PL2910570T3 - Stabilizowane względem proteaz, acylowane analogi insuliny - Google Patents

Stabilizowane względem proteaz, acylowane analogi insuliny

Info

Publication number
PL2910570T3
PL2910570T3 PL14198513T PL14198513T PL2910570T3 PL 2910570 T3 PL2910570 T3 PL 2910570T3 PL 14198513 T PL14198513 T PL 14198513T PL 14198513 T PL14198513 T PL 14198513T PL 2910570 T3 PL2910570 T3 PL 2910570T3
Authority
PL
Poland
Prior art keywords
insulin analogues
acylated insulin
protease stabilized
protease
stabilized
Prior art date
Application number
PL14198513T
Other languages
English (en)
Inventor
Thomas Hoeg-Jensen
Tina Møller Tagmose
Thomas Børglum Kjeldsen
Tine Glendorf
Patrick W. Garibay
Peter Madsen
Palle Jakobsen
János Tibor Kodra
Jacob Sten Petersen
Original Assignee
Novo Nordisk A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk A/S filed Critical Novo Nordisk A/S
Publication of PL2910570T3 publication Critical patent/PL2910570T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
PL14198513T 2008-03-18 2009-03-13 Stabilizowane względem proteaz, acylowane analogi insuliny PL2910570T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08102708 2008-03-18
EP08170231 2008-11-28
EP14198513.5A EP2910570B1 (en) 2008-03-18 2009-03-13 Protease stabilized, acylated insulin analogues

Publications (1)

Publication Number Publication Date
PL2910570T3 true PL2910570T3 (pl) 2017-06-30

Family

ID=40673840

Family Applications (2)

Application Number Title Priority Date Filing Date
PL09722934T PL2254906T3 (pl) 2008-03-18 2009-03-13 Stabilizowane względem proteaz, acylowane analogi insuliny
PL14198513T PL2910570T3 (pl) 2008-03-18 2009-03-13 Stabilizowane względem proteaz, acylowane analogi insuliny

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL09722934T PL2254906T3 (pl) 2008-03-18 2009-03-13 Stabilizowane względem proteaz, acylowane analogi insuliny

Country Status (20)

