SK283997B6 - Spôsob výroby fenylheterocyklických zlúčenín - Google Patents

Spôsob výroby fenylheterocyklických zlúčenín Download PDF

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Publication number
SK283997B6
SK283997B6 SK1793-98A SK179398A SK283997B6 SK 283997 B6 SK283997 B6 SK 283997B6 SK 179398 A SK179398 A SK 179398A SK 283997 B6 SK283997 B6 SK 283997B6
Authority
SK
Slovakia
Prior art keywords
compound
formula
reacting
hydrogen
dimethylformamide
Prior art date
Application number
SK1793-98A
Other languages
English (en)
Slovak (sk)
Other versions
SK179398A3 (en
Inventor
Richard Desmond
Ulf H. Dolling
Lisa F. Frey
Richard D. Tillyer
David M. Tschaen
Original Assignee
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.
Publication of SK179398A3 publication Critical patent/SK179398A3/sk
Publication of SK283997B6 publication Critical patent/SK283997B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
SK1793-98A 1996-07-03 1997-06-27 Spôsob výroby fenylheterocyklických zlúčenín SK283997B6 (sk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2120096P 1996-07-03 1996-07-03
GBGB9615867.0A GB9615867D0 (en) 1996-07-03 1996-07-29 Process of preparing phenyl heterocycles useful as cox-2 inhibitors
PCT/US1997/011466 WO1998000416A1 (en) 1996-07-03 1997-06-27 Process of preparing phenyl heterocycles useful as cox-2 inhibitors

Publications (2)

Publication Number Publication Date
SK179398A3 SK179398A3 (en) 2000-04-10
SK283997B6 true SK283997B6 (sk) 2004-07-07

Family

ID=26309770

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1793-98A SK283997B6 (sk) 1996-07-03 1997-06-27 Spôsob výroby fenylheterocyklických zlúčenín

Country Status (26)

Country Link
US (1) US5840924A (de)
EP (1) EP0912537B1 (de)
JP (1) JP3071472B2 (de)
CN (1) CN1097046C (de)
AR (1) AR007695A1 (de)
AT (1) ATE266651T1 (de)
AU (1) AU717835B2 (de)
BR (1) BR9710099A (de)
CA (1) CA2258048C (de)
CZ (1) CZ297257B6 (de)
DE (1) DE69729096T2 (de)
DK (1) DK0912537T3 (de)
EA (1) EA001629B1 (de)
ES (1) ES2218691T3 (de)
GB (1) GB9615867D0 (de)
HK (1) HK1017355A1 (de)
HR (1) HRP970351B1 (de)
HU (1) HU224840B1 (de)
NZ (1) NZ333379A (de)
PL (1) PL195025B1 (de)
PT (1) PT912537E (de)
RS (1) RS49591B (de)
SK (1) SK283997B6 (de)
TW (1) TW419474B (de)
UA (1) UA57029C2 (de)
WO (1) WO1998000416A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040072889A1 (en) * 1997-04-21 2004-04-15 Pharmacia Corporation Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia
JP2002506024A (ja) * 1998-03-13 2002-02-26 メルク エンド カムパニー インコーポレーテッド 急性冠動脈虚血症候群および関連状態に対する併用療法および組成物
US6031108A (en) * 1998-09-16 2000-02-29 Bayer Corporation Process for the preparation of 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole (TDA sulfone)
US6649645B1 (en) * 1998-12-23 2003-11-18 Pharmacia Corporation Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia
MXPA03000161A (es) * 2000-05-22 2004-02-26 Reddy Research Foundation Compuestos novedosos los cuales tienen actividad antiinflamatoria, proceso para su preparacion y composiciones farmaceuticas que las contienen.
DE10129320A1 (de) * 2001-06-19 2003-04-10 Norbert Mueller Verwendung von COX-2 Inhibitoren zur Behandlung von Schizophrenie, wahnhaften Störungen, affektiven Störungen oder Ticstörungen
US20060167074A1 (en) * 2001-06-19 2006-07-27 Norbert Muller Methods and compositions for the treatment of psychiatric disorders
US7049459B2 (en) * 2001-10-10 2006-05-23 Shasun Chemicals And Drugs Limited 1-[(4-methyl thio)phenyl]-2-(phenyl acetoxy)-1-ethanone and a process for preparing the same
EP1463500A1 (de) * 2002-01-10 2004-10-06 PHARMACIA & UPJOHN COMPANY Verwendung von cox-2 hemmern zusammen mit antiviralen mitteln zur behandlung von papillomavirus infektionen
TW200403072A (en) * 2002-01-23 2004-03-01 Upjohn Co Combination therapy for the treatment of bacterial infections
US20040147581A1 (en) * 2002-11-18 2004-07-29 Pharmacia Corporation Method of using a Cox-2 inhibitor and a 5-HT1A receptor modulator as a combination therapy
US20040220155A1 (en) * 2003-03-28 2004-11-04 Pharmacia Corporation Method of providing a steroid-sparing benefit with a cyclooxygenase-2 inhibitor and compositions therewith
AU2004237438B2 (en) * 2003-05-07 2011-01-20 Osteologix A/S Strontium combinations for prophylaxis/treatment of cartilage and/or bone conditions
ATE342722T1 (de) * 2003-05-07 2006-11-15 Osteologix As Behandlung von knorpel/knochen-erkrankungen mit wasserlöslichen strontiumsalzen
WO2005009342A2 (en) * 2003-07-16 2005-02-03 Pharmacia Corporation Method for the treatment or prevention of dermatological disorders with a cyclooxygenase-2 inhibitor alone and in combination with a dermatological treatment agent and compositions therewith
US20050119262A1 (en) * 2003-08-21 2005-06-02 Pharmacia Corporation Method for preventing or treating an optic neuropathy with a cox-2 inhibitor and an intraocular pressure reducing agent
US20050113409A1 (en) * 2003-09-03 2005-05-26 Pharmacia Corporation Method for the prevention or treatment of pain, inflammation and inflammation-related disorders with a Cox-2 selective inhibitor in combination with a nitric oxide-donating agent and compositions therewith
US20080096927A1 (en) 2004-08-24 2008-04-24 Simon Thomas J Combination Therapy for Treating Cyclooxygenase-2 Mediated Diseases or Conditions in Patients at Risk of Thrombotic Cardiovascular Events
CA2607913C (en) * 2005-05-05 2014-03-18 Cook Biotech Incorporated Implantable materials and methods for inhibiting tissue adhesion formation
CN104774186A (zh) * 2015-04-28 2015-07-15 江苏中旗作物保护股份有限公司 农药除草剂异恶唑草酮的合成方法
MX2021005967A (es) * 2018-11-21 2021-10-13 Tremeau Pharmaceuticals Inc Formas purificadas de rofecoxib, métodos de fabricación y uso.
US10945992B1 (en) 2019-11-13 2021-03-16 Tremeau Pharmaceuticals, Inc. Dosage forms of rofecoxib and related methods
US11161833B1 (en) 2021-04-09 2021-11-02 Tremeau Pharmaceuticals, Inc. Deuterated etoricoxib, methods of manufacture, and use thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5916884A (ja) * 1982-07-19 1984-01-28 Fujisawa Pharmaceut Co Ltd 新規フラン化合物
US4968817A (en) * 1984-07-27 1990-11-06 National Distillers And Chemical Corporation Manufacture of gamma-crotonolactone by carbonylation of glycidol
DE3615157A1 (de) * 1986-05-05 1987-11-12 Schwabe Willmar Gmbh & Co 5-arylalkyl-4-alkoxy-2(5h)-furanone, zwischenprodukte und verfahren zu ihrer herstellung sowie ihre anwendung als therapeutische wirkstoffe
DE3718527A1 (de) * 1987-06-03 1988-12-15 Basf Ag Verfahren zur herstellung von 2(5h)-furanonen
US5207817A (en) * 1989-09-23 1993-05-04 Bayer Aktiengesellschaft Herbicidal 5H-furan-2-one derivatives
DE4014420A1 (de) * 1989-09-23 1991-04-04 Bayer Ag 5h-furan-2-on-derivate
EP0524979A4 (en) * 1990-04-17 1993-03-10 Allergan, Inc. 2(5h)-furanones substituted in the 5 and or in the 4 position, as anti-inflammatory agents
US5393150A (en) * 1991-09-05 1995-02-28 Fort; Chris Bifurcated keyboard arrangement
IT1254558B (it) * 1992-03-26 1995-09-25 Mini Ricerca Scient Tecnolog Composti a base di 3,4-diaril-(5h)-furan-2-one ad attivita' fungicida 3
AU6027694A (en) * 1993-01-15 1994-08-15 G.D. Searle & Co. Novel 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
KR960703901A (ko) * 1993-08-19 1996-08-31 로즈 암스트롱 치환된 2(5H)푸라논, 2(5H)티오페논 및 2(5H)피롤론 유도체, 그의 제조 방법 및 엔도텔린 길항제로서의 그의 용도(Substituted 2(5H)Furanone, 2(5H)Thiophenone and 2(5H)Pyrrolone Derivatives, Their Preparation and Their Use as Endothelin antagonists)
WO1995018799A1 (en) * 1994-01-10 1995-07-13 Merck Frosst Canada Inc. Phenyl heterocycles as cox-2 inhibitors
US5475995A (en) * 1994-05-16 1995-12-19 Livingston; George G. Truck spare tire locking rod

