SK287012B6 - Farmaceutický prostriedok obsahujúci cyklopeptid, použitie tohto prostriedku alebo cyklopeptidu na výrobu liečiva a kit s jeho obsahom - Google Patents

Farmaceutický prostriedok obsahujúci cyklopeptid, použitie tohto prostriedku alebo cyklopeptidu na výrobu liečiva a kit s jeho obsahom Download PDF

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Publication number
SK287012B6
SK287012B6 SK337-2001A SK3372001A SK287012B6 SK 287012 B6 SK287012 B6 SK 287012B6 SK 3372001 A SK3372001 A SK 3372001A SK 287012 B6 SK287012 B6 SK 287012B6
Authority
SK
Slovakia
Prior art keywords
physiologically acceptable
acceptable salt
cyclo
phe
gly
Prior art date
Application number
SK337-2001A
Other languages
English (en)
Slovak (sk)
Other versions
SK3372001A3 (en
Inventor
Alfred Jonczyk
Astrid Perschl
Simon Goodman
Sigrid R�SENER
Jutta Haunschild
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of SK3372001A3 publication Critical patent/SK3372001A3/sk
Publication of SK287012B6 publication Critical patent/SK287012B6/sk

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SK337-2001A 1998-09-16 1999-09-09 Farmaceutický prostriedok obsahujúci cyklopeptid, použitie tohto prostriedku alebo cyklopeptidu na výrobu liečiva a kit s jeho obsahom SK287012B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19842415A DE19842415A1 (de) 1998-09-16 1998-09-16 Pharmazeutische Zubereitung
PCT/EP1999/006654 WO2000015244A2 (de) 1998-09-16 1999-09-09 Pharmazeutische zubereitung enthaltend ein cyclo-peptide und ein chemotherapeutikum oder einen angiogeneseinhibitor

Publications (2)

Publication Number Publication Date
SK3372001A3 SK3372001A3 (en) 2001-11-06
SK287012B6 true SK287012B6 (sk) 2009-09-07

Family

ID=7881169

Family Applications (1)

Application Number Title Priority Date Filing Date
SK337-2001A SK287012B6 (sk) 1998-09-16 1999-09-09 Farmaceutický prostriedok obsahujúci cyklopeptid, použitie tohto prostriedku alebo cyklopeptidu na výrobu liečiva a kit s jeho obsahom

Country Status (31)

Country Link
US (1) US6683051B1 (pt)
EP (2) EP1113809B1 (pt)
JP (2) JP2002524526A (pt)
KR (1) KR100703253B1 (pt)
CN (2) CN1201812C (pt)
AR (2) AR022382A1 (pt)
AT (2) ATE432707T1 (pt)
AU (1) AU765073B2 (pt)
BR (1) BR9913737A (pt)
CA (1) CA2344151A1 (pt)
CO (1) CO5140070A1 (pt)
CZ (1) CZ302908B6 (pt)
DE (3) DE19842415A1 (pt)
DK (2) DK1466615T3 (pt)
ES (2) ES2327331T3 (pt)
HU (1) HUP0103521A3 (pt)
ID (1) ID29226A (pt)
IL (2) IL141516A0 (pt)
MY (1) MY129572A (pt)
NO (1) NO331734B1 (pt)
NZ (1) NZ510040A (pt)
PE (1) PE20001046A1 (pt)
PL (1) PL201902B1 (pt)
PT (2) PT1113809E (pt)
RU (1) RU2227041C2 (pt)
SI (1) SI1113809T1 (pt)
SK (1) SK287012B6 (pt)
TR (1) TR200100765T2 (pt)
TW (1) TW576744B (pt)
WO (1) WO2000015244A2 (pt)
ZA (1) ZA200103073B (pt)