Country Link
US (5) US8691759B2 (pl)
EP (4) EP2910570B1 (pl)
JP (4) JP5749155B2 (pl)
KR (3) KR101755529B1 (pl)
CN (1) CN102037008B (pl)
AU (1) AU2009226910B2 (pl)
BR (1) BRPI0910348B1 (pl)
CA (1) CA2718738C (pl)
DK (2) DK2910570T3 (pl)
ES (2) ES2609288T3 (pl)
FI (1) FIC20240029I1 (pl)
HU (2) HUE032284T2 (pl)
IL (3) IL207748A0 (pl)
MX (1) MX2010009850A (pl)
NL (1) NL301283I2 (pl)
PL (2) PL2254906T3 (pl)
PT (2) PT2910570T (pl)
RU (1) RU2571857C2 (pl)
WO (1) WO2009115469A1 (pl)
ZA (1) ZA201006126B (pl)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1969004T3 (pl) 2005-12-28 2012-01-31 Novo Nordisk As Kompozycje zawierające acylowaną insulinę i cynk oraz sposób wytwarzania tych kompozycji
AU2007298919C1 (en) 2006-09-22 2014-02-06 Novo Nordisk A/S Protease resistant insulin analogues
CN101674812B (zh) 2007-04-30 2013-12-11 诺沃-诺迪斯克有限公司 干燥蛋白组合物的方法、干燥的蛋白组合物和包含干燥的蛋白的药物组合物
EP2514406A1 (en) * 2007-06-01 2012-10-24 Novo Nordisk A/S Spontaneously dispersible preconcentrates including a peptide drug in a solid or semisolid carrier
JP5762001B2 (ja) * 2008-03-14 2015-08-12 ノボ・ノルデイスク・エー／エス プロテアーゼ安定化インスリンアナログ
CN102037008B (zh) * 2008-03-18 2016-08-31 诺沃-诺迪斯克有限公司 蛋白酶稳定化的、酰化胰岛素类似物
WO2010066636A1 (en) * 2008-12-09 2010-06-17 Novo Nordisk A/S Novel insulin analogues
CN102481343A (zh) 2009-09-16 2012-05-30 诺沃—诺迪斯克有限公司 稳定的含胰岛素的非水液体药物组合物
JP5908847B2 (ja) * 2010-01-12 2016-04-26 ノヴォ ノルディスク アー／エス インスリンペプチドを経口投与するための医薬組成物
ES2541369T3 (es) 2010-02-16 2015-07-17 Novo Nordisk A/S Factor VIII recombinante modificado
KR20130036290A (ko) 2010-06-23 2013-04-11 노보 노르디스크 에이/에스 추가 이황화 결합을 함유하는 인슐린 유도체
CN103154024A (zh) 2010-10-15 2013-06-12 诺沃—诺迪斯克有限公司 新型n末端修饰的胰岛素衍生物
JP6049625B2 (ja) 2010-10-27 2016-12-21 ノヴォ ノルディスク アー／エス 様々な注射間隔を用いて施されるインスリン注射を使用する、真性糖尿病の治療
CN103370075A (zh) * 2011-02-15 2013-10-23 诺沃—诺迪斯克有限公司 长效il-1受体拮抗剂
EP2696847A1 (en) * 2011-04-14 2014-02-19 Novo Nordisk A/S Fatty acid acylated amino acids for oral peptide delivery
WO2012171994A1 (en) * 2011-06-15 2012-12-20 Novo Nordisk A/S Multi substituted insulins
WO2013093009A1 (en) 2011-12-21 2013-06-27 Novo Nordisk A/S N -terminally modified insulin derivatives
EP2836508B1 (en) 2012-04-11 2016-06-29 Novo Nordisk A/S Insulin formulations
US20150111820A1 (en) * 2012-07-09 2015-04-23 Novo Nordisk A/S Novel use of insulin derivatives
JP6285447B2 (ja) 2012-10-17 2018-02-28 ノヴォ ノルディスク アー／エス 経口ペプチド送達用の脂肪酸アシル化ｄ−アミノ酸
WO2014077575A1 (ko) * 2012-11-13 2014-05-22 다인바이오 주식회사 덱에이 효소반응으로 조제한 항비만 및 항당뇨 효능을 갖는 한천 유래 네오아가로올리고당 복합 조성물
CN103897053B (zh) * 2012-12-25 2019-01-15 深圳先进技术研究院 化学修饰的胸腺肽α1及其合成方法
JP2016519127A (ja) 2013-04-30 2016-06-30 ノヴォ ノルディスク アー／エス 新規投与レジメン
US20160106814A1 (en) * 2013-05-30 2016-04-21 Novo Nordisk A/S Novel Oral Pharmaceutical Composition for Treatment of Diabetes
GB201315335D0 (en) 2013-08-29 2013-10-09 Of Singapore Amino diacids containing peptide modifiers
US9896496B2 (en) * 2013-10-07 2018-02-20 Novo Nordisk A/S Derivative of an insulin analogue
MA46146A1 (fr) 2014-01-20 2020-12-31 Hanmi Pharm Ind Co Ltd Insuline a action prolongée et utilisation associée
AR099569A1 (es) * 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
US20180000742A1 (en) * 2015-01-29 2018-01-04 Novo Nordisk A/S Pharmaceutical Composition for Oral Insulin Administration Comprising a Tablet Core and a Polyvinyl Alcohol Coating
AR105616A1 (es) * 2015-05-07 2017-10-25 Lilly Co Eli Proteínas de fusión
US11352406B2 (en) * 2015-08-25 2022-06-07 Novo Nordisk A/S Insulin derivatives and the medical uses hereof
EP3341401A1 (en) * 2015-08-25 2018-07-04 Novo Nordisk A/S Novel insulin derivatives and the medical uses hereof
EP3341402A1 (en) 2015-08-25 2018-07-04 Novo Nordisk A/S Novel insulin derivatives and the medical uses hereof
UY36870A (es) 2015-08-28 2017-03-31 Hanmi Pharm Ind Co Ltd Análogos de insulina novedosos
GB201607918D0 (en) 2016-05-06 2016-06-22 Arecor Ltd Novel formulations
JP7432361B2 (ja) * 2016-08-02 2024-02-16 江蘇恒瑞医薬股▲ふん▼有限公司 ヒトインスリンまたはそのアナログのアシル化誘導体
BR112019005637A2 (pt) * 2016-09-23 2019-07-30 Hanmi Pharm Ind Co Ltd análogos da insulina com afinidade reduzida para o receptor de insulina e seu uso
MA46568A (fr) * 2016-10-24 2019-08-28 Novo Nordisk As Dosage biologique de formulations d'insuline
MA46780A (fr) 2016-11-07 2019-09-11 Novo Nordisk As Esters à dchbs actif de composés peg et leur utilisation
US20180169190A1 (en) * 2016-12-16 2018-06-21 Novo Nordisk A/S Insulin containing pharmaceutical compositions
WO2018174668A2 (ko) 2017-03-23 2018-09-27 한미약품 주식회사 인슐린 수용체와의 결합력이 감소된 인슐린 아날로그의 결합체 및 이의 용도
JOP20190273A1 (ar) * 2017-05-26 2019-11-24 Lilly Co Eli مركب إنسولين معالج بأسيل
CN108929383B (zh) * 2017-05-26 2021-10-15 阿思科力(苏州)生物科技有限公司 重组Slit2D2(C386S)-HSA融合蛋白及其在预防和/或治疗肺部炎症中的应用
PE20211264A1 (es) * 2017-08-17 2021-07-15 Novo Nordisk As Analogos de insulina acilados novedosos y usos de estos
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin
KR102666154B1 (ko) 2018-08-08 2024-05-20 주식회사 대웅제약 지속형 인슐린 아날로그 및 그 복합체
CN112789289A (zh) 2018-10-05 2021-05-11 诺和诺德股份有限公司 包含胰岛素肽和egf(a)肽的双功能化合物
KR20210102347A (ko) * 2018-12-11 2021-08-19 사노피 인슐린 수용체 결합 친화성이 감소된 인슐린 유사체
CN111574585B (zh) * 2019-01-30 2021-10-01 浙江省医学科学院 一种鳕鱼皮寡肽及其分离纯化方法和应用
CN110041219B (zh) * 2019-05-09 2020-09-25 南京工业大学 一种索马鲁肽侧链的液相合成方法
TW202123960A (zh) 2019-08-30 2021-07-01 美商默沙東藥廠 Pcsk9拮抗劑化合物
BR112022011291A2 (pt) 2019-12-10 2022-09-06 Sanofi Sa Método para formar um conjugado de uma sulfonamida e um polipeptídeo
TWI773009B (zh) 2019-12-11 2022-08-01 丹麥商諾佛 儂迪克股份有限公司 新穎之胰島素類似物及其用途
KR20220119731A (ko) * 2019-12-30 2022-08-30 간 앤 리 파마슈티칼스 컴퍼니, 리미티드 장기 지속형 glp-1 화합물
CN118480114A (zh) * 2019-12-30 2024-08-13 甘李药业股份有限公司 胰岛素衍生物
KR20220145888A (ko) 2020-03-06 2022-10-31 사노피 선택적 gip 수용체 작용제로서의 펩티드
PL4199946T3 (pl) 2020-08-19 2024-08-19 Sanofi Agoniści receptora crf2 i ich zastosowanie w terapii
WO2022090448A1 (en) 2020-10-30 2022-05-05 Novo Nordisk A/S Novel acylating reagents
CA3200351A1 (en) * 2020-11-27 2022-06-02 Ok Cheol Jeon Oral formulation of biologically active material conjugate having biotin moiety, fatty acid moiety, or combination thereof coupled thereto
JP2023553362A (ja) * 2020-11-27 2023-12-21 ディーアンドディー ファーマテック インコーポレイテッド ビオチン部分、脂肪酸部分またはその組合せを連結されて有する生物学的活性材料結合体
CN112679701B (zh) * 2020-12-28 2022-02-25 重庆宸安生物制药有限公司 一种固定化赖氨酸内肽酶及其制备方法与用途
KR20240013778A (ko) * 2021-05-24 2024-01-30 선샤인 레이크 파르마 컴퍼니 리미티드 신규한 아실화된 인슐린 유사체
WO2023012263A1 (en) 2021-08-04 2023-02-09 Novo Nordisk A/S Solid oral peptide formulations
AU2022332278A1 (en) * 2021-08-23 2024-01-25 Eli Lilly And Company Compounds and methods for liquid phase synthesis
CN118159552A (zh) 2021-09-06 2024-06-07 赛诺菲 作为强效的且选择性的gip受体激动剂的新肽
WO2023143458A1 (zh) * 2022-01-28 2023-08-03 甘李药业股份有限公司 酰化胰岛素
TW202342552A (zh) * 2022-03-16 2023-11-01 大陸商北京拓界生物醫藥科技有限公司 人胰島素類似物、其融合蛋白及醫藥用途
WO2024051787A1 (zh) * 2022-09-09 2024-03-14 北京惠之衡生物科技有限公司 一种长效酰化胰岛素衍生物及其应用