Also Published As

Publication number Publication date
JP3071472B2 (ja) 2000-07-31
ATE266651T1 (de) 2004-05-15
PL195025B1 (pl) 2007-08-31
SK179398A3 (en) 2000-04-10
CA2258048C (en) 2006-08-15
DE69729096D1 (de) 2004-06-17
UA57029C2 (uk) 2003-06-16
RS49591B (sr) 2007-06-04
EA199900079A1 (ru) 1999-06-24
YU59298A (sh) 2000-03-21
CN1224422A (zh) 1999-07-28
CZ436898A3 (cs) 1999-06-16
HUP9903836A2 (hu) 2001-05-28
US5840924A (en) 1998-11-24
HRP970351B1 (en) 2003-02-28
HUP9903836A3 (en) 2001-06-28
PT912537E (pt) 2004-08-31
CZ297257B6 (cs) 2006-10-11
HK1017355A1 (en) 1999-11-19
CA2258048A1 (en) 1998-01-08
ES2218691T3 (es) 2004-11-16
GB9615867D0 (en) 1996-09-11
JPH11514002A (ja) 1999-11-30
CN1097046C (zh) 2002-12-25
AU3588697A (en) 1998-01-21
DE69729096T2 (de) 2005-04-28
EA001629B1 (ru) 2001-06-25
BR9710099A (pt) 1999-08-10
WO1998000416A1 (en) 1998-01-08
TW419474B (en) 2001-01-21
NZ333379A (en) 2000-09-29
HRP970351A2 (en) 1998-06-30
PL330750A1 (en) 1999-05-24
EP0912537B1 (de) 2004-05-12
AU717835B2 (en) 2000-04-06
EP0912537A1 (de) 1999-05-06
DK0912537T3 (da) 2004-08-30
HU224840B1 (en) 2006-03-28
AR007695A1 (es) 1999-11-10

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Legal Events

Date Code Title Description
TC4A Change of owner's name

Owner name: MERCK SHARP & DOHME CORP., RAHWAY, NJ, US

Effective date: 20100203

MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20120627