SK285993B6 - Spôsob výroby derivátov pyrimidínu substituovaných aminoskupinou a ich medziprodukty - Google Patents
Spôsob výroby derivátov pyrimidínu substituovaných aminoskupinou a ich medziprodukty Download PDFInfo
- Publication number
- SK285993B6 SK285993B6 SK22-2002A SK222002A SK285993B6 SK 285993 B6 SK285993 B6 SK 285993B6 SK 222002 A SK222002 A SK 222002A SK 285993 B6 SK285993 B6 SK 285993B6
- Authority
- SK
- Slovakia
- Prior art keywords
- formula
- compound
- alkyl
- fluorophenyl
- reaction
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/05—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99113711 | 1999-07-13 | ||
EP99120417 | 1999-10-14 | ||
US18537100P | 2000-02-28 | 2000-02-28 | |
US18546500P | 2000-02-28 | 2000-02-28 | |
EP00106303 | 2000-03-23 | ||
PCT/EP2000/006099 WO2001004100A1 (en) | 1999-07-13 | 2000-06-30 | Process for preparing 2-amino-4-(4-fluorphenyl)-6-alkylpyrimidine-5-carboxylate |
Publications (2)
Publication Number | Publication Date |
---|---|
SK222002A3 SK222002A3 (en) | 2002-06-04 |
SK285993B6 true SK285993B6 (sk) | 2008-01-07 |
Family
ID=27513029
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK22-2002A SK285993B6 (sk) | 1999-07-13 | 2000-06-30 | Spôsob výroby derivátov pyrimidínu substituovaných aminoskupinou a ich medziprodukty |
Country Status (17)
Country | Link |
---|---|
US (3) | US6579984B1 (zh) |
EP (1) | EP1194414B1 (zh) |
JP (1) | JP4649813B2 (zh) |
KR (1) | KR100649927B1 (zh) |
CN (1) | CN1164577C (zh) |
AT (1) | ATE307120T1 (zh) |
AU (1) | AU6266600A (zh) |
CA (1) | CA2378782C (zh) |
CZ (1) | CZ304307B6 (zh) |
DE (1) | DE60023296T2 (zh) |
ES (1) | ES2251392T3 (zh) |
HK (1) | HK1046682B (zh) |
HU (1) | HU228303B1 (zh) |
NO (2) | NO328103B1 (zh) |
PL (1) | PL211797B1 (zh) |
SK (1) | SK285993B6 (zh) |
WO (1) | WO2001004100A1 (zh) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0003305D0 (en) * | 2000-02-15 | 2000-04-05 | Zeneca Ltd | Pyrimidine derivatives |
PL366831A1 (en) * | 2001-07-13 | 2005-02-07 | Astrazeneca Uk Limited | Preparation of aminopyrimidine compounds |
GB0218781D0 (en) * | 2002-08-13 | 2002-09-18 | Astrazeneca Ab | Chemical process |
EP1578731B1 (en) | 2002-12-16 | 2009-11-11 | AstraZeneca UK Limited | Process for the preparation of pyrimidine compounds |
GB0428328D0 (en) | 2004-12-24 | 2005-02-02 | Astrazeneca Uk Ltd | Chemical process |
EP2423195A1 (en) | 2010-07-26 | 2012-02-29 | LEK Pharmaceuticals d.d. | Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof |
ES2879314T3 (es) | 2010-08-18 | 2021-11-22 | Biosplice Therapeutics Inc | Dicetonas e hidroxicetonas como activadores de la vía de señalización de catenina |
JP6401189B2 (ja) | 2013-02-22 | 2018-10-03 | サミュメッド リミテッド ライアビリティ カンパニー | Wnt/β−カテニンシグナル伝達経路活性化剤としてのγ−ジケトン |
CN103910644B (zh) * | 2014-04-21 | 2015-06-24 | 广西师范大学 | β-烯胺酮酯类化合物及其合成方法和应用 |
EP3206686B1 (en) | 2014-08-20 | 2019-10-09 | Samumed, LLC | Gamma-diketones for treatment and prevention of aging skin and wrinkles |
CN110483341A (zh) * | 2019-07-23 | 2019-11-22 | 上海药明康德新药开发有限公司 | 一种1-氰基-n-甲基甲磺酰胺的合成方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4013706A (en) | 1973-11-14 | 1977-03-22 | Sucreries Du Soissonnais Et Compagnie Sucriere | Derivatives of substituted urea, acyl ureas, and sulphonyl ureas, and a process for producing the same |
DE3717815A1 (de) * | 1987-05-27 | 1988-12-15 | Bayer Ag | Fungizide mittel auf basis von substituierten cyanamiden |
JP2648897B2 (ja) * | 1991-07-01 | 1997-09-03 | 塩野義製薬株式会社 | ピリミジン誘導体 |
JP3197971B2 (ja) * | 1993-03-01 | 2001-08-13 | 塩野義製薬株式会社 | 5−カルボアルコキシピリミジン誘導体の合成方法 |
-
2000
- 2000-06-30 CA CA002378782A patent/CA2378782C/en not_active Expired - Lifetime
- 2000-06-30 HU HU0202006A patent/HU228303B1/hu not_active IP Right Cessation
- 2000-06-30 CZ CZ2002-61A patent/CZ304307B6/cs not_active IP Right Cessation
- 2000-06-30 DE DE60023296T patent/DE60023296T2/de not_active Expired - Lifetime
- 2000-06-30 CN CNB008116768A patent/CN1164577C/zh not_active Expired - Lifetime
- 2000-06-30 SK SK22-2002A patent/SK285993B6/sk not_active IP Right Cessation
- 2000-06-30 KR KR1020027000488A patent/KR100649927B1/ko active IP Right Grant
- 2000-06-30 AU AU62666/00A patent/AU6266600A/en not_active Abandoned
- 2000-06-30 AT AT00949231T patent/ATE307120T1/de active
- 2000-06-30 ES ES00949231T patent/ES2251392T3/es not_active Expired - Lifetime
- 2000-06-30 EP EP00949231A patent/EP1194414B1/en not_active Expired - Lifetime
- 2000-06-30 US US10/030,077 patent/US6579984B1/en not_active Expired - Lifetime
- 2000-06-30 WO PCT/EP2000/006099 patent/WO2001004100A1/en active IP Right Grant
- 2000-06-30 JP JP2001509711A patent/JP4649813B2/ja not_active Expired - Lifetime
- 2000-06-30 PL PL353058A patent/PL211797B1/pl unknown
-
2002
- 2002-01-11 NO NO20020163A patent/NO328103B1/no not_active IP Right Cessation
- 2002-11-13 HK HK02108215.0A patent/HK1046682B/zh not_active IP Right Cessation
-
2003
- 2003-05-23 US US10/443,797 patent/US6710178B2/en not_active Expired - Lifetime
-
2004
- 2004-03-23 US US10/806,315 patent/US6984757B2/en not_active Expired - Lifetime
-
2009
- 2009-06-23 NO NO20092393A patent/NO334937B1/no not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Patent lapsed due to non-payment of maintenance fees |
Effective date: 20190630 |