Family Cites Families (231)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US487000A (en) 1892-11-29 Shirt
US2832685A (en) 1952-05-24 1958-04-29 Crest Foods Co Inc Solubilization of milk proteins
GB894095A (en) 1960-02-08 1962-04-18 Tanaka Shoichi A therapeutic device for personal wear
US3528960A (en) 1968-10-07 1970-09-15 Lilly Co Eli N-carboxyaroyl insulins
US3719655A (en) 1969-12-05 1973-03-06 Lilly Co Eli Process for the crystallization of the ammonium and alkali metal salts in insulin
US3950517A (en) 1970-05-08 1976-04-13 National Research Development Corporation Insulin derivatives
US3869437A (en) 1970-05-08 1975-03-04 Nat Res Dev Mono-, di, and N{HD A1{B , N{HU B1{B , N{HU B29{B -tri-acylated insulin
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4033941A (en) 1975-12-17 1977-07-05 Eli Lilly And Company Process for purifying glucagon
GB1492997A (en) 1976-07-21 1977-11-23 Nat Res Dev Insulin derivatives
JPS6030650B2 (ja) 1979-10-26 1985-07-17 日本油脂株式会社 座薬基剤組成物
JPS5767548A (en) 1980-10-14 1982-04-24 Shionogi & Co Ltd Insulin analog and its preparation
NL193099C (nl) 1981-10-30 1998-11-03 Novo Industri As Gestabiliseerde insuline-oplossing.
US4546082A (en) 1982-06-17 1985-10-08 Regents Of The Univ. Of California E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins
US4870008A (en) 1983-08-12 1989-09-26 Chiron Corporation Secretory expression in eukaryotes
US4839341A (en) 1984-05-29 1989-06-13 Eli Lilly And Company Stabilized insulin formulations
DK347086D0 (da) 1986-07-21 1986-07-21 Novo Industri As Novel peptides
PH25772A (en) 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
US4849227A (en) 1986-03-21 1989-07-18 Eurasiam Laboratories, Inc. Pharmaceutical compositions
PH23446A (en) 1986-10-20 1989-08-07 Novo Industri As Peptide preparations
NZ222907A (en) 1986-12-16 1990-08-28 Novo Industri As Preparation for intranasal administration containing a phospholipid absorption enhancing system
DK463887D0 (da) 1987-09-07 1987-09-07 Novo Industri As Gaerleader
US5266310A (en) 1987-09-17 1993-11-30 Boehringer Ingelheim International Gmbh Stabilization of therapeutically active proteins in pharmaceutical preparations
JPH01254699A (ja) 1988-04-05 1989-10-11 Kodama Kk インスリン誘導体及びその用途
DK257988D0 (da) 1988-05-11 1988-05-11 Novo Industri As Nye peptider
JPH03506023A (ja) 1988-07-20 1991-12-26 ノボ　ノルデイスク　アクツイエセルスカプ ポリペプチド
GB2222770B (en) 1988-09-16 1992-07-29 Sandoz Ltd Pharmaceutical compositions containing cyclosporins
US5225323A (en) 1988-11-21 1993-07-06 Baylor College Of Medicine Human high-affinity neurotransmitter uptake system
US5716927A (en) 1988-12-23 1998-02-10 Novo Nordisk A/S Insulin analogs having a modified B-chain
JPH04502465A (ja) 1988-12-23 1992-05-07 ノボ　ノルディスク　アクティーゼルスカブ ヒトインシュリン類似物質
DE3844211A1 (de) 1988-12-29 1990-07-05 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
DK105489D0 (da) 1989-03-03 1989-03-03 Novo Nordisk As Polypeptid
US5514646A (en) 1989-02-09 1996-05-07 Chance; Ronald E. Insulin analogs modified at position 29 of the B chain
ATE120762T1 (de) 1989-04-20 1995-04-15 Sinai School Medicine Hepatospezifische insulin-analoga.
CA1340994C (en) 1989-09-21 2000-05-16 Rudolf Edgar Dr. Falk Treatment of conditions and disease
AU6417790A (en) 1989-09-22 1991-04-18 Tsi-Madison Research Institute Method and compositions for one-step cryopreservation of embryos
KR930001305B1 (ko) 1989-10-19 1993-02-25 니뽕 유우시 가부시끼가이샤 당 응답형 고분자 복합체(Polymer Complexes of Sugar Response Type)
US5179189A (en) 1990-01-19 1993-01-12 Nova Pharmaceutical Corporation Fatty acid terminated polyanhydrides
DK45590D0 (pl) 1990-02-21 1990-02-21 Novo Nordisk As
DK155690D0 (da) 1990-06-28 1990-06-28 Novo Nordisk As Nye peptider
DK158390D0 (da) 1990-07-02 1990-07-02 Novo Nordisk As Nye peptider
WO1992001476A1 (en) 1990-07-26 1992-02-06 University Of Iowa Research Foundation Novel drug delivery systems for proteins and peptides using albumin as a carrier molecule
JPH06501003A (ja) 1990-09-13 1994-01-27 スミスクライン・ビーチャム・コーポレイション 非水性液状経口懸濁液
DK10191D0 (da) 1991-01-22 1991-01-22 Novo Nordisk As Hidtil ukendte peptider
US5336782A (en) 1991-04-24 1994-08-09 Kuraray Co., Ltd. Long chain carboxylic acid imide ester
CA2268476A1 (en) 1991-07-03 1998-04-30 Hyal Pharmaceutical Corporation Use of hyaluronan in gene therapy
ES2093269T3 (es) 1991-07-26 1996-12-16 Smithkline Beecham Corp Microemulsiones del tipo agua en aceite.
US5268453A (en) 1991-08-08 1993-12-07 Scios Inc. Tissue-selective insulin analogs
US5206219A (en) 1991-11-25 1993-04-27 Applied Analytical Industries, Inc. Oral compositions of proteinaceous medicaments
CZ342492A3 (en) 1991-11-26 1993-06-16 Lilly Co Eli Derivatives of tri-arginine insulin, process of their preparation and a pharmaceutical composition in which said derivatives are comprised