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US7740841B1 (en) * 2000-01-28 2010-06-22 Sunnybrook Health Science Center Therapeutic method for reducing angiogenesis
WO2002055106A2 (en) * 2001-01-09 2002-07-18 Merck Patent Gmbh Combination therapy using receptor tyrosine kinase inhibitors and angiogenesis inhibitors
WO2003074045A1 (fr) * 2002-03-05 2003-09-12 Eisai Co., Ltd. Agent antitumoral comprenant une combinaison d'un compose heterocyclique contenant un sulfamide et d'un inhibiteur d'angiogenese
EP2394662B1 (en) 2004-04-02 2018-03-21 The Regents of The University of California Methods and compositions for treating and preventing disease associated with alpha v beta 5 integrin
WO2007056061A2 (en) * 2005-11-02 2007-05-18 Duke University Concurrent chemotherapy and immunotherapy
US20110165150A1 (en) * 2006-01-18 2011-07-07 Merck Patent Gmbh Isolated organ perfusion combination therapy of cancer
WO2007084670A2 (en) * 2006-01-18 2007-07-26 Merck Patent Gmbh Specific therapy using integrin ligands for treating cancer
EA017864B1 (ru) 2007-01-18 2013-03-29 Мерк Патент Гмбх Специфическая терапия и лекарственное средство на основе интегриновых лигандов для лечения рака
ES2395799T3 (es) 2007-07-17 2013-02-15 Merck Patent Gmbh Anticuerpos híbridos anti- integrina alfa V modificados genéticamente
WO2010051667A1 (zh) * 2008-11-10 2010-05-14 复旦大学 一种环肽纳米管药物组合物及其应用
EP2346524A2 (en) * 2008-11-20 2011-07-27 Merck Patent GmbH New therapy and medicament using integrin ligands for treating cancer
JP2012528079A (ja) 2009-05-25 2012-11-12 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 癌を治療するためのインテグリンリガンドの連続投与
JP5755647B2 (ja) 2009-07-24 2015-07-29 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア αvβ5インテグリンに関連する疾患の処置および予防のための方法および組成物
EP2509583B1 (en) 2009-12-10 2019-05-15 Merck Patent GmbH Pharmaceutical composition comprising oligopeptides, preferably cilengitide
AU2011278700A1 (en) 2010-07-16 2013-02-28 Merck Patent Gmbh Peptide for use in the treatment of breast cancer and/or bone metastases
WO2012069149A1 (en) 2010-11-23 2012-05-31 Merck Patent Gmbh Solution comprising cyclic oligopeptides
MX352025B (es) 2011-02-11 2017-11-07 Merck Patent Gmbh Anticuerpo anti-integrina alfa v para el tratamiento de cancer de prostata.
WO2012110200A1 (en) 2011-02-18 2012-08-23 Merck Patent Gmbh Cyclic peptide cyclo (l -arginyl - glycyl - l -aspartyl - d - phenylalanyl - n-methyl - l -valyl), compositions thereof, and use thereof in methods for treating graft -versus - host disease
EP2717854B1 (en) * 2011-06-09 2019-01-16 Merck Patent GmbH Treatment of cancers and metastases with suspensions of cilengitide in carrier
WO2013130775A1 (en) * 2012-03-01 2013-09-06 Dizerega, Gere, S. Methods for treating patients undergoing multi-cycle chemotherapy
CN103333227B (zh) * 2013-06-07 2015-10-07 东南大学 转移肿瘤缺失蛋白小分子环肽抑制剂及其制备方法与应用
WO2018046610A1 (en) 2016-09-08 2018-03-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosing and treating nephrotic syndrome
JP2019208422A (ja) * 2018-06-04 2019-12-12 コリア・インスティテュート・オブ・サイエンス・アンド・テクノロジー ヒアルロニダーゼを含む新規な組換えエキソソーム及びその用途
GB201911816D0 (en) * 2019-08-16 2019-10-02 Univ London Queen Mary Treatment
GB202103122D0 (en) * 2021-03-05 2021-04-21 Univ London Queen Mary Treatment

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JPH04367367A (ja) 1991-06-11 1992-12-18 Nkk Corp ロータリノズル
US5786373A (en) 1992-10-14 1998-07-28 Merck & Co., Inc. Fibrinogen receptor antagonists
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JPH1081631A (ja) * 1996-07-17 1998-03-31 Takeda Chem Ind Ltd 癌転移または再発抑制剤
DE19629817A1 (de) 1996-07-24 1998-01-29 Hoechst Ag Neue Imino-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
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UA60311C2 (uk) 1996-10-02 2003-10-15 Смітклайн Бічам Корпорейшн Антагоністи рецептора вітронектину, спосіб одержання цих сполук та фармацевтична композиція
JP2001509176A (ja) 1997-01-17 2001-07-10 メルク エンド カンパニー インコーポレーテッド インテグリンアンタゴニスト
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Also Published As

Publication number Publication date
PL348026A1 (en) 2002-05-06
KR20010073155A (ko) 2001-07-31
DE59911881D1 (de) 2005-05-12
ES2241363T3 (es) 2005-10-16
IL141516A0 (en) 2002-03-10
EP1466615B1 (de) 2009-06-03
AR022382A1 (es) 2002-09-04
PE20001046A1 (es) 2000-10-14
TR200100765T2 (tr) 2001-08-21
MY129572A (en) 2007-04-30
CA2344151A1 (en) 2000-03-23
RU2227041C2 (ru) 2004-04-20
EP1113809A2 (de) 2001-07-11
SK3372001A3 (en) 2001-11-06
NO20011308D0 (no) 2001-03-15
NO331734B1 (no) 2012-03-12
DE19842415A1 (de) 2000-03-23
ATE432707T1 (de) 2009-06-15
AU5975899A (en) 2000-04-03
WO2000015244A2 (de) 2000-03-23
EP1113809B1 (de) 2005-04-06
NO20011308L (no) 2001-03-15
ID29226A (id) 2001-08-16
CZ302908B6 (cs) 2012-01-18
DE59915033D1 (de) 2009-07-16
US6683051B1 (en) 2004-01-27
CN1329499A (zh) 2002-01-02
JP2011252012A (ja) 2011-12-15
PT1466615E (pt) 2009-09-07
CN100352494C (zh) 2007-12-05
ZA200103073B (en) 2002-08-21
DK1466615T3 (da) 2009-08-31
CN1636590A (zh) 2005-07-13
CO5140070A1 (es) 2002-03-22
CN1201812C (zh) 2005-05-18
HUP0103521A2 (hu) 2002-02-28
PL201902B1 (pl) 2009-05-29
AU765073B2 (en) 2003-09-11
ATE292470T1 (de) 2005-04-15
NZ510040A (en) 2003-12-19
ES2327331T3 (es) 2009-10-28
IL141516A (en) 2009-09-22
PT1113809E (pt) 2005-08-31
BR9913737A (pt) 2001-06-05
CZ2001932A3 (cs) 2001-09-12
DK1113809T3 (da) 2005-08-08
AR078175A2 (es) 2011-10-19
TW576744B (en) 2004-02-21
WO2000015244A3 (de) 2000-06-22
KR100703253B1 (ko) 2007-04-03
EP1466615A1 (de) 2004-10-13
SI1113809T1 (en) 2005-10-31
HUP0103521A3 (en) 2002-05-28
JP2002524526A (ja) 2002-08-06

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MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20130909