date
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Landscapes
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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AT0178900A AT410635B (de) | 2000-10-18 | 2000-10-18 | Vakzin-zusammensetzung |
PCT/EP2001/012041 WO2002032451A1 (en) | 2000-10-18 | 2001-10-18 | Vaccine composition comprising an antigen and a peptide having adjuvant properties |
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SK5752003A3 SK5752003A3 (en) | 2003-12-02 |
SK287618B6 true SK287618B6 (sk) | 2011-04-05 |
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SK575-2003A SK287618B6 (sk) | 2000-10-18 | 2001-10-18 | Vakcína obsahujúca aspoň jeden antigén a peptid a použitie tohto peptidu |
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US (3) | US8361476B2 (da) |
EP (1) | EP1326634B1 (da) |
JP (2) | JP4227407B2 (da) |
KR (1) | KR100598302B1 (da) |
CN (1) | CN1248736C (da) |
AT (2) | AT410635B (da) |
AU (2) | AU1232602A (da) |
BR (1) | BRPI0114994B8 (da) |
CA (1) | CA2426490C (da) |
CZ (1) | CZ303303B6 (da) |
DE (1) | DE60119145T2 (da) |
DK (1) | DK1326634T3 (da) |
ES (1) | ES2263668T3 (da) |
HK (1) | HK1055899A1 (da) |
HU (1) | HU228382B1 (da) |
IL (2) | IL154605A0 (da) |
IS (1) | IS2608B (da) |
MX (1) | MXPA03002828A (da) |
NO (1) | NO330274B1 (da) |
NZ (1) | NZ524532A (da) |
PL (1) | PL209016B1 (da) |
PT (1) | PT1326634E (da) |
RU (2) | RU2328305C2 (da) |
SI (1) | SI1326634T1 (da) |
SK (1) | SK287618B6 (da) |
WO (1) | WO2002032451A1 (da) |
ZA (1) | ZA200301465B (da) |
Families Citing this family (80)
Publication number | Priority date | Publication date | Assignee | Title |
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AT410635B (de) * | 2000-10-18 | 2003-06-25 | Cistem Biotechnologies Gmbh | Vakzin-zusammensetzung |
US7244438B2 (en) | 2001-01-05 | 2007-07-17 | Intercell Ag | Uses for polycationic compounds |
JP2004519452A (ja) * | 2001-01-05 | 2004-07-02 | インターツェル・アクチェンゲゼルシャフト | ポリカチオン性化合物の用途 |
AT410798B (de) | 2001-01-26 | 2003-07-25 | Cistem Biotechnologies Gmbh | Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen |
EP1279404A1 (en) | 2001-07-26 | 2003-01-29 | Istituto Superiore di Sanità | Use of HIV-1 tat, fragments or derivatives thereof, to target or to activate antigen-presenting cells, to deliver cargo molecules for vaccination or to treat other diseases |
MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
JP2005533855A (ja) | 2002-07-24 | 2005-11-10 | インターツェル・アクチェンゲゼルシャフト | 病原性ウイルスからの別のリーディングフレームによりコードされる抗原 |
US7785608B2 (en) | 2002-08-30 | 2010-08-31 | Wyeth Holdings Corporation | Immunogenic compositions for the prevention and treatment of meningococcal disease |
AU2003258672B2 (en) | 2002-09-13 | 2008-10-30 | Intercell Ag | Method for isolating hepatitis C virus peptides |
WO2004035618A2 (en) | 2002-10-15 | 2004-04-29 | Intercell Ag | Nucleic acids coding for adhesion factor of group b streptococcus, adhesion factors of group b streptococcus and further uses thereof |
CN1756843B (zh) | 2003-03-04 | 2012-03-21 | 英特塞尔股份公司 | 化脓链球菌抗原 |
EP1608402B1 (en) | 2003-03-24 | 2010-10-20 | Intercell AG | Improved vaccines |
AU2004224747A1 (en) * | 2003-03-24 | 2004-10-07 | Intercell Ag | Use of Alum and a th1 immune response inducing adjuvant for enhancing immune responses |
