SK282495B6 - Acylovaný inzulínový derivát a farmaceutický prostriedok, ktorý ho obsahuje - Google Patents
Acylovaný inzulínový derivát a farmaceutický prostriedok, ktorý ho obsahuje Download PDFInfo
- Publication number
- SK282495B6 SK282495B6 SK324-96A SK32496A SK282495B6 SK 282495 B6 SK282495 B6 SK 282495B6 SK 32496 A SK32496 A SK 32496A SK 282495 B6 SK282495 B6 SK 282495B6
- Authority
- SK
- Slovakia
- Prior art keywords
- human insulin
- insulin
- glu
- gly
- xaa
- Prior art date
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- XVNZEJIEGYIBLT-UHFFFAOYSA-N methyl 2-aminotetradecanoate;hydrochloride Chemical compound Cl.CCCCCCCCCCCCC(N)C(=O)OC XVNZEJIEGYIBLT-UHFFFAOYSA-N 0.000 description 1
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- BTTOHPHUMDSRNO-UHFFFAOYSA-N octyl 1-hydroxy-2,5-dioxopyrrolidine-3-carboxylate Chemical compound CCCCCCCCOC(=O)C1CC(=O)N(O)C1=O BTTOHPHUMDSRNO-UHFFFAOYSA-N 0.000 description 1
- VFXVAXFIFHSGNR-UHFFFAOYSA-N octyl carbonochloridate Chemical compound CCCCCCCCOC(Cl)=O VFXVAXFIFHSGNR-UHFFFAOYSA-N 0.000 description 1
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- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000004317 sodium nitrate Substances 0.000 description 1
- 235000010344 sodium nitrate Nutrition 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
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- TYFQFVWCELRYAO-UHFFFAOYSA-N suberic acid Chemical group OC(=O)CCCCCCC(O)=O TYFQFVWCELRYAO-UHFFFAOYSA-N 0.000 description 1
- 229940014800 succinic anhydride Drugs 0.000 description 1
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- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/01—DNA viruses
- C07K14/02—Hepadnaviridae, e.g. hepatitis B virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK104493A DK104493D0 (da) | 1993-09-17 | 1993-09-17 | Hidtil ukendte peptider |
| US19082994A | 1994-02-02 | 1994-02-02 | |
| PCT/DK1994/000347 WO1995007931A1 (en) | 1993-09-17 | 1994-09-16 | Acylated insulin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK32496A3 SK32496A3 (en) | 1996-11-06 |
| SK282495B6 true SK282495B6 (sk) | 2002-02-05 |
Family
ID=26065125
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK324-96A SK282495B6 (sk) | 1993-09-17 | 1994-09-16 | Acylovaný inzulínový derivát a farmaceutický prostriedok, ktorý ho obsahuje |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US5750497A (en, 2012) |
| EP (2) | EP1132404A3 (en, 2012) |
| JP (3) | JP3014764B2 (en, 2012) |
| KR (1) | KR100310122B1 (en, 2012) |
| CN (1) | CN1056618C (en, 2012) |
| AT (1) | ATE204882T1 (en, 2012) |
| AU (2) | AU682061B2 (en, 2012) |
| BG (1) | BG61611B1 (en, 2012) |
| BR (1) | BR9407508A (en, 2012) |
| CA (1) | CA2171424C (en, 2012) |
| CZ (1) | CZ287945B6 (en, 2012) |
| DE (2) | DE69428134T2 (en, 2012) |
| DK (1) | DK0792290T3 (en, 2012) |
| ES (1) | ES2163451T3 (en, 2012) |
| FI (1) | FI117055B (en, 2012) |
| FR (1) | FR04C0020I2 (en, 2012) |
| HU (1) | HU217684B (en, 2012) |
| IL (1) | IL110977A (en, 2012) |
| LU (1) | LU91101I2 (en, 2012) |
| NL (1) | NL300160I2 (en, 2012) |
| NO (3) | NO316944B1 (en, 2012) |
| NZ (1) | NZ273285A (en, 2012) |
| PL (1) | PL178466B1 (en, 2012) |
| PT (1) | PT792290E (en, 2012) |
| RO (1) | RO112873B1 (en, 2012) |
| RU (1) | RU2164520C2 (en, 2012) |
| SI (1) | SI0792290T1 (en, 2012) |
| SK (1) | SK282495B6 (en, 2012) |
| UA (1) | UA45321C2 (en, 2012) |
