SK287570B6 - Spôsob prípravy S-N,N'-bis[2-hydroxy-1-(hydroxymetyl)etyl]-5-[(2- hydroxy-1-oxopropyl)amino]-2,4,6-trijód-1,3-benzéndikarboxamidu a medziprodukty - Google Patents

Spôsob prípravy S-N,N'-bis[2-hydroxy-1-(hydroxymetyl)etyl]-5-[(2- hydroxy-1-oxopropyl)amino]-2,4,6-trijód-1,3-benzéndikarboxamidu a medziprodukty Download PDF

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Publication number
SK287570B6
SK287570B6 SK656-2003A SK6562003A SK287570B6 SK 287570 B6 SK287570 B6 SK 287570B6 SK 6562003 A SK6562003 A SK 6562003A SK 287570 B6 SK287570 B6 SK 287570B6
Authority
SK
Slovakia
Prior art keywords
formula
compound
group
linear
hydroxy
Prior art date
Application number
SK656-2003A
Other languages
English (en)
Slovak (sk)
Other versions
SK6562003A3 (en
Inventor
Pier Lucio Anelli
Marino Brocchetta
Giovanna Lux
Enrico Cappelletti
Original Assignee
Bracco Imaging S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging S.P.A. filed Critical Bracco Imaging S.P.A.
Publication of SK6562003A3 publication Critical patent/SK6562003A3/sk
Publication of SK287570B6 publication Critical patent/SK287570B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SK656-2003A 2000-12-01 2001-11-29 Spôsob prípravy S-N,N'-bis[2-hydroxy-1-(hydroxymetyl)etyl]-5-[(2- hydroxy-1-oxopropyl)amino]-2,4,6-trijód-1,3-benzéndikarboxamidu a medziprodukty SK287570B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2000MI002601A IT1319671B1 (it) 2000-12-01 2000-12-01 Processo per la preparazione di (s)-n,n'-bis(2-idrossi-1-(idrossimetil)etil)-5-((2-idrossi-1-ossopropil)ammino)
PCT/EP2001/013939 WO2002044132A1 (en) 2000-12-01 2001-11-29 A process for the preparation of iopamidol and the new intermediates therein

Publications (2)

Publication Number Publication Date
SK6562003A3 SK6562003A3 (en) 2003-10-07
SK287570B6 true SK287570B6 (sk) 2011-03-04

Family

ID=11446159

Family Applications (1)

Application Number Title Priority Date Filing Date
SK656-2003A SK287570B6 (sk) 2000-12-01 2001-11-29 Spôsob prípravy S-N,N'-bis[2-hydroxy-1-(hydroxymetyl)etyl]-5-[(2- hydroxy-1-oxopropyl)amino]-2,4,6-trijód-1,3-benzéndikarboxamidu a medziprodukty

Country Status (22)