WO2004087746A2 (en) | 2003-03-31 | 2004-10-14 | Intercell Ag | Staphylococcus epidermidis antigens |
CA2522238A1 (en) | 2003-04-15 | 2004-10-28 | Intercell Ag | S. pneumoniae antigens |
US8076059B2 (en) | 2003-04-16 | 2011-12-13 | Duke University | Adjuvant capable of specifically activating the adaptive immune response |
AU2004235952A1 (en) | 2003-05-07 | 2004-11-18 | Intercell Ag | Streptococcus agalactiae antigens I + II |
CN102304527A (zh) | 2003-05-30 | 2012-01-04 | 英特塞尔股份公司 | 肠球菌抗原 |
ATE489967T1 (de) * | 2003-07-11 | 2010-12-15 | Intercell Ag | Hcv-vakzin |
ES2297688T3 (es) | 2004-03-12 | 2008-05-01 | Intercell Ag | Procedimiento para solubizar mezclas de peptidos. |
ES2344739T3 (es) | 2004-09-24 | 2010-09-06 | Intercell Ag | Proteina capsidial vp1 modificada del parvovirus b19. |
US20090269358A1 (en) | 2005-10-07 | 2009-10-29 | Shone Clifford C | Proteins with Improved Solubility and Methods for Producing and Using Same |
TW200806315A (en) | 2006-04-26 | 2008-02-01 | Wyeth Corp | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
DK2040745T3 (da) | 2006-06-28 | 2013-03-18 | Statens Seruminstitut | Udvidelse af T-celle repertoiret til at omfatter subdominante epitoper ved vacci-nation med antigener leveret som proteinfragmenter eller peptidblandinger |
EP2292645A3 (en) | 2006-07-07 | 2011-05-25 | Intercell AG | Small Streptococcus pyogenes antigens and their use |
EP2059526A2 (en) | 2006-09-15 | 2009-05-20 | Intercell AG | Borrelia antigens |
EP1923069A1 (en) | 2006-11-20 | 2008-05-21 | Intercell AG | Peptides protective against S. pneumoniae and compositions, methods and uses relating thereto |
AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
EP2269624A3 (en) | 2007-01-12 | 2012-08-08 | Intercell AG | Protective proteins of S. agalactiae, combinations thereof and methods of using the same |
CA2685805A1 (en) | 2007-05-02 | 2008-11-13 | Intercell Ag | Klebsiella antigens |
DK2158211T3 (da) | 2007-05-31 | 2016-12-05 | Medigene Ag | Muteret strukturprotein af en parvovirus |
EP2012122A1 (en) | 2007-07-06 | 2009-01-07 | Medigene AG | Mutated parvovirus structural proteins as vaccines |
EP2511291A3 (en) | 2007-06-18 | 2012-11-07 | Intercell AG | Chlamydia antigens |
US8241643B2 (en) | 2008-03-17 | 2012-08-14 | Intercell Ag | Peptides protective against S. pneumoniae and compositions, methods and uses relating thereto |
JP5473899B2 (ja) | 2008-04-02 | 2014-04-16 | 国立大学法人徳島大学 | 合成ペプチドを含有する抗原薬物ビークルとこれを用いる粘膜ワクチン |
RU2010151562A (ru) | 2008-06-20 | 2012-07-27 | ВАЙЕТ ЭлЭлСи (US) | Композиции и способы применения orf1358 из бета-гемолитических стрептококковых штаммов |
US20100015171A1 (en) * | 2008-07-15 | 2010-01-21 | Statens Serum Institute | Vaccines comprising tb 10.4 |
EP2424882A2 (en) | 2009-02-05 | 2012-03-07 | Intercell AG | Peptides protective against e. faecalis, methods and uses relating thereto |
US8617574B2 (en) | 2009-02-13 | 2013-12-31 | Valneva Austria Gmbh | Nontypable Haemophilus influenzae antigens |
CA2766418C (en) | 2009-06-22 | 2016-03-29 | Wyeth Llc | Compositions and methods for preparing staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions |
JP5395264B2 (ja) | 2009-06-22 | 2014-01-22 | ワイス・エルエルシー | 黄色ブドウ球菌(staphylococcusaureus)抗原の免疫原性組成物 |
EP2470205A1 (en) | 2009-08-27 | 2012-07-04 | Novartis AG | Adjuvant comprising aluminium, oligonucleotide and polycation |
EP2319871A1 (en) | 2009-11-05 | 2011-05-11 | Sanofi-aventis | Polypeptides for binding to the "receptor for advanced glycation endproducts" as well as compositions and methods involving the same |
KR20120089863A (ko) | 2009-10-09 | 2012-08-14 | 사노피 | “개선된 당화반응 최종 생성물에 대한 수용체”에 결합하기 위한 폴리펩타이드 및 이를 포함하는 조성물 및 방법 |
EP2308896A1 (en) | 2009-10-09 | 2011-04-13 | Sanofi-aventis | Polypeptides for binding to the "receptor for advanced glycation endproducts" as well as compositions and methods involving the same |
WO2011101465A1 (en) | 2010-02-19 | 2011-08-25 | Intercell Ag | Ic31 nanoparticles |
JP2013522287A (ja) | 2010-03-18 | 2013-06-13 | ノバルティス アーゲー | 血清群b髄膜炎菌のためのアジュバント添加ワクチン |
PL3170508T3 (pl) | 2010-06-04 | 2020-04-30 | Wyeth Llc | Preparaty szczepionek |
FI3831406T3 (fi) | 2010-08-23 | 2024-08-06 | Wyeth Llc | Neisseria meningitidis rlp2086 -antigeenien stabiileja formulaatioita |
KR101907434B1 (ko) | 2010-09-03 | 2018-10-12 | 발네바 오스트리아 게엠베하 | C. 디피실의 a 독소 및 b 독소 단백질의 분리된 폴리펩타이드 및 이의 용도 |
AR082925A1 (es) | 2010-09-08 | 2013-01-16 | Medigene Ag | Proteinas estructurales mutadas por parvovirus con epitopo de celulas b de proteccion cruzada, producto y metodos relacionados |
ES2864635T3 (es) | 2010-09-10 | 2021-10-14 | Wyeth Llc | Variantes no lipidadas de antígenos ORF2086 de Neisseria meningitidis |
KR101808398B1 (ko) | 2010-12-22 | 2017-12-12 | 와이어쓰 엘엘씨 | 스타필로코커스 아우레우스 항원의 안정한 면역원성 조성물 |
BRPI1100857A2 (pt) * | 2011-03-18 | 2013-05-21 | Alexandre Eduardo Nowill | agente imunomodulador e suas combinaÇÕes, seu uso e mÉtodo imunoterÁpico para a recontextualizaÇço, reprogramaÇço e reconduÇço do sistema imune em tempo real |
ITMI20111182A1 (it) | 2011-06-28 | 2012-12-29 | Canio Buonavoglia | Vaccino per coronavirus canino |
SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
WO2013132452A2 (en) | 2012-03-09 | 2013-09-12 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
CA2872656A1 (en) | 2012-05-08 | 2013-11-14 | Western University Of Health Sciences | Standardized ex vivo platforms for the antigen-specific expansion of cd4+t cell populations |
EA031234B1 (ru) * | 2012-10-29 | 2018-12-28 | Дзе Борд Оф Трастиз Оф Дзе Юниверсити Оф Арканзас | Вакцина с адъювантом на основе маннозилированного хитозана |
SI3363806T1 (sl) | 2012-12-20 | 2023-04-28 | Pfizer Inc. | Postopek glikokonjugacije |
EP2964665B1 (en) | 2013-03-08 | 2018-08-01 | Pfizer Inc | Immunogenic fusion polypeptides |
US20140271723A1 (en) * | 2013-03-15 | 2014-09-18 | Saint Louis University | Adjuvant compositions and methods of using thereof |
CA2923129C (en) | 2013-09-08 | 2020-06-09 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
WO2016130569A1 (en) | 2015-02-09 | 2016-08-18 | Mj Biologics, Inc. | A composition comprising pedv antigens and methods for making and using the composition |
WO2016132294A1 (en) | 2015-02-19 | 2016-08-25 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
MX368897B (es) | 2015-05-04 | 2019-10-21 | Pfizer | Conjugados proteina-polisacarido de estreptococo grupo b, metodos para producir conjugados, composiciones inmunogenas que comprenden conjugados y sus usos. |