| WO (1) | WO1995007931A1 (en, 2012) |
Families Citing this family (193)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9316895D0 (en) * | 1993-08-13 | 1993-09-29 | Guy S And St Thomas Hospitals | Hepatoselective insulin analogues |
| US6342225B1 (en) | 1993-08-13 | 2002-01-29 | Deutshces Wollforschungsinstitut | Pharmaceutical active conjugates |
| US6869930B1 (en) | 1993-09-17 | 2005-03-22 | Novo Nordisk A/S | Acylated insulin |
| US5504188A (en) * | 1994-06-16 | 1996-04-02 | Eli Lilly And Company | Preparation of stable zinc insulin analog crystals |
| US5474978A (en) * | 1994-06-16 | 1995-12-12 | Eli Lilly And Company | Insulin analog formulations |
| DE4437604A1 (de) * | 1994-10-21 | 1996-04-25 | Basf Ag | Konjugate aus einem Poly- oder Oligopeptid und einer niedermolekularen lipophilen Verbindung |
| US5693609A (en) * | 1994-11-17 | 1997-12-02 | Eli Lilly And Company | Acylated insulin analogs |
| US5646242A (en) * | 1994-11-17 | 1997-07-08 | Eli Lilly And Company | Selective acylation of epsilon-amino groups |
| KR19980703039A (ko) * | 1995-03-17 | 1998-09-05 | 켈스버그 라아스 | 인슐린 유도체 |
| US6251856B1 (en) | 1995-03-17 | 2001-06-26 | Novo Nordisk A/S | Insulin derivatives |
| US20010041786A1 (en) * | 1995-06-07 | 2001-11-15 | Mark L. Brader | Stabilized acylated insulin formulations |
| GB9513967D0 (en) * | 1995-07-08 | 1995-09-06 | Univ Leicester | Insulin |
| US6451970B1 (en) * | 1996-02-21 | 2002-09-17 | Novo Nordisk A/S | Peptide derivatives |
| BR9709845B1 (pt) * | 1996-06-20 | 2008-11-18 | preparaÇço aquosa de insulina, formulaÇço farmacÊutica parenteral, e, processso para aumentar a estabilidade quÍmica de uma preparaÇço de insulina. | |
| DE69731105T2 (de) * | 1996-07-11 | 2005-11-17 | Novo Nordisk A/S | Verfahren zur selektiven acetylierung |
| US5905140A (en) * | 1996-07-11 | 1999-05-18 | Novo Nordisk A/S, Novo Alle | Selective acylation method |
| ES2218622T3 (es) * | 1996-07-26 | 2004-11-16 | Aventis Pharma Deutschland Gmbh | Derivados de insulina con actividad de union al zinc incrementada. |
| US20020025933A1 (en) * | 1996-08-30 | 2002-02-28 | Knudsen Liselotte Bjerre | GLP-2 derivatives |
| US7235627B2 (en) | 1996-08-30 | 2007-06-26 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| US6268343B1 (en) | 1996-08-30 | 2001-07-31 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| US6458924B2 (en) | 1996-08-30 | 2002-10-01 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| US5898067A (en) * | 1997-02-07 | 1999-04-27 | Novo Nordisk A/S | Crystallization of proteins |
| KR20000076419A (ko) * | 1997-03-20 | 2000-12-26 | 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 | 폐 투여용 무아연 인슐린 결정 조성물 |
| US6310038B1 (en) * | 1997-03-20 | 2001-10-30 | Novo Nordisk A/S | Pulmonary insulin crystals |
| US6043214A (en) * | 1997-03-20 | 2000-03-28 | Novo Nordisk A/S | Method for producing powder formulation comprising an insulin |
| US6451762B1 (en) | 1997-10-24 | 2002-09-17 | Novo Nordisk A/S | Aggregates of human insulin derivatives |
| EA200000453A1 (ru) | 1997-10-24 | 2000-10-30 | Эли Лилли Энд Компани | Композиции нерастворимого инсулина |
| US6444641B1 (en) | 1997-10-24 | 2002-09-03 | Eli Lilly Company | Fatty acid-acylated insulin analogs |
| EP0911035A3 (en) * | 1997-10-24 | 2002-08-21 | Eli Lilly And Company | Insoluble insulin compositions |
| DK1025125T3 (da) * | 1997-10-24 | 2003-10-06 | Novo Nordisk As | Aggregater for humane insulinderivater |