EP0547544B1 (de) * 1991-12-18 1997-03-12 Hoechst Aktiengesellschaft Verfahren zur Gewinnung von insulinhaltigen Lösungen
WO1994008599A1 (en) 1992-10-14 1994-04-28 The Regents Of The University Of Colorado Ion-pairing of drugs for improved efficacy and delivery
WO1994008603A1 (en) 1992-10-16 1994-04-28 Smithkline Beecham Corporation Compositions
JPH08502492A (ja) 1992-10-16 1996-03-19 スミスクライン・ビーチャム・コーポレイション 治療用ミクロエマルジョン
EP0684834A4 (en) 1993-02-17 1996-09-25 Smithkline Beecham Corp MICROEMULSIONS CONTAINING THERAPEUTIC PEPTIDES.
EP0684833A4 (en) 1993-02-17 1996-09-11 Smithkline Beecham Corp MICRO-EMULSIONS COMPRISING THERAPEUTIC PEPTIDES.
US5589167A (en) 1993-02-23 1996-12-31 Genentech, Inc. Excipient stabilization of polypeptides treated with organic solvents
US5359030A (en) 1993-05-10 1994-10-25 Protein Delivery, Inc. Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
US5424286A (en) 1993-05-24 1995-06-13 Eng; John Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same
US5506203C1 (en) 1993-06-24 2001-02-06 Astra Ab Systemic administration of a therapeutic preparation
DK82893D0 (da) 1993-07-08 1993-07-08 Novo Nordisk As Peptid
RO112873B1 (ro) 1993-09-17 1998-01-30 Novo Nordisk As Derivati de insulina
US6869930B1 (en) * 1993-09-17 2005-03-22 Novo Nordisk A/S Acylated insulin
GB9323588D0 (en) 1993-11-16 1994-01-05 Cortecs Ltd Hydrophobic preparation
AU689217B2 (en) 1994-03-07 1998-03-26 Novartis Ag Methods and compositions for pulmonary delivery of insulin
US5639642A (en) 1994-06-16 1997-06-17 Novo Nordisk A/S Synthetic leader peptide sequences
US6500645B1 (en) 1994-06-17 2002-12-31 Novo Nordisk A/S N-terminally extended proteins expressed in yeast
IL114160A (en) 1994-06-17 2006-12-31 Novo Nordisk As Dna constructs encoding heterologous proteins and processes for the heterologous protein production in yeast
US5693609A (en) 1994-11-17 1997-12-02 Eli Lilly And Company Acylated insulin analogs
US5646242A (en) 1994-11-17 1997-07-08 Eli Lilly And Company Selective acylation of epsilon-amino groups
US6251856B1 (en) 1995-03-17 2001-06-26 Novo Nordisk A/S Insulin derivatives
WO1996029344A1 (en) 1995-03-17 1996-09-26 Novo Nordisk A/S Insulin derivatives
US5824638A (en) 1995-05-22 1998-10-20 Shire Laboratories, Inc. Oral insulin delivery
US20010041786A1 (en) * 1995-06-07 2001-11-15 Mark L. Brader Stabilized acylated insulin formulations
DE69630527T2 (de) 1995-06-30 2004-08-05 Novo Nordisk A/S Vorbeugung einer krankheit mit diabetes charakter
US20030104981A1 (en) 1995-11-03 2003-06-05 Jelena Mandic Human insulin analogues
US6451970B1 (en) 1996-02-21 2002-09-17 Novo Nordisk A/S Peptide derivatives
WO1998001473A1 (en) 1996-07-05 1998-01-15 Novo Nordisk A/S Method for the production of precursors of insulin, precursors of insulin analogues, and insulin like peptides
DE69731105T2 (de) 1996-07-11 2005-11-17 Novo Nordisk A/S Verfahren zur selektiven acetylierung
US5981489A (en) 1996-07-18 1999-11-09 Alza Corporation Non-aqueous protic peptide formulations
DK0821006T3 (da) 1996-07-26 2004-08-16 Aventis Pharma Gmbh Insulinderivater med öget zinkbinding
IL119029A0 (en) 1996-08-07 1996-11-14 Yeda Res & Dev Long-acting drugs and pharamaceutical compositions comprising them
HU227021B1 (en) 1996-08-30 2010-05-28 Novo Nordisk As Glp-1 derivatives
WO1998032867A1 (en) 1997-01-24 1998-07-30 Novo Nordisk A/S Synthetic leader peptide sequences
KR20050084502A (ko) 1997-01-30 2005-08-26 노파르티스 아게 오일을 함유하지 않은 사이클로스포린 ａ 함유 제약 조성물
US5898067A (en) 1997-02-07 1999-04-27 Novo Nordisk A/S Crystallization of proteins
US6310038B1 (en) 1997-03-20 2001-10-30 Novo Nordisk A/S Pulmonary insulin crystals
AR012894A1 (es) 1997-06-13 2000-11-22 Lilly Co Eli Formulacion de insulina en solucion estable, su uso para preparar un medicamento y proceso para la preparacion de la misma.
ID24890A (id) 1997-10-24 2000-08-31 Lilly Co Eli Komposisi-komposisi insulin yang tidak dapat larut
PL195845B1 (pl) 1997-10-24 2007-10-31 Novo Nordisk As Rozpuszczalny w wodzie agregat pochodnych insuliny
ZA989744B (en) 1997-10-31 2000-04-26 Lilly Co Eli Method for administering acylated insulin.
CA2309818C (en) 1997-11-12 2009-05-05 Alza Corporation Buffered drug formulations for transdermal electrotransport delivery
US6531448B1 (en) 1997-12-23 2003-03-11 Eli Lilly And Company Insoluble compositions for controlling blood glucose
EP1060191B1 (en) 1998-02-27 2010-04-28 Novo Nordisk A/S Derivatives of glp-1 analogs
JP2002518408A (ja) 1998-06-12 2002-06-25 キングス・カレツジ・ロンドン インスリン類似体
GB9814172D0 (en) 1998-06-30 1998-08-26 Andaris Ltd Formulation for inhalation