CN113521007B (zh) * | 2016-07-01 | 2022-11-18 | 四川大学 | 抗菌肽衍生物在制备免疫佐剂中的用途 |
US10751402B2 (en) | 2016-11-09 | 2020-08-25 | Pfizer Inc. | Immunogenic compositions and uses thereof |
PE20191107A1 (es) | 2017-01-31 | 2019-08-26 | Pfizer | Composiciones de neisseria meningitidis y metodos respectivos |
CN107266585B (zh) * | 2017-07-13 | 2019-08-06 | 陕西科技大学 | 一种mlh融合抗菌肽及其制备方法和应用 |
EP3527223A1 (en) | 2018-02-16 | 2019-08-21 | 2A Pharma AB | Mutated parvovirus structural protein |
WO2019158636A1 (en) | 2018-02-16 | 2019-08-22 | 2A Pharma Ab | Parvovirus structural protein for the treatment of autoimmune diseases |
CN109745556A (zh) * | 2019-03-01 | 2019-05-14 | 龙阔(苏州)生物工程有限公司 | 一种疫苗佐剂及其应用及猪繁殖与呼吸综合征疫苗 |
GB2598494B (en) | 2019-05-20 | 2024-07-24 | Valneva Se | A subunit vaccine for treatment or prevention of a respiratory tract infection |
US20230137756A1 (en) * | 2020-03-30 | 2023-05-04 | The Wistar Institute Of Anatomy And Biology | Synthetic Soluble Receptor Mimics and Methods of Use for Treatment of COVID-19 |
US20230146256A1 (en) | 2020-04-17 | 2023-05-11 | Regents Of The University Of Minnesota | SARS-CoV-2 SPIKE RECEPTOR BINDING DOMAIN AND COMPOSITIONS AND METHODS THEREOF |
EP4203995A1 (en) | 2020-08-26 | 2023-07-05 | Pfizer Inc. | Group b streptococcus polysaccharide-protein conjugates, methods for producing conjugates, immunogenic compositions comprising conjugates, and uses thereof |
WO2022214678A2 (en) | 2021-04-09 | 2022-10-13 | Valneva Se | Human metapneumo virus vaccine |
WO2023083964A1 (en) | 2021-11-11 | 2023-05-19 | 2A Pharma Ab | Parvovirus structural protein against beta- and gamma-hpv |
WO2024069420A2 (en) | 2022-09-29 | 2024-04-04 | Pfizer Inc. | Immunogenic compositions comprising an rsv f protein trimer |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995004542A1 (en) * | 1993-08-06 | 1995-02-16 | Cytel Corporation | Cloning and characterization of the complete mage-1 gene |
JP3442824B2 (ja) * | 1993-08-30 | 2003-09-02 | 理化学研究所 | 抗菌性ペプチド類 |
JP3547504B2 (ja) * | 1994-11-01 | 2004-07-28 | 独立行政法人理化学研究所 | 新規なポリペプチド及びその用途 |
EP0991767A1 (en) * | 1997-06-11 | 2000-04-12 | Institut Pasteur | Attenuated recombinant mycobacteria useful as immunogens or as vaccine components |
CA2301587C (en) * | 1997-08-29 | 2008-07-08 | Corixa Corporation | Rapid release encapsulated bioactive agents for inducing or potentiating an immune response and methods of using thereof |
CU22700A1 (es) * | 1997-09-29 | 2001-07-31 | Ct Ingenieria Genetica Biotech | Formulación farmacéutica anti-viral que contiene un péptido de la proteína factor anti-lps de limulus y su uso |
US20020072495A1 (en) * | 2000-09-21 | 2002-06-13 | Oleg Chertov | LL-37 is an immunostimulant |
AT410635B (de) | 2000-10-18 | 2003-06-25 | Cistem Biotechnologies Gmbh | Vakzin-zusammensetzung |
AU2004224747A1 (en) * | 2003-03-24 | 2004-10-07 | Intercell Ag | Use of Alum and a th1 immune response inducing adjuvant for enhancing immune responses |
EP1608402B1 (en) * | 2003-03-24 | 2010-10-20 | Intercell AG | Improved vaccines |
ATE489967T1 (de) * | 2003-07-11 | 2010-12-15 | Intercell Ag | Hcv-vakzin |
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