Country Link
US (2) US7034183B2 (ru)
EP (2) EP1353899B1 (ru)
JP (1) JP4263910B2 (ru)
KR (1) KR100855765B1 (ru)
CN (1) CN100345821C (ru)
AU (1) AU2002217068B8 (ru)
BG (1) BG66276B1 (ru)
BR (1) BRPI0115785B8 (ru)
CA (1) CA2430339C (ru)
CZ (1) CZ304015B6 (ru)
EA (1) EA005922B1 (ru)
HU (1) HU230702B1 (ru)
IL (2) IL156188A0 (ru)
IT (1) IT1319671B1 (ru)
MX (1) MXPA03004774A (ru)
NO (1) NO328627B1 (ru)
NZ (1) NZ526188A (ru)
PL (1) PL204819B1 (ru)
SK (1) SK287570B6 (ru)
UA (1) UA75956C2 (ru)
WO (1) WO2002044132A1 (ru)
ZA (1) ZA200304199B (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2365963T3 (en) 2008-11-18 2017-10-09 Bracco Imaging Spa PROCEDURE FOR THE PREPARATION OF IODATED CONTRACTOR
EP2230227A1 (en) * 2009-03-20 2010-09-22 Bracco Imaging S.p.A Process for the preparation of triiodinated carboxylic aromatic derivatives
US20110021822A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As continuous deacetylation and purification process in synthesis of non-ionic x-ray contrast agents
US20110021833A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Crystallization of an intermediate for synthesizing non-ionic x-ray contrast agents
PT105770B (pt) * 2011-06-24 2013-07-08 Hovione Farmaciencia S A Novo intermediário e seu uso na preparação de agente de contrate triiodado
CN103382160B (zh) * 2012-05-02 2017-10-27 上海海神化学生物科技有限公司 碘帕醇的合成及其合成中间体的制备
CA2927706C (en) 2013-11-05 2018-05-29 Bracco Imaging Spa Process for the preparation of iopamidol
CN104098484A (zh) * 2014-07-21 2014-10-15 杭州杜易科技有限公司 一种碘帕醇的制备方法
CN106366015B (zh) * 2015-07-22 2019-01-25 正大天晴药业集团股份有限公司 一种碘普罗胺的制备方法及其中间体
CN106366016B (zh) * 2015-07-22 2019-03-05 连云港润众制药有限公司 一种碘普罗胺的制备方法及其中间体
WO2018104228A1 (en) * 2016-12-05 2018-06-14 Bracco Imaging Spa Mechanochemical synthesis of radiographic agents intermediates
GB202009917D0 (en) 2020-06-29 2020-08-12 Ge Healthcare As Process for the preparation of iopamidol
CN115010617B (zh) * 2022-07-11 2024-06-11 安徽普利药业有限公司 一种碘帕醇的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH608189A5 (ru) * 1974-12-13 1978-12-29 Savac Ag
CH616403A5 (en) * 1975-10-29 1980-03-31 Bracco Ind Chimica Spa Process for the preparation of 2,4,6-triodoisophthalamides which are readily soluble in water.
CH627653A5 (en) 1977-03-28 1982-01-29 Bracco Ind Chimica Spa Non-ionic X-ray contrast media and process for the preparation of their radiopaque components
IT1193211B (it) * 1979-08-09 1988-06-15 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono
IT1207226B (it) * 1979-08-09 1989-05-17 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
US4396598A (en) * 1982-01-11 1983-08-02 Mallinckrodt, Inc. Triiodoisophthalamide X-ray contrast agent
US5278311A (en) 1992-06-05 1994-01-11 E. R. Squibb & Sons, Inc. Nonionic radiographic contrast agents
IL110391A (en) 1993-07-30 1998-12-06 Zambon Spa Process for the formation of infamidol
US5811581A (en) 1994-08-04 1998-09-22 Dibra S.P.A. Process for the purification of opacifying contrast agents
IT1282653B1 (it) 1996-02-20 1998-03-31 Bracco Spa Dispositivo e metodo per la rigenerazione di letti misti di resine a scambio ionico
US6803485B2 (en) * 1999-02-26 2004-10-12 Bracco Imaging S.P.A. Process for the preparation of iopamidol

Also Published As

Publication number Publication date
US7034183B2 (en) 2006-04-25
BR0115785A (pt) 2003-10-21
ITMI20002601A1 (it) 2002-06-01
EP2975021B1 (en) 2017-07-26
KR100855765B1 (ko) 2008-09-01
PL204819B1 (pl) 2010-02-26
AU2002217068B2 (en) 2006-11-02
EP2975021A1 (en) 2016-01-20
ZA200304199B (en) 2004-06-24
UA75956C2 (en) 2006-06-15
US20060106253A1 (en) 2006-05-18
WO2002044132A1 (en) 2002-06-06
AU1706802A (en) 2002-06-11
IL156188A0 (en) 2003-12-23
CZ304015B6 (cs) 2013-08-21
MXPA03004774A (es) 2004-03-26
PL363799A1 (en) 2004-11-29
CN1478068A (zh) 2004-02-25
CN100345821C (zh) 2007-10-31
AU2002217068B8 (en) 2007-02-01
BR0115785B1 (pt) 2014-11-04
NO20032440L (no) 2003-05-28
US20040082812A1 (en) 2004-04-29
HUP0302758A3 (en) 2005-04-28
NZ526188A (en) 2004-11-26
BG66276B1 (bg) 2012-12-28
HU230702B1 (hu) 2017-10-30
JP4263910B2 (ja) 2009-05-13
NO328627B1 (no) 2010-04-12
JP2004514705A (ja) 2004-05-20
EA005922B1 (ru) 2005-08-25
EP1353899B1 (en) 2016-01-20
BRPI0115785B8 (pt) 2021-05-25
KR20030077546A (ko) 2003-10-01
BG107824A (bg) 2004-02-27
EP1353899A1 (en) 2003-10-22
CA2430339A1 (en) 2002-06-06
HUP0302758A2 (hu) 2003-12-29
NO20032440D0 (no) 2003-05-28
IL156188A (en) 2008-12-29
IT1319671B1 (it) 2003-10-23
EA200300513A1 (ru) 2003-12-25
US7368101B2 (en) 2008-05-06
CZ20031506A3 (cs) 2003-08-13
SK6562003A3 (en) 2003-10-07
CA2430339C (en) 2011-01-25

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Expiry date: 20211129