ES2553108T3 (es) 1998-08-10 2015-12-04 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Diferenciación de células no productoras de insulina en células productoras de insulina mediante GLP-1 o exendina-4 y utilizaciones de las mismas
ES2289823T3 (es) 1998-08-25 2008-02-01 Advanced Inhalation Research, Inc. Formulaciones proteicas estables secadas por atomizacion.
TW570805B (en) 1998-09-01 2004-01-11 Hoffmann La Roche Water-soluble pharmaceutical composition in an ionic complex
US7030083B2 (en) 1998-09-09 2006-04-18 University Of Washington Treatment of eclampsia and preeclampsia
HUP0104111A3 (en) 1998-10-16 2002-05-28 Novo Nordisk As Stable concentrated insulin preparations for pulmonary delivery
US6660715B2 (en) 1998-11-19 2003-12-09 Massachusetts Institute Of Technology Nonaqueous solutions and suspensions of macromolecules for pulmonary delivery
US7425541B2 (en) 1998-12-11 2008-09-16 Medarex, Inc. Enzyme-cleavable prodrug compounds
DE60000288T2 (de) 1999-01-26 2003-01-16 Lilly Co Eli Monodisperse formulierungen, die hexamere acylierte insulinanaloge enthalten
WO2000047203A1 (en) 1999-02-12 2000-08-17 Mqs, Inc. Formulation and system for intra-oral delivery of pharmaceutical agents
US6267985B1 (en) 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions
WO2000061178A1 (en) 1999-04-13 2000-10-19 Inhale Therapeutics Systems, Inc. Pulmonary administration of dry powder formulations for treating infertility
EP1173482A1 (en) 1999-04-27 2002-01-23 Eli Lilly And Company Insulin crystals for pulmonary administration
US6746853B1 (en) 1999-05-19 2004-06-08 Xencor, Inc. Proteins with insulin-like activity useful in the treatment of diabetes
WO2000069901A2 (en) 1999-05-19 2000-11-23 Xencor, Inc. Proteins with insulin-like activity useful in the treatment of diabetes
US6309633B1 (en) 1999-06-19 2001-10-30 Nobex Corporation Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
WO2001000674A1 (en) 1999-06-29 2001-01-04 Eli Lilly And Company Insulin crystals for pulmonary administration
WO2001043762A2 (en) 1999-12-16 2001-06-21 Eli Lilly And Company Polypeptide compositions with improved stability
US6734162B2 (en) 2000-01-24 2004-05-11 Minimed Inc. Mixed buffer system for stabilizing polypeptide formulations
EP1265630B1 (en) 2000-03-24 2006-06-07 Genentech, Inc. Use of insulin for the treatment of cartilagenous disorders
AU2001263775A1 (en) 2000-06-02 2001-12-11 Novo-Nordisk A/S Glucose dependent release of insulin from glucose sensing insulin derivatives
CN1141974C (zh) 2000-06-07 2004-03-17 张昊 结肠定位释放的口服生物制剂
US6459965B1 (en) 2000-11-22 2002-10-01 Ge-Harris Railway Electronics, Llc Method for advanced communication-based vehicle control
KR100508695B1 (ko) 2001-02-13 2005-08-17 한국과학기술연구원 인슐린의 경구투여용 제형과 그의 제조방법
US6867183B2 (en) 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7060675B2 (en) 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
WO2002067969A2 (en) 2001-02-21 2002-09-06 Medtronic Minimed, Inc. Stabilized insulin formulations
CN1160122C (zh) 2001-04-20 2004-08-04 清华大学 一种制备口服胰岛素油相制剂的方法
WO2002094200A2 (en) 2001-05-21 2002-11-28 Nektar Therapeutics Pulmonary administration of chemically modified insulin
US6858580B2 (en) 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
EP1423136A4 (en) 2001-08-10 2007-07-25 Epix Pharm Inc POLYPEPTIDE CONJUGATES HAVING INCREASED CIRCULATION HALF-VIES
JP4318546B2 (ja) 2001-09-07 2009-08-26 バイオコン・リミテッド インスリンポリペプチド−オリゴマーコンジュゲートの合成方法、ならびにプロインスリンポリペプチド−オリゴマーコンジュゲートおよびその合成方法
US7030082B2 (en) 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
US6770625B2 (en) 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
US7312192B2 (en) 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7317000B2 (en) 2001-12-02 2008-01-08 Novo Nordisk A/S Glucose-dependent insulins
JP2005526009A (ja) 2001-12-02 2005-09-02 ノボ　ノルディスク　アクティーゼルスカブ 新規グルコース依存性インスリン
US8535650B2 (en) 2001-12-03 2013-09-17 Soligenix, Inc. Stabilized reverse micelle compositions and uses thereof
WO2003050276A1 (en) 2001-12-05 2003-06-19 Dow Global Technologies Inc. Method for immobilizing a biologic in a polyurethane-hydrogel composition, a composition prepared from the method, and biomedical applications
WO2003053460A1 (en) 2001-12-19 2003-07-03 Eli Lilly And Company Crystalline compositions for controlling blood glucose
SK2432004A3 (sk) 2001-12-20 2005-04-01 Eli Lilly And Company Inzulínová zlúčenina s protrahovaným účinkom
UA46669C2 (uk) 2001-12-29 2005-12-15 Товариство З Обмеженою Відповідальністю "Мако" Спосіб приготування готової лікарської форми інсуліну пролонгованої дії
WO2003075950A1 (en) 2002-03-13 2003-09-18 Novo Nordisk A/S Minimising body weight gain in insulin treatment
DE60335797D1 (de) 2002-05-07 2011-03-03 Novo Nordisk As Lösliche formulierungen, die monomeres insulin und acyliertes insulin enthalten