| ZA989744B (en) * | 1997-10-31 | 2000-04-26 | Lilly Co Eli | Method for administering acylated insulin. |
| CO4970787A1 (es) * | 1997-12-23 | 2000-11-07 | Lilly Co Eli | Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea |
| EP1396272A1 (en) * | 1997-12-23 | 2004-03-10 | Eli Lilly & Company | Insoluble Insulin Compositions for Controlling Blood Glucose |
| EP1044016B1 (en) * | 1998-01-09 | 2005-03-16 | Novo Nordisk A/S | Stabilised insulin compositions |
| AU2712899A (en) * | 1998-02-27 | 1999-09-15 | Novo Nordisk A/S | Glp-2 derivatives with helix-content exceeding 25 percent, forming partially structured micellar-like aggregates |
| DE19825447A1 (de) * | 1998-06-06 | 1999-12-09 | Hoechst Marion Roussel De Gmbh | Neue Insulinanaloga mit erhöhter Zinkbildung |
| WO1999065941A1 (en) * | 1998-06-12 | 1999-12-23 | Kings College London | Insulin analogue |
| US7169889B1 (en) * | 1999-06-19 | 2007-01-30 | Biocon Limited | Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin |
| DE60120372T2 (de) | 2000-03-24 | 2007-07-05 | Genentech Inc., San Francisco | Verwendung von insulin zur behandlung von knorpelkrankheiten |
| WO2001085256A2 (en) * | 2000-05-05 | 2001-11-15 | Novo Nordisk A/S | Critical illness neuropathy |
| US7316999B2 (en) | 2000-06-02 | 2008-01-08 | Novo Nordisk A/S | Glucose dependent release of insulin from glucose sensing insulin derivatives |
| AU2001269307A1 (en) * | 2000-07-10 | 2002-01-21 | Btg International Limited | Insulin derivatives and synthesis thereof |
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| EP4299071A1 (en) | 2022-07-01 | 2024-01-03 | Adocia | Compositions comprising a peptide or a protein and an acylated amino acid |
| WO2024051787A1 (zh) * | 2022-09-09 | 2024-03-14 | 北京惠之衡生物科技有限公司 | 一种长效酰化胰岛素衍生物及其应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3823125A (en) * | 1969-10-14 | 1974-07-09 | American Home Prod | N-aminoacyl-substituted insulins |
| US3950517A (en) * | 1970-05-08 | 1976-04-13 | National Research Development Corporation | Insulin derivatives |
| GB1381274A (en) * | 1971-01-28 | 1975-01-22 | Nat Res Dev | Insulin derivatives |
| GB1381273A (en) * | 1971-01-28 | 1975-01-22 | Nat Res Dev | Insulin derivatives |
| US3907763A (en) * | 1972-03-01 | 1975-09-23 | Bayer Ag | Insulin derivatives crosslinked by a dicarboxylic acid moiety |
| DK319780A (da) * | 1980-07-24 | 1982-01-25 | Forenede Bryggerier As | Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner |
| NL8201650A (nl) * | 1982-04-21 | 1983-11-16 | Akzo Nv | Semisynthetische bereiding van humane insuline. |
| IL68769A (en) * | 1983-05-23 | 1986-02-28 | Hadassah Med Org | Pharmaceutical compositions containing insulin for oral administration |
| US5008241A (en) * | 1985-03-12 | 1991-04-16 | Novo Nordisk A/S | Novel insulin peptides |
| JPH01254699A (ja) * | 1988-04-05 | 1989-10-11 | Kodama Kk | インスリン誘導体及びその用途 |
| DK45590D0 (en, 2012) * | 1990-02-21 | 1990-02-21 | Novo Nordisk As | |
| DK155690D0 (da) * | 1990-06-28 | 1990-06-28 | Novo Nordisk As | Nye peptider |
| AU8091091A (en) * | 1990-07-26 | 1992-02-18 | University Of Iowa Research Foundation, The | Novel drug delivery systems for proteins and peptides using albumin as a carrier molecule |
| US5336782A (en) * | 1991-04-24 | 1994-08-09 | Kuraray Co., Ltd. | Long chain carboxylic acid imide ester |
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1994
- 1994-09-16 JP JP7508923A patent/JP3014764B2/ja not_active Expired - Lifetime
- 1994-09-16 PL PL94313444A patent/PL178466B1/pl unknown
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- 1994-09-16 DK DK94926816T patent/DK0792290T3/da active
- 1994-09-16 KR KR1019960701400A patent/KR100310122B1/ko not_active Expired - Lifetime
- 1994-09-16 CN CN94193852A patent/CN1056618C/zh not_active Expired - Lifetime
- 1994-09-16 AU AU76520/94A patent/AU682061B2/en not_active Expired
- 1994-09-16 HU HU9600676A patent/HU217684B/hu active Protection Beyond IP Right Term
- 1994-09-16 EP EP01112992A patent/EP1132404A3/en not_active Withdrawn
- 1994-09-16 RO RO96-00583A patent/RO112873B1/ro unknown
- 1994-09-16 RU RU96108249/04A patent/RU2164520C2/ru active Protection Beyond IP Right Term
- 1994-09-16 SK SK324-96A patent/SK282495B6/sk active Protection Beyond IP Right Term
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- 1994-09-16 CA CA002171424A patent/CA2171424C/en not_active Expired - Lifetime
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- 1994-09-16 AT AT94926816T patent/ATE204882T1/de active
- 1994-09-16 BR BR9407508A patent/BR9407508A/pt not_active Application Discontinuation
- 1994-09-16 UA UA96030967A patent/UA45321C2/uk unknown
- 1994-09-16 EP EP94926816A patent/EP0792290B1/en not_active Expired - Lifetime
- 1994-09-16 DE DE69428134T patent/DE69428134T2/de not_active Expired - Lifetime
- 1994-09-16 DE DE122004000035C patent/DE122004000035I2/de active Active
- 1994-09-16 WO PCT/DK1994/000347 patent/WO1995007931A1/en active IP Right Grant
- 1994-09-16 IL IL11097794A patent/IL110977A/xx active Protection Beyond IP Right Term
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1995
- 1995-03-08 US US08/400,256 patent/US5750497A/en not_active Expired - Lifetime
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1996
- 1996-03-13 BG BG100420A patent/BG61611B1/bg unknown
- 1996-03-15 FI FI961220A patent/FI117055B/fi active Protection Beyond IP Right Term
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1997
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1999
- 1999-08-04 JP JP22163299A patent/JP3917333B2/ja not_active Expired - Lifetime
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2001
- 2001-12-19 JP JP2001385921A patent/JP4060583B2/ja not_active Expired - Lifetime
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2004
- 2004-09-06 FR FR04C0020C patent/FR04C0020I2/fr active Active
- 2004-09-08 LU LU91101C patent/LU91101I2/xx unknown
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2017
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK4A | Patent expired |
Expiry date: 20140916 |
|
| SPCF | Filing of an spc |
Free format text: PRODUCT NAME: NEB29-TETRADEKANOYL-DES(B30) HUMANNY INZULIN; NAT. REGISTRATION: EU/1/04/278/001, EU/1/04/278/002, EU/1/04/278/003, EU/1/04/278/004, EU/1/04/278/005, EU/1/04/278/006, EU/1/04/278/007, EU/1/04/278/008, EU/1/04/278/009, 20040601; FIRST REGISTRATION: CH 56370, 56371, 56372, 20031110 Spc suppl protection certif: 5001-2004 Filing date: 20151113 |
|
| SPCZ | Extension of validity of an spc |
Free format text: PRODUCT NAME: NEPSILONB29-TETRADEKANOYL-DES(B30) HUMANNY; NAT. REGISTRATION NO/DATE: EU/1/04/278/001 - EU/1/04/278/009 20040601; FIRST REGISTRATION: CH 56370 - 56372 20031110 Spc suppl protection certif: 21 5001-2004 Filing date: 20151113 Extension date: 20190510 |