AU2003218635A1 (en) 2002-05-07 2003-11-11 Novo Nordisk A/S Soluble formulations comprising insulin aspart and insulin detemir
US7601688B2 (en) 2002-06-13 2009-10-13 Biocon Limited Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
CN1165549C (zh) 2002-06-15 2004-09-08 江苏万邦生化医药股份有限公司 胰岛素的纯化方法
EP1545526A4 (en) 2002-09-17 2009-09-23 Merck & Co Inc ELIMINATION OF AN ALDEHYDE IMPURITY IN A REACTIVE POLYSTYRENE RESIN
US20040185068A1 (en) 2003-03-18 2004-09-23 Zhi-Jian Yu Self-emulsifying compositions, methods of use and preparation
WO2004105790A1 (en) 2003-06-03 2004-12-09 Novo Nordisk A/S Stabilized pharmaceutical peptide compositions
CN1812808B (zh) 2003-06-03 2012-07-04 诺沃挪第克公司 稳定化的药物肽组合物
ES2313018T3 (es) * 2003-06-17 2009-03-01 Sembiosys Genetics Inc. Procedimiento de produccion de insulina en plantas.
US20050054818A1 (en) 2003-07-02 2005-03-10 Brader Mark Laurence Crystalline compositions for controlling blood glucose
EP1644411A2 (en) 2003-07-11 2006-04-12 Novo Nordisk A/S Stabilised insulin compositions
DK1648933T3 (da) 2003-07-25 2009-09-07 Conjuchem Biotechnologies Inc Langvarige insulinderivater og fremgangsm der
EP1660531A2 (en) 2003-08-05 2006-05-31 Novo Nordisk A/S Novel insulin derivatives
US20060198819A1 (en) 2003-08-08 2006-09-07 Novo Nordisk Healthcare A/G Use of galactose oxidase for selective chemical conjugation of protractor molecules to proteins of therapeutic interest
PL1660047T3 (pl) 2003-08-13 2014-05-30 Biocon Ltd Formulacje dawek stałych mikrocząsteczek soli kwasów tłuszczowych do środków terapeutycznych
CA2539253A1 (en) 2003-09-19 2005-03-31 Novo Nordisk A/S Albumin-binding derivatives of therapeutic peptides
WO2005047508A1 (en) 2003-11-14 2005-05-26 Novo Nordisk A/S Processes for making acylated insulin
US20050118206A1 (en) 2003-11-14 2005-06-02 Luk Andrew S. Surfactant-based gel as an injectable, sustained drug delivery vehicle
AU2004290862B2 (en) 2003-11-20 2010-06-03 Novo Nordisk A/S Propylene glycol-containing peptide formulations which are optimal for production and for use in injection devices
US7371381B2 (en) 2003-12-12 2008-05-13 Amgen Inc. Anti-galanin antibodies and uses thereof
DE10358387A1 (de) 2003-12-13 2005-07-07 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulver enthaltend niedermolekulares Dextran und Verfahren zu deren Herstellung
JP4792457B2 (ja) 2004-03-26 2011-10-12 ユニヴァーシタ’デグリ ステュディ ディ パルマ 高度に呼吸に適したインスリンのマイクロ粒子
NZ550320A (en) 2004-04-15 2010-02-26 Chiasma Inc Compositions capable of facilitating penetration across a biological barrier
AU2005247369A1 (en) 2004-05-10 2005-12-08 Mdrna, Inc. Compositions and methods for enhanced mucosal delivery of parathyroid hormone
KR20070029247A (ko) 2004-07-08 2007-03-13 노보 노르디스크 에이/에스 폴리펩티드 연장 태그
EP1768694A1 (en) 2004-07-09 2007-04-04 Novo Nordisk A/S Phamaceutical preparations comprising insulin
UA91512C2 (ru) 2004-07-19 2010-08-10 Биокон Лимитед Коньюгати олигомеров инсулина, их композиция (варианты) и применение
EP1789074A4 (en) 2004-08-09 2009-08-12 Alios Biopharma Inc PROTEASE-RESISTANT HYPERGLYCOSYL SYNTHETIC POLYPEPTIDE VARIANTS, ORAL FORMULATIONS AND METHODS OF USING THE SAME
EP1791542B1 (en) 2004-08-23 2015-05-20 Mannkind Corporation Diketopiperazine salts for drug delivery
US20070292523A1 (en) 2004-09-27 2007-12-20 Joey Moodley Dihydropyrimidine Formulations
EP1817050B1 (en) 2004-12-03 2015-04-15 Rhode Island Hospital Diagnosis and treatment of alzheimer's disease
US20090036353A1 (en) 2005-01-27 2009-02-05 Novo Nordisk A/S Insulin Derivatives Conjugated with Structurally Well Defined Branched Polymers
JP5410020B2 (ja) 2005-02-02 2014-02-05 ノヴォ ノルディスク アー／エス インスリン誘導体
US8067362B2 (en) 2005-02-02 2011-11-29 Novo Nordisk As Insulin derivatives
US20090123563A1 (en) 2005-02-07 2009-05-14 Novo Nordisk A/S Pharmaceutical Preparations Comprising Insulin, Zinc Ions and Zinc-Binding Ligand
WO2006086856A1 (en) 2005-02-15 2006-08-24 Messadek, Jallal Combination therapeutic compositions and method of use
TWI372629B (en) 2005-03-18 2012-09-21 Novo Nordisk As Acylated glp-1 compounds
JP2008533100A (ja) 2005-03-18 2008-08-21 ノボ ノルディスク アクティーゼルスカブ Ｐｅｇ化された単鎖インスリン
WO2006103657A2 (en) 2005-03-31 2006-10-05 Dexcel Pharma Technologies Ltd. A solid composition for intra-oral delivery of insulin
WO2006110551A2 (en) 2005-04-08 2006-10-19 Amylin Pharmaceuticals, Inc. Pharmaceutical formulations comprising incretin peptide and aprotic polar solvent
JP5235661B2 (ja) 2005-05-25 2013-07-10 ノボ・ノルデイスク・エー／エス 安定化ポリペプチド製剤
WO2007006320A1 (en) 2005-07-12 2007-01-18 Sherine Hassan Abbas Helmy Drinkable oral insulin liquid and capsules
WO2007041481A1 (en) 2005-09-29 2007-04-12 Biodel, Inc. Rapid acting and prolonged acting insulin preparations
JP4710533B2 (ja) 2005-10-07 2011-06-29 株式会社豊田自動織機 牽引車両のドローバー装置
KR20080064171A (ko) 2005-10-20 2008-07-08 나스텍 파마수티컬 컴퍼니 인코포레이티드 속효성 인슐린의 비강내 투여
PL1969004T3 (pl) 2005-12-28 2012-01-31 Novo Nordisk As Kompozycje zawierające acylowaną insulinę i cynk oraz sposób wytwarzania tych kompozycji
US8343914B2 (en) 2006-01-06 2013-01-01 Case Western Reserve University Fibrillation resistant proteins
WO2007096332A1 (en) 2006-02-21 2007-08-30 Novo Nordisk A/S Single-chain insulin analogues and pharmaceutical formulations thereof
ATE482977T1 (de) * 2006-02-27 2010-10-15 Novo Nordisk As Insulinderivate
WO2007104738A2 (en) 2006-03-13 2007-09-20 Novo Nordisk A/S Acylated single chain insulin
US20090069215A1 (en) 2006-03-13 2009-03-12 Novo Nordisk A/S Acylated Single Chain Insulin
EP2386572B1 (en) 2006-05-09 2015-07-08 Novo Nordisk A/S Insulin derivative
JP5269766B2 (ja) 2006-05-09 2013-08-21 ノボ・ノルデイスク・エー／エス インスリン誘導体
WO2008015099A2 (en) 2006-07-31 2008-02-07 Novo Nordisk A/S Pegylated, extended insulins
AU2007298919C1 (en) * 2006-09-22 2014-02-06 Novo Nordisk A/S Protease resistant insulin analogues
EP2074140B8 (en) 2006-10-04 2015-10-28 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues
EP2152243A2 (en) 2007-04-30 2010-02-17 Novo Nordisk A/S Highly concentrated insulin solutions and compositions
CN101674812B (zh) 2007-04-30 2013-12-11 诺沃-诺迪斯克有限公司 干燥蛋白组合物的方法、干燥的蛋白组合物和包含干燥的蛋白的药物组合物
EP2164458A1 (en) 2007-06-01 2010-03-24 Novo Nordisk A/S Stable non-aqueous pharmaceutical compositions
EP2514406A1 (en) 2007-06-01 2012-10-24 Novo Nordisk A/S Spontaneously dispersible preconcentrates including a peptide drug in a solid or semisolid carrier
ES2744384T3 (es) 2007-06-13 2020-02-24 Novo Nordisk As Formulación farmacéutica que comprende un derivado de insulina
US20100216691A1 (en) 2007-07-16 2010-08-26 Novo Nordisk A/S Protease Stabilized, Pegylated Insulin Analogues
WO2009021955A1 (en) 2007-08-13 2009-02-19 Novo Nordisk A/S Rapid acting insulin analogues
KR20100053561A (ko) 2007-08-15 2010-05-20 노보 노르디스크 에이/에스 아실 및 알킬렌 글리콜 부분을 갖는 인슐린 유사체
ES2526924T3 (es) * 2007-08-15 2015-01-16 Novo Nordisk A/S Insulinas con una fracción acilo que comprende unidades repetitivas de aminoácidos que contienen alquilenglicol
US20090087484A1 (en) 2007-09-28 2009-04-02 Alza Corporation Formulation and dosage form for increasing oral bioavailability of hydrophilic macromolecules
BRPI0820535B8 (pt) 2007-11-16 2021-05-25 Novo Nordisk As composições farmacêuticas contendo insulina e um peptídeo insulinotrópico
JP5762001B2 (ja) 2008-03-14 2015-08-12 ノボ・ノルデイスク・エー／エス プロテアーゼ安定化インスリンアナログ
CN102037008B (zh) 2008-03-18 2016-08-31 诺沃-诺迪斯克有限公司 蛋白酶稳定化的、酰化胰岛素类似物
US8993516B2 (en) 2008-04-14 2015-03-31 Case Western Reserve University Meal-time insulin analogues of enhanced stability
TWI451876B (zh) 2008-06-13 2014-09-11 Lilly Co Eli 聚乙二醇化之離脯胰島素化合物
KR20110085985A (ko) 2008-10-30 2011-07-27 노보 노르디스크 에이/에스 하루 한번 주사 빈도보다 적은 인슐린 주사를 사용한 진성 당뇨병의 치료
WO2010060667A1 (en) 2008-11-28 2010-06-03 Novo Nordisk A/S Pharmaceutical compositions suitable for oral administration of derivatized insulin peptides
WO2010066636A1 (en) 2008-12-09 2010-06-17 Novo Nordisk A/S Novel insulin analogues
CN102481343A (zh) 2009-09-16 2012-05-30 诺沃—诺迪斯克有限公司 稳定的含胰岛素的非水液体药物组合物
EP2496213B1 (en) 2009-11-02 2015-08-12 Novo Nordisk A/S Pharmaceutical solution of non covalently bound albumin and acylated insulin
WO2011061125A2 (de) 2009-11-23 2011-05-26 Basf Se Verfahren zur herstellung wasserabsorbierender polymerpartikel mit verbesserter farbstabilität
JP5908847B2 (ja) 2010-01-12 2016-04-26 ノヴォ ノルディスク アー／エス インスリンペプチドを経口投与するための医薬組成物
US8815798B2 (en) 2010-06-23 2014-08-26 Novo Nordisk A/S Insulin analogues containing additional disulfide bonds
KR20130036290A (ko) 2010-06-23 2013-04-11 노보 노르디스크 에이/에스 추가 이황화 결합을 함유하는 인슐린 유도체
CN103154024A (zh) 2010-10-15 2013-06-12 诺沃—诺迪斯克有限公司 新型n末端修饰的胰岛素衍生物
CN103249427A (zh) 2010-12-14 2013-08-14 诺沃—诺迪斯克有限公司 速效胰岛素联合长效胰岛素
WO2012171994A1 (en) 2011-06-15 2012-12-20 Novo Nordisk A/S Multi substituted insulins
EP2836508B1 (en) 2012-04-11 2016-06-29 Novo Nordisk A/S Insulin formulations
US20150111820A1 (en) 2012-07-09 2015-04-23 Novo Nordisk A/S Novel use of insulin derivatives
JP2016519127A (ja) 2013-04-30 2016-06-30 ノヴォ ノルディスク アー／エス 新規投与レジメン
US9896496B2 (en) 2013-10-07 2018-02-20 Novo Nordisk A/S Derivative of an insulin analogue
FR3013049B1 (fr) 2013-11-14 2015-11-13 You-Ping Chan Analogue de l'insuline glargine
WO2015131902A1 (en) 2014-03-07 2015-09-11 Jørgensen Klavs Holger Novel fast acting insulin preparations
TWI685348B (zh) 2014-05-08 2020-02-21 美國禮來大藥廠 速效胰島素組合物
TW201630622A (zh) 2014-12-16 2016-09-01 美國禮來大藥廠 速效胰島素組合物
US20180169190A1 (en) 2016-12-16 2018-06-21 Novo Nordisk A/S Insulin containing pharmaceutical compositions

Also Published As

Publication number Publication date
BRPI0910348A2 (pt) 2020-08-11
IL207748A0 (en) 2010-12-30
JP2011515358A (ja) 2011-05-19
US9688737B2 (en) 2017-06-27
JP2015155421A (ja) 2015-08-27
EP2910569B1 (en) 2016-10-05
PT2254906T (pt) 2017-01-03
BRPI0910348B1 (pt) 2021-06-29
DK2910570T3 (en) 2017-01-30
ES2609288T3 (es) 2017-04-19
US20150210748A1 (en) 2015-07-30
EP2910571B1 (en) 2016-10-05
KR101755434B1 (ko) 2017-07-10
RU2010141481A (ru) 2012-04-27
KR20160124929A (ko) 2016-10-28
IL250548A0 (en) 2017-03-30
EP2910571A1 (en) 2015-08-26
EP2254906A1 (en) 2010-12-01
ES2611007T3 (es) 2017-05-04
HUE032284T2 (en) 2017-09-28
ZA201006126B (en) 2011-11-30
CA2718738A1 (en) 2009-09-24
WO2009115469A1 (en) 2009-09-24
CN102037008B (zh) 2016-08-31
RU2571857C2 (ru) 2015-12-20
CN102037008A (zh) 2011-04-27
JP2015147782A (ja) 2015-08-20
KR20160073431A (ko) 2016-06-24
KR20110004366A (ko) 2011-01-13
AU2009226910A1 (en) 2009-09-24
HUE032287T2 (en) 2017-09-28
EP2254906B1 (en) 2016-10-05
CA2718738C (en) 2019-05-07
IL250548B (en) 2019-03-31
US20150210747A1 (en) 2015-07-30
JP2015147781A (ja) 2015-08-20
NL301283I2 (nl) 2024-08-08
US20110105720A1 (en) 2011-05-05
EP2910570A1 (en) 2015-08-26
US20190112348A1 (en) 2019-04-18
FIC20240029I1 (fi) 2024-08-09
DK2254906T3 (en) 2017-01-23
US9045560B2 (en) 2015-06-02
KR101755529B1 (ko) 2017-07-07
IL250549A0 (en) 2017-03-30
AU2009226910B2 (en) 2014-02-06
PT2910570T (pt) 2017-01-24
IL250549B (en) 2018-12-31
US8691759B2 (en) 2014-04-08
MX2010009850A (es) 2010-09-30
US10259856B2 (en) 2019-04-16
US20140073564A1 (en) 2014-03-13
PL2254906T3 (pl) 2017-04-28
JP5749155B2 (ja) 2015-07-15
EP2910569A1 (en) 2015-08-26
EP2910570B1 (en) 2016-10-12

Similar Documents

Publication Publication Date Title
ZA201006126B (en) Protease stabilized, acylated insulin analogues
EP2296692A4 (en) INSULIN ANALOGUES SPECIFIC TO ISOFORMS
IL197609A0 (en) Protease resistant insulin analogues
AP2012006107A0 (en) Acylated glucagon analogues.
HK1203531A1 (en) Glucagon analogues
HK1161275A1 (en) Halogen-stabilized insulin
EP2376520A4 (en) INSULIN ANALOGS
ZA201104592B (en) Glucagon analogues
ZA201104593B (en) Glucagon analogues
ZA201104591B (en) Glucagon analogues
ZA201007843B (en) Structured coauthoring
ZA201200261B (en) Cyclohexene 1,4-carboxylates
HK1146064A1 (en) Oxytocin analogues
ZA201106755B (en) Fast-acting insulin formulation
AP2011005896A0 (en) Head assembly.
HK1220701A1 (zh) 胰島素樣肽
GB0812019D0 (en) Insulin
GB0819001D0 (en) Contacts on diamond
HK1156630A1 (en) Schweinfurthin analogues schweinfurthin
AP2544A (en) Pumping arrangement
GB0621847D0 (en) Stabilized creatine
GB0816620D0 (en) Multi-Coloured Codes
GB0816531D0 (en) Multi-coloured codes
GB0712182D0 (en) Protease inhabitors